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  1. Article: Re: A New Hope in the Treatment of Intraventricular Hemorrhage in Preterm Infants: Mesenchymal Stem Cells.

    Ovali, Fahri

    Turkish neurosurgery

    2022  Volume 32, Issue 3, Page(s) 523

    MeSH term(s) Cerebral Hemorrhage/surgery ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Mesenchymal Stem Cells
    Language English
    Publishing date 2022-03-03
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1203779-5
    ISSN 1019-5149
    ISSN 1019-5149
    DOI 10.5137/1019-5149.JTN.37470-21.0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4081: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Hemodynamic changes and evaluation during hypoxic-ischemic encephalopathy and therapeutic hypothermia.

    Ovali, Fahri

    Early human development

    2022  Volume 167, Page(s) 105563

    Abstract: Multiorgan damage is a hallmark of hypoxic-ischemic encephalopathy and cardiovascular and hemodynamic changes during asphyxia contribute significantly to the brain damage. The main insult to the heart is myocardial damage and associated ventricular ... ...

    Abstract Multiorgan damage is a hallmark of hypoxic-ischemic encephalopathy and cardiovascular and hemodynamic changes during asphyxia contribute significantly to the brain damage. The main insult to the heart is myocardial damage and associated ventricular dysfunction, which is manifested by reduced preload and afterload. The immature myocardium reacts to asphyxia by bradycardia and reduced contractile capacity. Pulmonary hypertension aggrevates cardiac dysfunction. Hypothermia is the only effective treatment for HIE but it may also affect the heart and peripheral vascular system leading to bradycardia and peripheral vasoconstriction. In fact, these effects might be cardioprotective also. Rewarming after hypothermia may increase the heart rate and cardiac metabolism, augmenting the cardiac output. Monitoring of patient with HIE during and after hypothermia is possible by using near-infrared spectroscopy, echocardiography and electrocardiography. Cerebral effects may be monitored by magnetic resonance imaging also. Management should include the physiological status of the patient and appropriate treatments, including inotropes, vasopressors or rarely fluid boluses. Dopamine should not be used unless absolutely necessary. Drugs like melatonin and magnesium are under investigation. All treatments should be evidence-based and targeted echocardiography should be used more often in these vulnerable infants.
    MeSH term(s) Hemodynamics ; Humans ; Hypothermia, Induced/methods ; Hypoxia-Ischemia, Brain/diagnostic imaging ; Hypoxia-Ischemia, Brain/therapy ; Infant ; Magnetic Resonance Imaging/methods ; Rewarming
    Language English
    Publishing date 2022-02-26
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 752532-1
    ISSN 1872-6232 ; 0378-3782
    ISSN (online) 1872-6232
    ISSN 0378-3782
    DOI 10.1016/j.earlhumdev.2022.105563
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1373: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Re: Bronchopulmonary dysplasia predicted at birth by artificial intelligence.

    Ovalı, Fahri

    Acta paediatrica (Oslo, Norway : 1992)

    2020  Volume 110, Issue 2, Page(s) 724

    MeSH term(s) Artificial Intelligence ; Bronchopulmonary Dysplasia/epidemiology ; Female ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight ; Parturition ; Pregnancy
    Language English
    Publishing date 2020-09-01
    Publishing country Norway
    Document type Letter ; Comment
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.15500
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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.95: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Molecular and Mechanical Mechanisms Regulating Ductus Arteriosus Closure in Preterm Infants.

    Ovalı, Fahri

    Frontiers in pediatrics

    2020  Volume 8, Page(s) 516

    Abstract: Failure of ductus arteriosus closure after preterm birth is associated with significant morbidities. Ductal closure requires and is regulated by a complex interplay of molecular and mechanical mechanisms with underlying genetic factors. ...

    Abstract Failure of ductus arteriosus closure after preterm birth is associated with significant morbidities. Ductal closure requires and is regulated by a complex interplay of molecular and mechanical mechanisms with underlying genetic factors.
    Language English
    Publishing date 2020-08-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.00516
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  5. Article: SARS-CoV-2 Infection and the Newborn.

    Ovalı, Fahri

    Frontiers in pediatrics

    2020  Volume 8, Page(s) 294

    Abstract: Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) affects people at all ages and it may be encountered in pregnant women and newborns also. The information about its clinical features, laboratory findings and prognosis in children and ... ...

    Abstract Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) affects people at all ages and it may be encountered in pregnant women and newborns also. The information about its clinical features, laboratory findings and prognosis in children and newborns is scarce. All the reported cases in pregnant women were in the 2nd or 3rd trimester and only 1% of them developed severe disease. Miscarriages are rare. Materno-fetal transmission of the disease is controversial. Definitive diagnosis can be made by a history of contact with a proven case, fever, pneumonia and gastrointestinal disorder and a Polymerase chain reaction (PCR) test of nasopharyngeal swabs. Lymphopenia as well as liver and renal dysfunctions may be seen. Suspected or proven cases of newborns with symptoms should be quarantined in the neonatal intensive care unit for at least 14 days with standart and droplet isolation precautions. Asymptomatic infants may be quaratined at home. Transport of the neonates should be performed in a dedicated transport incubator and ambulance with isolation precautions. There is no specific treatment for the disease, but hemodynamic stabilization of the infant, respiratory management and other daily care are essential. Drugs against cytokine storm syndrome such as corticosteroids or tocilizumab are under investigation. Routine antibiotics are not recommended. No deaths have been reported so far in the neonatal population. Families and healthcare staff should receive pyschological support. Since the infection is quite new and knowledge is constantly accumulating, following developments and continuous updates are crucial.
    Keywords covid19
    Language English
    Publishing date 2020-05-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.00294
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  6. Article ; Online: SARS-CoV-2 Infection and the Newborn

    Fahri Ovalı

    Frontiers in Pediatrics, Vol

    2020  Volume 8

    Abstract: Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) affects people at all ages and it may be encountered in pregnant women and newborns also. The information about its clinical features, laboratory findings and prognosis in children and ... ...

    Abstract Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) affects people at all ages and it may be encountered in pregnant women and newborns also. The information about its clinical features, laboratory findings and prognosis in children and newborns is scarce. All the reported cases in pregnant women were in the 2nd or 3rd trimester and only 1% of them developed severe disease. Miscarriages are rare. Materno-fetal transmission of the disease is controversial. Definitive diagnosis can be made by a history of contact with a proven case, fever, pneumonia and gastrointestinal disorder and a Polymerase chain reaction (PCR) test of nasopharyngeal swabs. Lymphopenia as well as liver and renal dysfunctions may be seen. Suspected or proven cases of newborns with symptoms should be quarantined in the neonatal intensive care unit for at least 14 days with standart and droplet isolation precautions. Asymptomatic infants may be quaratined at home. Transport of the neonates should be performed in a dedicated transport incubator and ambulance with isolation precautions. There is no specific treatment for the disease, but hemodynamic stabilization of the infant, respiratory management and other daily care are essential. Drugs against cytokine storm syndrome such as corticosteroids or tocilizumab are under investigation. Routine antibiotics are not recommended. No deaths have been reported so far in the neonatal population. Families and healthcare staff should receive pyschological support. Since the infection is quite new and knowledge is constantly accumulating, following developments and continuous updates are crucial.
    Keywords newborn ; COVID 19 infection ; breast milk ; pregnancy ; SARS- CoV-2 ; Pediatrics ; RJ1-570 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: SARS-CoV-2 Infection and the Newborn

    Ovalı, Fahri

    Frontiers in Pediatrics

    2020  Volume 8

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.00294
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Coronavirus-2019 Disease (COVID-19) in Children.

    Ovali, Fahri

    Medeniyet medical journal

    2020  Volume 35, Issue 3, Page(s) 242–252

    Abstract: COVID-19 disease affects all ages, but severe cases of the disease and mortality are very rarely seen among children. In most cases, they acquire the virus from their parents or from an another infected person. The exact reasons why the disease has a ... ...

    Abstract COVID-19 disease affects all ages, but severe cases of the disease and mortality are very rarely seen among children. In most cases, they acquire the virus from their parents or from an another infected person. The exact reasons why the disease has a milder course in children is unknown but high numbers of Angiotensin Converting Enzyme-2 (ACE2) receptors, underdeveloped immune responses, cross-reaction with other viruses, protective effect of fetal hemoglobin and fewer outdoor activities as well as journeys, and nonexposure to air pollution, and smoking. Although many cases are asymptomatic, they can still shed the virus. Materno-fetal vertical transmission has not been shown so far. In symptomatic cases, clinical findings include fever and respiratory symptoms, followed by diarrhea and vomiting. There are signs indicating a possible association between Kawasaki disease and COVID-19. Clinical findings and diagnostic procedures in newborns, and older children are similar. Supportive therapy is essential and antiviral agents are not required in most cases. During cytokine storm, anti-inflammatory treatments may be tried. There is no evidence for transmission through breastmilk; therefore infected mothers should breastfeed their infants by taking all precautions. Routine immunizations of children should not be deferred during COVID-19 outbreak period. Psychological support for children who need to stay at home and for healthcare personnel should be provided.
    Keywords covid19
    Language English
    Publishing date 2020-09-30
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 3035195-9
    ISSN 2149-4606 ; 2149-2042
    ISSN (online) 2149-4606
    ISSN 2149-2042
    DOI 10.5222/MMJ.2020.77675
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  9. Article: SARS-CoV-2 Infection and the Newborn

    Ovalı, Fahri

    Front. Pediatr.

    Abstract: Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) affects people at all ages and it may be encountered in pregnant women and newborns also. The information about its clinical features, laboratory findings and prognosis in children and ... ...

    Abstract Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) affects people at all ages and it may be encountered in pregnant women and newborns also. The information about its clinical features, laboratory findings and prognosis in children and newborns is scarce. All the reported cases in pregnant women were in the 2nd or 3rd trimester and only 1% of them developed severe disease. Miscarriages are rare. Materno-fetal transmission of the disease is controversial. Definitive diagnosis can be made by a history of contact with a proven case, fever, pneumonia and gastrointestinal disorder and a Polymerase chain reaction (PCR) test of nasopharyngeal swabs. Lymphopenia as well as liver and renal dysfunctions may be seen. Suspected or proven cases of newborns with symptoms should be quarantined in the neonatal intensive care unit for at least 14 days with standart and droplet isolation precautions. Asymptomatic infants may be quaratined at home. Transport of the neonates should be performed in a dedicated transport incubator and ambulance with isolation precautions. There is no specific treatment for the disease, but hemodynamic stabilization of the infant, respiratory management and other daily care are essential. Drugs against cytokine storm syndrome such as corticosteroids or tocilizumab are under investigation. Routine antibiotics are not recommended. No deaths have been reported so far in the neonatal population. Families and healthcare staff should receive pyschological support. Since the infection is quite new and knowledge is constantly accumulating, following developments and continuous updates are crucial.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #612433
    Database COVID19

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  10. Article ; Online: COVID-19 Infections in Newborns ; Yenidoğanlarda COVID-19 Enfeksiyonları

    OVALI, Fahri

    Volume: 25, Issue: Supplement 1 23-45 ; 2149-5254 ; 2458-8849 ; Anatolian Clinic the Journal of Medical Sciences

    2020  

    Abstract: Novel type Coronavirus-19 is seen mainly in elderly people but it may be encountered in pregnant women and newborns also. The information about its clinical features, laboratory findings and prognosis in children and newborns is scarce. Since the ... ...

    Abstract Novel type Coronavirus-19 is seen mainly in elderly people but it may be encountered in pregnant women and newborns also. The information about its clinical features, laboratory findings and prognosis in children and newborns is scarce. Since the immunological systems of the newborns have not developed completely, it may be considered that their risks are larger. All the reported cases in pregnant women were in the 3rd trimestr and only 1% of them developed severe disease. There is no data yet on the materno-fetal transmission of the disease. Case reports of newborns are similar to those of adults. Definitive diagnosis can be made by a history of contact with a proven case, fever, pneumonia and gastrointestinal disorder. Lymphopenia, liver and renal function disorders may be seen. Suspected or proven cases of newborns should be isolated in the neonatal intensive care unit for at least 14 days with standart and droplet isolation precautions. If needed, the transport of the neonate should be performed in a transport incubator with isolation precautions. The incubator and the ambulance should be disenfected before and after the transport. There is no specific treatment for the disease, but hemodynamic stabilization of the infant, respiratory management and other daily care are essential. Some drugs are under investigation. Routine antibiotics are not recommended. No deaths have been reported in infected cases. Possible hyperbilirubinemia of the infant should be managed appropiately. Families and healthcare staff should receive pyschological support. Since the infection is quite new and knowledge is constantly accumulating, following scientific developments is crucial.

    Yeni tip Coronavirüs-19, genellikle yaşlı bireylerde görülmesine rağmen gebelerde ve yenidoğan bebeklerde de görülebilmektedir. Virüsün çocuklarda ve yenidoğanlardaki klinik özellikleri, laboratuvar bulguları ve prognozu hakkında yeteri kadar bilgi yoktur. Yenidoğanların immün sistemleri yeteri kadar gelişmemiş olduğundan daha büyük risk altında oldukları düşünülebilir. Şimdiye kadar bildirilen gebelerin hemen hepsi 3. trimestrde enfekte olmuşlardır. Bu kadınların ancak % 1’inde kritik hastalık gelişmiştir. Ancak şimdiye kadar materno-fetal vertikal geçişi kanıtlayabilecek bir veri elde edilememiştir. Yenidoğanlardaki vaka tanımları erişkinlerdekine benzerdir. Kesin tanılı hasta biriyle temasın yanı sıra, ateş, solunum yolu bulguları, pnömoni ve gastrointestinal bulgular gözlenebilir. Hastalarda lenfopeni bulunabileceği gibi karaciğer ve böbrek fonksiyon bozukluklarına da rastlanabilir. Şüpheli veya kesin tanılı yenidoğanların yenidoğan yoğun bakım ünitesinde 14 gün süreyle izole edilmeleri ve standart ve damlacık enfeksiyonu temas önlemlerinin alınması gerekir. Yenidoğanların transportu gerekirse, küvöz içinde, gerekli önlemler alınarak transport edilmeli, transport öncesi ve sonrasında ambulans dahil tüm ekipman dezenfekte edilmelidir. Hastalığın kesin bir tedavisi olmadığı için yenidoğanın hemodinamik stabilitesinin sağlanması, solunum desteği verilmesi ve diğer rutin bakımlarının yapılması yerinde olur. Rutin antibiyotik kullanımına gerek yoktur. Şimdiye kadar enfekte olan yenidoğanlar arasında ölüm bildirilmemiştir. Taburcu edilen bebeklerde muhtemel sarılık gelişimine karşı da önlem alınmalıdır. Ailelere de psikolojik ve sosyal destek sağlanması yerinde olur. Hastalık hakkındaki bilgiler az olduğu için yeni gelişmeler takip edilmelidir.
    Keywords Newborn,COVID-19,vertical transmission ; Yenidoğan,COVID-19,vertikal geçiş ; covid19
    Language Turkish
    Publishing date 2020-03-20T00:00:00Z
    Publisher Hayat Sağlık ve Sosyal Hizmetler Vakfı
    Publishing country tr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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