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  1. Article ; Online: Infection prevention in medical education - results of a descriptive cross-sectional study in Germany.

    Tingelhoff, Paul-Dierk / Hufert, Frank / Kiessling, Claudia / Otto, Bertram

    GMS journal for medical education

    2024  Volume 41, Issue 1, Page(s) Doc4

    Abstract: Objective: The aim of the study was to assess the current curricular status of content on infection prevention in hospitals during medical education prior to the development of a serious game on infection prevention in hospitals. In addition, the data ... ...

    Abstract Objective: The aim of the study was to assess the current curricular status of content on infection prevention in hospitals during medical education prior to the development of a serious game on infection prevention in hospitals. In addition, the data collected was to be contrasted with the training for a specialist nurse in hygiene and infection prevention (FKHI).
    Methodology: In an online survey, persons in charge of medical degree programs and continuing education centers for FKHI, SkillsLabs and professional associations in Germany were asked to answer 28 questions on framework conditions, teaching, examinations, and gamification.
    Results: Data was collected for 22 medical degree programs and 5 FKHI continuing education centers. Due to the low response rate, the data for the FKHI was only analyzed in summary form. On average, 13.5 teaching units (median) are available in medical studies. Six degree programs have a longitudinal curriculum. In 7 of the 22 degree programs, teaching is based on the National Competency-Based Learning Objectives Catalogue (NKLM). Almost all locations teach this content in lectures (n=18) and/or in internships (n=13). Teaching and examinations are most common in the third year of study (n=12). In addition to practical OSCE examinations (n=5), written (n=12) and computer-based (n=8) examinations are used in particular. Gamification is known as a didactic approach to some extent but is not used for teaching infection prevention.
    Conclusions: Infection prevention in hospitals is given relatively low priority in medical education. Teaching and examinations are based on traditional knowledge-oriented formats, although practical teaching and practical examinations are established at some locations. In contrast to the FKHI, learning objectives currently appear to be less standardized. Further interprofessional development of teaching would be desirable in the future.
    MeSH term(s) Cross-Sectional Studies ; Curriculum ; Education, Medical ; Learning ; Germany ; Education, Medical, Undergraduate
    Language English
    Publishing date 2024-02-15
    Publishing country Germany
    Document type Journal Article
    ISSN 2366-5017
    ISSN (online) 2366-5017
    DOI 10.3205/zma001659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Coronaviren: von der banalen Erkältung zum schweren Lungenversagen: Chronologie einer Pandemie.

    Hufert, F / Spiegel, M

    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde

    2020  Volume 168, Issue 6, Page(s) 488–501

    Abstract: In December 2019 a new human coronavirus emerged in Wuhan, China, which is known as SARS-CoV‑2. The clinical course of the disease known as coronavirus disease 2019 (COVID-19) ranges from mild respiratory symptoms to severe lung failure. The virus is ... ...

    Title translation Coronavirus: from common cold to severe pulmonary failure.
    Abstract In December 2019 a new human coronavirus emerged in Wuhan, China, which is known as SARS-CoV‑2. The clinical course of the disease known as coronavirus disease 2019 (COVID-19) ranges from mild respiratory symptoms to severe lung failure. The virus is currently rapidly spreading around the world and pushing health systems to the limits of their capacity due to the exponential increase in the number of cases. The origin of SARS-CoV‑2 lies in the bat coronavirus pool and has now emerged in the human population due to interspecies transmission. Molecular diagnostic methods have been established in a very short time and a number of clinical studies on the effectiveness of different antiviral drugs are ongoing. The development of a vaccine using different approaches is also under investigation.Considering the high number of cases and mortality rates of up to 9% there is an urgent need for action. This article summarizes the current state of knowledge on human coronaviruses with a strong focus on the current data on SARS-CoV‑2. Due to the daily changing level of knowledge, the article reflects the status up to 21 March 2020.
    Keywords covid19
    Language German
    Publishing date 2020-04-01
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 137102-2
    ISSN 1433-0474 ; 0026-9298
    ISSN (online) 1433-0474
    ISSN 0026-9298
    DOI 10.1007/s00112-020-00910-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Infection prevention in medical education – results of a descriptive cross-sectional study in Germany

    Tingelhoff, Paul-Dierk / Hufert, Frank / Kiessling, Claudia / Otto, Bertram

    GMS Journal for Medical Education

    2024  Volume 41, Issue 1, Page(s) 4

    Abstract: Zielsetzung: Ziel der Studie war es, den curricularen Ist-Zustand von Inhalten zur Infektionsprävention im Krankenhaus im Medizinstudium im Vorfeld der Entwicklung eines Serious Game zur Infektionsprävention im Krankenhaus zu erheben. Zusätzlich sollten ...

    Title translation Infektionsprävention in der medizinischen Ausbildung – Ergebnisse einer deskriptiven Querschnittstudie in Deutschland
    Abstract Zielsetzung: Ziel der Studie war es, den curricularen Ist-Zustand von Inhalten zur Infektionsprävention im Krankenhaus im Medizinstudium im Vorfeld der Entwicklung eines Serious Game zur Infektionsprävention im Krankenhaus zu erheben. Zusätzlich sollten die erhobenen Daten mit der Weiterbildung zur Fachgesundheits- & Krankenpflege Hygiene und Infektionsprävention (FKHI) kontrastiert werden.
    Methodik: Mittels Onlinebefragung wurden Fachverantwortliche der Medizinstudiengänge und Weiterbildungsstätten für FKHI, von SkillsLabs und Fachschaften in Deutschland gebeten, 28 Fragen zu Rahmenbedingungen, Unterricht, Prüfungen sowie Gamification auszufüllen.
    Ergebnisse: Es wurden Daten für 22 Medizinstudiengänge und 5 FKHI-Weiterbildungsstätten erhoben. Aufgrund des geringen Rücklaufs wurden die Daten für die FKHI nur zusammenfassend ausgewertet. Im Medizinstudium stehen im Durchschnitt 13,5 Unterrichtseinheiten (Median) zur Verfügung. Sechs Studiengänge haben ein longitudinales Curriculum. In sieben der 22 Studiengänge orientiert sich die Lehre am Nationalen kompetenzbasierten Lernzielkatalog (NKLM). Fast alle Standorte vermitteln diese Inhalte in Vorlesungen (n=18) und/oder in Praktika (n=13). Am häufigsten wird im dritten Studienjahr unterrichtet und geprüft (n=12). Neben praktischen OSCE-Prüfungen (n=5), werden vor allem schriftliche (n=12) und computerbasierte (n=8) Klausuren eingesetzt. Gamification ist als didaktischer Ansatz zum Teil bekannt, wird jedoch nicht für den Unterricht der Infektionsprävention angewendet.
    Schlussfolgerungen: Der Infektionsprävention im Krankenhaus wird im Medizinstudium ein relativ geringer Stellenwert zugewiesen. Lehre und Prüfungen orientieren sich an traditionellen wissensorientierten Formaten, wobei praktischer Unterricht und praktische Prüfungen an einigen Standorten etabliert sind. Lernziele erscheinen aktuell im Gegensatz zur FKHI wenig standardisiert. Eine interprofessionelle Weiterentwicklung der Lehre wäre zukünftig anzustreben. ; Objective: The aim of the study was to assess the current curricular status of content on infection prevention in hospitals during medical education prior to the development of a serious game on infection prevention in hospitals. In addition, the data collected was to be contrasted with the training for a specialist nurse in hygiene and infection prevention (FKHI).
    Methodology: In an online survey, persons in charge of medical degree programs and continuing education centers for FKHI, SkillsLabs and professional associations in Germany were asked to answer 28 questions on framework conditions, teaching, examinations, and gamification.
    Results: Data was collected for 22 medical degree programs and 5 FKHI continuing education centers. Due to the low response rate, the data for the FKHI was only analyzed in summary form. On average, 13.5 teaching units (median) are available in medical studies. Six degree programs have a longitudinal curriculum. In 7 of the 22 degree programs, teaching is based on the National Competency-Based Learning Objectives Catalogue (NKLM). Almost all locations teach this content in lectures (n=18) and/or in internships (n=13). Teaching and examinations are most common in the third year of study (n=12). In addition to practical OSCE examinations (n=5), written (n=12) and computer-based (n=8) examinations are used in particular. Gamification is known as a didactic approach to some extent but is not used for teaching infection prevention.
    Conclusions: Infection prevention in hospitals is given relatively low priority in medical education. Teaching and examinations are based on traditional knowledge-oriented formats, although practical teaching and practical examinations are established at some locations. In contrast to the FKHI, learning objectives currently appear to be less standardized. Further interprofessional development of teaching would be desirable in the future.
    Keywords Medizin, Gesundheit ; medical education ; infection prevention ; curriculum development ; examinations ; serious games ; gamification ; innovative teaching methods ; hygiene ; medizinische Ausbildung ; Infektionsprävention ; Curriculumsentwicklung ; Prüfungen ; Serious Games ; Gamification ; innovative Lehrmethoden ; Hygiene ; prevention of infections ; Infektionsprävention
    Publishing date 2024-02-15
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Article ; Online
    ISSN 2366-5017
    ISSN (online) 2366-5017
    DOI 10.3205/zma001659
    Database German Medical Science

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  4. Article: Coronaviren: von der banalen Erkältung zum schweren Lungenversagen: Chronologie einer Pandemie./ [Coronavirus: from common cold to severe pulmonary failure]

    Hufert, F / Spiegel, M

    Monatsschr Kinderheilkd

    Abstract: In December 2019 a new human coronavirus emerged in Wuhan, China, which is known as SARS-CoV­2. The clinical course of the disease known as coronavirus disease 2019 (COVID-19) ranges from mild respiratory symptoms to severe lung failure. The virus is ... ...

    Abstract In December 2019 a new human coronavirus emerged in Wuhan, China, which is known as SARS-CoV­2. The clinical course of the disease known as coronavirus disease 2019 (COVID-19) ranges from mild respiratory symptoms to severe lung failure. The virus is currently rapidly spreading around the world and pushing health systems to the limits of their capacity due to the exponential increase in the number of cases. The origin of SARS-CoV­2 lies in the bat coronavirus pool and has now emerged in the human population due to interspecies transmission. Molecular diagnostic methods have been established in a very short time and a number of clinical studies on the effectiveness of different antiviral drugs are ongoing. The development of a vaccine using different approaches is also under investigation.Considering the high number of cases and mortality rates of up to 9% there is an urgent need for action. This article summarizes the current state of knowledge on human coronaviruses with a strong focus on the current data on SARS-CoV­2. Due to the daily changing level of knowledge, the article reflects the status up to 21 March 2020.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32292213
    Database COVID19

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  5. Article ; Online: A comparison of COVID-19 mortality rates between European and Asian States.

    Küpper, J-H / Jung, F / Krieger, V / Hufert, F

    Clinical hemorheology and microcirculation

    2020  Volume 75, Issue 1, Page(s) 3–5

    Keywords covid19
    Language English
    Publishing date 2020-06-26
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1381750-4
    ISSN 1875-8622 ; 1386-0291
    ISSN (online) 1875-8622
    ISSN 1386-0291
    DOI 10.3233/CH-209008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [No title information]

    Behrmann, Ole / Bachmann, Iris / Hufert, Frank / Dame, Gregory

    Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)

    2020  Volume 26, Issue 6, Page(s) 624–627

    Abstract: The COVID-19 pandemic highlights the need for fast and simple assays for nucleic acid detection. As an isothermal alternative to RT-qPCR, we outline the development of a detection scheme for SARS-CoV-2 RNA based ... ...

    Title translation Schnellnachweis von SARS-CoV-2 mit
    Abstract The COVID-19 pandemic highlights the need for fast and simple assays for nucleic acid detection. As an isothermal alternative to RT-qPCR, we outline the development of a detection scheme for SARS-CoV-2 RNA based on
    Keywords covid19
    Language German
    Publishing date 2020-10-14
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2203536-9
    ISSN 1868-6249 ; 0947-0867
    ISSN (online) 1868-6249
    ISSN 0947-0867
    DOI 10.1007/s12268-020-1458-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Herd immunity or suppression strategy to combat COVID-19.

    Jung, F / Krieger, V / Hufert, F T / Küpper, J-H

    Clinical hemorheology and microcirculation

    2020  Volume 75, Issue 1, Page(s) 13–17

    Abstract: Some months ago, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan, China, and spread rapidly around the world. Some states, such as the Netherlands, Germany, Great Britain, Sweden and the USA initially focused on keeping ... ...

    Abstract Some months ago, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan, China, and spread rapidly around the world. Some states, such as the Netherlands, Germany, Great Britain, Sweden and the USA initially focused on keeping the restrictions for economy and society as low as possible. The responsible authorities were of the opinion - and still are e.g. in Sweden - that it is sufficient enough to protect particularly vulnerable persons such as the elderly or people with pre-existing conditions. The idea behind this is that as soon as 60 to 70 percent of the population is infected with a pathogen, a so-called "herd immunity" has developed. However, the increasing numbers of deaths and modelling studies showed the expected overload of the hospitals. Therefore, most countries decided for a temporary lockdown with the exception of Sweden.Based on the number of the total population, three times more people died from COVID-19 in Sweden (2679 deaths per 10 million inhabitants) compared to Germany (6848 deaths per 80 million inhabitants). The comparison Sweden versus Taiwan is even worse because 1072 times more people died in Sweden based on the number of the population (6 deaths per 24 million inhabitants).In the face of the lack of an antiviral treatment and the lack of a protective vaccine one must state Taiwan has made the best out of the pandemic situation whereas Sweden failed completely.
    MeSH term(s) Betacoronavirus/immunology ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Female ; Humans ; Immunity, Herd ; Male ; Pandemics/prevention & control ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1381750-4
    ISSN 1875-8622 ; 1386-0291
    ISSN (online) 1875-8622
    ISSN 1386-0291
    DOI 10.3233/CH-209006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: How we should respond to the Coronavirus SARS-CoV-2 outbreak: A German perspective.

    Jung, F / Krieger, V / Hufert, F T / Küpper, J-H

    Clinical hemorheology and microcirculation

    2020  Volume 74, Issue 4, Page(s) 363–372

    Abstract: Background: In the early phase of the COVID-19 pandemic Germany missed to set up efficient containment measures. Consequently, the number of cases increased exponentially until a lockdown was implemented to suppress the spread of SARS-CoV-2. Fortunately, ...

    Abstract Background: In the early phase of the COVID-19 pandemic Germany missed to set up efficient containment measures. Consequently, the number of cases increased exponentially until a lockdown was implemented to suppress the spread of SARS-CoV-2. Fortunately, Germany has a high capability for coronavirus lab testing and more than 30,000 ICU beds. These capabilities and the lockdown turned out to be an advantage to combat the pandemic and to prevent a health-system overload.
    Aim: The aim was to predict the plateau day of SARS-CoV-2 infections or deaths.
    Results: The effect on the viral spread of the German measures taken and the impact on the peak of new infection cases is shown. By normalizing daily case numbers, the plateau day of the current outbreak in Germany could be calculated to be reached at April 12, 2020 (day 103 of 2020).
    Conclusion: Normalized case number curves are helpful to predict the time point at which no further new infections will occur if the epidemic situation remains stable. Upon reaching the plateau day during a lockdown phase, a residual time-period of about 2-3 weeks can be utilized to prepare a safe unlocking period. As can be learned from Asian countries such as South Korea and Taiwan there must be strict rules to keep the risk of infection low. Those include social distancing, face mask wearing in combination with digital contact tracing and serosurveillance studies. Following those rules, a safe dance around the infection curve allows to keep the population at a reduced infection rate.
    MeSH term(s) Betacoronavirus ; COVID-19 ; China/epidemiology ; Communicable Disease Control/methods ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Disease Outbreaks ; Germany/epidemiology ; Humans ; Infectious Disease Medicine/trends ; Intensive Care Units ; Linear Models ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; Quarantine ; SARS-CoV-2 ; World Health Organization
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1381750-4
    ISSN 1875-8622 ; 1386-0291
    ISSN (online) 1875-8622
    ISSN 1386-0291
    DOI 10.3233/CH-209004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Protection From COVID-19–The Efficacy of Face Masks.

    Hemmer, Christoph Josef / Hufert, Frank / Siewert, Stefan / Reisinger, Emil

    Deutsches Arzteblatt international

    2021  Volume 118, Issue 5, Page(s) 59–65

    Abstract: Background: Since the beginning of 2020 the SARS-CoV-2 virus has spread to nearly every country in the world. The mainly airborne pathogen has led to large numbers of deaths, principally in elderly and vulnerable segments of the population. Protective ... ...

    Abstract Background: Since the beginning of 2020 the SARS-CoV-2 virus has spread to nearly every country in the world. The mainly airborne pathogen has led to large numbers of deaths, principally in elderly and vulnerable segments of the population. Protective vaccines have recently become available, but it is not yet clear whether and when population-wide immunity will be achieved. The existence of evidence for the protective effect of masks covering the mouth and nose is a topic of public debate.
    Methods: A selective literature search was carried out in PubMed. Data from the German Robert Koch Institute and the Centers for Disease Control and Prevention were also taken into account.
    Results: When talking, as many as 20 000 droplets ranging in size from 20 to 500 μM are released every second. According to PCR tests, the amount of virus exhaled is highest immediately before the onset of symptoms. No randomized trials have been conducted on the effect of masks covering the mouth and nose. A metaanalysis of 29 studies on infection with SARS-CoV-2, SARS, or MERS revealed that type N-95 masks (corresponding approximately to FFP-2), surgical masks, or similar multilayer cotton masks can greatly reduce the infection risk for the wearers (RR 0.34 [0.26; 0.45], with moderate heterogeneity [I2 = 48%]). Model experiments and case reports suggest that masks covering the mouth and nose afford considerable protection against transmission of SARS-CoV-2 and other airborne diseases by reducing release of and exposure to potentially infectious droplets; in addition, infections that do occur take a milder course. A limitation of the studies analyzed is that in most cases, this effect cannot be viewed in isolation from the protective impact of other measures (distancing, hygiene precautions).
    Conclusion: It can plausibly be assumed that consistent use of masks covering the mouth and nose can play an important role in containing the spread of SARSCoV- 2.
    MeSH term(s) Aged ; COVID-19 ; Humans ; Masks ; SARS-CoV-2 ; United States
    Language English
    Publishing date 2021-03-29
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2021.0119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Rapid detection of human coronavirus NL63 by isothermal reverse transcription recombinase polymerase amplification.

    Dorendorf, Aline / Bachmann, Iris / Spiegel, Martin / Abd El Wahed, Ahmed / Dame, Gregory / Hufert, Frank

    Journal of clinical virology plus

    2022  Volume 2, Issue 4, Page(s) 100115

    Language English
    Publishing date 2022-10-08
    Publishing country England
    Document type Journal Article
    ISSN 2667-0380
    ISSN (online) 2667-0380
    DOI 10.1016/j.jcvp.2022.100115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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