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  1. Article ; Online: Comment on "Malnutrition and Polypharmacy in Older Adult Patients Receiving Home Care Nursing Services: A Cross-sectional Study".

    Naharci, Mehmet Ilkin

    Journal of the American Medical Directors Association

    2024  , Page(s) 104951

    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Letter
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2024.01.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5971: Show issues Location:
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  2. Article ; Online: Comment on the article titled "Serum cystatin C is associated with peripheral artery stiffness in patients with type 2 diabetes mellitus combined with chronic kidney disease".

    Naharci, Mehmet Ilkin

    Clinical biochemistry

    2023  Volume 123, Page(s) 110699

    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Cystatin C ; Risk Factors ; Renal Insufficiency, Chronic/complications ; Arteries
    Chemical Substances Cystatin C
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Letter
    ZDB-ID 390372-2
    ISSN 1873-2933 ; 0009-9120
    ISSN (online) 1873-2933
    ISSN 0009-9120
    DOI 10.1016/j.clinbiochem.2023.110699
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    Zs.A 624: Show issues Location:
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  3. Article ; Online: Comment on the article titled "Association of the triglyceride-glucose index with subclinical left ventricular dysfunction in type 2 diabetes mellitus patients: A retrospective cross-sectional study".

    Naharci, Mehmet Ilkin

    Journal of diabetes investigation

    2023  Volume 15, Issue 4, Page(s) 517–518

    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Cross-Sectional Studies ; Glucose ; Retrospective Studies ; Triglycerides ; Ventricular Dysfunction, Left/complications
    Chemical Substances Glucose (IY9XDZ35W2) ; Triglycerides
    Language English
    Publishing date 2023-10-20
    Publishing country Japan
    Document type Letter
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.14093
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    Zs.A 6920: Show issues Location:
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  4. Article ; Online: Is very high HdL-cholesterol level related to cardiovascular mortality affected by chronic kidney disease and alcohol use? Comment on Palatini et al.

    Naharci, Mehmet Ilkin

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2023  Volume 33, Issue 4, Page(s) 913–914

    MeSH term(s) Humans ; Cholesterol, HDL ; Renal Insufficiency, Chronic/diagnosis ; Cardiovascular Diseases/diagnosis ; Alcohol Drinking/adverse effects ; Cardiovascular System ; Risk Factors
    Chemical Substances Cholesterol, HDL
    Language English
    Publishing date 2023-02-23
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2023.02.016
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    Zs.A 3149: Show issues Location:
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  5. Article ; Online: Comment on "Plasma Leptin Is Associated With Amyloid CSF Biomarkers and Alzheimer's Disease Diagnosis in Cognitively Impaired Patients".

    Naharci, Mehmet Ilkin

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2023  Volume 78, Issue 6, Page(s) 1081

    MeSH term(s) Humans ; Alzheimer Disease/diagnosis ; Leptin ; Amyloid beta-Peptides ; tau Proteins ; Amyloidogenic Proteins ; Biomarkers
    Chemical Substances Leptin ; Amyloid beta-Peptides ; tau Proteins ; Amyloidogenic Proteins ; Biomarkers
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glad093
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    Uc I Zs.242/A: Show issues Location:
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  6. Article ; Online: Letter to the Editor Regarding "Cognitive Decline Is Associated With an Accelerated Rate of Bone Loss and Increased Fracture Risk in Women: A Prospective Study from the Canadian Multicentre Osteoporosis Study".

    Naharci, Mehmet Ilkin

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    2022  Volume 37, Issue 5, Page(s) 1073–1074

    MeSH term(s) Bone Density ; Canada/epidemiology ; Cognitive Dysfunction/complications ; Female ; Fractures, Bone/complications ; Fractures, Bone/epidemiology ; Humans ; Osteoporosis/complications ; Prospective Studies
    Language English
    Publishing date 2022-02-05
    Publishing country United States
    Document type Letter ; Multicenter Study ; Comment
    ZDB-ID 632783-7
    ISSN 1523-4681 ; 0884-0431
    ISSN (online) 1523-4681
    ISSN 0884-0431
    DOI 10.1002/jbmr.4510
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    Zs.A 2142: Show issues Location:
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  7. Article ; Online: Predictors of two-year mortality in patients with dementia with Lewy bodies.

    Satış, Neslihan Kayahan / Naharcı, Mehmet İlkin

    Turkish journal of medical sciences

    2023  Volume 53, Issue 1, Page(s) 366–373

    Abstract: Background: Data on adverse prognostic factors for mortality in patients with dementia with Lewy bodies (DLB) are limited. The objective of this study was to evaluate two-year mortality predictors in patients with DLB.: Methods: : Individuals aged ≥ ... ...

    Abstract Background: Data on adverse prognostic factors for mortality in patients with dementia with Lewy bodies (DLB) are limited. The objective of this study was to evaluate two-year mortality predictors in patients with DLB.
    Methods: : Individuals aged ≥ 60 years with a diagnosis of DLB, followed by a tertiary-referral geriatric outpatient clinic from 2006 to 2021, were assessed retrospectively using medical or patient records. The mortality status of the patients in the second year after diagnosis was determined. Demographic and clinical characteristics were reviewed to determine their impact on mortality prediction.
    Results: A total of 108 patients with DLB participated in this study. The mean age was 78.9 ± 6.6 years, and 49.1% were females. At the end of the two-year follow-up, 23 patients (21.3%) died and 85 patients (78.7%) were still alive. Malnutrition, and cognitive and functional impairments were significantly more common in the mortality group. Age, female sex, functional impairment, moderateto-severe clinical dementia rating, and malnutrition were associated with an increased mortality risk. On the multivariable analysis, malnutrition (HR = 5.00; 95% CI: 1.64-15.24; p: 0.005) was the only independent predictor of two-year-mortality.
    Discussion: Patients with DLB had an unfavorable survival outcomes. Approaches to prevent malnutrition can improve prognosis and reduce early mortality in this vulnerable group. However, further studies are needed to determine mortality risk factors in this population.
    MeSH term(s) Humans ; Female ; Aged ; Aged, 80 and over ; Male ; Lewy Body Disease/complications ; Lewy Body Disease/diagnosis ; Retrospective Studies ; Disease Progression ; Alzheimer Disease
    Language English
    Publishing date 2023-02-22
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.55730/1300-0144.5593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3242: Show issues Location:
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  8. Article ; Online: Incidence of Motoric Cognitive Risk Syndrome and Associated Factors in Older Adults in Türkiye.

    Demirdel, Senem / Keskin Demircan, Sultan / Naharcı, Mehmet İlkin

    Balkan medical journal

    2024  Volume 41, Issue 1, Page(s) 64–69

    Abstract: Background: Motoric cognitive risk syndrome (MCRS) is characterized by slow gait and subjective cognitive decline. It is a predementia syndrome associated with an increased risk of dementia and mortality.: Aims: To investigate the incidence of MCRS ... ...

    Abstract Background: Motoric cognitive risk syndrome (MCRS) is characterized by slow gait and subjective cognitive decline. It is a predementia syndrome associated with an increased risk of dementia and mortality.
    Aims: To investigate the incidence of MCRS and its associated factors in older adults in Türkiye.
    Study design: A retrospective study.
    Methods: This study enrolled community-dwelling older adults admitted to the geriatric outpatient clinic. Participants were assessed for MCRS according to previously described criteria. Logistic regression analysis was conducted to evaluate the association among MCRS and demographic features, clinical status, and geriatric syndromes.
    Results: Of the 1,352 older adults examined, 577 met the inclusion criteria, and the mean age was 75.2 years. The overall incidence of MCRS was 7.8%. The MCRS group was predominantly older, female, and unmarried, with polypharmacy and higher Deyo-Charlson comorbidity index and Yesavage geriatric depression scale scores than the non-MCRS group. In the multivariate model, significant associations were found between MCRS and age and polypharmacy [odds ratios (OR), 2.22; 95% confidence interval (CI), 1.04-4.71,
    Conclusion: The overall incidence of MCRS was found in 7.8% of older adults. Advanced age and polypharmacy are risk factors associated with MCRS.
    MeSH term(s) Humans ; Female ; Aged ; Retrospective Studies ; Incidence ; Turkey ; Risk Factors ; Cognition
    Language English
    Publishing date 2024-01-03
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2612982-6
    ISSN 2146-3131 ; 2146-3131
    ISSN (online) 2146-3131
    ISSN 2146-3131
    DOI 10.4274/balkanmedj.galenos.2023.2023-9-41
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  9. Article ; Online: Investigating the association of anticholinergic burden with depression in older adults: a cross-sectional study.

    Kayahan Satış, Neslihan / Naharcı, Mehmet İlkin

    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

    2024  Volume 24, Issue 3, Page(s) 597–604

    Abstract: Background: Although depression and anticholinergic drug use are common comorbidities that impair health status in later life, there are insufficient data on their relationship. This study aimed to investigate the relationship between depressive ... ...

    Abstract Background: Although depression and anticholinergic drug use are common comorbidities that impair health status in later life, there are insufficient data on their relationship. This study aimed to investigate the relationship between depressive symptoms and anticholinergic use in older individuals.
    Methods: Community-dwelling older adults (≥65 years) admitted to the tertiary referral geriatric outpatient clinic were included. Participants were evaluated for depressive symptoms using the Geriatric Depression Scale (GDS) with a cut-off score of ≥6 for depression. Exposure to anticholinergic drugs was assessed using the anticholinergic cognitive burden (ACB) scale and three subgroups were created: ACB = 0, ACB = 1, and ACB ≥ 2. The relationship between these two parameters was assessed using multivariate logistic regression analysis considering other potential variables.
    Results: The study included 1232 participants (mean age 78.4 ± 7.2 years and 65.2% female) and the prevalence of depression was 24%. After adjusting for potential confounders, compared to ACB = 0, having ACB ≥ 2 was related to depression symptoms (odds ratio (OR): 1.56, 95% CI: 1.04-2.35, P = 0.034), whereas having ACB = 1 did not increase the risk (OR: 1.27, 95% CI: 0.88-1.83, P = 0.205).
    Conclusion: Our findings indicate that special attention should be paid to drug therapy in preventing depression in older adults, as exposure to a high anticholinergic load is negatively associated with psychological status.
    MeSH term(s) Humans ; Aged ; Female ; Male ; Cholinergic Antagonists/adverse effects ; Cross-Sectional Studies ; Depression/epidemiology ; Depression/drug therapy ; Aged, 80 and over ; Independent Living ; Geriatric Assessment/methods ; Prevalence ; Psychiatric Status Rating Scales ; Comorbidity ; Logistic Models
    Chemical Substances Cholinergic Antagonists
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2213105-X
    ISSN 1479-8301 ; 1346-3500
    ISSN (online) 1479-8301
    ISSN 1346-3500
    DOI 10.1111/psyg.13102
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  10. Article ; Online: Comment on a Recent Article Titled "Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts".

    Naharci, Mehmet Ilkin

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    2021  Volume 36, Issue 7, Page(s) 1419

    MeSH term(s) Aged ; Biomarkers ; Bone Density ; Cohort Studies ; Humans ; Osteoblasts
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-02-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632783-7
    ISSN 1523-4681 ; 0884-0431
    ISSN (online) 1523-4681
    ISSN 0884-0431
    DOI 10.1002/jbmr.4269
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