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  1. Article ; Online: Disease clearance in ulcerative colitis: A new therapeutic target for the future.

    Hassan, Syed Adeel / Kapur, Neeraj / Sheikh, Fahad / Fahad, Anam / Jamal, Somia

    World journal of gastroenterology

    2024  Volume 30, Issue 13, Page(s) 1801–1809

    Abstract: Advancements in murine modeling systems for ulcerative colitis have diversified our understanding of the pathophysiological factors involved in disease onset and progression. This has fueled the identification of molecular targets, resulting in a rapidly ...

    Abstract Advancements in murine modeling systems for ulcerative colitis have diversified our understanding of the pathophysiological factors involved in disease onset and progression. This has fueled the identification of molecular targets, resulting in a rapidly expanding therapeutic armamentarium. Subsequently, management strategies have evolved from symptomatic resolution to well-defined objective endpoints, including clinical remission, endoscopic remission and mucosal healing. While the incorporation of these assessment modalities has permitted targeted intervention in the context of a natural disease history and the prevention of complications, studies have consistently depicted discrepancies associated with ascertaining disease status through clinical and endoscopic measures. Current recommendations lack consideration of histological healing. The simultaneous achievement of clinical, endoscopic, and histologic remission has not been fully investigated. This has laid the groundwork for a novel therapeutic outcome termed disease clearance (DC). This article summarizes the concept of DC and its current evidence.
    MeSH term(s) Colitis, Ulcerative/therapy ; Colitis, Ulcerative/diagnosis ; Humans ; Animals ; Intestinal Mucosa/pathology ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; Disease Models, Animal ; Remission Induction/methods ; Treatment Outcome ; Mice ; Disease Progression ; Molecular Targeted Therapy/methods ; Colon/pathology ; Colon/drug effects
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Review ; Journal Article ; Editorial
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v30.i13.1801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
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  2. Article ; Online: COVID-19 Pandemic: Are Patients with Inflammatory Bowel Disease Really at Risk?

    Hassan, Syed Adeel / Ezeh, Jude

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2020  Volume 30, Issue 6, Page(s) 79–80

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Disease Outbreaks/prevention & control ; Humans ; Inflammatory Bowel Diseases/therapy ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-28
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2020.Supp1.S79
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6532: Show issues Location:
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  3. Article ; Online: Efficacy of Smear Layer Removal at the Apical One-Third of the Root Using Different Protocols of Erbium-Doped Yttrium Aluminium Garnet (Er:YAG) Laser.

    Habshi, Amel Yousif / Aga, Nausheen / Habshi, Khadija Yousif / Hassan, Muna Eisa Mohamed / Choudhry, Ziaullah / Ahmed, Muhammad Adeel / Syed, Azeem Ul Yaqin / Jouhar, Rizwan

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 3

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Humans ; Aluminum ; Edetic Acid ; Erbium ; Lasers, Solid-State/therapeutic use ; Root Canal Irrigants/therapeutic use ; Root Canal Preparation/methods ; Smear Layer ; Yttrium
    Chemical Substances Aluminum (CPD4NFA903) ; Edetic Acid (9G34HU7RV0) ; Erbium (77B218D3YE) ; Root Canal Irrigants ; Yttrium (58784XQC3Y)
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59030433
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  4. Article ; Online: Author Correction: Influence of natural and non‑natural diets on the fitness and rearing of Pectinophora gossypiella Saunders.

    Saeed, Rabia / Hassan, Muhammad Waqar Ul / Jaleel, Waqar / Ikhlaq, Muhammad / Shah, Syed Ishfaq Ali / Niaz, Safia / Azad, Rashid / Akbar, Rasheed / Mahmood, Zahid / Mukhtar, Adeel / Zaka, Syed Muhammad / Rasool, Khawaja G / Husain, Mureed / Hassan, Montaser M / Aldawood, Abdulrahman S / Shakeel, Muhammad

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 20561

    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-47960-6
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  5. Article: COVID-19 Pandemic: Are Patients with Inflammatory Bowel Disease Really at Risk?

    Hassan, Syed Adeel / Ezeh, Jude

    J Coll Physicians Surg Pak

    Abstract: Null. ...

    Abstract Null.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #690566
    Database COVID19

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  6. Article: Enhanced mucosal mitochondrial function corrects dysbiosis and OXPHOS metabolism in IBD.

    Kapur, Neeraj / Alam, M Ashfaqul / Hassan, Syed Adeel / Patel, Parth H / Wempe, Lesley A / Bhogoju, Sarayu / Goretsky, Tatiana / Kim, Jong Hyun / Herzog, Jeremy / Ge, Yong / Awuah, Samuel G / Byndloss, Mariana / Baumler, Andreas J / Zadeh, Mansour M / Sartor, R Balfour / Barrett, Terrence

    bioRxiv : the preprint server for biology

    2024  

    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.14.584471
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  7. Article: Lead Toxicity-Mediated Growth and Metabolic Alterations at Early Seedling Stages of Maize (

    Talha, Muhammad / Shani, Muhammad Yousaf / Ashraf, Muhammad Yasin / De Mastro, Francesco / Brunetti, Gennaro / Khan, Muhammad Kashif Riaz / Gillani, Syed Wajih Ul Hassan Shah / Khan, Adeel / Abbas, Shahid / Cocozza, Claudio

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 18

    Abstract: To investigate the toxic effects of lead (Pb) on key metabolic activities essential for proper germination and seedling growth of maize seeds, experiments were carried out with different levels of Pb (0 to 120 mg of Pb ... ...

    Abstract To investigate the toxic effects of lead (Pb) on key metabolic activities essential for proper germination and seedling growth of maize seeds, experiments were carried out with different levels of Pb (0 to 120 mg of Pb L
    Language English
    Publishing date 2023-09-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12183335
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  8. Article ; Online: Influence of natural and non-natural diets on the fitness and rearing of Pectinophora gossypiella Saunders.

    Saeed, Rabia / Hassan, Muhammad Waqar Ul / Jaleel, Waqar / Ikhlaq, Muhammad / Ali Shah, Syed Ishfaq / Niaz, Safia / Azad, Rashid / Akbar, Rasheed / Mahmood, Zahid / Mukhtar, Adeel / Zaka, Syed Muhammad / Rasool, Khawaja G / Husain, Mureed / Hassan, Montaser M / Aldawood, Abdulrahman S / Shakeel, Muhammad

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 13666

    Abstract: In order to develop integrated management approaches for Pectinophora gossypiella, basic studies are crucial. The two-sex life table is the most important tool for describing the fitness and population parameters of both sexes (male and female) of an ... ...

    Abstract In order to develop integrated management approaches for Pectinophora gossypiella, basic studies are crucial. The two-sex life table is the most important tool for describing the fitness and population parameters of both sexes (male and female) of an insect, while the traditional life table only explains the female sex of an insect. However, no study has reported on the biology of P. gossypiella using two-sex life table tools. Therefore, this study explains the rearing dynamics of P. gossypiella on a cotton seed-based artificial diet and a natural diet (mature cotton bolls). According to the results, the oviposition period of P. gossypiella was recorded to be longer on the artificial diet (9.07 ± 0.24) compared to the natural diet (7.40 ± 0.11). The total fecundity of P. gossypiella was greater on the artificial diet (125.94 ± 3.06) in comparison to the natural diet (60.37 ± 1.10). The population parameters, including intrinsic rate of increase, finite rate of increase, gross reproductive rate, and net reproductive rate of P. gossypiella were highest on the artificial diet in comparison to the natural diet. This study concluded that the cotton seed-based artificial diet was most suitable for the rearing of P. gossypiella. In the future, P. gossypiella may be studied in depth in light of the findings in this study.
    MeSH term(s) Female ; Male ; Animals ; Diet ; Lepidoptera ; Fertility ; Gossypium ; Life Tables
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-40712-6
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  9. Article: An Unusual Case of Klebsiella pneumoniae Endocarditis.

    Hassan, Syed Adeel / Akhtar, Ali / Falah, Noor Ul / Khan, Maham

    Cureus

    2020  Volume 12, Issue 2, Page(s) e6999

    Abstract: Klebsiella pneumoniae notoriously causes life-threatening community-acquired or hospital-acquired pneumonia. In the United States, community-acquired pneumonia is a relatively common diagnosis. However, community-acquired pneumonia due to Klebsiella ... ...

    Abstract Klebsiella pneumoniae notoriously causes life-threatening community-acquired or hospital-acquired pneumonia. In the United States, community-acquired pneumonia is a relatively common diagnosis. However, community-acquired pneumonia due to Klebsiella pneumoniae is fairly uncommon. Delayed antibiotic administration can result in bacteremia, septicemia and other systemic complications. Infective endocarditis arising as a complication of community-acquired Klebsiella pneumoniae infection has rarely been reported. Our patient is an 88-year-old diabetic female, who was admitted to our intensive care unit due to a high-grade fever, worsening dyspnea and hypotension. Chest x-ray and blood culture were conclusive for pneumonia due to Klebsiella pneumoniae. Importantly, the species was only susceptible to colistin. Furthermore, an echocardiogram revealed mobile vegetations of the non-coronary cusp of the aortic valve. Treatment with colistin resulted in clinical improvement and an uneventful discharge from the hospital. Follow up echocardiography was scheduled upon discharge to monitor the resolution of cardiac vegetations.
    Language English
    Publishing date 2020-02-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.6999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Electrical neuromodulation therapy for inflammatory bowel disease.

    Yasmin, Farah / Sahito, Abdul Moiz / Mir, Syeda Lamiya / Khatri, Govinda / Shaikh, Somina / Gul, Ambresha / Hassan, Syed Adeel / Koritala, Thoyaja / Surani, Salim

    World journal of gastrointestinal pathophysiology

    2022  Volume 13, Issue 5, Page(s) 128–142

    Abstract: Inflammatory bowel disease (IBD) is an inflammatory disease of the gastrointestinal (GI) tract. It has financial and quality of life impact on patients. Although there has been a significant advancement in treatments, a considerable number of patients do ...

    Abstract Inflammatory bowel disease (IBD) is an inflammatory disease of the gastrointestinal (GI) tract. It has financial and quality of life impact on patients. Although there has been a significant advancement in treatments, a considerable number of patients do not respond to it or have severe side effects. Therapeutic approaches such as electrical neuromodulation are being investigated to provide alternate options. Although bioelectric neuromodulation technology has evolved significantly in the last decade, sacral nerve stimulation (SNS) for fecal incontinence remains the only neuromodulation protocol commonly utilized use for GI disease. For IBD treatment, several electrical neuromodulation techniques have been studied, such as vagus NS, SNS, and tibial NS. Several animal and clinical experiments were conducted to study the effectiveness, with encouraging results. The precise underlying mechanisms of action for electrical neuromodulation are unclear, but this modality appears to be promising. Randomized control trials are required to investigate the efficacy of intrinsic processes. In this review, we will discuss the electrical modulation therapy for the IBD and the data pertaining to it.
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2583474-5
    ISSN 2150-5330
    ISSN 2150-5330
    DOI 10.4291/wjgp.v13.i5.128
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