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Article: On-Chip Modification of Titanium Electrothermal Characteristics by Joule Heating: Application to Terahertz Microbolometer.

Elamaran, Durgadevi / Akiba, Ko / Satoh, Hiroaki / Banerjee, Amit / Hiromoto, Norihisa / Inokawa, Hiroshi

2024 Volume 14, Issue 2

Abstract: ... to the heating. A negative large temperature coefficient of resistance (TCR) of -0.32%/K was also observed owing ...

Abstract	This study demonstrates the conversion of metallic titanium (Ti) to titanium oxide just by conducting electrical current through Ti thin film in vacuum and increasing the temperature by Joule heating. This led to the improvement of electrical and thermal properties of a microbolometer. A microbolometer with an integrated Ti thermistor and heater width of 2.7 µm and a length of 50 µm was fabricated for the current study. Constant-voltage stresses were applied to the thermistor wire to observe the effect of the Joule heating on its properties. Thermistor resistance ~14 times the initial resistance was observed owing to the heating. A negative large temperature coefficient of resistance (TCR) of -0.32%/K was also observed owing to the treatment, leading to an improved responsivity of ~4.5 times from devices with untreated Ti thermistors. However, this does not improve the noise equivalent power (NEP), due to the increased flicker noise. Microstructural analyses with transmission electron microscopy (TEM), transmission electron diffraction (TED) and energy dispersive X-ray (EDX) confirm the formation of a titanium oxide (TiO
Language	English
Publishing date	2024-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano14020225
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Coronavirus Disease (COVID-19) Pandemic: A Race Against Time.

Banerjee, Amit K / Arora, Neelima

Current topics in medicinal chemistry

2020 Volume 20, Issue 16, Page(s) 1434–1437

MeSH term(s)	Adenosine Monophosphate/administration & dosage ; Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/administration & dosage ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Antiviral Agents/administration & dosage ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/genetics ; Betacoronavirus/immunology ; COVID-19 ; COVID-19 Vaccines ; Clinical Trials as Topic ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Hand Hygiene ; Humans ; International Cooperation ; Masks ; Pandemics/prevention & control ; Patient Education as Topic ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; Quarantine ; SARS-CoV-2 ; Viral Vaccines
Chemical Substances	Antiviral Agents ; COVID-19 Vaccines ; Viral Vaccines ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
Keywords	covid19
Language	English
Publishing date	2020-04-13
Publishing country	United Arab Emirates
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	2064823-6
ISSN	1873-4294 ; 1568-0266
ISSN (online)	1873-4294
ISSN	1568-0266
DOI	10.2174/1568026620999200413145654
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Article: Coronavirus Disease (COVID-19) Pandemic: A Race Against Time

Banerjee, Amit K / Arora, Neelima

Curr Top Med Chem

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #52610
Database	COVID19

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Article ; Online: Coronavirus Disease (COVID-19) Pandemic

Banerjee, Amit K. / Arora, Neelima

Current Topics in Medicinal Chemistry

A Race Against Time

2020 Volume 20, Issue 16, Page(s) 1434–1437

Keywords	Drug Discovery ; General Medicine ; covid19
Language	English
Publisher	Bentham Science Publishers Ltd.
Publishing country	nl
Document type	Article ; Online
ZDB-ID	2064823-6
ISSN	1873-4294 ; 1568-0266
ISSN (online)	1873-4294
ISSN	1568-0266
DOI	10.2174/1568026620999200413145654
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A critical review on the particle generation and other applications of rapid expansion of supercritical solution.

Kumar, Rahul / Thakur, Amit K / Banerjee, Nilanjana / Chaudhari, Pranava

International journal of pharmaceutics

2021 Volume 608, Page(s) 121089

Abstract: The novel particle generation processes of Active Pharmaceutical Ingredient (API)/drug have been extensively explored in recent decades due to their wide-range applications in the pharmaceutical industry. The Rapid Expansion of Supercritical Solutions ( ... ...

Abstract	The novel particle generation processes of Active Pharmaceutical Ingredient (API)/drug have been extensively explored in recent decades due to their wide-range applications in the pharmaceutical industry. The Rapid Expansion of Supercritical Solutions (RESS) is one of the promising techniques to obtain the fine particles (micro to nano-size) of APIs with narrow particle size distribution (PSD). In RESS, supercritical carbon dioxide (SC CO
MeSH term(s)	Nanoparticles ; Particle Size ; Solubility ; Solutions ; Solvents
Chemical Substances	Solutions ; Solvents
Language	English
Publishing date	2021-09-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2021.121089
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Zs.A 1409: Show issues

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Article ; Online: Quantification and Standardization of Andrographolide in Andrographis Paniculata Samples by Validated RP-HPLC and HPTLC Methods.

Jana, Shibu Narayan / Banerjee, Subhadip / Biswas, Sayan / Sing, Dilip / Kar, Amit / Bandyopadhayay, Rajib / Haldar, Pallab K / Sharma, Nanaocha / Mukherjee, Pulok K

Journal of chromatographic science

2023 Volume 61, Issue 6, Page(s) 514–521

Abstract: Andrographis paniculata (family Acanthaceae) is known as Kalmegh, one of the traditionally used important medicinal plant contains several biologically active phytochemical including andrographolide. A. paniculata is broadly used by healthcare ... ...

Abstract	Andrographis paniculata (family Acanthaceae) is known as Kalmegh, one of the traditionally used important medicinal plant contains several biologically active phytochemical including andrographolide. A. paniculata is broadly used by healthcare practitioners in India and also used in different traditional medicinal system. In this study, the leaves of A. paniculata were collected from West Medinipur, East Medinipur, South 24 Parganas, Purulia and Hooghly district of West Bengal, India. This study aiming towards validation and development of a simple, precise and reproducible reverse-phase high-performance liquid chromatography (RP-HPLC) and high-performance thin layer chromatography (HPTLC) methods for quantification of andrographolide in A. paniculata extracts. The validated RP-HPLC and HPTLC study confirmed that different concentrations of andrographolide content present in the plant samples, which are collected from above different districts of West Bengal, India. The amounts of andrographolide were found to be 2.71% (w/w), 3.19% (w/w), 1.83% (w/w), 1.73% (w/w) and 2.94% (w/w) in RP-HPLC study and 2.13% (w/w), 2.51% (w/w), 1.01% (w/w), 1.25% (w/w) and 2.15% (w/w) in HPTLC study. This precise, reproducible, accurate and specific method can be used for the quantification of andrographolide in kalmegh, as per the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines recommendations.
MeSH term(s)	Humans ; Andrographis paniculata ; Chromatography, Thin Layer ; Chromatography, High Pressure Liquid ; Andrographis/chemistry ; Plant Extracts/chemistry ; Diterpenes/analysis ; Reference Standards
Chemical Substances	Andrographis paniculata extract (0P49L952WZ) ; andrographolide (410105JHGR) ; Plant Extracts ; Diterpenes
Language	English
Publishing date	2023-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	80141-0
ISSN	1945-239X ; 0021-9665
ISSN (online)	1945-239X
ISSN	0021-9665
DOI	10.1093/chromsci/bmad004
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Article ; Online: Impacts of gut microbiota alteration on age-related chronic liver diseases.

Adhikary, Subhamay / Esmeeta, Akanksha / Dey, Amit / Banerjee, Antara / Saha, Biki / Gopan, Pournami / Duttaroy, Asim K / Pathak, Surajit

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2023 Volume 56, Issue 1, Page(s) 112–122

Abstract: The gut microbiome and its metabolites are involved in developing and progressing liver disease. Various liver illnesses, such as non-alcoholic fatty liver disease, alcoholic liver disease, hepatitis C, and hepatocellular carcinoma, are made worse and ... ...

Abstract	The gut microbiome and its metabolites are involved in developing and progressing liver disease. Various liver illnesses, such as non-alcoholic fatty liver disease, alcoholic liver disease, hepatitis C, and hepatocellular carcinoma, are made worse and have worse prognoses with aging. Dysbiosis, which occurs when the symbiosis between the microbiota and the host is disrupted, can significantly negatively impact health. Liver disease is linked to qualitative changes, such as an increase in hazardous bacteria and a decrease in good bacteria, as well as quantitative changes in the overall amount of bacteria (overgrowth). Intestinal gut microbiota and their metabolites may lead to chronic liver disease development through various mechanisms, such as increasing gut permeability, persistent systemic inflammation, production of SCFA, bile acids, and alteration in metabolism. Age-related gut dysbiosis can disrupt the communication between gut microbiota and the host, impacting the host's health and lifespan. With aging, a gradual loss of the ability to maintain homeostasis because of structural alteration and gut dysbiosis leads to the disease progression in end-stage liver disease. Recently chronic liver disease has been identified as a global problem. A large number of patients are receiving liver transplants yearly. Thereby gut microbiome ecology is changing in the patients of the gut due to the changes in pathophysiology during the preoperative stage. The present review summarises the age-associated dysbiosis of gut microbial composition and its contribution to chronic liver disease. This review also provides information about the impact of liver transplant on the gut microbiome and possible disadvantageous effects of alteration in gut microbiota.
MeSH term(s)	Humans ; Gastrointestinal Microbiome/physiology ; Dysbiosis/metabolism ; Liver/metabolism ; Non-alcoholic Fatty Liver Disease/metabolism ; Liver Neoplasms/metabolism
Language	English
Publishing date	2023-07-03
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2023.06.017
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Article ; Online: Liquid antisolvent crystallization of pharmaceutical compounds: current status and future perspectives.

Kumar, Rahul / Thakur, Amit K / Banerjee, Nilanjana / Kumar, Ashutosh / Gaurav, Gajendra Kumar / Arya, Raj Kumar

Drug delivery and translational research

2022 Volume 13, Issue 2, Page(s) 400–418

Abstract: The present work reviews the liquid antisolvent crystallization (LASC) to prepare the nanoparticle of pharmaceutical compounds to enhance their solubility, dissolution rate, and bioavailability. The application of ultrasound and additives is discussed to ...

Abstract	The present work reviews the liquid antisolvent crystallization (LASC) to prepare the nanoparticle of pharmaceutical compounds to enhance their solubility, dissolution rate, and bioavailability. The application of ultrasound and additives is discussed to prepare the particles with narrow size distribution. The use of ionic liquid as an alternative to conventional organic solvent is presented. Herbal compounds, also known for low aqueous solubility and limited clinical application, have been crystalized by LASC and discussed here. The particle characteristics such as particle size and particle size distribution are interpreted in terms of supersaturation, nucleation, and growth phenomena. To overcome the disadvantage of batch crystallization, the scientific literature on continuous flow reactors is also reviewed. LASC in a microfluidic device is emerging as a promising technique. The different design of the microfluidic device and their application in LASC are discussed. The combination of the LASC technique with traditional techniques such as high-pressure homogenization and spray drying is presented. A comparison of product characteristics prepared by LASC and the supercritical CO
MeSH term(s)	Crystallization/methods ; Solvents/chemistry ; Water ; Nanoparticles/chemistry ; Pharmaceutical Preparations ; Particle Size ; Solubility ; Technology, Pharmaceutical
Chemical Substances	Solvents ; Water (059QF0KO0R) ; Pharmaceutical Preparations
Language	English
Publishing date	2022-08-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2590155-2
ISSN	2190-3948 ; 2190-393X
ISSN (online)	2190-3948
ISSN	2190-393X
DOI	10.1007/s13346-022-01219-1
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Article ; Online: Combination synergy between β-carotene and lupeol against breast adenocarcinoma in vitro and in vivo using combination index

Sandipan Jana / Nilanjan Sarkar / Mainak Chakraborty / Amit Kar / Subhadip Banerjee / Sanjib Bhattacharya / Pulok K. Mukherjee / Pallab K. Haldar

Phytomedicine Plus, Vol 3, Iss 1, Pp 100392- (2023)

2023

Abstract: Background: Breast adenocarcinoma is one of the leading causes of death among women regardless of development in the field of diagnosis, treatment and prevention. Synergistic approaches are emerging as a strategy to overcome monotherapy resistance in ... ...

Abstract	Background: Breast adenocarcinoma is one of the leading causes of death among women regardless of development in the field of diagnosis, treatment and prevention. Synergistic approaches are emerging as a strategy to overcome monotherapy resistance in cancer treatment. Purpose: Evaluation of the combinatory activity of β-carotene (BC) and lupeol (LUP) for anti-proliferative activity by median effect equation and combination index. Validation was performed by fixed dose combination against murine mammary adenocarcinoma namely Ehrlich ascites carcinoma (EAC). Methods: Cytotoxicity assay was performed using the MTT and Trypan blue methods. Isobologram and combination index analysis were used to analyze the type of interaction between β-carotene (BC) and lupeol (LUP). Based on the synergistic dose combination determination of in-vivo antitumor activity was performed using EAC cells inoculated in mice treated with BC, LUP and their combination (BC+LUP). Tumor volume, cell count, weight along with hematological, biochemical and antioxidant parameters were evaluated. Results: The combination (BC+LUP) exhibited the highest inhibition (IC50=54.8 ± 1.84) compare to the standard inhibitor, wher eas BC and LUP showed moderate inhibition with an IC50 of 101.5 ± 2.66, and 84.08±3.56 respectively. The hematological, biochemical, and tissue antioxidant parameters were reverted to normal levels in the treated animal groups. BC and Lupeol reduced the volume, weight, and viable cell count of the tumor; increased the life span of EAC tumor-bearing mice. Conclusion: β-Carotene and lupeol were found to be more effective in combination for the anti-proliferative activity. Thus combination techniques must be employed to find out the synergistic activity of the molecules.
Keywords	β-carotene ; Lupeol ; Combination index ; Antioxidant ; Anti-proliferation ; Synergy ; Other systems of medicine ; RZ201-999
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Molecular combination networks in medicinal plants: understanding synergy by network pharmacology in Indian traditional medicine

Mukherjee, Pulok K. / Banerjee, Subhadip / Kar, Amit

Phytochemistry reviews. 2021 Aug., v. 20, no. 4

2021

Abstract: Translation of traditional medicine is moving away from the reductionist approach towards harnessing the synergy of poly-pharmacological phyto-combinations that modulate the activity of target networks of underlying disease phenotypes. Metabolomics ... ...

Abstract	Translation of traditional medicine is moving away from the reductionist approach towards harnessing the synergy of poly-pharmacological phyto-combinations that modulate the activity of target networks of underlying disease phenotypes. Metabolomics enabled the profiling of herbal extracts and formulations in high resolution through LC-MS/MS, GC-MS and NMR providing the possibility of multi-component drug discovery. Phytopharmaceuticals are multi-molecular combinations which follow a combinatory treatment module which minimizes off-target toxicity by synergistic potency and improve outcomes by synergistic efficacy. Combination synergy is a multi-dimensional concept where synergy can be observed from a network pharmacology perspective. Network pharmacology uses systems-level drug–response phenotypes originating from various ‘omics’ platforms. This network pharmacology with metabolomics has been proven to be effective in elucidating the mechanisms of action of medicinal plants and complex traditional formulations. LC-MS/MS of medicinal plants along with network pharmacology unveil synergistic molecular combinations which interact with neighbouring targets in a combination synergy network. Case studies on some traditional herbs mentioned in Ayurveda, has been reported based on the combination of network-based methods and metabolomics for establishing the mechanism for their therapeutic potentials. The synergistic combination of molecules interacts with target-disease networks which provide novel, mechanistic insights towards understanding their therapeutic potentials. This review along with case-studies illustrates various strategies to explore the mechanism of action for different synergistic natural products combinations through neighbourhood-based network pharmacology approach.
Keywords	Ayurvedic medicine ; case studies ; drugs ; mechanism of action ; metabolomics ; pharmacology ; phytopharmaceuticals ; therapeutics ; toxicity
Language	English
Dates of publication	2021-08
Size	p. 693-703.
Publishing place	Springer Netherlands
Document type	Article
Note	Review
ZDB-ID	2065661-0
ISSN	1572-980X ; 1568-7767
ISSN (online)	1572-980X
ISSN	1568-7767
DOI	10.1007/s11101-020-09730-4
Database	NAL-Catalogue (AGRICOLA)

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