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  1. Article ; Online: Subconjunctival triamcinolone injection for infectious necrotizing scleritis.

    Santos, Matthew C / Paley, Grace L / El Sayyad, Fouad / Sollenberger, Eric L / Huang, Andrew J W

    The ocular surface

    2022  Volume 26, Page(s) 97–99

    Language English
    Publishing date 2022-08-09
    Publishing country United States
    Document type Letter
    ZDB-ID 2208578-6
    ISSN 1937-5913 ; 1542-0124
    ISSN (online) 1937-5913
    ISSN 1542-0124
    DOI 10.1016/j.jtos.2022.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tofacitinib for refractory ocular mucous membrane pemphigoid.

    James, Hayley / Paley, Grace L / Brasington, Richard / Custer, Philip L / Margolis, Todd P / Paley, Michael A

    American journal of ophthalmology case reports

    2021  Volume 22, Page(s) 101104

    Abstract: Purpose: To report the successful use of tofacitinib in the treatment of refractory ocular mucous membrane pemphigoid (MMP).: Observations: Two patients with ocular MMP presented with refractory disease after failure of multiple therapies. Treatment ... ...

    Abstract Purpose: To report the successful use of tofacitinib in the treatment of refractory ocular mucous membrane pemphigoid (MMP).
    Observations: Two patients with ocular MMP presented with refractory disease after failure of multiple therapies. Treatment with tofacitinib led to durable control of conjunctival inflammation within 8 weeks and no apparent progression of sub-conjunctival fibrosis. One patient maintained absence of apparent disease activity over 16 months of follow-up. Cessation of tofacitinib in the other patient led to disease relapse which was reversed by re-initiation of therapy.
    Conclusions and importance: Small molecule inhibitors of Janus kinases, such as tofacitinib, may offer an effective treatment option for refractory ocular MMP.
    Language English
    Publishing date 2021-04-21
    Publishing country United States
    Document type Case Reports
    ISSN 2451-9936
    ISSN (online) 2451-9936
    DOI 10.1016/j.ajoc.2021.101104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Histopathologic Analysis of Explanted KAMRA Corneal Inlays Demonstrating Adherent Fibroconnective Tissue Scar Formation.

    Paley, Grace L / Harocopos, George J

    Ocular oncology and pathology

    2019  Volume 5, Issue 6, Page(s) 440–444

    Abstract: Objective: To investigate the histologic composition of opaque membranes associated with corneal intrastromal inlays implanted for the surgical treatment of presbyopia.: Methods: This is an observational case series of KAMRA corneal inlays explanted ... ...

    Abstract Objective: To investigate the histologic composition of opaque membranes associated with corneal intrastromal inlays implanted for the surgical treatment of presbyopia.
    Methods: This is an observational case series of KAMRA corneal inlays explanted due to the presence of adherent opaque membranes associated with peri-inlay corneal stromal haze and sent for histopathologic analysis. Routine histology was performed in addition to immunohistochemical staining with myofibroblast and keratocyte markers.
    Results: Eleven explanted inlay specimens were received, of which, after histologic processing, four demonstrated suf-ficient cellular material for histopathologic analysis. The opaque membranes surrounding the explanted inlays were composed of fibroconnective tissue, and myofibroblasts (positive for smooth muscle actin immunostain) were the predominant cell type. Immunostaining for the keratocyte marker CD34 was negative, confirming that the membranes were the result of a reactive scar-tissue formation process and not simply normal corneal stroma adherent to the explant.
    Conclusions: Corneal inlay implantation can lead to the formation of an adherent fibroconnective tissue membrane, suggesting keratocyte-to-myofibroblast transdifferentiation and reactive fibroconnective tissue scar formation that could potentially impact visual potential. Prospective patients should be counseled regarding the risk of this complication, as this may be associated with some risk of incomplete reversibility of the procedure.
    Language English
    Publishing date 2019-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2806965-1
    ISSN 2296-4657 ; 2296-4681
    ISSN (online) 2296-4657
    ISSN 2296-4681
    DOI 10.1159/000498944
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  4. Article ; Online: Aqueous Macrophages Contribute to Conserved CCL2 and CXCL10 Gradients in Uveitis.

    Lin, Joseph B / Pepple, Kathryn L / Concepcion, Christian / Korshunova, Yulia / Paley, Michael A / Paley, Grace L / Laurent, Jennifer / Apte, Rajendra S / Hassman, Lynn M

    Ophthalmology science

    2023  Volume 4, Issue 4, Page(s) 100453

    Abstract: Purpose: Uveitis is a heterogenous group of inflammatory eye disease for which current cytokine-targeted immune therapies are effective for only a subset of patients. We hypothesized that despite pathophysiologic nuances that differentiate individual ... ...

    Abstract Purpose: Uveitis is a heterogenous group of inflammatory eye disease for which current cytokine-targeted immune therapies are effective for only a subset of patients. We hypothesized that despite pathophysiologic nuances that differentiate individual disease states, all forms of eye inflammation might share common mechanisms for immune cell recruitment. Identifying these mechanisms is critical for developing novel, broadly acting therapeutic strategies.
    Design: Experimental study.
    Subjects: Biospecimens from patients with active or inactive uveitis and healthy controls.
    Methods: Protein concentration and single cell gene expression were assessed in aqueous fluid biopsies and plasma samples from deidentified patients with uveitis or healthy controls.
    Main outcome measures: The concentration of 31 inflammatory proteins was measured in all aqueous samples, as well as plasma samples from patients with active uveitis. Chemokine and cytokine ligand and receptor expression were assessed in individual cell types from aqueous biopsies obtained from patients with active uveitis.
    Results: We identified 6 chemokines that were both elevated in active uveitis compared with controls and enriched in aqueous compared with plasma during active uveitis (C-C motif chemokine ligand [CCL]2, C-X-C motif chemokine ligand [CXCL]10, CXCL9, CXCL8, CCL3, and CCL14), forming potential gradients for migration of immune cells from the blood to the eye. Of these, CCL2 and CXCL10 were consistently enriched in the aqueous of all patients in our cohort, as well as in a larger cohort of patients from a previously published study. These data suggest that CCL2 and CXCL10 are key mediators in immune cell migration to the eye during uveitis. Next, single cell RNA sequencing suggested that macrophages contribute to aqueous enrichment of CCL2 and CXCL10 during human uveitis. Finally, using chemokine ligand and receptor expression mapping, we identified a broad signaling network for macrophage-derived CCL2 and CXCL10 in human uveitis.
    Conclusions: These data suggest that ocular macrophages may play a central role, via CCL2 and CXCL10 production, in recruiting inflammatory cells to the eye in patients with uveitis.
    Financial disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
    Language English
    Publishing date 2023-12-14
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-9145
    ISSN (online) 2666-9145
    DOI 10.1016/j.xops.2023.100453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effects of acetazolamide on linear growth in children with pseudotumor cerebri syndrome

    Claire A. Sheldon / Sara N. Reggie / Grace L. Paley / Shana E. McCormack / Grant T. Liu

    Frontiers in Ophthalmology, Vol

    2023  Volume 2

    Abstract: Background/introductionWhile oral acetazolamide is a cornerstone of management of adult and pediatric PTCS, previous studies have suggested that acetazolamide used in children with other conditions may influence growth.Aims and methodsRetrospective chart ...

    Abstract Background/introductionWhile oral acetazolamide is a cornerstone of management of adult and pediatric PTCS, previous studies have suggested that acetazolamide used in children with other conditions may influence growth.Aims and methodsRetrospective chart review involving a single tertiary medical center. Thirty-four children with definite or probable PTCS were identified. Analysis was restricted to individuals from whom anthropometric data were available before and during acetazolamide treatment (n=22).ResultsHalf of individuals (n=11/22) showed a decline in BMI Z-scores. Sixty-three percent (n=14/22) showed a decrease in height Z-scores during treatment with acetazolamide; in 6 of these 14 children who had complete data, 3 showed at least a partial recovery of height Z-scores after discontinuation of acetazolamide.ConclusionAcetazolamide may be associated with growth suppression in some children treated for pediatric PTCS. In some cases, the growth suppression appears to reverse once the acetazolamide is stopped.
    Keywords acetazolamide ; pseudotumor cerebri (PTC) ; idiopathic intracranial hypertension (IIH) ; weight ; growth ; Medicine ; R
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Histopathologic Analysis of Explanted KAMRA Corneal Inlays Demonstrating Adherent Fibroconnective Tissue Scar Formation

    Paley, Grace L. / Harocopos, George J.

    Ocular Oncology and Pathology

    2019  Volume 5, Issue 6, Page(s) 440–444

    Abstract: Objective: To investigate the histologic composition of opaque membranes associated with corneal intrastromal inlays implanted for the surgical treatment of presbyopia. Methods: This is an observational case series of KAMRA corneal inlays explanted due ... ...

    Institution Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA
    Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
    Abstract Objective: To investigate the histologic composition of opaque membranes associated with corneal intrastromal inlays implanted for the surgical treatment of presbyopia. Methods: This is an observational case series of KAMRA corneal inlays explanted due to the presence of adherent opaque membranes associated with peri-inlay corneal stromal haze and sent for histopathologic analysis. Routine histology was performed in addition to immunohistochemical staining with myofibroblast and keratocyte markers. Results: Eleven explanted inlay specimens were received, of which, after histologic processing, four demonstrated suf­ficient cellular material for histopathologic analysis. The opaque membranes surrounding the explanted inlays were composed of fibroconnective tissue, and myofibroblasts (positive for smooth muscle actin immunostain) were the predominant cell type. Immunostaining for the keratocyte marker CD34 was negative, confirming that the membranes were the result of a reactive scar-tissue formation process and not simply normal corneal stroma adherent to the explant. Conclusions: Corneal inlay implantation can lead to the formation of an adherent fibroconnective tissue membrane, suggesting keratocyte-to-myofibroblast transdifferentiation and reactive fibroconnective tissue scar formation that could potentially impact visual potential. Prospective patients should be counseled regarding the risk of this complication, as this may be associated with some risk of incomplete reversibility of the procedure.
    Keywords Corneal inlay ; Inlay explant ; Fibroconnective tissue scar ; Presbyopia
    Language English
    Publishing date 2019-04-17
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Research Article
    ZDB-ID 2806965-1
    ISSN 2296-4657 ; 2296-4681
    ISSN (online) 2296-4657
    ISSN 2296-4681
    DOI 10.1159/000498944
    Database Karger publisher's database

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  7. Article ; Online: Conjunctival Lesion in a Patient With Ocular Graft-vs-Host Disease.

    Paley, Grace L / Farooq, Asim V / Lubniewski, Anthony J

    JAMA ophthalmology

    2017  Volume 135, Issue 8, Page(s) 883–884

    MeSH term(s) Aged ; Antineoplastic Agents/therapeutic use ; Bone Marrow Transplantation/adverse effects ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/etiology ; Carcinoma, Squamous Cell/therapy ; Combined Modality Therapy ; Conjunctival Neoplasms/diagnosis ; Conjunctival Neoplasms/etiology ; Conjunctival Neoplasms/therapy ; Cryotherapy ; Graft vs Host Disease/drug therapy ; Graft vs Host Disease/etiology ; Humans ; Immunosuppressive Agents/therapeutic use ; Interferon alpha-2/therapeutic use ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Leukemia, Lymphocytic, Chronic, B-Cell/therapy ; Male ; Tacrolimus/therapeutic use ; Transplantation, Homologous
    Chemical Substances Antineoplastic Agents ; Immunosuppressive Agents ; Interferon alpha-2 ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2017-05-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2016.5483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul I Zs.26: Show issues Location:
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  8. Article: Autism Spectrum Disorder in Pediatric Idiopathic Intracranial Hypertension.

    Jensen, Anne K / Sheldon, Claire A / Paley, Grace L / Szperka, Christina L / Liu, Geraldine W / Liu, Grant T / McCormack, Shana E

    Life (Basel, Switzerland)

    2021  Volume 11, Issue 9

    Abstract: In recent years, the substantial burden of medical comorbidities in autism spectrum disorder (ASD) populations has been described. We report a retrospective observational case series of pediatric patients with suspected idiopathic intracranial ... ...

    Abstract In recent years, the substantial burden of medical comorbidities in autism spectrum disorder (ASD) populations has been described. We report a retrospective observational case series of pediatric patients with suspected idiopathic intracranial hypertension (IIH) and concurrent ASD. Pediatric subjects with suspected IIH aged 2-18 years were identified by review of a pediatric neuro-ophthalmologist's database spanning from July 1993 to April 2013. ASD diagnoses were identified within this cohort by an ICD-9 diagnosis code search and database review. Three subjects had concurrent ASD diagnoses; all were non-obese males. Since the retrospective observational case series was performed in April 2013, we identified three additional IIH cases in boys with ASD. Our experience suggests that IIH may be a comorbidity of ASD, particularly in non-obese boys.
    Language English
    Publishing date 2021-09-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life11090972
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  9. Article: Corneal-Based Surgical Presbyopic Therapies and Their Application in Pseudophakic Patients.

    Paley, Grace L / Chuck, Roy S / Tsai, Linda M

    Journal of ophthalmology

    2016  Volume 2016, Page(s) 5263870

    Abstract: Purpose. The purpose of this review is to provide a summary of laser refractive surgery and corneal inlay approaches to treat presbyopia in patients after cataract surgery. Summary. The presbyopic population is growing rapidly along with increasing ... ...

    Abstract Purpose. The purpose of this review is to provide a summary of laser refractive surgery and corneal inlay approaches to treat presbyopia in patients after cataract surgery. Summary. The presbyopic population is growing rapidly along with increasing demands for spectacle independence. This review will focus on the corneal-based surgical options to address presbyopia including various types of corneal intrastromal inlays and laser ablation techniques to generate either a multifocal cornea ("PresbyLASIK") or monovision. The natural history of presbyopia develops prior to cataracts, and these presbyopic surgeries have been largely studied in phakic patients. Nevertheless, pseudophakic patients may also undergo these presbyopia-compensating procedures for enhanced quality of life. This review examines the published reports that apply these technologies to patients after cataract surgery and discusses unique considerations for this population.
    Language English
    Publishing date 2016-03-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2546525-9
    ISSN 2090-0058 ; 2090-004X
    ISSN (online) 2090-0058
    ISSN 2090-004X
    DOI 10.1155/2016/5263870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Toxic Keratoconjunctivitis.

    Paley, Grace L / Lubniewski, Anthony J / Reidy, James J / Farooq, Asim V

    Eye & contact lens

    2017  Volume 44 Suppl 1, Page(s) S8–S15

    Abstract: Toxic keratoconjunctivitis (TK) is an underrecognized complication of ophthalmic drug use and various environmental or occupational exposures. A detailed history and clinical examination are important to identify the offending agent(s). Common drug- ... ...

    Abstract Toxic keratoconjunctivitis (TK) is an underrecognized complication of ophthalmic drug use and various environmental or occupational exposures. A detailed history and clinical examination are important to identify the offending agent(s). Common drug-related causes of TK include preservatives in ophthalmic medications, topical antimicrobials, and topical anesthetics. Alternatives to benzalkonium chloride as well as preservative-free formulations should be considered in patients requiring long-term topical medication. More advanced cases of TK may require preservative-free topical steroids and/or antibiotics, and occasionally surgical intervention. Early recognition and appropriate management of TK may help prevent permanent ocular and visual damage.
    MeSH term(s) Anesthetics/adverse effects ; Anti-Bacterial Agents/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Antihypertensive Agents/adverse effects ; Benzalkonium Compounds/adverse effects ; Humans ; Keratoconjunctivitis/chemically induced ; Keratoconjunctivitis/physiopathology ; Keratoconjunctivitis/therapy ; Ophthalmic Solutions/adverse effects ; Preservatives, Pharmaceutical/adverse effects
    Chemical Substances Anesthetics ; Anti-Bacterial Agents ; Anti-Inflammatory Agents, Non-Steroidal ; Antihypertensive Agents ; Benzalkonium Compounds ; Ophthalmic Solutions ; Preservatives, Pharmaceutical
    Language English
    Publishing date 2017-05-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2103049-2
    ISSN 1542-233X ; 1542-2321
    ISSN (online) 1542-233X
    ISSN 1542-2321
    DOI 10.1097/ICL.0000000000000392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1724: Show issues Location:
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