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  1. Article ; Online: Tradeoffs among root functional traits for phosphorus acquisition in 13 soybean genotypes contrasting in mycorrhizal colonization.

    Fang, Yizeng / Lu, Luwen / Chen, Kang / Wang, Xiurong

    Annals of botany

    2024  

    Abstract: Background and aims: Plants have adapted to acquire phosphorus (P) primarily through advantageous root morphologies, responsive physiological pathways, and associations with mycorrhizal fungi. Yet, to date, little information exists on how variation in ... ...

    Abstract Background and aims: Plants have adapted to acquire phosphorus (P) primarily through advantageous root morphologies, responsive physiological pathways, and associations with mycorrhizal fungi. Yet, to date, little information exists on how variation in arbuscular mycorrhizal (AM) colonization is coordinated with root morphological and physiological traits to enhance P acquisition.
    Methods: Thirteen root functional traits associated with P acquisition were characterized at full bloom stage in pot cultures under low soil P availability conditions for 13 soybean genotypes contrasting in AM colonization.
    Key results: Significant variation in root functional traits was observed in response to low P stress among the 13 tested soybean genotypes contrasting in AM colonization. Genotypes with low AM colonization exhibited greater root proliferation but with less advantageous root physiological characteristics for P acquisition. In contrast, genotypes with high AM colonization exhibited less root growth but higher phosphatase activities and carboxylate content in the rhizosheath. Root dry weights, and contents of carbon and P were positively correlated with root morphological traits of different root orders and whole root systems, and were negatively correlated with AM colonization of fine roots and whole root systems, as well as, rhizosheath phosphatase activities and carboxylate contents. These results taken in combination with significant positive correlation between plant P content and root morphological traits indicate that root morphological traits play a primary role in soybean P acquisition.
    Conclusions: The results suggest that efficient P acquisition involves tradeoffs among carbon allocation to root proliferation, mycorrhizal symbiosis, or P-mobilizing exudation. Complementarity and complexity in the selection of P acquisition strategies was notable among soybean genotypes contrasting in AM colonization, which is closely related to plant C budgeting.
    Language English
    Publishing date 2024-04-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1461328-1
    ISSN 1095-8290 ; 0305-7364
    ISSN (online) 1095-8290
    ISSN 0305-7364
    DOI 10.1093/aob/mcae060
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  2. Article ; Online: Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure.

    Li, Wenyuan / Li, Wei / Li, Xun / Wang, Luwen / Wang, Yao

    Apoptosis : an international journal on programmed cell death

    2023  Volume 28, Issue 7-8, Page(s) 1226–1240

    Abstract: This study investigated whether G3BP1 could regulate ferroptosis in hepatocytes during ALF by affecting the entry of P53 into the nucleus. Promoting G3BP1 expression could inhibit P53 entry by binding to the nuclear localization sequence of P53. The ... ...

    Abstract This study investigated whether G3BP1 could regulate ferroptosis in hepatocytes during ALF by affecting the entry of P53 into the nucleus. Promoting G3BP1 expression could inhibit P53 entry by binding to the nuclear localization sequence of P53. The inhibition of SLC7A11 transcription was weakened after blocking of P53 binding to the promoter region of the SLC7A11 gene. The SLC7A11-GSH-GPX4 antiferroptotic pathway was subsequently activated, and the level of ferroptosis in ALF hepatocytes was inhibited.
    MeSH term(s) Humans ; Ferroptosis/genetics ; DNA Helicases ; Tumor Suppressor Protein p53/genetics ; Poly-ADP-Ribose Binding Proteins ; RNA Helicases ; RNA Recognition Motif Proteins ; Apoptosis ; Liver Failure, Acute
    Chemical Substances DNA Helicases (EC 3.6.4.-) ; Tumor Suppressor Protein p53 ; Poly-ADP-Ribose Binding Proteins ; RNA Helicases (EC 3.6.4.13) ; RNA Recognition Motif Proteins ; G3BP1 protein, human (EC 3.6.4.12)
    Language English
    Publishing date 2023-05-27
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1452360-7
    ISSN 1573-675X ; 1360-8185
    ISSN (online) 1573-675X
    ISSN 1360-8185
    DOI 10.1007/s10495-023-01856-y
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  3. Article ; Online: SARS-CoV-2 Infection Results in Serious Kidney Impairment: More Studies Need to Be Explored.

    Wang, Luwen / Gong, Zuojiong

    American journal of nephrology

    2020  Volume 51, Issue 7, Page(s) 576–578

    MeSH term(s) Acute Kidney Injury ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-29
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 604540-6
    ISSN 1421-9670 ; 0250-8095
    ISSN (online) 1421-9670
    ISSN 0250-8095
    DOI 10.1159/000508089
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  4. Article: Epidemiological and Antimicrobial Resistant Patterns, and Molecular Mechanisms of Carbapenem-Resistant

    Lu, Fanbo / Zhang, Luwen / Ji, Juanjuan / Xu, Yuanhong / Wang, Bo / Xia, Jinxing

    Infection and drug resistance

    2023  Volume 16, Page(s) 2813–2827

    Abstract: Objective: To study the epidemiological and antimicrobial resistant patterns, clinical characteristics and risk factors of critically ill patients infected with carbapenem-resistant : Methods: Totally, 201 ICU patients infected with : Results: Of ... ...

    Abstract Objective: To study the epidemiological and antimicrobial resistant patterns, clinical characteristics and risk factors of critically ill patients infected with carbapenem-resistant
    Methods: Totally, 201 ICU patients infected with
    Results: Of the 201
    Conclusion: Featured epidemiology and typical clinical characteristics existed extensively in
    Language English
    Publishing date 2023-05-09
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S410657
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  5. Article: Survival prognosis model for elderly women with epithelial ovarian cancer based on the SEER database.

    Zhou, Yingping / Wang, Aifen / Sun, Xin / Zhang, Rong / Zhao, Luwen

    Frontiers in oncology

    2023  Volume 13, Page(s) 1257615

    Abstract: Objectives: We aimed to analyze the risk factors of elderly women with epithelial ovarian cancer (EOC) using data on the SEER database, and to generate a nomogram model their 1-, 3-, and 5-year prognoses. The resulting nomogram model should be useful ... ...

    Abstract Objectives: We aimed to analyze the risk factors of elderly women with epithelial ovarian cancer (EOC) using data on the SEER database, and to generate a nomogram model their 1-, 3-, and 5-year prognoses. The resulting nomogram model should be useful for clinical diagnoses and treatment.
    Methods: We collected clinical data of women older than 70 years with epithelial ovarian cancer (diagnosed on the basis of surgical pathology) from the SEER database including datasets between 2010 and 2019. We randomly grouped the data into two groups (7:3 ratio) using the R language software. We divided the independent prognostic factors obtained by univariate and multi-factor Cox regression analyses into training and validation sets, and we plotted the same independent prognostic factors in a nomogram model of overall survival (OS) at 1, 3, and 5 years. We used the C-index, calibration curve, and area under the curve to validate the nomograms. We further evaluated the model and its clinical applicability using decision curve analyses.
    Results: We identified age, race, marital status, histological type, AJCC staging, differentiation degree, unilateral and bilateral tumor involvement, number of positive lymph nodes, chemotherapy, surgery, sequence of systemic treatment versus surgery, and time from diagnosis to treatment as independent prognostic factors for elderly women with EOC (
    Conclusion: The nomogram model in this study can provide an accurate assessment of the overall survival of women older than 70 years with EOC at the time of the first treatment, and it provides a basis for individualized clinical treatment.
    Language English
    Publishing date 2023-09-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1257615
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  6. Article ; Online: Immediate effects of electroacupuncture in oculomotor nerve palsy following brainstem infarction: A case report.

    Wang, Linjing / Gao, Weibin / Tang, Qiang / Zhu, Luwen / Wu, Minmin

    Explore (New York, N.Y.)

    2023  Volume 19, Issue 6, Page(s) 861–864

    Abstract: Introduction: Research has demonstrated that electroacupuncture (EA) stimulation of paralyzed muscles significantly improves nerve regeneration and functional recovery.: Description: An 81-year-old man with no history of diabetes mellitus or ... ...

    Abstract Introduction: Research has demonstrated that electroacupuncture (EA) stimulation of paralyzed muscles significantly improves nerve regeneration and functional recovery.
    Description: An 81-year-old man with no history of diabetes mellitus or hypertension presented with a history of brainstem infarction. Initially, the patient had medial rectus palsy in the left eye and diplopia to the right in both eyes, which almost returned to normal after six sessions of EA.
    Methods: The CARE guidelines informed the case study report. The patient was diagnosed with oculomotor nerve palsy (ONP) and photographed to document ONP recovery after treatment. The selected acupuncture points and surgical methods are listed in the table.
    Discussion: Pharmacological treatment of oculomotor palsy is not ideal, and its long-term use has side effects. Although acupuncture is a promising treatment for ONP, existing treatments involve many acupuncture points and long cycles, resulting in poor patient compliance. We chose an innovative modality, electrical stimulation of paralyzed muscles, which may be an effective and safe complementary alternative therapy for ONP.
    MeSH term(s) Male ; Humans ; Aged, 80 and over ; Electroacupuncture/adverse effects ; Intracranial Aneurysm/complications ; Intracranial Aneurysm/surgery ; Oculomotor Nerve Diseases/therapy ; Oculomotor Nerve Diseases/surgery ; Brain Stem Infarctions/complications ; Brain Stem Infarctions/therapy ; Paralysis/therapy ; Paralysis/complications
    Language English
    Publishing date 2023-04-29
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2183945-1
    ISSN 1878-7541 ; 1550-8307
    ISSN (online) 1878-7541
    ISSN 1550-8307
    DOI 10.1016/j.explore.2023.04.008
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  7. Article ; Online: Author Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease.

    Yan, Tingxiang / Liang, Jingjing / Gao, Ju / Wang, Luwen / Fujioka, Hisashi / Zhu, Xiaofeng / Wang, Xinglong

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 4006

    Language English
    Publishing date 2022-07-11
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-31711-8
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  8. Article ; Online: Prebiotics and probiotics for autism spectrum disorder: a systematic review and meta-analysis of controlled clinical trials.

    Song, Wenjing / Zhang, Mei / Teng, Lili / Wang, Yu / Zhu, Luwen

    Journal of medical microbiology

    2022  Volume 71, Issue 4

    Abstract: Introduction. ...

    Abstract Introduction.
    MeSH term(s) Autism Spectrum Disorder/therapy ; Child ; Gastrointestinal Diseases/therapy ; Gastrointestinal Microbiome ; Humans ; Prebiotics ; Probiotics/therapeutic use
    Chemical Substances Prebiotics
    Language English
    Publishing date 2022-04-19
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.001510
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    Zs.A 634: Show issues Location:
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  9. Article ; Online: Epidemiology, Drug Susceptibility, and Clinical Risk Factors in Patients With Invasive Aspergillosis.

    Wang, Yuerong / Zhang, Luwen / Zhou, Longrong / Zhang, Min / Xu, Yuanhong

    Frontiers in public health

    2022  Volume 10, Page(s) 835092

    Abstract: Background: This study aimed to investigate the : Methods: In the present study, 156 : Results: The : Conclusions: ... ...

    Abstract Background: This study aimed to investigate the
    Methods: In the present study, 156
    Results: The
    Conclusions: The
    MeSH term(s) Antifungal Agents/pharmacology ; Aspergillosis/drug therapy ; Aspergillosis/epidemiology ; Aspergillosis/microbiology ; Aspergillus fumigatus/genetics ; Azoles/pharmacology ; Drug Resistance, Fungal/genetics ; Flucytosine ; Fungal Proteins/genetics ; Humans ; Lung Diseases ; Risk Factors
    Chemical Substances Antifungal Agents ; Azoles ; Fungal Proteins ; Flucytosine (D83282DT06)
    Language English
    Publishing date 2022-04-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.835092
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  10. Article ; Online: GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease.

    Wang, Meitian / He, Xiuqing / Li, Jie / Han, Daobin / You, Pan / Yu, Hui / Wang, Luwen / Su, Bo

    Biochimica et biophysica acta. Molecular basis of disease

    2024  Volume 1870, Issue 4, Page(s) 167093

    Abstract: Accumulation of insoluble deposits of amyloid β-peptide (Aβ), derived from amyloid precursor protein (APP) processing, represents one of the major pathological hallmarks of Alzheimer's disease (AD). Perturbations in APP transport and hydrolysis could ... ...

    Abstract Accumulation of insoluble deposits of amyloid β-peptide (Aβ), derived from amyloid precursor protein (APP) processing, represents one of the major pathological hallmarks of Alzheimer's disease (AD). Perturbations in APP transport and hydrolysis could lead to increased Aβ production. However, the precise mechanisms underlying APP transport remain elusive. The GDP dissociation inhibitor2 (GDI2), a crucial regulator of Rab GTPase activity and intracellular vesicle and membrane trafficking, was investigated for its impact on AD pathogenesis through neuron-specific knockout of GDI2 in 5xFAD mice. Notably, deficiency of GDI2 significantly ameliorated cognitive impairment, prevented neuronal loss in the subiculum and cortical layer V, reduced senile plaques as well as astrocyte activation in 5xFAD mice. Conversely, increased activated microglia and phagocytosis were observed in GDI2 ko mice. Further investigation revealed that GDI2 knockout led to more APP co-localized with the ER rather than the Golgi apparatus and endosomes in SH-SY5Y cells, resulting in decreased Aβ production. Collectively, these findings suggest that GDI2 may regulate Aβ production by modulating APP intracellular transport and localization dynamics. In summary, our study identifies GDI2 as a pivotal regulator governing APP transport and process implicated in AD pathology; thus highlighting its potential as an attractive pharmacological target for future drug development against AD.
    MeSH term(s) Humans ; Mice ; Animals ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Neuroblastoma ; Memory Disorders/genetics ; Neurons/metabolism ; Guanine Nucleotide Dissociation Inhibitors
    Chemical Substances Amyloid beta-Peptides ; GDI2 protein, human ; Guanine Nucleotide Dissociation Inhibitors
    Language English
    Publishing date 2024-02-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2024.167093
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