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  1. Article ; Online: Complications in image-guided musculoskeletal injections.

    Hynes, John P / Kavanagh, Eoin C

    Skeletal radiology

    2022  Volume 51, Issue 11, Page(s) 2097–2104

    Abstract: Complications in musculoskeletal interventions are rare and where they do occur tend to be minor, and often short-lived or self-limiting. Nonetheless, the potential for significant complications exists, and a thorough understanding of both the mechanisms ...

    Abstract Complications in musculoskeletal interventions are rare and where they do occur tend to be minor, and often short-lived or self-limiting. Nonetheless, the potential for significant complications exists, and a thorough understanding of both the mechanisms which contribute and the manner in which they may clinically present is of critical importance for all musculoskeletal radiologists involved in performing procedures, both to mitigate against the occurrence of complications and to aid rapid recognition. The purpose of this review is to analyse the relevant literature to establish the frequency with which complications occur following musculoskeletal intervention. Furthermore, we highlight some of the more commonly discussed and feared complications in musculoskeletal intervention, such as the risk of infection, potential deleterious articular consequences including accelerated joint destruction and the poorly understood and often underestimated systemic effects of locally injected corticosteroids. We also consider both extremely rare but emergent scenarios such as anaphylactic reactions to medications, and much more common but less significant complications such as post-procedural pain. We suggest that meticulous attention to detail including strict adherence to aseptic technique and precise needle placement may reduce the frequency with which complications occur.
    MeSH term(s) Adrenal Cortex Hormones/adverse effects ; Humans ; Injections ; Needles
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2022-05-27
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-022-04076-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1304: Show issues Location:
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  2. Article: Electric scooter-related triple cervical artery dissection.

    Glynn, David / Hynes, John P / Marnane, Michael / Kavanagh, Eoin C

    Radiology case reports

    2023  Volume 18, Issue 3, Page(s) 1342–1344

    Abstract: A 34-year-old female presented to the emergency department with neck pain, dysphonia and dysphagia ten days after a fall from an electric scooter. Subsequent computed tomography of the neck revealed bilateral vertebral artery and unilateral internal ... ...

    Abstract A 34-year-old female presented to the emergency department with neck pain, dysphonia and dysphagia ten days after a fall from an electric scooter. Subsequent computed tomography of the neck revealed bilateral vertebral artery and unilateral internal carotid artery non-occlusive dissections, which were managed with antiplatelet therapy. This case describes mechanisms of injury, clinical presentation, imaging appearances, and subsequent management of cervical artery dissection.
    Language English
    Publishing date 2023-01-19
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2022.12.050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Denervation pseudo hypertrophy of the calf: An important cause of lower limb swelling.

    Hynes, John P / Glynn, David / Eustace, Stephen J

    Radiology case reports

    2022  Volume 17, Issue 5, Page(s) 1702–1704

    Abstract: Denervation pseudohypertrophy is an uncommon cause of limb swelling, which may be overlooked. It is an important diagnosis to arrive at, as it instructs the search for an underlying cause which may itself require intervention. We present the case of a 32- ...

    Abstract Denervation pseudohypertrophy is an uncommon cause of limb swelling, which may be overlooked. It is an important diagnosis to arrive at, as it instructs the search for an underlying cause which may itself require intervention. We present the case of a 32-year-old male rugby player with a 2-year history of left calf swelling and intermittent pain and tightness. He described a previous history of 2 left sided lumbar micro-discectomy surgeries. There was no tenderness or sensory deficit on examination. MRI of the left calf revealed muscular enlargement, with fat interspersed between the muscle fibers, in keeping with pseudohypertrophy. This has a number of causes, in this cause attributed to lumbar radiculopathy. This case highlights a rare but important cause of limb swelling which should be considered in the workup of a unilateral swollen limb.
    Language English
    Publishing date 2022-03-22
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2022.02.066
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  4. Article ; Online: Coronavirus Disease (COVID-19) Detected at the Lung Apices During CT Angiography in Acute Stroke Assessment.

    Hynes, John P / Moore, Paul / Murray, John G

    AJR. American journal of roentgenology

    2020  Volume 215, Issue 3, Page(s) W40

    MeSH term(s) Betacoronavirus ; COVID-19 ; Computed Tomography Angiography ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Stroke
    Keywords covid19
    Language English
    Publishing date 2020-06-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.20.23484
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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Are brake response times altered post CT-guided cervical spine nerve root injections?

    Hanley, Marion / Eustace, Sarah K / Ryan, David T / McLoughlin, Stephen / Hynes, John P / Kavanagh, Eoin C / Eustace, Stephen J

    The British journal of radiology

    2024  Volume 97, Issue 1156, Page(s) 834–837

    Abstract: ... response times; 0.94 s (range 0.4-1.2 s) and 0.93 s (range 0.5-1.25 s), respectively (P = .77).: Conclusions ...

    Abstract Objectives: To assess if brake response times are altered pre and post CT-guided cervical spine nerve root injections.
    Methods: Brake response times were assessed before and after CT-guided cervical spine nerve root injections in a cohort of patients. The average of 3 brake response times was recorded before and 30 min after injection. Statistical analysis was performed using GraphPad. A paired Student t-test was used to compare the times before and after the injections.
    Results: Forty patients were included in this study. The mean age was 55 years. There were 17 male and 23 female patients. There was no significant difference in the mean pre and post CT-guided cervical spine nerve root injection brake response times; 0.94 s (range 0.4-1.2 s) and 0.93 s (range 0.5-1.25 s), respectively (P = .77).
    Conclusions: Brake response time did not significantly differ pre and 30 min post CT-guided cervical spine nerve root injections.
    Advances in knowledge: To the authors' best knowledge, there are no current studies assessing brake response times post CT-guided cervical spine nerve root injections. While driving safety cannot be proven by a single metric, it is a useful study in demonstrating that this is not inhibited in a cohort of patients.
    MeSH term(s) Humans ; Male ; Female ; Middle Aged ; Radiculopathy ; Reaction Time ; Spinal Nerve Roots/diagnostic imaging ; Cervical Vertebrae/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1093/bjr/tqae034
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  6. Article: Voriconazole-induced periostitis post lung transplantation.

    Murray, Orla M / Hynes, John P / Murray, Michelle A / Kavanagh, Eoin C

    Radiology case reports

    2022  Volume 17, Issue 5, Page(s) 1587–1590

    Abstract: Voriconazole is a broad-spectrum triazole antifungal used to treat invasive fungal infections. It is commonly used prophylactically in immunocompromized patient cohorts, including transplant recipients. Diffuse periostitis is a very rare complication of ... ...

    Abstract Voriconazole is a broad-spectrum triazole antifungal used to treat invasive fungal infections. It is commonly used prophylactically in immunocompromized patient cohorts, including transplant recipients. Diffuse periostitis is a very rare complication of chronic voriconazole use. It is associated with diffuse bone pain, elevated serum alkaline phosphatase and fluorine levels. Characteristic imaging findings include periosteal thickening with a dense, nodular, irregular and often bilateral pattern. We describe the case of a 71-year-old female who presented with multifocal bone pain six years following double lung transplantation. Her post transplantation course had been complicated by a life threatening episode of sepsis secondary to Scedosporium apiospermum, a rare invasive fungal infection following which lifelong prophylaxis with oral Voriconazole was commenced. We discuss the characteristic clinical and imaging manifestations of this rare condition.
    Language English
    Publishing date 2022-03-11
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2022.01.078
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  7. Article: Identification of a Gene Signature That Predicts Dependence upon YAP/TAZ-TEAD.

    Kanai, Ryan / Norton, Emily / Stern, Patrick / Hynes, Richard O / Lamar, John M

    Cancers

    2024  Volume 16, Issue 5

    Abstract: Targeted therapies are effective cancer treatments when accompanied by accurate diagnostic tests that can help identify patients that will respond to those therapies. The YAP/TAZ-TEAD axis is activated and plays a causal role in several cancer types, and ...

    Abstract Targeted therapies are effective cancer treatments when accompanied by accurate diagnostic tests that can help identify patients that will respond to those therapies. The YAP/TAZ-TEAD axis is activated and plays a causal role in several cancer types, and TEAD inhibitors are currently in early-phase clinical trials in cancer patients. However, a lack of a reliable way to identify tumors with YAP/TAZ-TEAD activation for most cancer types makes it difficult to determine which tumors will be susceptible to TEAD inhibitors. Here, we used a combination of RNA-seq and bioinformatic analysis of metastatic melanoma cells to develop a YAP/TAZ gene signature. We found that the genes in this signature are TEAD-dependent in several melanoma cell lines, and that their expression strongly correlates with YAP/TAZ activation in human melanomas. Using DepMap dependency data, we found that this YAP/TAZ signature was predictive of melanoma cell dependence upon YAP/TAZ or TEADs. Importantly, this was not limited to melanoma because this signature was also predictive when tested on a panel of over 1000 cancer cell lines representing numerous distinct cancer types. Our results suggest that YAP/TAZ gene signatures like ours may be effective tools to predict tumor cell dependence upon YAP/TAZ-TEAD, and thus potentially provide a means to identify patients likely to benefit from TEAD inhibitors.
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16050852
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  9. Article ; Online: Imaging of groin pain in athletes: patterns of injury at MRI and gender differences therein.

    Hynes, John P / O'Flaherty, Meadhbh / Glynn, David / Eustace, Sarah / Kavanagh, Eoin C

    Irish journal of medical science

    2022  Volume 192, Issue 3, Page(s) 1411–1418

    Abstract: ... rectus abdominis-adductor longus (RR = 0.31, p = .017), short adductor (RR = 0.14, p = .005) or hip (RR = 0.41, p ... 003) injuries. Pubic bone degenerative changes were much more common in female athletes (RR = 7.37, p ...

    Abstract Aim: The purpose of our study was to review a large cohort of athletes of all levels presenting with groin pain who underwent investigation with MRI and to determine what the commonest patterns of injury were. We aimed to explore whether particular findings were commonly found in association and whether measurable gender differences exist in the incidence of specific injuries.
    Materials and methods: Imaging records were reviewed to identify MRI studies of the pelvis performed for the investigation of groin pain in patients who were active in sports/athletic pursuits. Findings were classified and recorded as follows: injury to the common rectus abdominis/adductor longus origin, injury to the short adductor muscles, pubic bone oedema, pubic symphysis degenerative changes, hip joint injury and 'other'. The prevalence of specific injuries in female athletes compared to males was analysed using relative risk ratios.
    Results: A total of 470 athletes underwent MRI for the investigation of groin pain during the study period. Forty-six were female, and 424 were male. Female athletes were significantly less likely to have rectus abdominis-adductor longus (RR = 0.31, p = .017), short adductor (RR = 0.14, p = .005) or hip (RR = 0.41, p = .003) injuries. Pubic bone degenerative changes were much more common in female athletes (RR = 7.37, p = .002).
    Conclusion: Significant gender differences exist in the frequency with which specific injuries are observed. Female athletes are also significantly underrepresented; this is likely a multifactorial phenomenon; however, the possibility of unconscious referrer bias must be considered.
    MeSH term(s) Humans ; Male ; Female ; Athletic Injuries/diagnostic imaging ; Athletic Injuries/epidemiology ; Athletic Injuries/complications ; Groin/diagnostic imaging ; Groin/injuries ; Sex Factors ; Magnetic Resonance Imaging/methods ; Athletes ; Pain/etiology
    Language English
    Publishing date 2022-08-16
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 390895-1
    ISSN 1863-4362 ; 0021-1265
    ISSN (online) 1863-4362
    ISSN 0021-1265
    DOI 10.1007/s11845-022-03126-3
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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Imaging of acute lower limb muscle injury and potential gender differences.

    Hanley, Marion / Ryan, David T / Hynes, John P / Long, Niamh M / Eustace, Stephen J / Kavanagh, Eoin C

    Irish journal of medical science

    2023  

    Abstract: ... p = 0.19). Females were 1.5 times more likely to have a lower grade AMI than males ... although this did not reach statistical significance (p = 0.7) owing to a striking lower number of female patients ... quadricep AMI (hamstrings OR = 2.47, p = 0.14 and quadriceps OR = 0.926, p 0.99).: Conclusions: Grade 1a ...

    Abstract Objectives: To assess the most common lower limb acute muscle injuries on MRI imaging in a national specialist centre for orthopaedics and sports medicine and to explore potential gender differences.
    Methods: Over a 3-year time period, all MRI lower limb studies with acute muscle injury (AMI) were reviewed. A British Athletics muscle injury classification (BAMIC) was given and a statistical analysis was performed.
    Results: A total of 195 AMIs were diagnosed: 177 (91%) male and 18 (9%) female injuries (M to F = 9.8:1). The most common lower limb AMIs were BAMIC grade 1a injuries (n = 48, 25%). The most commonly injured muscle was biceps femoris (n = 87, 45%), specifically grade 1b and grade 2b injuries. There was no significant difference in age between men and women with acute lower limb muscle injuries (p = 0.19). Females were 1.5 times more likely to have a lower grade AMI than males, although this did not reach statistical significance (p = 0.7) owing to a striking lower number of female patients. There was no significant difference between genders in the likelihood of sustaining a hamstring or quadricep AMI (hamstrings OR = 2.47, p = 0.14 and quadriceps OR = 0.926, p 0.99).
    Conclusions: Grade 1a is the most common lower limb AMI grade in our institution, accounting for 25%. Biceps femoris is the most commonly injured muscle (45%) with grade 1b and grade 2b being the most frequently encountered grades of biceps femoris injuries. Lower-grade injuries are more common in females compared to males, although not significantly so. Further studies are required to explore possible reasons for this gender gap.
    Language English
    Publishing date 2023-11-10
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 390895-1
    ISSN 1863-4362 ; 0021-1265
    ISSN (online) 1863-4362
    ISSN 0021-1265
    DOI 10.1007/s11845-023-03562-9
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