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Article ; Online: Wohin mit den Ansiedlungen, wenn die Flächen ausgehen? Rine bundesweite Regionalplananalyse regionaler Gewerbe- und Industriestandorte unter besonderer Berücksichtigung des Fallbeispiels der "Regionalen Kooperationsstandorte" in der Metropole Ruhr ; Where to locate new industrial sites in case of land shortage? A nationwide analysis of regional development plans with particular regard to the conception of "Regionale Kooperationsstandorte" in the Ruhr Metropolis

Iwer, Nicole / Gerber, Markus

2022

Abstract: Aufgrund steigender Flächennutzungskonkurrenzen ist es in hoch verdichteten Regionen schwierig, neue Gewerbeflächen planerisch zu sichern. Dies betrifft insbesondere Standorte für Betriebe mit größerem Flächenbedarf. Die Wirtschaft drängt zum Erhalt der ... ...

Abstract	Aufgrund steigender Flächennutzungskonkurrenzen ist es in hoch verdichteten Regionen schwierig, neue Gewerbeflächen planerisch zu sichern. Dies betrifft insbesondere Standorte für Betriebe mit größerem Flächenbedarf. Die Wirtschaft drängt zum Erhalt der Wettbewerbsfähigkeit auf (regional)planerisches Handeln, zugleich erheben die Bevölkerung und kommunalpolitische Entscheidungsträger vermehrt Bedenken gegen neue Baugebiete. Der Regionalplanung stellt sich daher die Aufgabe, wie die Akzeptanz für die Festlegung neuer, größerer Gewerbestandorte bei den unterschiedlichen Planadressaten erreicht werden kann. Hier setzen Instrumente an, bei denen in Kooperation aller Akteure geeignete, restriktionsarme Flächen im Einzugsbereich der Kommunen mit Flächenengpässen und hoher Nachfrage identifiziert werden, um diese regionalplanerisch festzulegen. Am Fallbeispiel der "Regionalen Kooperationsstandorte" in der Metropole Ruhr behandelt der Beitrag die Frage, welche Mehrwerte und Herausforderungen die Akteure mit dem Instrument verbinden. Demnach ist zu erkennen, dass das Instrument im Grundsatz hohe Zustimmung erfährt, bei einzelnen Regelungsinhalten und Standorten jedoch, aufgrund divergierender Interessen zwischen unterschiedlichen Akteuren, zwischen Belegenheits- und Nichtbelegenheitskommunen oder sich ändernder politischer Rahmenbedingungen, einer konsensualen Verständigung Grenzen gesetzt sind. Due to increasing density-dependent competitions in land use, it is difficult to plan new industrial areas, especially for factories and businesses with a need for large-scaled sites. Economic interest groups demand to plan new industrial areas to keep the region in a competitive position. At the same time, many citizens and local politicians are concerned about new specific land use areas for industries. To locate suitable industrial sites in the catchment area of municipalities with land shortage and a high demand for space and to involve regional stakeholders into the planning process, new regional planning tools are ...
Keywords	ddc:710 ; Regionalplanung ; Regionalverband Ruhr ; Gewerbeflächen ; flächenintensive Betriebe ; Wirtschaftsförderung ; interkommunale Kooperation ; Regional planning ; Regionale Kooperationsstandorte ; Ruhr regional association ; Commercial areas ; Space intensive companies ; Business development ; Inter-municipal cooperation
Language	German
Publisher	München: oekom verlag
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Coronary Artery Dilation in an Asymptomatic Pediatric Patient with COVID19 Antibodies.

Gerber, Nicole / Flynn, Patrick A / Holzer, Ralf J

Pediatric cardiology

2021 Volume 42, Issue 2, Page(s) 460–462

Abstract: We describe a 16-year-old asymptomatic male who presented with coronary artery dilation (z score + 2.3) identified on echo performed solely for presence of COVID-19 antibodies. This case raises the question of whether cardiac screening should be ... ...

Abstract	We describe a 16-year-old asymptomatic male who presented with coronary artery dilation (z score + 2.3) identified on echo performed solely for presence of COVID-19 antibodies. This case raises the question of whether cardiac screening should be considered for all patients with a history of COVID-19.
MeSH term(s)	Adolescent ; COVID-19/complications ; Coronary Aneurysm/diagnostic imaging ; Coronary Aneurysm/etiology ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/etiology ; Dilatation, Pathologic ; Echocardiography ; Humans ; Male ; SARS-CoV-2
Language	English
Publishing date	2021-02-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-021-02566-5
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Zs.A 1528: Show issues

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Article ; Online: Osteomyelitis in an Unusual Location With an Atypical Presentation: A Case Report and Review of the Literature of Scapular Osteomyelitis in Pediatric Patients.

Gerber, Nicole / Fawcett, Kelsey / Bittman, Mark / Beiner, Joshua

Pediatric emergency care

2021 Volume 37, Issue 3, Page(s) e149–e151

Abstract: Abstract: Bacterial osteomyelitis of the scapula is rare in pediatric patients. When it occurs, it usually affects young infants and patients often exhibit fever and functional limitation of the extremity. We present a case of a 12-year-old boy with ... ...

Abstract	Abstract: Bacterial osteomyelitis of the scapula is rare in pediatric patients. When it occurs, it usually affects young infants and patients often exhibit fever and functional limitation of the extremity. We present a case of a 12-year-old boy with subacute bacterial scapular osteomyelitis and a normal physical examination. The patient was briefly treated with intravenous antibiotics and then transitioned to oral antibiotics to complete a 4-week course for methicillin-sensitive Staphylococcus aureus osteomyelitis.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Child ; Humans ; Male ; Osteomyelitis/diagnosis ; Osteomyelitis/drug therapy ; Scapula/pathology ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-03-04
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	632588-9
ISSN	1535-1815 ; 0749-5161
ISSN (online)	1535-1815
ISSN	0749-5161
DOI	10.1097/PEC.0000000000002362
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Zs.A 2083: Show issues

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Article ; Online: Coronary artery dilation in non-hospitalised children with asymptomatic or mild COVID-19.

Gerber, Nicole / Lutrario, Christopher / Rosenthal, Michelle / Platt, Shari / Holzer, Ralf / Flynn, Patrick

Cardiology in the young

2023 Volume 34, Issue 4, Page(s) 854–858

Abstract: Introduction: Infection with Sars-CoV-2 is known to cause cardiac injury and coronary artery changes in moderate to severe acute COVID-19 and post-acute multisystem inflammatory syndrome in children (MIS-C). However, little is known about the potential ... ...

Abstract	Introduction: Infection with Sars-CoV-2 is known to cause cardiac injury and coronary artery changes in moderate to severe acute COVID-19 and post-acute multisystem inflammatory syndrome in children (MIS-C). However, little is known about the potential for cardiac involvement, in particular coronary artery dilation, in asymptomatic or mild cases of COVID-19. Methods: A retrospective review of children ≤ 18 years of age with a history of asymptomatic or mild COVID-19 disease who underwent echocardiography after Sars-CoV-2 infection is conducted. Patients were excluded if they had been hospitalised for COVID-19/MIS-C or had a history of cardiac disease that could affect coronary artery dimension. Coronary artery dilation was defined as the Boston Z-score greater than 2.0. Results: One hundred and fifty-seven patients met inclusion criteria with a mean age of 9.4 years (+/- 5.4 years). Eighty-four (54%) patients were identified as having COVID-19 through positive antibody testing. All patients underwent electrocardiogram and echocardiogram as part of their cardiology evaluation. One hundred and thirty-five (86%) patients had a normal evaluation or only a minor variant on electrocardiogram, while 22 patients had abnormalities on echocardiogram, 4 of which demonstrated coronary artery dilation based on the Boston Z-score. Conclusions: Much of the literature for post-infectious screening and follow-up focuses on patients with a history of moderate to severe COVID-19 disease, emphasising the need for surveillance for the potential development of myocarditis. In this study, 4 out of 157 (2.5%) children with a history of asymptomatic or mild COVID-19 disease without MIS-C were found to have some degree of coronary artery dilation. The significance of this finding currently remains unknown.
MeSH term(s)	Child ; Humans ; Coronary Vessels/diagnostic imaging ; Dilatation ; COVID-19/complications ; SARS-CoV-2 ; Coronary Aneurysm ; Systemic Inflammatory Response Syndrome
Language	English
Publishing date	2023-10-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951123003694
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Zs.A 4050: Show issues

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Article ; Online: Rapid Absolute Neutrophil Count Testing Guides Targeted Antimicrobial Therapy in Febrile Pediatric Oncology Patients.

Gerber, Nicole / Vella, Adam / Racine-Brzostek, Sabrina / Platt, Shari L

Pediatric emergency care

2022 Volume 38, Issue 2, Page(s) e743–e745

Abstract: Objectives: It is well established that early antibiotic administration leads to improved outcomes in febrile neutropenic patients. To achieve this, many institutions administer empiric antibiotics to all febrile oncology patients in the emergency ... ...

Abstract	Objectives: It is well established that early antibiotic administration leads to improved outcomes in febrile neutropenic patients. To achieve this, many institutions administer empiric antibiotics to all febrile oncology patients in the emergency setting, before knowing their neutropenic status. This study evaluates the role of rapid absolute neutrophil count (ANC) testing in the targeted antimicrobial management of nonneutropenic febrile oncology patients. Methods: We conducted a retrospective review of patients 19 years or younger presenting to the pediatric emergency service with an oncologic process and fever or history of fever. We examined the administration of antibiotics and outcomes in nonneutropenic patients. Results: We included 101 patient encounters, representing 62 distinct patients. The rapid ANC test influenced antibiotic management in 94% (95/101) of patient encounters and resulted in no antibiotics or targeted antibiotic therapy in 88% (60/68) of nonneutropenic patients. Use of the rapid ANC test to guide treatment would have spared antibiotic administration in 68% (46/68) of well-appearing nonneutropenic patients with no alternate indication. No well-appearing, nonneutropenic patient had a positive blood culture, and only 1 required hospital admission on a repeat visit. Conclusions: The rapid ANC is a useful tool to balance the goal of early antibiotic administration in febrile neutropenic oncology patients while promoting antibiotic stewardship in this vulnerable population.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Child ; Fever/drug therapy ; Fever/etiology ; Humans ; Neoplasms/complications ; Neoplasms/drug therapy ; Neutrophils ; Retrospective Studies
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-01-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	632588-9
ISSN	1535-1815 ; 0749-5161
ISSN (online)	1535-1815
ISSN	0749-5161
DOI	10.1097/PEC.0000000000002354
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Zs.A 2083: Show issues

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Article ; Online: Winter is coming: care of the febrile children in the time of COVID-19.

Gerber, Nicole / Farkas, Jonathan S / Ratner, Adam J

World journal of pediatrics : WJP

2020 Volume 17, Issue 1, Page(s) 6–7

MeSH term(s)	COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; Child ; Fever/etiology ; Humans ; Seasons
Keywords	covid19
Language	English
Publishing date	2020-11-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2236681-7
ISSN	1867-0687 ; 1708-8569
ISSN (online)	1867-0687
ISSN	1708-8569
DOI	10.1007/s12519-020-00396-8
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Article: Impact of COVID-19 on Residency Training.

Early, Nicole K / Gerber, Dawn Knudsen / Spencer, Ricarrdo

The Senior care pharmacist

2020 Volume 35, Issue 11, Page(s) 473–475

Abstract: The novel coronavirus disease 2019 (COVID-19) pandemic has impacted pharmacists in a variety of ways, including increased workloads, reduced hours, and ever-changing recommendations for managing this unique infection. Trainees, both students and ... ...

Abstract	The novel coronavirus disease 2019 (COVID-19) pandemic has impacted pharmacists in a variety of ways, including increased workloads, reduced hours, and ever-changing recommendations for managing this unique infection. Trainees, both students and residents, have also dealt with numerous challenges and changes during this pandemic.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Education, Pharmacy/trends ; Humans ; Internship and Residency/trends ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Workload
Keywords	covid19
Language	English
Publishing date	2020-10-29
Publishing country	United States
Document type	Journal Article
ISSN	2639-9636
ISSN	2639-9636
DOI	10.4140/TCP.n.2020.473
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Article ; Online: Dysbiosis is not present in horses with fecal water syndrome when compared to controls in spring and autumn.

Schoster, Angelika / Weese, J Scott / Gerber, Vinzenz / Nicole Graubner, Claudia

Journal of veterinary internal medicine

2020 Volume 34, Issue 4, Page(s) 1614–1621

Abstract: Background: Fecal water syndrome (FWS) is long-standing and common in horses, particularly in central Europe. No large epidemiological data sets exist, and the cause remains elusive. Dysbiosis could play a role in pathogenesis.: Objectives: To ... ...

Abstract	Background: Fecal water syndrome (FWS) is long-standing and common in horses, particularly in central Europe. No large epidemiological data sets exist, and the cause remains elusive. Dysbiosis could play a role in pathogenesis. Objectives: To evaluate whether dysbiosis is present in horses with FWS when compared to stable-matched control horses in spring and autumn. Animals: Fecal samples were collected from horses with FWS (n = 16; 9 mares, 7 geldings) and controls (n = 15; 8 mares, 7 geldings). Methods: The bacterial microbiome of samples collected in spring and autumn of 2016 was analyzed using high-throughput sequencing. Differences in relative abundance of bacterial taxa, alpha diversity, and beta diversity indices were assessed between horses with FWS and controls based on season. Results: Differences in microbial community composition based on time point and health status were not observed on any taxonomic level. Limited differences were seen on linear discriminant analysis effect size analysis. No difference in alpha diversity indices was observed including richness, diversity based on health status, or time point. No effect of health status on microbial community membership structure was observed. Conclusions and clinical importance: Limited differences were found in the bacterial microbiota of horses with and without FWS, regardless of season. Further research is needed to elucidate the role of microbiota in the development of FWS.
MeSH term(s)	Animals ; Bacteria/classification ; Case-Control Studies ; Diarrhea/etiology ; Diarrhea/microbiology ; Diarrhea/veterinary ; Dysbiosis/veterinary ; Feces/microbiology ; Female ; Gastrointestinal Microbiome ; Horse Diseases/etiology ; Horse Diseases/microbiology ; Horses ; Male ; Prospective Studies ; Seasons
Language	English
Publishing date	2020-06-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	92798-3
ISSN	1939-1676 ; 0891-6640
ISSN (online)	1939-1676
ISSN	0891-6640
DOI	10.1111/jvim.15778
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Zs.A 4095: Show issues

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Article: Winter is coming: care of the febrile children in the time of COVID-19

Gerber, Nicole / Farkas, Jonathan S / Ratner, Adam J

World j. pediatr

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #919761
Database	COVID19

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Article ; Online: Randomized Trial to Improve Body Composition and Micronutrient Status Among South African Children.

Long, Kurt Z / Beckmann, Johanna / Lang, Christin / Seelig, Harald / Nqweniso, Siphesihle / Probst-Hensch, Nicole / Pühse, Uwe / Steinmann, Peter / Randt, Rosa du / Walter, Cheryl / Utzinger, Jürg / Gerber, Markus

American journal of preventive medicine

2024

Abstract: Introduction: Physical activity (PA) promotion combined with multimicronutrient supplementation (MMNS) among school-age children may reduce fat mass accrual and increase muscle mass through different mechanisms and so benefit child health. This study ... ...

Abstract	Introduction: Physical activity (PA) promotion combined with multimicronutrient supplementation (MMNS) among school-age children may reduce fat mass accrual and increase muscle mass through different mechanisms and so benefit child health. This study determined the efficacy of combined interventions on body composition among South African schoolchildren and determined if micronutrients mediate these effects. Study design: Longitudinal cluster randomized controlled trial of children followed from 2019 to 2021. Statistical analyses carried from 2022 to 2023. Setting/participants: A total of 1,304 children 6-12 years of age recruited from public schools in Gqeberha, South Africa. Intervention: Children were randomized by classes to either: (a) a physical activity group (PA); (b) a MMNS group; (c) a physical activity + multimicronutrient supplementation group (PA + MMNS); and (d) a placebo control group. Main outcome measures: Trajectories of overall and truncal fat free mass (FFM) and fat mass (FM) estimates in modeled at 9 and 21 months using latent growth curve models (LGCM). Changes in micronutrient concentrations at 9 months from baseline. Results: An increased FFM trajectory was found among children in the MMNS arm at 9 months (Beta 0.16, 95% CI = 0.12, 0.31). The PA and MMNS arms both had positive indirect effects on this trajectory at 9 months (Beta 0.66, 95% CI = 0.44, 0.88 and Beta 0.32 95% CI = 0.1 0.5, respectively) and similarly at 21 months when mediated by zinc concentration changes. A reduced FM trajectory was found among children in the PA promotion arm at 9 months when using this collection point as the referent intercept. This arm was inversely associated with the FM trajectory at 9 months when mediated by zinc changes. Conclusions: PA and MMNS promotion in school-based interventions directly contributed to reductions in FM and increased FFM among South African children and indirectly through changes in micronutrient status. Trial registration: ISRCTN, ISRCTN29534081. Registered on August 9, 2018 Institutional review board: Ethikkommission Nordwest- und Zentralschweiz" (EKNZ, project number: Req-2018-00608). Date of approval: 2018.
Language	English
Publishing date	2024-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	632646-8
ISSN	1873-2607 ; 0749-3797
ISSN (online)	1873-2607
ISSN	0749-3797
DOI	10.1016/j.amepre.2024.01.017
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