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  1. Article ; Online: Importance of ABC Transporters in the Survival of Parasitic Nematodes and the Prospect for the Development of Novel Control Strategies

    Ali Raza / Andrew R. Williams / Muhammad Mustafa Abeer

    Pathogens, Vol 12, Iss 755, p

    2023  Volume 755

    Abstract: ABC transporters, a family of ATP-dependent transmembrane proteins, are responsible for the active transport of a wide range of molecules across cell membranes, including drugs, toxins, and nutrients. Nematodes possess a great diversity of ABC ... ...

    Abstract ABC transporters, a family of ATP-dependent transmembrane proteins, are responsible for the active transport of a wide range of molecules across cell membranes, including drugs, toxins, and nutrients. Nematodes possess a great diversity of ABC transporters; however, only P-glycoproteins have been well-characterized compared to other classes. The ABC transport proteins have been implicated in developing resistance to various classes of anthelmintic drugs in parasitic nematodes; their role in plant and human parasitic nematodes still needs further investigation. Therefore, ABC transport proteins offer a potential opportunity to develop nematode control strategies. Multidrug resistance inhibitors are becoming more attractive for controlling nematodes due to their potential to increase drug efficacy in two ways: (i) by limiting drug efflux from nematodes, thereby increasing the amount of drug that reaches its target site, and (ii) by reducing drug excretion by host animals, thereby enhancing drug bioavailability. This article reviews the role of ABC transporters in the survival of parasitic nematodes, including the genes involved, their regulation and physiological roles, as well as recent developments in their characterization. It also discusses the association of ABC transporters with anthelmintic resistance and the possibility of targeting them with next-generation inhibitors or nutraceuticals (e.g., polyphenols) to control parasitic infections.
    Keywords ABC transporters ; P-glycoproteins ; parasitic nematodes ; physiology ; anthelmintic resistance ; multidrug resistance inhibitors ; Medicine ; R
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Importance of ABC Transporters in the Survival of Parasitic Nematodes and the Prospect for the Development of Novel Control Strategies.

    Raza, Ali / Williams, Andrew R / Abeer, Muhammad Mustafa

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 6

    Abstract: ABC transporters, a family of ATP-dependent transmembrane proteins, are responsible for the active transport of a wide range of molecules across cell membranes, including drugs, toxins, and nutrients. Nematodes possess a great diversity of ABC ... ...

    Abstract ABC transporters, a family of ATP-dependent transmembrane proteins, are responsible for the active transport of a wide range of molecules across cell membranes, including drugs, toxins, and nutrients. Nematodes possess a great diversity of ABC transporters; however, only P-glycoproteins have been well-characterized compared to other classes. The ABC transport proteins have been implicated in developing resistance to various classes of anthelmintic drugs in parasitic nematodes; their role in plant and human parasitic nematodes still needs further investigation. Therefore, ABC transport proteins offer a potential opportunity to develop nematode control strategies. Multidrug resistance inhibitors are becoming more attractive for controlling nematodes due to their potential to increase drug efficacy in two ways: (i) by limiting drug efflux from nematodes, thereby increasing the amount of drug that reaches its target site, and (ii) by reducing drug excretion by host animals, thereby enhancing drug bioavailability. This article reviews the role of ABC transporters in the survival of parasitic nematodes, including the genes involved, their regulation and physiological roles, as well as recent developments in their characterization. It also discusses the association of ABC transporters with anthelmintic resistance and the possibility of targeting them with next-generation inhibitors or nutraceuticals (e.g., polyphenols) to control parasitic infections.
    Language English
    Publishing date 2023-05-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12060755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction: An

    Kiran, Saira / Mumtaz, Umair / Mustafa, Aymen / Imran, Muhammad / Hussain, Fayyaz / Rasheed, Umbreen / Khalil, R M A / Khera, Ejaz Ahmad / Nazir, Alia

    RSC advances

    2023  Volume 13, Issue 19, Page(s) 12925

    Abstract: This corrects the article DOI: 10.1039/D3RA00078H.]. ...

    Abstract [This corrects the article DOI: 10.1039/D3RA00078H.].
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Published Erratum
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra90038j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Improving crop productivity and nitrogen use efficiency using sulfur and zinc-coated urea: A review.

    Mustafa, Ayesha / Athar, Fareeha / Khan, Imran / Chattha, Muhammad Umer / Nawaz, Muhammad / Shah, Adnan Noor / Mahmood, Athar / Batool, Maria / Aslam, Muhammad Talha / Jaremko, Mariusz / Abdelsalam, Nader R / Ghareeb, Rehab Y / Hassan, Muhammad Umair

    Frontiers in plant science

    2022  Volume 13, Page(s) 942384

    Abstract: Nitrogen (N) is an important macro-nutrient required for crop production and is considered an important commodity for agricultural systems. Urea is a vital source of N that is used widely across the globe to meet crop N requirements. However, N applied ... ...

    Abstract Nitrogen (N) is an important macro-nutrient required for crop production and is considered an important commodity for agricultural systems. Urea is a vital source of N that is used widely across the globe to meet crop N requirements. However, N applied in the form of urea is mostly lost in soil, posing serious economic and environmental issues. Therefore, different approaches such as the application of urea coated with different substances are used worldwide to reduce N losses. Urea coating is considered an imperative approach to enhance crop production and reduce the corresponding nitrogen losses along with its impact on the environment. In addition, given the serious food security challenges in meeting the current and future demands for food, the best agricultural management strategy to enhance food production have led to methods that involve coating urea with different nutrients such as sulfur (S) and zinc (Zn). Coated urea has a slow-release mechanism and remains in the soil for a longer period to meet the demand of crop plants and increases nitrogen use efficiency, growth, yield, and grain quality. These nutrient-coated urea reduce nitrogen losses (volatilization, leaching, and N
    Language English
    Publishing date 2022-10-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.942384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Co-infections and antimicrobial use among hospitalized COVID-19 patients in Punjab, Pakistan: findings from a multicenter, point prevalence survey.

    Mustafa, Zia Ul / Saleem, Muhammad Salman / Ikram, Muhammad Nabeel / Salman, Muhammad / Butt, Sanan Amjad / Khan, Shehroze / Godman, Brian / Seaton, R Andrew

    Pathogens and global health

    2021  Volume 116, Issue 7, Page(s) 421–427

    Abstract: There are reports of high rates of antibiotic prescribing among hospitalized patients with COVID-19 around the world. To date, however, there are few reports of prescribing in relation to COVID-19 in Pakistan. Herein, we describe a point prevalence ... ...

    Abstract There are reports of high rates of antibiotic prescribing among hospitalized patients with COVID-19 around the world. To date, however, there are few reports of prescribing in relation to COVID-19 in Pakistan. Herein, we describe a point prevalence survey of antibiotic prescribing amongst patients hospitalized with suspected or proven COVID-19 in Pakistan. A Point Prevalence Survey (PPS) was undertaken in seven tertiary care health facilities in Punjab Provence, Pakistan. Baseline information about antimicrobial use according to the World Health Organization (WHO) standardized methodology was collected on a single day between 5
    MeSH term(s) Adult ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/therapeutic use ; Azithromycin/therapeutic use ; Bacterial Infections/epidemiology ; COVID-19/drug therapy ; COVID-19/epidemiology ; Ceftriaxone/therapeutic use ; Coinfection/drug therapy ; Coinfection/epidemiology ; Drug Prescriptions ; Female ; Humans ; Male ; Meropenem/therapeutic use ; Pakistan/epidemiology ; Prevalence
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Ceftriaxone (75J73V1629) ; Azithromycin (83905-01-5) ; Meropenem (FV9J3JU8B1)
    Language English
    Publishing date 2021-11-16
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2625162-0
    ISSN 2047-7732 ; 2047-7724
    ISSN (online) 2047-7732
    ISSN 2047-7724
    DOI 10.1080/20477724.2021.1999716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: An

    Kiran, Saira / Mumtaz, Umair / Mustafa, Aymen / Imran, Muhammad / Hussain, Fayyaz / Rasheed, Umbreen / Khalil, R M A / Khera, Ejaz Ahmad / Nazir, Alia

    RSC advances

    2023  Volume 13, Issue 16, Page(s) 11192–11200

    Abstract: Hybrid lead halide perovskites have been considered as promising candidates for a large variety of optoelectronic applications. By exploring novel combinations of lead-free double perovskite halides, it is possible to find a suitable replacement for ... ...

    Abstract Hybrid lead halide perovskites have been considered as promising candidates for a large variety of optoelectronic applications. By exploring novel combinations of lead-free double perovskite halides, it is possible to find a suitable replacement for poisonous lead halide perovskites, enhancing electronic and optical response for their application as optically-influenced resistive switching random access memory (RRAM). In this work, the structural, mechanical, elastic, electronic, optical, and thermoelectric characteristics of lead-free double halide perovskites were investigated by Vienna
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra00078h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A Case Series from Rantauprapat, La Belle Indifference: A Coping Mechanism or Is There Something Organic Behind?

    Khaddafi, Muhammad R / Amin, Mustafa M

    Open access Macedonian journal of medical sciences

    2019  Volume 7, Issue 16, Page(s) 2675–2678

    Abstract: Background: La belle indifference, a term that is inexhaustible to discuss, albeit there is no single definition that best describes the condition. To date, la belle indifference has gotten no place in the DSM-5 criteria for being a distinct entity of ... ...

    Abstract Background: La belle indifference, a term that is inexhaustible to discuss, albeit there is no single definition that best describes the condition. To date, la belle indifference has gotten no place in the DSM-5 criteria for being a distinct entity of mental health issue.
    Case reports: We reported 3 cases with la belle indifference. These patients include a stroke patient with right-sided hemiparesis, a patient suffering from neuropathic pain because of diabetic neuropathy, and a patient with cardiac dyspnea due to chronic heart failure - these three cases presented with a similar clinical profile that is the trigger for developing la belle indifference.
    Conclusions: La belle indifference has varying symptom spectrum, and there is always something called "trigger" to induce it.
    Language English
    Publishing date 2019-08-28
    Publishing country North Macedonia
    Document type Case Reports
    ISSN 1857-9655
    ISSN 1857-9655
    DOI 10.3889/oamjms.2019.405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Design and evaluation of a power tiller vegetable seedling transplanter with dibbler and furrow type.

    Miah, Md Sumon / Rahman, Md Mashiur / Hoque, Muhammad Arshadul / Ibrahim, Sobhy M / Sultan, Muhammad / Shamshiri, Redmond R / Ucgul, Mustafa / Hasan, Mahedi / Barna, Tasneem Nahar

    Heliyon

    2023  Volume 9, Issue 8, Page(s) e17827

    Abstract: Vegetable production plays a vital role in ensuring food security in Bangladesh. However, the majority of vegetable seedlings are currently transplanted manually, which is not only time-consuming but also labor-intensive and costly. In this context, a ... ...

    Abstract Vegetable production plays a vital role in ensuring food security in Bangladesh. However, the majority of vegetable seedlings are currently transplanted manually, which is not only time-consuming but also labor-intensive and costly. In this context, a semi-automated transplanter can be considered as an alternative solution for mechanized seedling transplanting. To mechanize seedling operations, two types of transplanters were designed, fabricated and tested: the power tiller-operated semi-automatic dibbler vegetable seedling (DVS) transplanter and the furrow opener vegetable seedling (FVS) transplanter. The goal was to evaluate their performance and impact on field crop productivity. In the DVS transplanter design, the larger sprocket was adjusted to enhance the precision of hole-making by pressing the dibbler into the soil, creating holes where seedlings would be transplanted. On the other hand, the FVS transplanter utilized a furrow opener to create furrows, and the seedling is placed in these furrow at a specific distance from the furrow opener wall, where the distance between seedlings within the furrow could be adjusted based on the specific requirements of the seedling crop. The results of the evaluation indicated that both transplanters successfully planted seedlings without any missing placements, while hole covering was achieved at 115 and 118.2% for the DVS and FVS transplanters, respectively. The field capacity and field efficiency for both transplanters were determined to be 0.05 ha h
    Language English
    Publishing date 2023-07-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e17827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Coronary aneurysms, myocardial dysfunction, and shock in a COVID-19 child, role of ECMO, immunomodulation, and cardiac CT.

    Mustafa, Muhammad R / Carter, Michael J / Wong, James / Bell, Aaron / Salih, Caner

    Cardiology in the young

    2021  Volume 31, Issue 6, Page(s) 1043–1047

    Abstract: Coronary artery aneurysms in children were observed as a rare complication associated with coronavirus disease 2019 (COVID-19). This case report describes the severe end of the spectrum of the new multisystem inflammatory syndrome in a 12-year-old child ... ...

    Abstract Coronary artery aneurysms in children were observed as a rare complication associated with coronavirus disease 2019 (COVID-19). This case report describes the severe end of the spectrum of the new multisystem inflammatory syndrome in a 12-year-old child with coronary aneurysms, myocardial dysfunction, and shock, managed successfully with extracorporeal membrane oxygenation support and immunomodulation therapy. This report also highlights the additional benefits of cardiac CT in the diagnosis and follow-up of coronary aneurysms.
    MeSH term(s) COVID-19 ; Child ; Coronary Aneurysm/diagnostic imaging ; Coronary Aneurysm/etiology ; Extracorporeal Membrane Oxygenation ; Humans ; Immunomodulation ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-01-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951121000147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4050: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: In silico

    Kamal, Hira / Minhas, Fayyaz-Ul-Amir Afsar / Farooq, Muhammad / Tripathi, Diwaker / Hamza, Muhammad / Mustafa, Roma / Khan, Muhammad Zuhaib / Mansoor, Shahid / Pappu, Hanu R / Amin, Imran

    Frontiers in plant science

    2019  Volume 10, Page(s) 656

    Abstract: Cotton leaf curl disease (CLCuD) caused by viruses of ... ...

    Abstract Cotton leaf curl disease (CLCuD) caused by viruses of genus
    Language English
    Publishing date 2019-05-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711035-7
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2019.00656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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