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  1. Article ; Online: Correction to: Beyond Response: Aiming for Quality Remission in Depression.

    Kennedy, Sidney H

    Advances in therapy

    2022  Volume 39, Issue 9, Page(s) 4391

    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-022-02247-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Improving the clinical effectiveness of antidepressant treatment

    Kennedy, Sidney H.

    (Journal of affective disorders ; 132, Suppl. 1)

    2011  

    Author's details guest ed.: Sidney H. Kennedy
    Series title Journal of affective disorders ; 132, Suppl. 1
    Collection
    Language English
    Size S28 S. : Ill.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016948775
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Beyond Response: Aiming for Quality Remission in Depression.

    Kennedy, Sidney H

    Advances in therapy

    2022  Volume 39, Issue Suppl 1, Page(s) 20–28

    Abstract: To define treatment response in depression as at least a 50% reduction in total symptom severity is to accept that up to half of patients will continue to have residual symptoms, most commonly low mood/loss of interest, cognitive problems, lack of energy, ...

    Abstract To define treatment response in depression as at least a 50% reduction in total symptom severity is to accept that up to half of patients will continue to have residual symptoms, most commonly low mood/loss of interest, cognitive problems, lack of energy, and difficulty sleeping. In fact, patients' goals for treatment are to return to premorbid levels of functioning. This highlights the importance of assessing both functional outcomes and symptom improvement when evaluating the efficacy of antidepressant medication. Not all patients who achieve symptomatic response/remission will achieve a functional response/remission. In two studies (one with agomelatine and one with escitalopram), 54% of patients receiving agomelatine and 47% of those receiving escitalopram achieved a symptomatic response, and 53% of patients in each study achieved a functional response. However, 42% of patients receiving agomelatine and 35% of those receiving escitalopram had both a symptomatic and a functional response. The four symptoms of depression with the most marked effect on function are sad mood, impaired concentration, fatigue, and loss of interest. Low energy is particularly associated with poor occupational functioning, highlighting the importance of ongoing assessment of patients with depression, focusing particular attention on the symptoms that affect their ability to function, such as fatigue. Depending on the type of residual symptoms, some patients may benefit from combination therapy, such as adding dopamine modulator therapy. Antidepressant therapy is only effective if patients continue to take their medication, and high rates of early discontinuation have been reported. Therefore, when selecting treatment for depression, physicians can maximize the likelihood of adherence and persistence by taking into account both the antidepressant efficacy of treatment, its adverse effects and acceptability to patients.
    MeSH term(s) Antidepressive Agents/therapeutic use ; Combined Modality Therapy ; Depression/drug therapy ; Depressive Disorder, Major/drug therapy ; Fatigue ; Humans
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2022-03-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-021-02030-z
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  4. Book: Treating depression effectively

    Kennedy, Sidney H.

    applying clinical guidelines

    2007  

    Author's details Sidney H. Kennedy
    Keywords Depressive Disorder / therapy
    Language English
    Size [4] Bl., 184 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Informa Healthcare
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015328088
    ISBN 978-0-415-43910-7 ; 0-415-43910-8
    Database Catalogue ZB MED Medicine, Health

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  5. Book: Canadian Network for Mood and Anxiety Treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults

    Kennedy, Sidney H.

    (Journal of affective disorders ; 117, Suppl. 1)

    2009  

    Title variant Clinical guidelines for the management of major depressive disorder in adults
    Institution Canadian Network for Mood and Anxiety Treatments
    Author's details guest ed.: Sidney H. Kennedy
    Series title Journal of affective disorders ; 117, Suppl. 1
    Collection
    Language English
    Size S64 S.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016101872
    Database Catalogue ZB MED Medicine, Health

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  6. Book: Clinical advances in monoamine oxidase inhibitor therapies

    Kennedy, Sidney H.

    (Progress in psychiatry ; 43)

    1994  

    Author's details ed. by Sidney H. Kennedy
    Series title Progress in psychiatry ; 43
    Progress in psychiatry series
    Collection Progress in psychiatry series
    Keywords Monoamine Oxidase Inhibitors / therapeutic use
    Language English
    Size XVI, 302 S. : graph. Darst.
    Edition 1. ed.
    Publisher American Psychiatric Press
    Publishing place Washington, DC u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT006636828
    ISBN 0-88048-474-8 ; 978-0-88048-474-9
    Database Catalogue ZB MED Medicine, Health

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  7. Article ; Online: Dr Uher and Colleagues Reply.

    Uher, Rudolf / Lam, Raymond W / Kennedy, Sidney H

    The Journal of clinical psychiatry

    2020  Volume 82, Issue 1

    MeSH term(s) Aripiprazole ; Citalopram ; Depressive Disorder, Major ; Humans
    Chemical Substances Citalopram (0DHU5B8D6V) ; Aripiprazole (82VFR53I78)
    Language English
    Publishing date 2020-12-08
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.20lr13628a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: More data, more answers: picking the optimal antidepressant.

    Parikh, Sagar V / Kennedy, Sidney H

    Lancet (London, England)

    2018  Volume 391, Issue 10128, Page(s) 1333–1334

    MeSH term(s) Antidepressive Agents
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2018-02-21
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(18)30421-5
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  9. Article ; Online: Vagus Nerve Stimulation: A Treatment in Evolution.

    Bhat, Venkat / Kennedy, Sidney H

    Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology

    2018  Volume 31, Issue 2, Page(s) 99–100

    Language English
    Publishing date 2018-06-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2108112-8
    ISSN 1543-3641 ; 1543-3633
    ISSN (online) 1543-3641
    ISSN 1543-3633
    DOI 10.1097/WNN.0000000000000155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Editorial: mood and anxiety disorders.

    Kennedy, Sidney H / Wittchen, Hans-Ulrich

    Current opinion in psychiatry

    2017  Volume 31, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2017-11-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 645162-7
    ISSN 1473-6578 ; 0951-7367
    ISSN (online) 1473-6578
    ISSN 0951-7367
    DOI 10.1097/YCO.0000000000000386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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