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  1. Article ; Online: Unwarranted clinical practice variation and resource overutilization in medical care: The example of transfusion practices in elderly hospital patients.

    Carneiro, António Vaz

    European journal of internal medicine

    2023  Volume 115, Page(s) 43–45

    MeSH term(s) Humans ; Aged ; Blood Transfusion ; Patient Care ; Inpatients ; Hospitals
    Language English
    Publishing date 2023-07-21
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.07.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
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  2. Article ; Online: Metodologia Prática de Gestão do Programa Choosing Wisely Portugal: Escolhas Criteriosas em Saúde.

    Vaz Carneiro, António

    Acta medica portuguesa

    2022  Volume 35, Issue 5, Page(s) 403

    Title translation Practical Management Methodology of the Program Choosing Wisely Portugal: Wise Health Decisions.
    MeSH term(s) Humans ; Portugal ; Medical Overuse ; Practice Patterns, Physicians'
    Language Portuguese
    Publishing date 2022-05-02
    Publishing country Portugal
    Document type Letter
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.18258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diagnosis is a probabilistic estimate of disease. A dynamic approach to diminish resource overuse.

    Carneiro, António Vaz

    European journal of internal medicine

    2021  Volume 95, Page(s) 40–41

    Language English
    Publishing date 2021-12-11
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2021.11.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Practical Management Methodology of the Program Choosing Wisely Portugal

    António Vaz Carneiro

    Acta Médica Portuguesa, Vol 35, Iss 5, Pp 403-

    Wise Health Decisions

    2022  Volume 403

    Abstract: N/a. ...

    Abstract N/a.
    Keywords adesão a directrizes ; medicina baseada em evidências ; melhoria de qualidade ; padrões de prática de médica ; portugal ; sobrediagnóstico ; sobremedicalização ; sobretratamento ; tomada de decisões ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Ordem dos Médicos
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: General health check-ups: To check or not to check? A question of choosing wisely.

    Kherad, Omar / Carneiro, Antonio Vaz

    European journal of internal medicine

    2023  Volume 109, Page(s) 1–3

    Abstract: In high-income countries, regular general health check-ups are part of the fabric of the health care systems. The hidden concept of general health check-ups, promoted for more than a century, is to identify diseases at a stage at which early intervention ...

    Abstract In high-income countries, regular general health check-ups are part of the fabric of the health care systems. The hidden concept of general health check-ups, promoted for more than a century, is to identify diseases at a stage at which early intervention can be effective. However, there has been little evidence to support the benefits of such checkups. Choosing wisely (CW) campaigns may represent a tremendous opportunity to eventually shift patients and physicians away from the non-evidence based yet firmly entrenched practice of the general health check-up. As campaign leaders and members of the CW working group of the European Federation of Internal Medicine, we want to join the discussion by giving our perspective based on the best available evidence.
    MeSH term(s) Humans ; Societies, Medical ; Physicians ; Internal Medicine ; Health Status
    Language English
    Publishing date 2023-01-05
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2022.12.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Ten year anniversary of choosing wisely campaigns.

    Kherad, Omar / Carneiro, Antonio Vaz

    European journal of internal medicine

    2022  Volume 103, Page(s) 118–119

    MeSH term(s) Anniversaries and Special Events ; Humans ; Societies, Medical
    Language English
    Publishing date 2022-05-31
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2022.05.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Prescribing patterns as a quality measure for hypertension treatment in Portugal.

    Vaz Carneiro, António

    Revista portuguesa de cardiologia

    2018  Volume 37, Issue 8, Page(s) 665–667

    MeSH term(s) Antihypertensive Agents ; Humans ; Hypertension ; Portugal ; Practice Patterns, Physicians'
    Chemical Substances Antihypertensive Agents
    Language Portuguese
    Publishing date 2018-07-19
    Publishing country Spain
    Document type Journal Article ; Comment
    ZDB-ID 2646972-8
    ISSN 2174-2049 ; 2174-2049
    ISSN (online) 2174-2049
    ISSN 2174-2049
    DOI 10.1016/j.repc.2018.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A Vitamina D na Prevenção de Doenças Crónicas: Uma Análise Baseada na Evidência Científica.

    Vaz-Carneiro, António

    Acta medica portuguesa

    2017  Volume 30, Issue 5, Page(s) 351–353

    Title translation Vitamin D in the Prevention of Chronic Diseases: An Evidence Based Analysis.
    Language Portuguese
    Publishing date 2017-05-31
    Publishing country Portugal
    Document type Journal Article
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.9176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2343: Show issues Location:
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  9. Article ; Online: Craniofacial syndromes and class III phenotype: common genotype fingerprints? A scoping review and meta-analysis.

    Faria-Teixeira, Maria Cristina / Tordera, Cristina / Salvado E Silva, Francisco / Vaz-Carneiro, António / Iglesias-Linares, Alejandro

    Pediatric research

    2024  

    Abstract: Skeletal Class III (SCIII) is among the most challenging craniofacial dysmorphologies to treat. There is, however, a knowledge gap regarding which syndromes share this clinical phenotype. The aims of this study were to: (i) identify the syndromes ... ...

    Abstract Skeletal Class III (SCIII) is among the most challenging craniofacial dysmorphologies to treat. There is, however, a knowledge gap regarding which syndromes share this clinical phenotype. The aims of this study were to: (i) identify the syndromes affected by the SCIII phenotype; (ii) clarify the involvement of maxillary and/or mandibular structures; (iii) explore shared genetic/molecular mechanisms. A two-step strategy was designed: [Step#1] OMIM, MHDD, HPO, GeneReviews and MedGen databases were explored; [Step#2]: Syndromic conditions indexed in [Step#1] were explored in Medline, Pubmed, Scopus, Cochrane Library, WOS and OpenGrey. Eligibility criteria were defined. Individual studies were assessed for risk of bias using the New Ottawa Scale. For quantitative analysis, a meta-analysis was conducted. This scoping review is a hypothesis-generating research. Twenty-two studies met the eligibility criteria. Eight syndromes affected by the SCIII were targeted: Apert syndrome, Crouzon syndrome, achondroplasia, X-linked hypohidrotic ectodermal dysplasia (XLED), tricho-dento-osseous syndrome, cleidocranial dysplasia, Klinefelter and Down syndromes. Despite heterogeneity between studies [p < 0.05], overall effects showed that midface components were affected in Apert and Down Syndromes, lower face in Klinefelter Syndrome and midface and lower face components in XLED. Our review provides new evidence on the craniofacial characteristics of genetically confirmed syndromes exhibiting the SCIII phenotype. Four major regulatory pathways might have a modulatory effect on this phenotype. IMPACT: What does this review add to the existing literature? To date, there is no literature exploring which particular syndromes exhibit mandibular prognathism as a common trait. Through this research, it was possibly to identify the particular syndromes that share the skeletal Class III phenotype (mandibular prognathism) as a common trait highlighting the common genetic and molecular pathways between different syndromes acknowledging their impact in craniofacial development.
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-02907-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 564: Show issues Location:
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  10. Article ; Online: Histology-Agnostic Drugs: A Paradigm Shift-A Narrative Review.

    Mansinho, André / Fernandes, Ricardo Miguel / Carneiro, António Vaz

    Advances in therapy

    2022  Volume 40, Issue 4, Page(s) 1379–1392

    Abstract: Cancer diagnosis and therapeutics have been traditionally based on pathologic classification at the organ of origin. The availability of an unprecedented amount of clinical and biologic data provides a unique window of opportunity for the development of ... ...

    Abstract Cancer diagnosis and therapeutics have been traditionally based on pathologic classification at the organ of origin. The availability of an unprecedented amount of clinical and biologic data provides a unique window of opportunity for the development of new drugs. What was once treated as a homogeneous disease with a one-size-fits-all approach was shown to be a rather heterogeneous condition, with multiple targetable mutations that can vary during the course of the disease. Clinical trial designs have had to adapt to the exponential growth of targetable mechanisms and new agents, with ensuing challenges that are closer to those experienced with rare diseases and orphan medicines. To face these problems, precision/enrichment and other novel trial designs have been developed, and the concept of histology-agnostic targeted therapeutic agents has emerged. Patients are selected for a specific agent based on specific genomic or molecular alterations, with the same compound used to potentially treat a multiplicity of cancers, granted that the actionable driver alteration is present. There are currently approved drugs for such indications, but this approach has raised issues on multiple levels. This review aims to address the challenges of this new concept and provide insights into possible solutions and frameworks on how to tackle them.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Neoplasms/pathology ; Antineoplastic Agents/therapeutic use ; Rare Diseases ; Precision Medicine
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2022-11-23
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-022-02362-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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