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  1. Article ; Online: Coronary thrombosis in a patient with COVID-19 and haemophagocytic lymphohistiocytosis.

    Dancy, Luke H / Abu-Own, Huda / Byrne, Jonathan / Pareek, Nilesh

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2021  Volume 16, Issue 18, Page(s) e1531–e1532

    MeSH term(s) COVID-19 ; Coronary Thrombosis/diagnostic imaging ; Humans ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2021-04-02
    Publishing country France
    Document type Journal Article
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJ-D-20-00636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Extensive coronary artery thrombosis complicating COVID-19 infection and haemophagocytic lymphohistiocytosis

    Dancy, Luke H / Abu-Own, Huda / Byrne, Jonathan / Pareek, Nilesh

    EuroIntervention

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #688783
    Database COVID19

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  3. Article ; Online: Coronary Wave Intensity Analysis as an Invasive and Vessel-Specific Index of Myocardial Viability.

    Ryan, Matthew / De Silva, Kalpa / Morgan, Holly / O'Gallagher, Kevin / Demir, Ozan M / Rahman, Haseeb / Ellis, Howard / Dancy, Luke / Sado, Daniel / Strange, Julian / Melikian, Narbeh / Marber, Michael / Shah, Ajay M / Chiribiri, Amedeo / Perera, Divaka

    Circulation. Cardiovascular interventions

    2022  Volume 15, Issue 12, Page(s) e012394

    Abstract: Background: Coronary angiography and viability testing are the cornerstones of diagnosing and managing ischemic cardiomyopathy. At present, no single test serves both needs. Coronary wave intensity analysis interrogates both contractility and ... ...

    Abstract Background: Coronary angiography and viability testing are the cornerstones of diagnosing and managing ischemic cardiomyopathy. At present, no single test serves both needs. Coronary wave intensity analysis interrogates both contractility and microvascular physiology of the subtended myocardium and therefore has the potential to fulfil the goal of completely assessing coronary physiology and myocardial viability in a single procedure. We hypothesized that coronary wave intensity analysis measured during coronary angiography would predict viability with a similar accuracy to late-gadolinium-enhanced cardiac magnetic resonance imaging.
    Methods: Patients with a left ventricular ejection fraction ≤40% and extensive coronary disease were enrolled. Coronary wave intensity analysis was assessed during cardiac catheterization at rest, during adenosine-induced hyperemia, and during low-dose dobutamine stress using a dual pressure-Doppler sensing coronary guidewire. Scar burden was assessed with cardiac magnetic resonance imaging. Regional left ventricular function was assessed at baseline and 6-month follow-up after optimization of medical-therapy±revascularization, using transthoracic echocardiography. The primary outcome was myocardial viability, determined by the retrospective observation of functional recovery.
    Results: Forty participants underwent baseline physiology, cardiac magnetic resonance imaging, and echocardiography, and 30 had echocardiography at 6 months; 21/42 territories were viable on follow-up echocardiography. Resting backward compression wave energy was significantly greater in viable than in nonviable territories (-5240±3772 versus -1873±1605 W m
    Conclusions: Backward compression wave energy has accuracy similar to that of late-gadolinium-enhanced cardiac magnetic resonance imaging in the prediction of viability. Coronary wave intensity analysis has the potential to streamline the management of ischemic cardiomyopathy, in a manner analogous to the effect of fractional flow reserve on the management of stable angina.
    MeSH term(s) Humans ; Stroke Volume ; Retrospective Studies ; Gadolinium ; Fractional Flow Reserve, Myocardial ; Ventricular Function, Left ; Treatment Outcome ; Myocardium ; Myocardial Ischemia/diagnosis ; Cardiomyopathies/pathology ; Ventricular Dysfunction, Left
    Chemical Substances Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2022-12-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2450797-0
    ISSN 1941-7632 ; 1941-7640
    ISSN (online) 1941-7632
    ISSN 1941-7640
    DOI 10.1161/CIRCINTERVENTIONS.122.012394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Heart failure guideline update: a guide for general practice.

    Harris, Hannah / Bromage, Daniel I / Dancy, Luke / O'Gallagher, Kevin / Nabeebaccus, Adam / Sargent, Arabella / Sado, Daniel

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2019  Volume 69, Issue 683, Page(s) 313–314

    MeSH term(s) Algorithms ; Family Practice ; General Practice ; Heart Failure/diagnosis ; Heart Failure/therapy ; Humans ; Practice Guidelines as Topic ; Time-to-Treatment
    Language English
    Publishing date 2019-05-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/bjgp19X704069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Direct cardiac versus systemic effects of inorganic nitrite on human left ventricular function.

    O'Gallagher, Kevin / Cabaco, Ana R / Ryan, Matthew / Roomi, Ali / Gu, Haotian / Dancy, Luke / Melikian, Narbeh / Chowienczyk, Philip J / Webb, Andrew J / Shah, Ajay M

    American journal of physiology. Heart and circulatory physiology

    2021  Volume 321, Issue 1, Page(s) H175–H184

    Abstract: Inorganic nitrite is a source of nitric oxide (NO) and is considered as a potential therapy in settings where endogenous NO bioactivity is reduced and left ventricular (LV) function impaired. However, the effects of nitrite on human cardiac contractile ... ...

    Abstract Inorganic nitrite is a source of nitric oxide (NO) and is considered as a potential therapy in settings where endogenous NO bioactivity is reduced and left ventricular (LV) function impaired. However, the effects of nitrite on human cardiac contractile function, and the extent to which these are direct or indirect, are unclear. We studied 40 patients undergoing diagnostic cardiac catheterization who had normal LV systolic function and were not found to have obstructive coronary disease. They received either an intracoronary sodium nitrite infusion (8.7-26 µmol/min,
    MeSH term(s) Aged ; Female ; Hemodynamics/drug effects ; Humans ; Male ; Middle Aged ; Myocardial Contraction/drug effects ; Sodium Nitrite/administration & dosage ; Stroke Volume/drug effects ; Systole/drug effects ; Ventricular Function, Left/drug effects
    Chemical Substances Sodium Nitrite (M0KG633D4F)
    Language English
    Publishing date 2021-05-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00081.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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