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  1. Book ; Online: Diagnosis and Management of Heart Failure

    Gladysheva, Inna P. / Sullivan, Ryan D.

    2022  

    Keywords Medicine ; Cardiovascular medicine ; biomarkers ; ST-segment elevation myocardial infarction ; preserved left ventricular ejection fraction ; reduced left ventricular ejection fraction ; heart failure ; NT-proBNP ; soluble ST2 ; galectin-3 ; matrix metalloproteinases ; tissue inhibitors of metalloproteinases ; mortality ; ejection fraction ; cardiopulmonary exercise test ; ventilatory inefficiency ; angiotensin receptor-neprilysin inhibitor ; echocardiography ; HFrEF ; risk stratification ; left ventricle end-diastolic diameter ; E/e' ratio ; left ventricle outflow tract velocity-time integral ; hospitalization predictor ; short-term prognosis ; heart failure readmission ; acute myocardial infarction ; blood biomarkers ; diagnosis ; congestion ; clinical assessment ; preserved ejection fraction ; type 2 diabetes mellitus ; myocardial infarction ; chronic heart failure ; heart rate variability ; 2D echocardiography ; 24-h ECG monitoring ; chronic kidney disease ; pulmonary hypertension ; arteriovenous fistulas ; overhydration ; heart transplant ; cardiac allograft vasculopathy ; heart transplant rejection ; transthoracic echocardiography ; longitudinal strain ; sensing parameters ; pacing parameters ; adverse left ventricular remodeling ; left ventricular-arterial coupling ; fatty liver ; cardiovascular disease ; fibrosis ; epicardial fat ; left atrial strain ; edema ; dilated cardiomyopathy ; fluid management ; endothelial dysfunction ; n/a
    Language 0|e
    Size 1 electronic resource (202 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021610740
    ISBN 9783036541532 ; 3036541535
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis.

    Gladysheva, Inna P / Wang, Dong / Reed, Guy L

    The New England journal of medicine

    2024  Volume 390, Issue 16, Page(s) 1538–1539

    MeSH term(s) Humans ; Arrhythmias, Cardiac/genetics ; Cardiomyopathies/genetics ; Fibrosis/genetics ; Heart Atria/pathology ; Heart Atria/diagnostic imaging ; Hypertension/genetics ; Serine Endopeptidases/genetics
    Chemical Substances CORIN protein, human (EC 3.4.21.-) ; Serine Endopeptidases (EC 3.4.21.-)
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2313870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Editorial: Edema in heart failure with reduced ejection fraction.

    Gladysheva, Inna P / Sullivan, Ryan D / Pellicori, Pierpaolo

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1141937

    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1141937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Falling corin and ANP activity levels accelerate development of heart failure and cardiac fibrosis.

    Gladysheva, Inna P / Sullivan, Ryan D / Reed, Guy L

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1120487

    Language English
    Publishing date 2023-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1120487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Advances and Challenges in Diagnosis and Management of Heart Failure.

    Sullivan, Ryan D / Gladysheva, Inna P

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 5

    Abstract: The prevalence of heart failure (HF) with reduced (r) and preserved (p) ejection fraction (EF ...

    Abstract The prevalence of heart failure (HF) with reduced (r) and preserved (p) ejection fraction (EF) continues to rise globally despite current advances in diagnostics and improvements to medical management [...].
    Language English
    Publishing date 2022-04-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12051103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Advances and Challenges in Diagnosis and Management of Heart Failure

    Ryan D. Sullivan / Inna P. Gladysheva

    Diagnostics, Vol 12, Iss 1103, p

    2022  Volume 1103

    Abstract: The prevalence of heart failure (HF) with reduced (r) and preserved (p) ejection fraction (EF ...

    Abstract The prevalence of heart failure (HF) with reduced (r) and preserved (p) ejection fraction (EF) continues to rise globally despite current advances in diagnostics and improvements to medical management [.]
    Keywords n/a ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Neprilysin and Corin in HF: Does Combining 2 Biomarkers Double Our Insights?

    Gladysheva, Inna P / Sullivan, Ryan D / Reed, Guy L

    JACC. Heart failure

    2021  Volume 9, Issue 5, Page(s) 406

    MeSH term(s) Biomarkers ; Heart Failure ; Humans ; Natriuretic Peptide, Brain ; Neprilysin ; Serine Endopeptidases
    Chemical Substances Biomarkers ; Natriuretic Peptide, Brain (114471-18-0) ; CORIN protein, human (EC 3.4.21.-) ; Serine Endopeptidases (EC 3.4.21.-) ; Neprilysin (EC 3.4.24.11)
    Language English
    Publishing date 2021-04-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2021.01.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Soluble (Pro)Renin Receptor Levels Are Regulated by Plasma Renin Activity and Correlated with Edema in Mice and Humans with HFrEF.

    Gladysheva, Inna P / Sullivan, Ryan D / Ramanathan, Kodangudi / Reed, Guy L

    Biomedicines

    2022  Volume 10, Issue 8

    Abstract: ... pro)renin receptor (s(P)RR) is released into circulation by proteolytic cleavage of tissue expressed ... P)RR and is a candidate biomarker of RAAS activation. However, previous studies linked elevated ... levels of s(P)RR in patients with HFrEF to renal dysfunction. Utilizing prospectively enrolled patients ...

    Abstract Symptomatic heart failure with reduced ejection fraction (HFrEF) is characterized by edema and chronic pathological activation of the classical renin-angiotensin-aldosterone system (RAAS). The soluble (pro)renin receptor (s(P)RR) is released into circulation by proteolytic cleavage of tissue expressed (P)RR and is a candidate biomarker of RAAS activation. However, previous studies linked elevated levels of s(P)RR in patients with HFrEF to renal dysfunction. Utilizing prospectively enrolled patients with comparable rEF, we show that increased plasma levels of s(P)RR are associated with symptomatic HF (characterized by edema), independent of chronic renal dysfunction. We also found that s(P)RR levels were positively correlated with patient plasma renin activity (PRA). Normotensive mice with dilated cardiomyopathy (DCM) and HFrEF, without renal dysfunction, showed plasma s(P)RR and PRA patterns similar to human HFrEF patients. Plasma s(P)RR levels positively correlated with PRA and systemic edema, but not with EF, resembling findings in patients with HFrEF without chronic kidney dysfunction. In female DCM mice with elevated PRA levels and plasma s(P)RR levels, a randomized, blinded trial comparing the direct renin inhibitor, aliskiren vs. vehicle control, showed that direct renin inhibition normalized PRA, lowered s(P)RR, and prevented symptomatic HFrEF. Considered in light of previous findings, these data suggest that, in HFrEF, in the absence of renal dysfunction, elevation of plasma s(P)RR levels is caused by increased PRA and associated with the development of systemic edema.
    Language English
    Publishing date 2022-08-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10081874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The anionic protease inhibitor BWI-1 from buckwheat seeds. Kinetic properties and possible biological role.

    Dunaevsky, Yakov E / Gladysheva, Inna P / Pavlukova, Ekaterina B / Beliakova, Galina A / Gladyshev, Dmitry P / Papisova, Alla I / Larionova, Natalja I / Belozersky, Mikhail A

    Physiologia plantarum

    2023  Volume 101, Issue 3, Page(s) 483–488

    Abstract: ... at the P ...

    Abstract Kinetic characteristics and effects on the growth of filamentous fungi of one of the main anionic protease inhibitors, BWI-1, isolated from buckwheat seeds, have been studied. The inhibition constants of bovine trypsin, chymotrypsin and cathepsin G from human granulocytes with BWI-1 were found to be 1.1, 67 and 200 nM, respectively. Analysis of the amino acid sequence of BWI-1 in the vicinity of the reactive site revealed its homology to the potato proteinase inhibitor I family. It is suggested that the inability of BWI-1 to bind elastase of human granulocytes is due to the basic nature of the amino acid residue (Arg) at the P
    Language English
    Publishing date 2023-06-20
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 2020837-6
    ISSN 1399-3054 ; 0031-9317
    ISSN (online) 1399-3054
    ISSN 0031-9317
    DOI 10.1111/j.1399-3054.1997.tb01027.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Suppression of Cardiogenic Edema with Sodium-Glucose Cotransporter-2 Inhibitors in Heart Failure with Reduced Ejection Fraction: Mechanisms and Insights from Pre-Clinical Studies.

    Sullivan, Ryan D / McCune, Mariana E / Hernandez, Michelle / Reed, Guy L / Gladysheva, Inna P

    Biomedicines

    2022  Volume 10, Issue 8

    Abstract: In heart failure with reduced ejection fraction (HFrEF), cardiogenic edema develops from impaired cardiac function, pathological remodeling, chronic inflammation, endothelial dysfunction, neurohormonal activation, and altered nitric oxide-related ... ...

    Abstract In heart failure with reduced ejection fraction (HFrEF), cardiogenic edema develops from impaired cardiac function, pathological remodeling, chronic inflammation, endothelial dysfunction, neurohormonal activation, and altered nitric oxide-related pathways. Pre-clinical HFrEF studies have shown that treatment with sodium-glucose cotransporter-2 inhibitors (SGLT-2i) stimulates natriuretic and osmotic/diuretic effects, improves overall cardiac function, attenuates maladaptive cardiac remodeling, and reduces chronic inflammation, oxidative stress, and endothelial dysfunction. Here, we review the mechanisms and effects of SGLT-2i therapy on cardiogenic edema in various models of HFrEF. Overall, the data presented suggest a high translational importance of these studies, and pre-clinical studies show that SGLT-2i therapy has a marked effect on suppressing the progression of HFrEF through multiple mechanisms, including those that affect the development of cardiogenic edema.
    Language English
    Publishing date 2022-08-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10082016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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