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  1. Article ; Online: Editorial: Current understanding of complications associated with diabetes.

    Srivastava, Swayam Prakash

    Frontiers in clinical diabetes and healthcare

    2023  Volume 4, Page(s) 1338656

    Language English
    Publishing date 2023-12-06
    Publishing country Switzerland
    Document type Editorial
    ISSN 2673-6616
    ISSN (online) 2673-6616
    DOI 10.3389/fcdhc.2023.1338656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Drugs for Diabetes: From Pharmacology to Clinical Application.

    Srivastava, Swayam Prakash

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 10

    Abstract: Type I and type II diabetes mellitus, characterized by increased blood glucose levels, affect almost half a billion people around the world [ ... ]. ...

    Abstract Type I and type II diabetes mellitus, characterized by increased blood glucose levels, affect almost half a billion people around the world [...].
    Language English
    Publishing date 2023-09-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16101346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Receptor biology and cell signaling in diabetes: volume II.

    Srivastava, Swayam Prakash / Kanasaki, Keizo

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1274914

    Language English
    Publishing date 2023-09-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1274914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: Diabetic kidney disease: routes to drug development, pharmacology and underlying molecular mechanisms.

    Bhatia, Divya / Srivastava, Swayam Prakash

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1252315

    Language English
    Publishing date 2023-08-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1252315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editorial: Receptor Biology and Cell Signaling in Diabetes.

    Srivastava, Swayam Prakash / Kanasaki, Keizo

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 864117

    Language English
    Publishing date 2022-03-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.864117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in

    Srivastava, Swayam Prakash / Goodwin, Julie E

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Endothelial cells play a key role in maintaining homeostasis and are deranged in many disease processes, including fibrotic conditions. Absence of the endothelial glucocorticoid receptor (GR) has been shown to accelerate diabetic kidney fibrosis in part ... ...

    Abstract Endothelial cells play a key role in maintaining homeostasis and are deranged in many disease processes, including fibrotic conditions. Absence of the endothelial glucocorticoid receptor (GR) has been shown to accelerate diabetic kidney fibrosis in part through up regulation of Wnt signaling. The db/db mouse model is a model of spontaneous type 2 diabetes that has been noted to develop fibrosis in multiple organs over time, including the kidneys. This study aimed to determine the effect of loss of endothelial GR on organ fibrosis in the
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.20.533532
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in

    Srivastava, Swayam Prakash / Goodwin, Julie E

    American journal of physiology. Renal physiology

    2023  Volume 325, Issue 4, Page(s) F519–F526

    Abstract: Endothelial cells play a key role in maintaining homeostasis and are deranged in many disease processes, including fibrotic conditions. Absence of the endothelial glucocorticoid receptor (GR) has been shown to accelerate diabetic kidney fibrosis in part ... ...

    Abstract Endothelial cells play a key role in maintaining homeostasis and are deranged in many disease processes, including fibrotic conditions. Absence of the endothelial glucocorticoid receptor (GR) has been shown to accelerate diabetic kidney fibrosis in part through upregulation of Wnt signaling. The
    MeSH term(s) Mice ; Animals ; Endothelial Cells ; Receptors, Glucocorticoid/genetics ; Diabetes Mellitus, Type 2 ; Mice, Inbred Strains ; Metformin/pharmacology
    Chemical Substances Receptors, Glucocorticoid ; Metformin (9100L32L2N)
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00105.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  8. Article: Editorial: Combating Diabetes and Diabetic Kidney Disease.

    Srivastava, Swayam Prakash / Kanasaki, Keizo / Goodwin, Julie E

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 716029

    Language English
    Publishing date 2021-07-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.716029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cancer Biology and Prevention in Diabetes.

    Srivastava, Swayam Prakash / Goodwin, Julie E

    Cells

    2020  Volume 9, Issue 6

    Abstract: The available evidence suggests a complex relationship between diabetes and cancer. Epidemiological data suggest a positive correlation, however, in certain types of cancer, a more complex picture emerges, such as in some site-specific cancers being ... ...

    Abstract The available evidence suggests a complex relationship between diabetes and cancer. Epidemiological data suggest a positive correlation, however, in certain types of cancer, a more complex picture emerges, such as in some site-specific cancers being specific to type I diabetes but not to type II diabetes. Reports share common and differential mechanisms which affect the relationship between diabetes and cancer. We discuss the use of antidiabetic drugs in a wide range of cancer therapy and cancer therapeutics in the development of hyperglycemia, especially antineoplastic drugs which often induce hyperglycemia by targeting insulin/IGF-1 signaling. Similarly, dipeptidyl peptidase 4 (DPP-4), a well-known target in type II diabetes mellitus, has differential effects on cancer types. Past studies suggest a protective role of DPP-4 inhibitors, but recent studies show that DPP-4 inhibition induces cancer metastasis. Moreover, molecular pathological mechanisms of cancer in diabetes are currently largely unclear. The cancer-causing mechanisms in diabetes have been shown to be complex, including excessive ROS-formation, destruction of essential biomolecules, chronic inflammation, and impaired healing phenomena, collectively leading to carcinogenesis in diabetic conditions. Diabetes-associated epithelial-to-mesenchymal transition (EMT) and endothelial-to-mesenchymal transition (EndMT) contribute to cancer-associated fibroblast (CAF) formation in tumors, allowing the epithelium and endothelium to enable tumor cell extravasation. In this review, we discuss the risk of cancer associated with anti-diabetic therapies, including DPP-4 inhibitors and SGLT2 inhibitors, and the role of catechol-o-methyltransferase (COMT), AMPK, and cell-specific glucocorticoid receptors in cancer biology. We explore possible mechanistic links between diabetes and cancer biology and discuss new therapeutic approaches.
    MeSH term(s) Diabetes Mellitus/drug therapy ; Diabetes Mellitus/pathology ; Epithelial-Mesenchymal Transition/drug effects ; Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Neoplasms/complications ; Neoplasms/drug therapy ; Neoplasms/epidemiology ; Neoplasms/prevention & control ; Prevalence ; Receptors, Glucocorticoid/metabolism
    Chemical Substances Hypoglycemic Agents ; Receptors, Glucocorticoid
    Language English
    Publishing date 2020-06-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9061380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: High Frequencies of Phenotypically and Functionally Senescent and Exhausted CD56

    Srivastava, Ruchi / Dhanushkodi, Nisha / Prakash, Swayam / Coulon, Pierre Gregoire / Vahed, Hawa / Zayou, Latifa / Quadiri, Afshana / BenMohamed, Lbachir

    bioRxiv : the preprint server for biology

    2022  

    Abstract: Unvaccinated COVID-19 patients display a large spectrum of symptoms, ranging from asymptomatic to severe symptoms, the latter even causing death. Distinct Natural killer (NK) and ... ...

    Abstract Unvaccinated COVID-19 patients display a large spectrum of symptoms, ranging from asymptomatic to severe symptoms, the latter even causing death. Distinct Natural killer (NK) and CD4
    Language English
    Publishing date 2022-07-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2022.07.26.501655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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