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Article ; Online: Physical Therapy in the Recovery of Young Fighters with Primary Shoulder Dislocation

A.I. POSTOLACHI / M. V. CORMAN / V. N. IVANOV

ACROSS, Vol 5, Iss

2022 Volume 4

Abstract: The interest and desire to practice wrestling among adolescents and young people in our republic is quite high. The large number of those who practice sports activities increases the incidence of trauma suffered in practical lessons, training and sports ... ...

Abstract	The interest and desire to practice wrestling among adolescents and young people in our republic is quite high. The large number of those who practice sports activities increases the incidence of trauma suffered in practical lessons, training and sports competitions. In a number of sports, including wrestling and martial arts, upper limb injuries range from 26 to 46%, mostly associated with shoulder injuries. Fortunately, most traumas are of medium severity and orthopedic treatment and physical therapy are often used to recover them
Keywords	recovery ; physical therapy ; dislocation ; shoulder ; trauma ; sport ; Social Sciences ; H ; Language and Literature ; P
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Galati University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A sensitive and selective electrochemical sensor based on molecularly imprinted polymer for the assay of teriflunomide

Çorman, M. Emin / Cetinkaya, Ahmet / Armutcu, Canan / Bellur Atici, Esen / Uzun, Lokman / Ozkan, Sibel A.

Talanta. 2022 Nov. 01, v. 249

2022

Abstract: In this work, pyrrole-histidine has been designed, synthesized and, used as a novel functional monomer to fabricate a molecularly imprinted electrochemical sensor for the selective and sensitive detection of teriflunomide (TER). The molecularly imprinted ...

Abstract	In this work, pyrrole-histidine has been designed, synthesized and, used as a novel functional monomer to fabricate a molecularly imprinted electrochemical sensor for the selective and sensitive detection of teriflunomide (TER). The molecularly imprinted thin film of electrochemical sensor was constructed by directly electropolymerization of co-polymer of pyrrole-histidine (PyHis) with pyrrole in the presence of a template, TER, on a glassy carbon electrode (GCE). After electropolymerization, the structure and morphology of the fabricated MIP sensor were characterized by Fourier-transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) and its electrochemical parameters such as cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS). The poly (pyrrole-co-pyrrole-histidine) [Poly (Py-co-PyHis)]@MIP/GCE sensor have a linear TER concentration in the of 0.1–1.0 pM with a low detection limit of 11.38 fM. The present strategy for electrochemical sensor have been also showed excellent recovery in synthetic serum samples and tablet dosage form with the recoveries 97.56% and 100.35%, respectively. The developed [Poly (Py-co-PyHis)]@MIP/GCE sensor exhibited an excellent electrochemical response for TER due to the synergistic effect of conducting polymer and molecularly imprinting techniques.
Keywords	Fourier transform infrared spectroscopy ; blood serum ; composite polymers ; detection limit ; dielectric spectroscopy ; dosage forms ; electrochemistry ; films (materials) ; glassy carbon electrode ; molecular imprinting ; polymerization ; pyrroles ; sensors (equipment) ; synergism ; voltammetry
Language	English
Dates of publication	2022-1101
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2022.123689
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Coronaviren als Ursache respiratorischer Infektionen.

Corman, V M / Lienau, J / Witzenrath, M

Der Internist

2019 Volume 60, Issue 11, Page(s) 1136–1145

Abstract: Background: There are six human pathogenic coronaviruses (CoV), which mainly cause infections of the respiratory system. In everyday clinical practice, it is helpful to know the relevance and characteristics of these pathogens.: Objective: To present ...

Title translation	Coronaviruses as the cause of respiratory infections.
Abstract	Background: There are six human pathogenic coronaviruses (CoV), which mainly cause infections of the respiratory system. In everyday clinical practice, it is helpful to know the relevance and characteristics of these pathogens. Objective: To present the epidemiology, clinical picture and differences of human pathogenic CoV and to provide information on the diagnostics and treatment of patients suspected of having CoV infections. Material and methods: Selective literature search, presentation of results and discussion of fundamental works and expert recommendations, including publications by the World Health Organization (WHO), the European Centre for Disease Prevention and Control (ECDC) and the Robert Koch Institute. Results: The four endemic human CoVs (HCoV-NL63, HCoV-229E, HCoV-OC43 and HCoV-HKU1) mainly cause mild respiratory tract infections. In addition to these four endemic HCoV, the two epidemic CoV, severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV can cause severe pneumonia. The SARS-CoV has not been detected in humans in the last 15 years and MERS-CoV has been circulating mainly on the Arabian Peninsula since 2012; however, neither a specific treatment nor approved vaccines exist for any of the six human pathogenic CoVs. Conclusion: All six human CoVs can be diagnosed using RT-PCR on respiratory specimens but this is rarely necessary for the four endemic strains. In current clinical practice SARS-CoV has no importance as it has not been detected in humans for 15 years; however, a possible MERS-CoV infection should be taken into account in patients with typical symptoms and travel history to endemic regions. In this case, rapid diagnostic and general hygiene practices are important to prevent further transmission.
MeSH term(s)	Betacoronavirus ; Coronavirus ; Coronavirus 229E, Human ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Coronavirus NL63, Human ; Coronavirus OC43, Human ; Humans ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/virology ; Severe Acute Respiratory Syndrome/diagnosis ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/prevention & control ; Severe Acute Respiratory Syndrome/virology
Keywords	covid19
Language	German
Publishing date	2019-08-27
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2913-0
ISSN	1432-1289 ; 0020-9554
ISSN (online)	1432-1289
ISSN	0020-9554
DOI	10.1007/s00108-019-00671-5
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Article: Metal-organic frameworks as an alternative smart sensing platform for designing molecularly imprinted electrochemical sensors

Çorman, M.E. / Ozcelikay, G. / Cetinkaya, A. / Kaya, S.I. / Armutcu, C. / Özgür, E. / Uzun, L. / Ozkan, S.A.

Trends in analytical chemistry. 2022 May, v. 150

2022

Abstract: Although molecularly imprinted electrochemical sensors (MIECS) have proposed an intriguing potential to compete with other sensor types, they are still subject to limitations such as heterogeneous binding sites, random polymerization, and a rigid and ... ...

Abstract	Although molecularly imprinted electrochemical sensors (MIECS) have proposed an intriguing potential to compete with other sensor types, they are still subject to limitations such as heterogeneous binding sites, random polymerization, and a rigid and dense network resulting in low sensitivity and specificity. Recently, MOFs as a promising sensory material have been proposed and designed to overcome the limitations mentioned above. In this context, the introduction of MOFs into MIECS shows excellent potential for fabricating a selective layer on an electrochemical sensor resulting in enhanced sensing performance. Herein, we focused our efforts on serving a comprehensive review for the researchers while revealing the cross-section of MOFs and MIECs to develop an alternative approach to improve the sensitivity of the electrochemical sensors by using MOFs-based materials. Moreover, the employment of various materials, including nanoparticles, carbon-based materials, and nanocomposites with specific functions on the performance of MIECS, has been assessed. This review will also cover the recent progress achieved in MOFs-based MIECs adapted for the detection wide range of analytes from small molecules such as amino acids, pharmaceuticals, pesticides to larger molecules, proteins. These make this review very attractive and have a great potential to result in new, further, and innovative approaches for solving challenges in MIPs and opening a new field for electrochemical sensors.
Keywords	chemical species ; drugs ; electrochemistry ; nanocomposites ; polymerization ; sensors (equipment)
Language	English
Dates of publication	2022-05
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2014041-1
ISSN	0165-9936
ISSN	0165-9936
DOI	10.1016/j.trac.2022.116573
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Article: Seropositivity and flight-associated risk factors for SARS-CoV-2 infection among asylum seekers arriving in Berlin, Germany - A cross-sectional study

Brandt, Ariadne / Breucker, Lena / Keller, Jan / Corman, Victor Max / Bethke, Norma / Seybold, Joachim

Frontiers in Public Health

2023

Abstract: Introduction: Refugees and asylum seekers might be at increased risk of SARS-CoV-2 infection due to precarious living conditions during flight. Methods: Between March 24th and June 15th 2021, we conducted a cross-sectional study among adult asylum ... ...

Title translation	Seropositivität und fluchtbedingte Risikofaktoren für eine SARS-CoV-2-Infektion bei Asylbewerbern, die in Berlin, Deutschland, ankommen - eine Querschnittstudie
Abstract	Introduction: Refugees and asylum seekers might be at increased risk of SARS-CoV-2 infection due to precarious living conditions during flight. Methods: Between March 24th and June 15th 2021, we conducted a cross-sectional study among adult asylum seekers arriving in Berlin. Each participant was tested for acute SARS-CoV-2 infection with a nasopharyngeal swab using reverse transcriptase PCR (rt-PCR), and for anti-SARS-CoV-2-S1 IgG antibodies using ELISA. Seropositivity, antibody avidity, and data on flight history were used to categorize individuals into two groups according to the estimated time of infection before or during flight. Sociodemographic characteristics, COVID-19 related symptoms, hygiene behaviors, and living conditions during transit were assessed using two self-report questionnaires. Results: Among 1041 participants (34.5% female, mean age 32.6 years), most frequently reported countries of origin were Moldova (20.5%), Georgia (18.9%), Syria (13.0%), Afghanistan (11.3%), and Vietnam (9.1%). Seropositivity rate was 25.1% and incidence rate of acute SARS-CoV-2 infection was 2.8%. A higher likelihood for seropositivity was observed in women (OR [95%CI]=1.64 [1.052.57]) but reduced by frequent hygiene behaviors (OR [95%CI]=0.75 [0.59-0.96]) or traveling by plane (OR [95%CI]=0.58 [0.35-0.96]). Other associated factors were lower educational level, accommodation in refugee shelters, traveling with children or by foot, and COVID-19 information seeking. Conclusion: Flight-associated risk factors such as accommodation in a refugee shelter and poor hygiene behaviors are associated with an elevated risk of infection, which should be addressed by public health interventions.
Keywords	At Risk Populations ; COVID-19 ; Flüchtlinge ; Hygiene ; Infectious Disorders ; Infektionskrankheiten ; Refugees ; Risikofaktoren ; Risikogruppen ; Risk Factors ; Schutzhäuser ; Shelters
Language	English
Document type	Article
ZDB-ID	2711781-9
ISSN	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1134546
Database	PSYNDEX

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Article ; Online: Molecular detection of cosaviruses in a patient with acute flaccid paralysis and in sewage samples in Germany.

Schneider, J / Engler, M / Hofmann, J / Selinka, H C / Jones, T C / Drosten, C / Diedrich, S / Corman, V M / Böttcher, S

Virus research

2021 Volume 297, Page(s) 198285

Abstract: Cosaviruses (CoSV) were first identified in stool samples collected from non-polio acute flaccid paralysis (AFP) cases and their healthy contacts in Pakistan in 2003. The clinical importance of CoSV remains unclear as data on epidemiology are scarce and ... ...

Abstract	Cosaviruses (CoSV) were first identified in stool samples collected from non-polio acute flaccid paralysis (AFP) cases and their healthy contacts in Pakistan in 2003. The clinical importance of CoSV remains unclear as data on epidemiology are scarce and no routine diagnostic testing is done. In this study, we characterized human CoSV (HCoSV) in a child with non-polio AFP and in sewage samples collected in Berlin, Germany. Using unbiased high-throughput sequencing and specific PCR, we characterized a HCoSV-D in stool samples of a three-year-old child hospitalized in Germany with non-polio AFP and travel history to Pakistan. The shedding pattern and absence of other relevant pathogens suggests that HCoSV-D may have been involved in the genesis of AFP. The HCoSV-RNA concentration was high, with 2.57 × 10
MeSH term(s)	Central Nervous System Viral Diseases/diagnosis ; Child, Preschool ; Feces ; Germany ; Humans ; Myelitis/diagnosis ; Myelitis/virology ; Neuromuscular Diseases/diagnosis ; Neuromuscular Diseases/virology ; Paralysis/diagnosis ; Paralysis/virology ; Phylogeny ; Picornaviridae/genetics ; Picornaviridae Infections/diagnosis ; Sewage/virology
Chemical Substances	Sewage
Language	English
Publishing date	2021-02-03
Publishing country	Netherlands
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605780-9
ISSN	1872-7492 ; 0168-1702
ISSN (online)	1872-7492
ISSN	0168-1702
DOI	10.1016/j.virusres.2020.198285
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Article ; Online: A semi-covalent molecularly imprinted electrochemical sensor for rapid and selective detection of tiotropium bromide

Cetinkaya, Ahmet / Kaya, S. Irem / Atici, Esen Bellur / Çorman, M. Emin / Uzun, Lokman / Ozkan, Sibel A.

Anal Bioanal Chem. 2022 Nov., v. 414, no. 28 p.8023-8033

2022

Abstract: Tiotropium bromide (TIO) is a long-acting bronchodilator used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma. Specifically, it is used to prevent patients from worsening breathing difficulties. In this study, a new TIO- ... ...

Abstract	Tiotropium bromide (TIO) is a long-acting bronchodilator used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma. Specifically, it is used to prevent patients from worsening breathing difficulties. In this study, a new TIO-imprinted electrochemical sensor was designed to detect TIO in serum and pharmaceutical samples. Methacryloyl-L-histidine-cobalt(II) [MAH-Co(II)] has been used as a metal-chelating monomer for synthesizing selective molecularly imprinted polymer (MIP). MIP film has been developed on glassy carbon electrodes using MAH-Co(II) as the functional monomer, 2-hydroxyethyl methacrylate (HEMA) as the basic monomer, and ethylene glycol dimethacrylate (EGDMA) as the cross-linker in the photopolymerization method. The surface characterization of the developed MAH-Co(II)@MIP/GCE electrochemical sensor was done using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Also, the electrochemical behavior of the sensor was provided by differential pulse voltammetry (DPV), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS) techniques. Under optimized experimental conditions, the linearity range was in the range of 10–100 fM, and the limit of detection (LOD) and limit of quantitation (LOQ) values were calculated as 2.73 fM and 9.75 fM, respectively. The MAH-Co(II)@MIP/GCE sensor was used to precisely determine TIO in capsule and commercial serum samples. The results demonstrated that the MIP could specifically recognize TIO compared to structurally related drugs and could be reliably applied to the direct determination of drugs from real samples.
Keywords	Fourier transform infrared spectroscopy ; asthma ; blood serum ; bronchodilators ; carbon ; detection limit ; dielectric spectroscopy ; electrochemistry ; electron microscopy ; ethylene glycol ; molecular imprinting ; polymers ; sensors (equipment) ; voltammetry
Language	English
Dates of publication	2022-11
Size	p. 8023-8033.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ISSN	1618-2642
DOI	10.1007/s00216-022-04335-6
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Biphasic MERS-CoV Incidence in Nomadic Dromedaries with Putative Transmission to Humans, Kenya, 2022-2023.

Ogoti, Brian Maina / Riitho, Victor / Wildemann, Johanna / Mutono, Nyamai / Tesch, Julia / Rodon, Jordi / Harichandran, Kaneemozhe / Emanuel, Jackson / Möncke-Buchner, Elisabeth / Kiambi, Stella / Oyugi, Julius / Mureithi, Marianne / Corman, Victor M / Drosten, Christian / Thumbi, Samuel M / Müller, Marcel A

Emerging infectious diseases

2024 Volume 30, Issue 3, Page(s) 581–585

Abstract: Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in dromedaries in Africa, but camel-to-human transmission is limited. Sustained 12-month sampling of dromedaries in a Kenya abattoir hub showed biphasic MERS-CoV incidence; peak ... ...

Abstract	Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in dromedaries in Africa, but camel-to-human transmission is limited. Sustained 12-month sampling of dromedaries in a Kenya abattoir hub showed biphasic MERS-CoV incidence; peak detections occurred in October 2022 and February 2023. Dromedary-exposed abattoir workers (7/48) had serologic signs of previous MERS-CoV exposure.
MeSH term(s)	Humans ; Animals ; Camelus ; Middle East Respiratory Syndrome Coronavirus ; Kenya/epidemiology ; Incidence ; Abattoirs
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid3003.231488
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Article ; Online: Feasibility of injected indocyanine green for ureteral identification during robotic left-sided colorectal resections.

Soriano, Celine R / Cheng, Ron Ron / Corman, John M / Moonka, Ravi / Simianu, Vlad V / Kaplan, Jennifer A

American journal of surgery

2021 Volume 223, Issue 1, Page(s) 14–20

Abstract: Background: Ureteral identification is essential to performing safe colorectal surgery. Injected immunofluorescence may aid with ureteral identification, but feasibility without ureteral catheterization is not well described.: Methods: Case series of ...

Abstract	Background: Ureteral identification is essential to performing safe colorectal surgery. Injected immunofluorescence may aid with ureteral identification, but feasibility without ureteral catheterization is not well described. Methods: Case series of robotic colorectal resections where indocyanine green (ICG) injection with or without ureteral catheter placement was performed. Imaging protocol, time to ureteral identification, and factors impacting visualization are reported. Results: From 2019 to 2020, 83 patients underwent ureteral ICG injection, 20 with catheterization and 63 with injection only. Main indications were diverticulitis (52%) and cancer (36%). Median time to instill ICG was faster with injection alone than with catheter placement (4min vs 13.5min, p < 0.001). Median time [IQR] to right ureter (0.3 [0.01-1.2] min after robot docking) and left ureter (5.5 [3.1-8.8] min after beginning dissection) visualization was not different between injection alone and catheterization. Conclusion: ICG injection alone is faster than with indwelling catheter placement and equally reliable at intraoperative ureteral identification.
MeSH term(s)	Aged ; Colectomy/adverse effects ; Colectomy/methods ; Colorectal Neoplasms/surgery ; Cystoscopy/instrumentation ; Cystoscopy/methods ; Diverticulitis, Colonic/surgery ; Feasibility Studies ; Female ; Humans ; Indocyanine Green/administration & dosage ; Intraoperative Care/instrumentation ; Intraoperative Care/methods ; Intraoperative Complications/etiology ; Intraoperative Complications/prevention & control ; Laparoscopy ; Male ; Middle Aged ; Robotic Surgical Procedures/adverse effects ; Robotic Surgical Procedures/methods ; Ureter/diagnostic imaging ; Ureter/injuries ; Urinary Catheters
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2021-07-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2021.07.012
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Article ; Online: MERS-CoV in sheep, goats, and cattle, United Arab Emirates, 2019: Virological and serological investigations reveal an accidental spillover from dromedaries.

Weidinger, Pia / Kolodziejek, Jolanta / Camp, Jeremy V / Loney, Tom / Kannan, Dafalla O / Ramaswamy, Sathishkumar / Tayoun, Ahmad Abou / Corman, Victor M / Nowotny, Norbert

Transboundary and emerging diseases

2021 Volume 69, Issue 5, Page(s) 3066–3072

Abstract: The recent COVID-19 pandemic has demonstrated again the global threat posed by emerging zoonotic coronaviruses. During the past two decades alone, humans have experienced the emergence of several coronaviruses, such as SARS-CoV in 2003, MERS-CoV in 2012, ...

Abstract	The recent COVID-19 pandemic has demonstrated again the global threat posed by emerging zoonotic coronaviruses. During the past two decades alone, humans have experienced the emergence of several coronaviruses, such as SARS-CoV in 2003, MERS-CoV in 2012, and SARS-CoV-2 in 2019. To date, MERS-CoV has been detected in 27 countries, with a case fatality ratio of approximately 34.5%. Similar to other coronaviruses, MERS-CoV presumably originated from bats; however, the main reservoir and primary source of human infections are dromedary camels. Other species within the Camelidae family, such as Bactrian camels, alpacas, and llamas, seem to be susceptible to the infection as well, although to a lesser extent. In contrast, susceptibility studies on sheep, goats, cattle, pigs, chickens, and horses obtained divergent results. In the present study, we tested nasal swabs and/or sera from 55 sheep, 45 goats, and 52 cattle, collected at the largest livestock market in the United Arab Emirates, where dromedaries are also traded, for the presence of MERS-CoV nucleic acid by RT-qPCR, and for specific antibodies by immunofluorescence assay. All sera were negative for MERS-CoV-reactive antibodies, but the nasal swab of one sheep (1.8%) repeatedly tested positive for MERS-CoV nucleic acid. Next generation sequencing (NGS) of the complete N gene of the sheep-derived MERS-CoV revealed >99% nucleotide identity to MERS-CoV sequences of five dromedaries in nearby pens and to three reference sequences. The NGS sequence of the sheep-derived MERS-CoV was confirmed by conventional RT-PCR of a part of the N gene and subsequent Sanger sequencing. All MERS-CoV sequences clustered within clade B, lineage 5. In conclusion, our study shows that noncamelid livestock, such as sheep, goats, and cattle do not play a major role in MERS-CoV epidemiology. The one sheep that tested positive most likely reflects an accidental viral spillover event from infected dromedaries in nearby pens.
MeSH term(s)	Animals ; COVID-19/veterinary ; Camelids, New World ; Camelus ; Cattle ; Cattle Diseases/epidemiology ; Chickens ; Goat Diseases/epidemiology ; Goats ; Horse Diseases/epidemiology ; Horses ; Humans ; Livestock ; Middle East Respiratory Syndrome Coronavirus/genetics ; Nucleic Acids ; Nucleotides ; Pandemics ; SARS-CoV-2 ; Sheep ; Sheep Diseases/epidemiology ; Swine ; Swine Diseases/epidemiology ; United Arab Emirates/epidemiology
Chemical Substances	Nucleic Acids ; Nucleotides
Language	English
Publishing date	2021-09-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2414822-2
ISSN	1865-1682 ; 1865-1674
ISSN (online)	1865-1682
ISSN	1865-1674
DOI	10.1111/tbed.14306
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