LIVIVO - Search results -

Search results

Result 1 - 10 of total 58

Book: Myokardinfarkt

Schneider, Simon / Pudritz, Yvonne Marina

Diagnose und Therapie : Vorträge und Arbeitsunterlagen der Fortbildungsveranstaltungen im Frühjahr 2017 in Augsburg, München, Würzburg, Nürnberg und Regensburg

(Schriftenreihe der Bayerischen Landesapothekerkammer ; Heft 94)

2017

Author's details	von Dr. med. Simon Schneider und Dr. Yvonne Hopf
Series title	Schriftenreihe der Bayerischen Landesapothekerkammer ; Heft 94
Collection
Keywords	Akut-PTCA ; Herzinfarkt ; Komplikationen ; Medikamente ; Myokardinfarkt ; Pathophysiologie ; Verfahren ; diagnostische ; klinische Präsentation ; koronare Herzerkrankung ; pharmazeutische Betreuung ; therapeutische
Subject code	610
Language	German
Size	88 Seiten, Illustrationen, 22 cm, 192 g
Edition	[Rot-weiße Ausgabe]
Publisher	Govi
Publishing place	Eschborn
Publishing country	Germany
Document type	Book
HBZ-ID	HT019368418
ISBN	978-3-7741-1353-4 ; 3-7741-1353-X
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2017 A 1115	available for loan (reading room)	Lesesaal EG

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: High-Throughput Miniaturized Synthesis of PROTAC-Like Molecules.

Tian, Ye / Seifermann, Maximilian / Bauer, Liana / Luchena, Charlotte / Wiedmann, Janne J / Schmidt, Stefan / Geisel, Alexander / Afonin, Sergii / Höpfner, Julius / Brehm, Marius / Liu, Xinyong / Hopf, Carsten / Popova, Anna A / Levkin, Pavel A

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2307215

Abstract: The development of miniaturized high-throughput in situ screening platforms capable of handling the entire process of drug synthesis to final screening is essential for advancing drug discovery in the future. In this study, an approach based on ... ...

Abstract	The development of miniaturized high-throughput in situ screening platforms capable of handling the entire process of drug synthesis to final screening is essential for advancing drug discovery in the future. In this study, an approach based on combinatorial solid-phase synthesis, enabling the efficient synthesis of libraries of proteolysis targeting chimeras (PROTACs) in an array format is presented. This on-chip platform allows direct biological screening without the need for transfer steps. UV-induced release of target molecules into individual droplets facilitates further on-chip experimentation. Utilizing a mitogen-activated protein kinase kinases (MEK1/2) degrader as a template, a series of 132 novel PROTAC-like molecules is synthesized using solid-phase Ugi reaction. These compounds are further characterized using various methods, including matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) imaging, while consuming only a few milligrams of starting materials in total. Furthermore, the feasibility of culturing cancer cells on the modified spots and quantifying the effect of MEK suppression is demonstrated. The miniaturized synthesis platform lays a foundation for high-throughput in situ biological screening of potent PROTACs for potential anticancer activity and offers the potential for accelerating the drug discovery process by integrating miniaturized synthesis and biological steps on the same array.
Language	English
Publishing date	2024-01-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202307215
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Reference ranges of oxidative stress biomarkers selected for non-invasive biological surveillance of nanotechnology workers: Study protocol and meta-analysis results for 8-OHdG in exhaled breath condensate.

Hemmendinger, M / Wild, P / Shoman, Y / Graille, M / Bergamaschi, E / Hopf, N / Guseva Canu, I

Toxicology letters

2020 Volume 327, Page(s) 41–47

Abstract: In the field of engineered nanomaterials (ENMs) and other airborne particulate exposure biomonitoring, circulating oxidative stress biomarkers appear promising. These biomarkers could be monitored in different biological matrices. Exhaled breath ... ...

Abstract	In the field of engineered nanomaterials (ENMs) and other airborne particulate exposure biomonitoring, circulating oxidative stress biomarkers appear promising. These biomarkers could be monitored in different biological matrices. Exhaled breath condensate (EBC) enables their measurements in the respiratory tract, without affecting airway function or creating inflammation. The 8-hydroxy-2-deoxyguanosine (8-OHdG) was found increased in the EBC of ENM-exposed workers. Our objectives were to assess the reference range of 8-OHdG in the EBC and to identify determinants of its inter- and intra-individual variability. The meta-analysis was stratified by analytical method (chemical versus immunochemical analysis) and resulted in a between-study variability over 99 % of the total variability. The between-study variability completely dominated the within-studies variability. By using a mixed model with study ID as a random effect rather than a meta-regression, only smoking was evidenced as a potential determinant of 8-OHdG inter-individual variability, and only when immunochemical analysis was used. To our knowledge, this is the first meta-analysis aimed at estimating reference values for 8-OHdG in the EBC. The estimated values should be considered preliminary, as they are based on a limited number of studies, mostly of moderate to low quality of evidence. Further research is necessary to standardize EBC sampling, storage and analytical methods. Such a standardization would enable a more accurate estimation of the reference ranges of the 8-OHdG and potentially other biomarkers measurable in the EBC, which are essential for a meaningful interpretation of the biomonitoring results.
MeSH term(s)	8-Hydroxy-2'-Deoxyguanosine/chemistry ; Biomarkers ; Breath Tests ; Humans ; Nanotechnology ; Occupational Exposure ; Oxidative Stress ; Reference Values
Chemical Substances	Biomarkers ; 8-Hydroxy-2'-Deoxyguanosine (88847-89-6)
Language	English
Publishing date	2020-03-28
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	433788-8
ISSN	1879-3169 ; 0378-4274
ISSN (online)	1879-3169
ISSN	0378-4274
DOI	10.1016/j.toxlet.2020.03.021
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1367: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Structure of CRL7

Hopf, Linus V M / Baek, Kheewoong / Klügel, Maren / von Gronau, Susanne / Xiong, Yue / Schulman, Brenda A

Nature structural & molecular biology

2022 Volume 29, Issue 9, Page(s) 854–862

Abstract: Most cullin-RING ubiquitin ligases (CRLs) form homologous assemblies between a neddylated cullin-RING catalytic module and a variable substrate-binding receptor (for example, an F-box protein). However, the vertebrate-specific ... ...

Abstract	Most cullin-RING ubiquitin ligases (CRLs) form homologous assemblies between a neddylated cullin-RING catalytic module and a variable substrate-binding receptor (for example, an F-box protein). However, the vertebrate-specific CRL7
MeSH term(s)	Carrier Proteins/metabolism ; Catalysis ; Cullin Proteins/chemistry ; Cullin Proteins/metabolism ; F-Box Proteins/metabolism ; Humans ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Chemical Substances	Carrier Proteins ; Cullin 1 ; Cullin Proteins ; F-Box Proteins ; FBXW8 protein, human ; RBX1 protein, human ; Ubiquitin ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2022-08-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2126708-X
ISSN	1545-9985 ; 1545-9993
ISSN (online)	1545-9985
ISSN	1545-9993
DOI	10.1038/s41594-022-00815-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4101: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 56: Show issues

Order via subito

Details ▾

Article ; Online: Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex.

Horn-Ghetko, Daniel / Hopf, Linus V M / Tripathi-Giesgen, Ishita / Du, Jiale / Kostrhon, Sebastian / Vu, D Tung / Beier, Viola / Steigenberger, Barbara / Prabu, J Rajan / Stier, Luca / Bruss, Elias M / Mann, Matthias / Xiong, Yue / Schulman, Brenda A

Nature structural & molecular biology

2024

Abstract: Ubiquitin ligation is typically executed by hallmark E3 catalytic domains. Two such domains, 'cullin-RING' and 'RBR', are individually found in several hundred human E3 ligases, and collaborate with E2 enzymes to catalyze ubiquitylation. However, the ... ...

Abstract	Ubiquitin ligation is typically executed by hallmark E3 catalytic domains. Two such domains, 'cullin-RING' and 'RBR', are individually found in several hundred human E3 ligases, and collaborate with E2 enzymes to catalyze ubiquitylation. However, the vertebrate-specific CUL9 complex with RBX1 (also called ROC1), of interest due to its tumor suppressive interaction with TP53, uniquely encompasses both cullin-RING and RBR domains. Here, cryo-EM, biochemistry and cellular assays elucidate a 1.8-MDa hexameric human CUL9-RBX1 assembly. Within one dimeric subcomplex, an E2-bound RBR domain is activated by neddylation of its own cullin domain and positioning from the adjacent CUL9-RBX1 in trans. Our data show CUL9 as unique among RBX1-bound cullins in dependence on the metazoan-specific UBE2F neddylation enzyme, while the RBR domain protects it from deneddylation. Substrates are recruited to various upstream domains, while ubiquitylation relies on both CUL9's neddylated cullin and RBR domains achieving self-assembled and chimeric cullin-RING/RBR E3 ligase activity.
Language	English
Publishing date	2024-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2126708-X
ISSN	1545-9985 ; 1545-9993
ISSN (online)	1545-9985
ISSN	1545-9993
DOI	10.1038/s41594-024-01257-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4101: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 56: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Imaging Scheme for 3-D High-Frame-Rate Intracardiac Echography: A Simulation Study.

Soozande, Mehdi / Ossenkoppele, Boudewine W / Hopf, Yannick / Pertijs, Michiel A P / Verweij, Martin D / de Jong, Nico / Vos, Hendrik J / Bosch, Johan G

IEEE transactions on ultrasonics, ferroelectrics, and frequency control

2022 Volume 69, Issue 10, Page(s) 2862–2874

Abstract: Atrial fibrillation (AF) is the most common cardiac arrhythmia and is normally treated by RF ablation. Intracardiac echography (ICE) is widely employed during RF ablation procedures to guide the electrophysiologist in navigating the ablation catheter, ... ...

Abstract	Atrial fibrillation (AF) is the most common cardiac arrhythmia and is normally treated by RF ablation. Intracardiac echography (ICE) is widely employed during RF ablation procedures to guide the electrophysiologist in navigating the ablation catheter, although only 2-D probes are currently clinically used. A 3-D ICE catheter would not only improve visualization of the atrium and ablation catheter, but it might also provide the 3-D mapping of the electromechanical wave (EW) propagation pattern, which represents the mechanical response of cardiac tissue to electrical activity. The detection of this EW needs 3-D high-frame-rate imaging, which is generally only realizable in tradeoff with channel count and image quality. In this simulation-based study, we propose a high volume rate imaging scheme for a 3-D ICE probe design that employs 1-D micro-beamforming in the elevation direction. Such a probe can achieve a high frame rate while reducing the channel count sufficiently for realization in a 10-Fr catheter. To suppress the grating-lobe (GL) artifacts associated with micro-beamforming in the elevation direction, a limited number of fan-shaped beams with a wide azimuthal and narrow elevational opening angle are sequentially steered to insonify slices of the region of interest. An angular weighted averaging of reconstructed subvolumes further reduces the GL artifacts. We optimize the transmit beam divergence and central frequency based on the required image quality for EW imaging (EWI). Numerical simulation results show that a set of seven fan-shaped transmission beams can provide a frame rate of 1000 Hz and a sufficient spatial resolution to visualize the EW propagation on a large 3-D surface.
MeSH term(s)	Artifacts ; Atrial Fibrillation/surgery ; Catheter Ablation ; Echocardiography/methods ; Heart Atria/diagnostic imaging ; Humans
Language	English
Publishing date	2022-09-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1525-8955
ISSN (online)	1525-8955
DOI	10.1109/TUFFC.2022.3186487
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Isolation of nuclei from frozen human subcutaneous adipose tissue for full-length single-nuclei transcriptional profiling.

Whytock, Katie L / Divoux, Adeline / Sun, Yifei / Hopf, Meghan / Yeo, Reichelle X / Pino, Maria F / Yu, GongXin / Smith, Steven R / Walsh, Martin J / Sparks, Lauren M

STAR protocols

2023 Volume 4, Issue 1, Page(s) 102054

Abstract: Automated single-cell dispensing is incompatible with white adipose tissue (WAT) due to lipid-laden adipocytes. Single-nuclei RNA-Seq permits transcriptional profiling of all cells from WAT. Human WAT faces unique technical challenges in isolating nuclei ...

Abstract	Automated single-cell dispensing is incompatible with white adipose tissue (WAT) due to lipid-laden adipocytes. Single-nuclei RNA-Seq permits transcriptional profiling of all cells from WAT. Human WAT faces unique technical challenges in isolating nuclei compared to rodent tissue due to greater extra-cellular matrix content and larger lipid droplets. In this protocol, we detail how to isolate nuclei from frozen subcutaneous human WAT for single-nuclei RNA-Seq. For complete information on the generation and use of this protocol, please refer to Whytock et al. (2022).
MeSH term(s)	Humans ; Adipose Tissue, White ; Subcutaneous Fat ; Cell Nucleus/genetics ; Adipocytes ; RNA-Seq
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2666-1667
ISSN (online)	2666-1667
DOI	10.1016/j.xpro.2023.102054
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Nos normes de pratique de la pharmacie favorisent-elles les soins intégrés?

Bond, Christine M / Hopf, Yvonne

The Canadian journal of hospital pharmacy

2014 Volume 67, Issue 1, Page(s) E1–3

Language	French
Publishing date	2014-03-14
Publishing country	Canada
Document type	Journal Article
ZDB-ID	413450-3
ISSN	1920-2903 ; 0008-4123
ISSN (online)	1920-2903
ISSN	0008-4123
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1844: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Do our pharmacy standards promote integrated care?

Bond, Christine M / Hopf, Yvonne

The Canadian journal of hospital pharmacy

2014 Volume 67, Issue 1, Page(s) 5–6

Language	English
Publishing date	2014-03-14
Publishing country	Canada
Document type	Journal Article
ZDB-ID	413450-3
ISSN	1920-2903 ; 0008-4123
ISSN (online)	1920-2903
ISSN	0008-4123
DOI	10.4212/cjhp.v67i1.1314
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1844: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Reference Ranges of 8-Isoprostane Concentrations in Exhaled Breath Condensate (EBC): A Systematic Review and Meta-Analysis.

Shoman, Yara / Wild, Pascal / Hemmendinger, Maud / Graille, Melanie / Sauvain, Jean-Jacques / Hopf, Nancy B / Guseva Canu, Irina

International journal of molecular sciences

2020 Volume 21, Issue 11

Abstract: Isoprostanes are physiopathologic mediators of oxidative stress, resulting in lipid peroxidation. 8-isoprostane seems particularly useful for measuring oxidative stress damage. However, no reference range values are available for 8-isoprosante in exhaled ...

Abstract	Isoprostanes are physiopathologic mediators of oxidative stress, resulting in lipid peroxidation. 8-isoprostane seems particularly useful for measuring oxidative stress damage. However, no reference range values are available for 8-isoprosante in exhaled breath condensate (EBC) of healthy adults, enabling its meaningful interpretation as a biomarker. We conducted this systematic review and meta-analysis according to the protocol following PROSPERO (CRD42020146623). After searching and analyzing the literature, we included 86 studies. After their qualitative synthesis and risk of bias assessment, 52 studies were included in meta-analysis. The latter focused on studies using immunological analytical methods and investigated how the concentrations of 8-isoprostane differ based on gender. We found that gender had no significant effect in 8-isoprostane concentration. Among other studied factors, such as individual characteristics and factors related to EBC collection, only the device used for EBC collection significantly affected measured 8-isoprostane concentrations. However, adjustment for the factors related to EBC collection, yielded uncertainty whether this effect is due to the device itself or to the other factors. Given this uncertainty, we estimated the reference range values of 8-isoprostane stratified by gender and EBC collection device. A better standardization of EBC collection seems necessary; as well more studies using chemical analytical methods to extend this investigation.
MeSH term(s)	Asthma/diagnosis ; Biomarkers/analysis ; Breath Tests/instrumentation ; Dinoprost/analogs & derivatives ; Dinoprost/analysis ; Exhalation ; Female ; Healthy Volunteers ; Humans ; Inflammation ; Lung/drug effects ; Male ; Nitric Oxide/analysis ; Oxidative Stress ; Reference Values ; Sex Factors
Chemical Substances	Biomarkers ; 8-epi-prostaglandin F2alpha (27415-26-5) ; Nitric Oxide (31C4KY9ESH) ; Dinoprost (B7IN85G1HY)
Language	English
Publishing date	2020-05-28
Publishing country	Switzerland
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21113822
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito