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  1. Article ; Online: Response to "Tomographic Findings and Thrombogenic Effects of COVID-19".

    Bao, Cuiping / Li, Yiming / Liu, Jun

    Journal of the American College of Radiology : JACR

    2020  Volume 17, Issue 12, Page(s) 1546

    MeSH term(s) COVID-19 ; Humans ; Pandemics ; SARS-CoV-2 ; Tomography, X-Ray Computed
    Keywords covid19
    Language English
    Publishing date 2020-10-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2274861-1
    ISSN 1558-349X ; 1546-1440
    ISSN (online) 1558-349X
    ISSN 1546-1440
    DOI 10.1016/j.jacr.2020.08.023
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  2. Article ; Online: Clinical Effects of Surgical Left Atrial Reduction and Concomitant Mitral Valve Replacement in Patients with Giant Left Atrium.

    Yang, Song / Wang, Cuiping / Zhang, Bao / Hou, Jian / Huang, Suiqing / Wang, Keke / Wu, Zhongkai

    Brazilian journal of cardiovascular surgery

    2023  Volume 38, Issue 5, Page(s) e20220469

    Abstract: Introduction: A giant left atrium may cause respiratory dysfunction and hemodynamic disturbance postoperatively. This retrospective study aimed to evaluate clinical effects of surgical left atrial reduction in concomitant cardiac valves operations.: ... ...

    Abstract Introduction: A giant left atrium may cause respiratory dysfunction and hemodynamic disturbance postoperatively. This retrospective study aimed to evaluate clinical effects of surgical left atrial reduction in concomitant cardiac valves operations.
    Methods: One hundred and thirty-five patients with heart valve diseases and giant left atriums from January 2004 to July 2021 were enrolled into this research. They were divided into the folded group (n=63) and the unfolded group (n=72). Patients in the folded group had undergone cardiac valve operations concomitantly with left atrial reductions. The perioperative characteristics were compared between both groups, and subgroup analysis was performed.
    Results: There were five deaths in the folded group and 25 deaths in the unfolded group (P<0.001). Complications including pneumonia, sepsis, multiple organs dysfunction syndrome, low cardiac output syndrome, and the use of continuous renal replacement therapy were significantly fewer in the folded group. The receiver operating characteristic curve of left atrial max. diameter predicting mortality was significant (area under the curve=0.878, P=0.005), and the cutoff point was 96.5 mm. The stratified analysis for sex showed that more female patients died in the unfolded group. Logistic regression for mortality showed that the left atrium unfolded, left atrial max. diameter, cardiopulmonary bypass time, and mechanical ventilation time increased the risk of death.
    Conclusion: Surgical left atrial reduction concomitantly with valves replacement could decrease mortality and was safe and effective in giant left atrium patients.
    MeSH term(s) Humans ; Female ; Mitral Valve/surgery ; Atrial Fibrillation/surgery ; Retrospective Studies ; Heart Atria/surgery ; Heart Valve Diseases/surgery ; Cardiomegaly/surgery ; Heart Valve Prosthesis Implantation
    Language English
    Publishing date 2023-08-04
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2031026-2
    ISSN 1678-9741 ; 1678-9741
    ISSN (online) 1678-9741
    ISSN 1678-9741
    DOI 10.21470/1678-9741-2022-0469
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  3. Article: Gut microbiota is correlated with gastrointestinal adverse events of metformin in patients with type 2 diabetes.

    Huang, Yuxin / Lou, Xudan / Jiang, Cuiping / Ji, Xueying / Tao, Xiaoming / Sun, Jiao / Bao, Zhijun

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 1044030

    Abstract: Aim: Gastrointestinal discomfort is the most common adverse event in metformin treatment for type 2 diabetes. The mechanism of action of metformin is associated with gut microbiota. However, the gut microbial community structure related to metformin- ... ...

    Abstract Aim: Gastrointestinal discomfort is the most common adverse event in metformin treatment for type 2 diabetes. The mechanism of action of metformin is associated with gut microbiota. However, the gut microbial community structure related to metformin-induced gastrointestinal adverse events remains unclear. This study aimed to investigate it.
    Methods: 50 patients with newly diagnosed diabetes were treated with metformin 1500mg/d for 12 weeks. The patients were divided into two groups according to whether gastrointestinal adverse events occurred (group B) or did not occur (group A) after treatment. The fecal bacterial communities and short-chain fatty acids (SCFAs) were sequenced and compared. 70 diabetes mice were randomly divided into 8 groups and treated with metformin (Met), clindamycin (Clin) and/or SCFA, which were the Met+/Clin+, Met+/Clin-, Met-/Clin+, Met-/Clin-, Met+/SCFA+, Met+/SCFA-, Met-/SCFA+ and Met-/SCFA- group. After 4 weeks of metformin treatment, blood glucose, food intake, fecal SCFAs, gut microbiota and gut hormones were measured.
    Results: Metformin increased the abundance of
    Conclusions: Our data suggest that metformin promotes the secretion of intestinal hormones such as GLP-1 by increasing the abundance of SCFA-producing bacteria, which not only plays an anti-diabetic role, but also may causes gastrointestinal adverse events.
    MeSH term(s) Animals ; Humans ; Mice ; Diabetes Mellitus, Type 2/drug therapy ; Gastrointestinal Hormones ; Gastrointestinal Microbiome ; Glucagon-Like Peptide 1 ; Metformin/adverse effects ; Propionates
    Chemical Substances Gastrointestinal Hormones ; Glucagon-Like Peptide 1 (89750-14-1) ; Metformin (9100L32L2N) ; Propionates ; propionic acid (JHU490RVYR)
    Language English
    Publishing date 2022-11-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.1044030
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  4. Article ; Online: Region-specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes: a cross-sectional study.

    Bao, Cuiping / Liu, Xuehuan / Li, Yiming / Yang, Jun / Wei, Feng / Gong, Yi / Ma, Zhihui / Liu, Jun

    Endocrine journal

    2023  Volume 70, Issue 12, Page(s) 1131–1140

    Abstract: To examine the association between prediabetes/type 2 diabetes mellitus (T2DM) and hippocampal subfields and to investigate the effects of glycemic control (HbA1c and FBG)/diabetes duration on the volume of hippocampal subfields in T2DM patients. This ... ...

    Abstract To examine the association between prediabetes/type 2 diabetes mellitus (T2DM) and hippocampal subfields and to investigate the effects of glycemic control (HbA1c and FBG)/diabetes duration on the volume of hippocampal subfields in T2DM patients. This cross-sectional study included 268 participants from Tianjin Union Medical Center between August 2019 and July 2022. The participants were divided into three groups: T2DM, prediabetes and no diabetes. All participants underwent brain MRI examination on a 3T MRI scanner. FreeSurfer was performed to segment hippocampus automatically based on T1 MPRAGE images. The relationships between glycemic status/glycemic control/diabetes duration and hippocampal subfield volumes were estimated by multiple linear regression analysis/generalized additive modeling (GAM). Among all participants, 76 (28.36%) had prediabetes, and 96 (35.82%) had T2DM. In multi-adjusted linear regression models, those with prediabetes had a significantly lower volume of bilateral parasubiculum (β
    MeSH term(s) Humans ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/pathology ; Prediabetic State/complications ; Prediabetic State/pathology ; Glycated Hemoglobin ; Glycemic Control ; Hippocampus/diagnostic imaging ; Hippocampus/pathology ; Magnetic Resonance Imaging/methods ; Hyperglycemia/pathology ; Atrophy/pathology
    Chemical Substances Glycated Hemoglobin
    Language English
    Publishing date 2023-11-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1151918-6
    ISSN 1348-4540 ; 0918-8959
    ISSN (online) 1348-4540
    ISSN 0918-8959
    DOI 10.1507/endocrj.EJ23-0211
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  5. Article ; Online: A CT-based radiomics nomogram for predicting histopathologic growth patterns of colorectal liver metastases.

    Sun, Chao / Liu, Xuehuan / Sun, Jie / Dong, Longchun / Wei, Feng / Bao, Cuiping / Zhong, Jin / Li, Yiming

    Journal of cancer research and clinical oncology

    2023  Volume 149, Issue 12, Page(s) 9543–9555

    Abstract: Purpose: To develop a computed tomography (CT)-based radiomics nomogram for pre-treatment prediction of histopathologic growth patterns (HGPs) in colorectal liver metastases (CRLM) and to validate its accuracy and clinical value.: Materials and ... ...

    Abstract Purpose: To develop a computed tomography (CT)-based radiomics nomogram for pre-treatment prediction of histopathologic growth patterns (HGPs) in colorectal liver metastases (CRLM) and to validate its accuracy and clinical value.
    Materials and methods: This retrospective study included a total of 197 CRLM from 92 patients. Lesions from CRLM were randomly divided into the training study (n = 137) and the validation study (n = 60) with the ratio of 3:1 for model construction and internal validation. The least absolute shrinkage and selection operator (LASSO) was used to screen features. Radiomics score (rad-score) was calculated to generate radiomics features. A predictive radiomics nomogram based on rad-score and clinical features was developed using random forest (RF). The performances of clinical model, radiomic model and radiomics nomogram were thoroughly evaluated by the DeLong test, decision curve analysis (DCA) and clinical impact curve (CIC) allowing for generation of an optimal predictive model.
    Results: The radiological nomogram model consists of three independent predictors, including rad-score, T-stage, and enhancement rim on PVP. Training and validation results demonstrated the high-performance level of the model of area under curve (AUC) of 0.86 and 0.84, respectively. The radiomic nomogram model can achieve better diagnostic performance than the clinical model, yielding greater net clinical benefit compared to the clinical model alone.
    Conclusions: A CT-based radiomics nomogram can be used to predict HGPs in CRLM. Preoperative non-invasive identification of HGPs could further facilitate clinical treatment and provide personalized treatment plans for patients with liver metastases from colorectal cancer.
    MeSH term(s) Humans ; Nomograms ; Retrospective Studies ; Tomography, X-Ray Computed ; Liver Neoplasms/diagnostic imaging ; Colorectal Neoplasms/diagnostic imaging
    Language English
    Publishing date 2023-05-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-023-04852-6
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  6. Article ; Online: Evaluation of the fermentation performance and functional properties of bacterial communities of amaranth silage supplemented with Limosilactobacillus fermentum and Latilactobacillus graminis

    Muqier Zhao / Jian Bao / Zhijun Wang / Shuai Du / Cuiping Gao / Dinghan Nan / Xingquan Yan / Gentu Ge

    Chemical and Biological Technologies in Agriculture, Vol 10, Iss 1, Pp 1-

    2023  Volume 16

    Abstract: Abstract Background The objective was to determine the effects of different lactic acid bacteria (LAB) on amaranth (Amaranthus hypochondriaus) silage fermentation characteristics, changes in bacterial communities and their functional properties, and to ... ...

    Abstract Abstract Background The objective was to determine the effects of different lactic acid bacteria (LAB) on amaranth (Amaranthus hypochondriaus) silage fermentation characteristics, changes in bacterial communities and their functional properties, and to investigate the preferential effects and mechanisms of action of Limosilactobacillus fermentum (L. fermentum) and Latilactobacillus graminis (L. graminis) on the bacterial communities of silage. LAB were screened and identified from native grasses and its naturally fermented silage, and their effects on fermentation performance and bacterial community of amaranth after 60 days of fermentation were investigated. BL1 and BL5 strains were identified as L. fermentum and L. graminis, respectively. They could grow normally at concentrations of 3.0% and 6.5% NaCl, tolerating pH and temperature ranges of 3.5 –9.0 and 4.0 – 9.0, 30 – 45 ℃ and 10 – 45 ℃, respectively. The distilled water, Lactiplantibacillus plantarum (commercial inoculant), L. fermentum, and L. graminis were inoculated into amaranth at a total of 1 × 105 cfu/g fresh material and labeled AhSCK, AhSLP, AhSLF, and AhSLG, respectively, while the fresh amaranth was labeled YLS. Results As expected, the water soluble carbohydrates of AhSCK was lower than AhSLG (p < 0.05). The highest number of LAB was found in AhSLF (p < 0.05). The lactic acid (LA) content of AhSLP was significantly higher (p < 0.05) than other silage. Nevertheless, acetic acid (AA) content of AhSLF was significantly different from other silage (p < 0.05). All the amaranth silage was well preserved with low pH (4.16 – 4.51) and acceptable levels of butyric acid (0.00 – 0.86%FM). At the species level, Pantoea agglomerans, Pseudomonas oryzihabitans, and Cenchrus americanus served as the dominant strains in fresh amaranth, with relative abundances lower than 1% after ensiling. Lentilactobacillus buchneri, Levilactobacillus brevis, and L. fermentum were the dominant strains of AhSCK, AhSLP and AhSLF. Nevertheless, the predominant strains ...
    Keywords Lactic acid bacteria ; Fermentation quality ; Bacterial community ; Amaranth ; Silage ; Agriculture ; S
    Subject code 630
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Response to “Tomographic Findings and Thrombogenic Effects of COVID-19”

    Bao, Cuiping / Liu, Jun / Li, Yiming

    Journal of the American College of Radiology ; ISSN 1546-1440

    2020  

    Keywords Radiology Nuclear Medicine and imaging ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.jacr.2020.08.023
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  9. Article: Effects of triclosan on the RedoximiRs/Sirtuin/Nrf2/ARE signaling pathway in mosquitofish (Gambusia affinis)

    Bao, Shuang / He, Cuiping / Ku, Peijia / Xie, Meinan / Lin, Jiawei / Lu, Songhui / Nie, Xiangping

    Elsevier B.V. Aquatic toxicology. 2021 Jan., v. 230

    2021  

    Abstract: Triclosan (TCS) has been widely used in daily life for its broad-spectrum antibacterial property and subsequently detected frequently in aquatic waterborne. Environmental relevant concentrations of TCS in water (ng-μg/L) may pose potential unexpected ... ...

    Abstract Triclosan (TCS) has been widely used in daily life for its broad-spectrum antibacterial property and subsequently detected frequently in aquatic waterborne. Environmental relevant concentrations of TCS in water (ng-μg/L) may pose potential unexpected impact on non-target aquatic organisms. In the present work, we investigated the transcriptional responses of Nrf2 as well as its downstream genes, sirtuins and redox-sensitive microRNAs (RedoximiRs) in livers of the small freshwater fish mosquitofish (Gambusia affinis) which were exposed to environmental relevant concentrations of TCS (0.05 μg/L, 0.5 μg/L and 5 μg/L for 24 h and 168 h). Results showed there were similar up-regulations in Nrf2 and its target genes (e. g. NQO1, CAT and SOD) at transcriptional, enzymatic and protein levels, reflecting oxidative stress of TCS to mosquitofish. Meanwhile, up-regulations of Sirt1, Sirt2 and down-regulations of miR-34b, miR-200b-5p and miR-21 could modulate antioxidant system via the Nrf2/ARE signaling pathway by the post-transcriptional regulations. Some oxidative stress-related biomarkers displayed in concentration-dependent manners (e. g. NQO1 mRNA, CAT mRNA) and/or time-dependent manners (e. g. GSH contents). This study indicated that the RedoximiRs/Sirtuin/Nrf2/ARE signaling pathway played a crucial role in mosquitofish exposed to TCS, and there might be potentially profound effects for TCS on the aquatic ecological safety.
    Keywords Gambusia affinis ; antibacterial properties ; antioxidants ; biomarkers ; freshwater fish ; microRNA ; oxidative stress ; sirtuins ; toxicology ; transcription (genetics) ; triclosan
    Language English
    Dates of publication 2021-01
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 782699-0
    ISSN 1879-1514 ; 0166-445X
    ISSN (online) 1879-1514
    ISSN 0166-445X
    DOI 10.1016/j.aquatox.2020.105679
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  10. Article ; Online: McAN: a novel computational algorithm and platform for constructing and visualizing haplotype networks.

    Li, Lun / Xu, Bo / Tian, Dongmei / Wang, Anke / Zhu, Junwei / Li, Cuiping / Li, Na / Zhao, Wei / Shi, Leisheng / Xue, Yongbiao / Zhang, Zhang / Bao, Yiming / Zhao, Wenming / Song, Shuhui

    Briefings in bioinformatics

    2023  Volume 24, Issue 3

    Abstract: ... ac.cn (Bao Y), zhangzhang@big.ac.cn (Zhang Z), ybxue@big.ac.cn (Xue Y). ...

    Abstract Haplotype networks are graphs used to represent evolutionary relationships between a set of taxa and are characterized by intuitiveness in analyzing genealogical relationships of closely related genomes. We here propose a novel algorithm termed McAN that considers mutation spectrum history (mutations in ancestry haplotype should be contained in descendant haplotype), node size (corresponding to sample count for a given node) and sampling time when constructing haplotype network. We show that McAN is two orders of magnitude faster than state-of-the-art algorithms without losing accuracy, making it suitable for analysis of a large number of sequences. Based on our algorithm, we developed an online web server and offline tool for haplotype network construction, community lineage determination, and interactive network visualization. We demonstrate that McAN is highly suitable for analyzing and visualizing massive genomic data and is helpful to enhance the understanding of genome evolution. Availability: Source code is written in C/C++ and available at https://github.com/Theory-Lun/McAN and https://ngdc.cncb.ac.cn/biocode/tools/BT007301 under the MIT license. Web server is available at https://ngdc.cncb.ac.cn/bit/hapnet/. SARS-CoV-2 dataset are available at https://ngdc.cncb.ac.cn/ncov/. Contact: songshh@big.ac.cn (Song S), zhaowm@big.ac.cn (Zhao W), baoym@big.ac.cn (Bao Y), zhangzhang@big.ac.cn (Zhang Z), ybxue@big.ac.cn (Xue Y).
    MeSH term(s) Humans ; Haplotypes ; SARS-CoV-2/genetics ; COVID-19/genetics ; Algorithms ; Genomics ; Software
    Language English
    Publishing date 2023-05-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2068142-2
    ISSN 1477-4054 ; 1467-5463
    ISSN (online) 1477-4054
    ISSN 1467-5463
    DOI 10.1093/bib/bbad174
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