LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: Core Warming of Coronavirus Disease 2019 Patients Undergoing Mechanical Ventilation: A Pilot Study.

    Bonfanti, Nathaniel P / Mohr, Nicholas M / Willms, David C / Bedimo, Roger J / Gundert, Emily / Goff, Kristina L / Kulstad, Erik B / Drewry, Anne M

    Therapeutic hypothermia and temperature management

    2023  Volume 13, Issue 4, Page(s) 225–229

    Abstract: Fever is a recognized protective factor in patients with sepsis, and growing data suggest beneficial effects on outcomes in sepsis with elevated temperature, with a recent pilot randomized controlled trial (RCT) showing lower mortality by warming ... ...

    Abstract Fever is a recognized protective factor in patients with sepsis, and growing data suggest beneficial effects on outcomes in sepsis with elevated temperature, with a recent pilot randomized controlled trial (RCT) showing lower mortality by warming afebrile sepsis patients in the intensive care unit (ICU). The objective of this prospective single-site RCT was to determine if core warming improves respiratory physiology of mechanically ventilated patients with coronavirus disease 2019 (COVID-19), allowing earlier weaning from ventilation, and greater overall survival. A total of 19 patients with mean age of 60.5 (±12.5) years, 37% female, mean weight 95.1 (±18.6) kg, and mean body mass index 34.5 (±5.9) kg/m
    MeSH term(s) Female ; Humans ; Middle Aged ; Male ; COVID-19/therapy ; Respiration, Artificial ; Pilot Projects ; Hypothermia, Induced ; Oxygen ; Sepsis
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2609342-X
    ISSN 2153-7933 ; 2153-7658
    ISSN (online) 2153-7933
    ISSN 2153-7658
    DOI 10.1089/ther.2023.0030
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Considerations for the Use of Intracardiac Echocardiography in Cardiac Arrest.

    Bonfanti, Nathaniel / Gundert, Emily / Malhotra, Anisha / Saleh, Jessica / Kulstad, Erik

    Resuscitation

    2020  Volume 149, Page(s) 158–161

    Abstract: The use of transthoracic echocardiography (TTE) is common during cardiopulmonary resuscitation (CPR) from cardiac arrest, but logistic and practical challenges of obtaining satisfactory images without sacrificing the quality of CPR have resulted in some ... ...

    Abstract The use of transthoracic echocardiography (TTE) is common during cardiopulmonary resuscitation (CPR) from cardiac arrest, but logistic and practical challenges of obtaining satisfactory images without sacrificing the quality of CPR have resulted in some centers utilizing transesophageal echocardiography (TEE) during CPR. Although TEE avoids many of the downsides of TTE, several challenges exist in routine deployment. An alternative approach, intracardiac echocardiography (ICE), is routinely used by electrophysiologists during regular cardiac electrophysiologic procedures, such as atrial ablation for the treatment of atrial fibrillation. In this review, we evaluate various considerations in the potential for use of ICE as a novel means of enhancing resuscitation during CPR.
    MeSH term(s) Atrial Fibrillation ; Cardiopulmonary Resuscitation ; Echocardiography ; Echocardiography, Transesophageal ; Heart Arrest/diagnostic imaging ; Heart Arrest/therapy ; Humans
    Language English
    Publishing date 2020-02-25
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2020.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1048: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Core warming of coronavirus disease 2019 (COVID-19) patients undergoing mechanical ventilation-A protocol for a randomized controlled pilot study.

    Bonfanti, Nathaniel / Gundert, Emily / Drewry, Anne M / Goff, Kristina / Bedimo, Roger / Kulstad, Erik

    PloS one

    2020  Volume 15, Issue 12, Page(s) e0243190

    Abstract: Background: Coronavirus disease 2019 (COVID-19), caused by the virus SARS-CoV-2, is spreading rapidly across the globe, with little proven effective therapy. Fever is seen in most cases of COVID-19, at least at the initial stages of illness. Although ... ...

    Abstract Background: Coronavirus disease 2019 (COVID-19), caused by the virus SARS-CoV-2, is spreading rapidly across the globe, with little proven effective therapy. Fever is seen in most cases of COVID-19, at least at the initial stages of illness. Although fever is typically treated (with antipyretics or directly with ice or other mechanical means), increasing data suggest that fever is a protective adaptive response that facilitates recovery from infectious illness.
    Objective: To describe a randomized controlled pilot study of core warming patients with COVID-19 undergoing mechanical ventilation.
    Methods: This prospective single-site randomized controlled pilot study will enroll 20 patients undergoing mechanical ventilation for respiratory failure due to COVID-19. Patients will be randomized 1:1 to standard-of-care or to receive core warming via an esophageal heat exchanger commonly utilized in critical care and surgical patients. The primary outcome is patient viral load measured by lower respiratory tract sample. Secondary outcomes include severity of acute respiratory distress syndrome (as measured by PaO2/FiO2 ratio) 24, 48, and 72 hours after initiation of treatment, hospital and intensive care unit length of stay, duration of mechanical ventilation, and 30-day mortality.
    Results: Resulting data will provide effect size estimates to guide a definitive multi-center randomized clinical trial. ClinicalTrials.gov registration number: NCT04426344.
    Conclusions: With growing data to support clinical benefits of elevated temperature in infectious illness, this study will provide data to guide further understanding of the role of active temperature management in COVID-19 treatment and provide effect size estimates to power larger studies.
    MeSH term(s) Body Temperature ; COVID-19/physiopathology ; COVID-19/therapy ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Ventilators, Mechanical
    Language English
    Publishing date 2020-12-01
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0243190
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Core warming of coronavirus disease 2019 (COVID-19) patients undergoing mechanical ventilation-A protocol for a randomized controlled pilot study.

    Nathaniel Bonfanti / Emily Gundert / Anne M Drewry / Kristina Goff / Roger Bedimo / Erik Kulstad

    PLoS ONE, Vol 15, Iss 12, p e

    2020  Volume 0243190

    Abstract: Background Coronavirus disease 2019 (COVID-19), caused by the virus SARS-CoV-2, is spreading rapidly across the globe, with little proven effective therapy. Fever is seen in most cases of COVID-19, at least at the initial stages of illness. Although ... ...

    Abstract Background Coronavirus disease 2019 (COVID-19), caused by the virus SARS-CoV-2, is spreading rapidly across the globe, with little proven effective therapy. Fever is seen in most cases of COVID-19, at least at the initial stages of illness. Although fever is typically treated (with antipyretics or directly with ice or other mechanical means), increasing data suggest that fever is a protective adaptive response that facilitates recovery from infectious illness. Objective To describe a randomized controlled pilot study of core warming patients with COVID-19 undergoing mechanical ventilation. Methods This prospective single-site randomized controlled pilot study will enroll 20 patients undergoing mechanical ventilation for respiratory failure due to COVID-19. Patients will be randomized 1:1 to standard-of-care or to receive core warming via an esophageal heat exchanger commonly utilized in critical care and surgical patients. The primary outcome is patient viral load measured by lower respiratory tract sample. Secondary outcomes include severity of acute respiratory distress syndrome (as measured by PaO2/FiO2 ratio) 24, 48, and 72 hours after initiation of treatment, hospital and intensive care unit length of stay, duration of mechanical ventilation, and 30-day mortality. Results Resulting data will provide effect size estimates to guide a definitive multi-center randomized clinical trial. ClinicalTrials.gov registration number: NCT04426344. Conclusions With growing data to support clinical benefits of elevated temperature in infectious illness, this study will provide data to guide further understanding of the role of active temperature management in COVID-19 treatment and provide effect size estimates to power larger studies.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Core warming of coronavirus disease 2019 (COVID-19) patients undergoing mechanical ventilation: protocol for a randomized controlled pilot study

    Bonfanti, Nathaniel / Gundert, Emily / Goff, Kristina / Drewry, Anne / Bedimo, Roger / Kulstad, Erik

    medRxiv

    Abstract: Background: Coronavirus disease 2019 (COVID-19), caused by the virus SARS-CoV-2, is spreading rapidly across the globe, with no proven effective therapy. Fever is seen in most cases of COVID-19, at least at the initial stages of illness. Although fever ... ...

    Abstract Background: Coronavirus disease 2019 (COVID-19), caused by the virus SARS-CoV-2, is spreading rapidly across the globe, with no proven effective therapy. Fever is seen in most cases of COVID-19, at least at the initial stages of illness. Although fever is typically treated (with antipyretics or directly with ice or other mechanical means), increasing data suggest that fever is a protective adaptive response that facilitates recovery from infectious illness. Objective: To describe a randomized controlled pilot study of core warming patients with COVID-19 undergoing mechanical ventilation. Methods: This prospective single-site randomized controlled pilot study will enroll 20 patients undergoing mechanical ventilation for respiratory failure due to COVID-19. Patients will be randomized 1:1 to standard-of-care or to receive core warming via an esophageal heat exchanger commonly utilized in critical care and surgical patients. The primary outcome is the severity of acute respiratory distress syndrome (as measured by PaO2/FiO2 ratio) 24 hours after initiation of treatment. Secondary outcomes include hospital and intensive care unit length of stay, duration of mechanical ventilation, amount of viral shedding, and 30-day mortality. Results: Resulting data will provide effect size estimates to guide a definitive multi-center randomized clinical trial. ClinicalTrials.gov registration number: pending. Conclusions: With growing data to support clinical benefits of elevated temperature in infectious illness, this study will provide data to guide further understanding of the role of active temperature management in COVID-19 treatment and provide effect size estimates to power larger studies.
    Keywords covid19
    Language English
    Publishing date 2020-04-06
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.04.03.20052001
    Database COVID19

    Full text online

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: The Use of Core Warming as a Treatment for Coronavirus Disease 2019 (COVID-19)

    Marcela Mercado-Montoya / Nathaniel Bonfanti / Emily Gundert / Anne Meredith Drewry / Roger Bedimo / Victor Kostov / Konstantin Kostov / Shailee Shah / Erik Kulstad

    Journal of Cardiac Arrhythmias, Vol 33, Iss 1, Pp 6-

    an Initial Mathematical Model

    2020  Volume 15

    Abstract: Introduction: Increasing data suggest that elevated body temperature may be helpful in resolving a variety of diseases, including sepsis, acute respiratory distress syndrome (ARDS), and viral illnesses such as SARS-CoV-2, which causes coronavirus disease ...

    Abstract Introduction: Increasing data suggest that elevated body temperature may be helpful in resolving a variety of diseases, including sepsis, acute respiratory distress syndrome (ARDS), and viral illnesses such as SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19). A mechanical provision of elevated temperature focused in a body region of high viral activity in patients undergoing mechanical ventilation may offer a therapeutic option that avoids arrhythmias seen with some pharmaceutical treatments. This study investigated the potential to actively provide core warming to the lungs of patients with a commercially available heat transfer device via mathematical modeling, and examined the influence of blood perfusion on temperature using this approach. Methods: Using the software Comsol Multiphysics, the authors modeled and simulated heat transfer in the body from an intraesophageal warming device, taking into account the airflow from patient ventilation. The simulation was focused on heat transfer and warming of the lungs and performed on a simplified geometry of an adult human body and airway from the pharynx to the lungs. Results: Simulations were run over a range of values for blood perfusion rate, since the heat capacity and density remain relatively constant. The highest temperature in this case is the device warming water temperature, and that heat diffuses by conduction to the nearby tissues, including the air flowing in the airways. At the range of blood perfusion investigated, maximum lung temperature ranged from 37.6 to 38.6°C. Conclusions: The provision of core warming may offer an innovative approach to treating infectious diseases from viral illnesses such as COVID-19, while avoiding the arrhythmogenic complications of currently used pharmaceutical treatments.
    Keywords covid-19 ; body temperature ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Linceu Editorial
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top