LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article ; Online: A Role for the Superior Colliculus in Decision Criteria.

    Crapse, Trinity B / Lau, Hakwan / Basso, Michele A

    Neuron

    2018  Volume 97, Issue 1, Page(s) 181–194.e6

    Abstract: Simple decisions arise from the evaluation of sensory evidence. But decisions are determined by more than just evidence. Individuals establish internal decision criteria that influence how they respond. Where or how decision criteria are established in ... ...

    Abstract Simple decisions arise from the evaluation of sensory evidence. But decisions are determined by more than just evidence. Individuals establish internal decision criteria that influence how they respond. Where or how decision criteria are established in the brain remains poorly understood. Here, we show that neuronal activity in the superior colliculus (SC) predicts changes in decision criteria. Using a novel "Yes-No" task that isolates changes in decision criterion from changes in decision sensitivity, and computing neuronal measures of sensitivity and criterion, we find that SC neuronal activity correlates with the decision criterion regardless of the location of the choice report. We also show that electrical manipulation of activity within the SC produces changes in decisions consistent with changes in decision criteria and are largely independent of the choice report location. Our correlational and causal results together provide strong evidence that SC activity signals the position of a decision criterion. VIDEO ABSTRACT.
    MeSH term(s) Animals ; Decision Making/physiology ; Macaca mulatta ; Male ; Neurons/physiology ; Superior Colliculi/physiology
    Language English
    Publishing date 2018-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2017.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 92: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Insights into decision making using choice probability.

    Crapse, Trinity B / Basso, Michele A

    Journal of neurophysiology

    2015  Volume 114, Issue 6, Page(s) 3039–3049

    Abstract: A long-standing question in systems neuroscience is how the activity of single neurons gives rise to our perceptions and actions. Critical insights into this question occurred in the last part of the 20th century when scientists began linking modulations ...

    Abstract A long-standing question in systems neuroscience is how the activity of single neurons gives rise to our perceptions and actions. Critical insights into this question occurred in the last part of the 20th century when scientists began linking modulations of neuronal activity directly to perceptual behavior. A significant conceptual advance was the application of signal detection theory to both neuronal activity and behavior, providing a quantitative assessment of the relationship between brain and behavior. One metric that emerged from these efforts was choice probability (CP), which provides information about how well an ideal observer can predict the choice an animal makes from a neuron's discharge rate distribution. In this review, we describe where CP has been studied, locational trends in the values found, and why CP values are typically so low. We discuss its dependence on correlated activity among neurons of a population, assess whether it arises from feedforward or feedback mechanisms, and investigate what CP tells us about how many neurons are required for a decision and how they are pooled to do so.
    MeSH term(s) Animals ; Brain/physiology ; Choice Behavior ; Feedback, Physiological ; Humans ; Models, Neurological ; Probability
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80161-6
    ISSN 1522-1598 ; 0022-3077
    ISSN (online) 1522-1598
    ISSN 0022-3077
    DOI 10.1152/jn.00335.2015
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.224: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Frontal eye field neurons assess visual stability across saccades.

    Crapse, Trinity B / Sommer, Marc A

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2012  Volume 32, Issue 8, Page(s) 2835–2845

    Abstract: The image on the retina may move because the eyes move, or because something in the visual scene moves. The brain is not fooled by this ambiguity. Even as we make saccades, we are able to detect whether visual objects remain stable or move. Here we test ... ...

    Abstract The image on the retina may move because the eyes move, or because something in the visual scene moves. The brain is not fooled by this ambiguity. Even as we make saccades, we are able to detect whether visual objects remain stable or move. Here we test whether this ability to assess visual stability across saccades is present at the single-neuron level in the frontal eye field (FEF), an area that receives both visual input and information about imminent saccades. Our hypothesis was that neurons in the FEF report whether a visual stimulus remains stable or moves as a saccade is made. Monkeys made saccades in the presence of a visual stimulus outside of the receptive field. In some trials, the stimulus remained stable, but in other trials, it moved during the saccade. In every trial, the stimulus occupied the center of the receptive field after the saccade, thus evoking a reafferent visual response. We found that many FEF neurons signaled, in the strength and timing of their reafferent response, whether the stimulus had remained stable or moved. Reafferent responses were tuned for the amount of stimulus translation, and, in accordance with human psychophysics, tuning was better (more prevalent, stronger, and quicker) for stimuli that moved perpendicular, rather than parallel, to the saccade. Tuning was sometimes present as well for nonspatial transaccadic changes (in color, size, or both). Our results indicate that FEF neurons evaluate visual stability during saccades and may be general purpose detectors of transaccadic visual change.
    MeSH term(s) Action Potentials/physiology ; Analysis of Variance ; Animals ; Brain Mapping ; Female ; Fixation, Ocular ; Frontal Lobe/cytology ; Macaca mulatta ; Male ; Orientation ; Photic Stimulation ; Psychophysics ; Reaction Time ; Saccades ; Sensory Receptor Cells/physiology ; Visual Fields
    Language English
    Publishing date 2012-02-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.1320-11.2012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Frontal eye field neurons with spatial representations predicted by their subcortical input.

    Crapse, Trinity B / Sommer, Marc A

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2009  Volume 29, Issue 16, Page(s) 5308–5318

    Abstract: The frontal eye field (FEF) is a cortical structure involved in cognitive aspects of eye movement control. Neurons in the FEF, as in most of cerebral cortex, primarily represent contralateral space. They fire for visual stimuli in the contralateral field ...

    Abstract The frontal eye field (FEF) is a cortical structure involved in cognitive aspects of eye movement control. Neurons in the FEF, as in most of cerebral cortex, primarily represent contralateral space. They fire for visual stimuli in the contralateral field and for saccadic eye movements made to those stimuli. Yet many FEF neurons engage in sophisticated functions that require flexible spatial representations such as shifting receptive fields and vector subtraction. Such functions require knowledge about all of space, including the ipsilateral hemifield. How does the FEF gain access to ipsilateral information? Here, we provide evidence that one source of ipsilateral information may be the opposite superior colliculus (SC) in the midbrain. We physiologically identified neurons in the FEF that receive input from the opposite SC, same-side SC, or both. We found a striking structure-function relationship: the laterality of the response field of an FEF neuron was predicted by the laterality of its SC inputs. FEF neurons with input from the opposite SC had ipsilateral fields, whereas neurons with input from the same-side SC had contralateral fields. FEF neurons with input from both SCs had lateralized fields that could point in any direction. The results suggest that signals from the two SCs provide each FEF with information about all of visual space, a prerequisite for higher level sensorimotor computations.
    MeSH term(s) Animals ; Cerebral Cortex/physiology ; Macaca mulatta ; Neurons/physiology ; Photic Stimulation/methods ; Predictive Value of Tests ; Psychomotor Performance/physiology ; Superior Colliculi/physiology ; Visual Fields/physiology ; Visual Pathways/physiology
    Language English
    Publishing date 2009-04-22
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.4906-08.2009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: The frontal eye field as a prediction map.

    Crapse, Trinity B / Sommer, Marc A

    Progress in brain research

    2008  Volume 171, Page(s) 383–390

    Abstract: Predictive processes are widespread in the motor and sensory areas of the primate brain. They enable rapid computations despite processing delays and assist in resolving noisy, ambiguous input. Here we propose that the frontal eye field, a cortical area ... ...

    Abstract Predictive processes are widespread in the motor and sensory areas of the primate brain. They enable rapid computations despite processing delays and assist in resolving noisy, ambiguous input. Here we propose that the frontal eye field, a cortical area devoted to sensorimotor aspects of eye movement control, implements a prediction map of the postsaccadic visual scene for the purpose of constructing a stable percept despite saccadic eye movements.
    MeSH term(s) Animals ; Humans ; Macaca mulatta ; Models, Biological ; Saccades/physiology ; Visual Fields/physiology ; Visual Perception/physiology
    Language English
    Publishing date 2008-08-22
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1875-7855 ; 0079-6123
    ISSN (online) 1875-7855
    ISSN 0079-6123
    DOI 10.1016/S0079-6123(08)00656-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Corollary discharge circuits in the primate brain.

    Crapse, Trinity B / Sommer, Marc A

    Current opinion in neurobiology

    2008  Volume 18, Issue 6, Page(s) 552–557

    Abstract: Movements are necessary to engage the world, but every movement results in sensorimotor ambiguity. Self-movements cause changes to sensory inflow as well as changes in the positions of objects relative to motor effectors (eyes and limbs). Hence the brain ...

    Abstract Movements are necessary to engage the world, but every movement results in sensorimotor ambiguity. Self-movements cause changes to sensory inflow as well as changes in the positions of objects relative to motor effectors (eyes and limbs). Hence the brain needs to monitor self-movements, and one way this is accomplished is by routing copies of movement commands to appropriate structures. These signals, known as corollary discharge (CD), enable compensation for sensory consequences of movement and preemptive updating of spatial representations. Such operations occur with a speed and accuracy that implies a reliance on prediction. Here we review recent CD studies and find that they arrive at a shared conclusion: CD contributes to prediction for the sake of sensorimotor harmony.
    MeSH term(s) Animals ; Behavior/physiology ; Behavior, Animal/physiology ; Brain/physiology ; Electrophysiology ; Humans ; Nerve Net/physiology ; Primates/physiology ; Vocalization, Animal/physiology
    Language English
    Publishing date 2008-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2008.09.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Corollary discharge across the animal kingdom.

    Crapse, Trinity B / Sommer, Marc A

    Nature reviews. Neuroscience

    2008  Volume 9, Issue 8, Page(s) 587–600

    Abstract: Our movements can hinder our ability to sense the world. Movements can induce sensory input (for example, when you hit something) that is indistinguishable from the input that is caused by external agents (for example, when something hits you). It is ... ...

    Abstract Our movements can hinder our ability to sense the world. Movements can induce sensory input (for example, when you hit something) that is indistinguishable from the input that is caused by external agents (for example, when something hits you). It is critical for nervous systems to be able to differentiate between these two scenarios. A ubiquitous strategy is to route copies of movement commands to sensory structures. These signals, which are referred to as corollary discharge (CD), influence sensory processing in myriad ways. Here we review the CD circuits that have been uncovered by neurophysiological studies and suggest a functional taxonomic classification of CD across the animal kingdom. This broad understanding of CD circuits lays the groundwork for more challenging studies that combine neurophysiology and psychophysics to probe the role of CD in perception.
    MeSH term(s) Action Potentials/physiology ; Animals ; Central Nervous System/cytology ; Central Nervous System/physiology ; Motor Neurons/physiology ; Movement/physiology ; Neural Pathways/cytology ; Neural Pathways/physiology ; Neurons, Afferent/physiology ; Perception/physiology ; Peripheral Nervous System/cytology ; Peripheral Nervous System/physiology ; Sensation/physiology ; Synaptic Transmission/physiology
    Language English
    Publishing date 2008-07-20
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2034150-7
    ISSN 1471-0048 ; 1471-0048 ; 1471-003X
    ISSN (online) 1471-0048
    ISSN 1471-0048 ; 1471-003X
    DOI 10.1038/nrn2457
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 47: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top