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  1. Article: Acute Decompensated Heart Failure in Patients with Heart Failure with Preserved Ejection Fraction.

    Sugimoto, Tadafumi

    Heart failure clinics

    2020  Volume 16, Issue 2, Page(s) 201–209

    Abstract: There are few treatment options for acute decompensated heart failure patients with preserved ejection fraction, but an increasing number of patients with heart failure with preserved ejection fraction. A deeper understanding of the cause, diagnosis, and ...

    Abstract There are few treatment options for acute decompensated heart failure patients with preserved ejection fraction, but an increasing number of patients with heart failure with preserved ejection fraction. A deeper understanding of the cause, diagnosis, and prognosis of heart failure with preserved ejection fraction may be informative for clinical practice or clinical decision making and therapeutic investigation in the acute care setting.
    MeSH term(s) Clinical Decision-Making ; Emergency Treatment/methods ; Heart Failure/physiopathology ; Heart Failure/therapy ; Hemodynamics ; Humans ; Prognosis ; Stroke Volume
    Language English
    Publishing date 2020-02-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2212019-1
    ISSN 1551-7136
    ISSN 1551-7136
    DOI 10.1016/j.hfc.2019.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Current status and issues regarding reference values for echocardiography: a short review.

    Sugimoto, Tadafumi / Dohi, Kaoru

    Journal of medical ultrasonics (2001)

    2021  Volume 49, Issue 1, Page(s) 17–19

    Abstract: In general, the reference values of diagnostic test parameters are specified based on the values of 95% confidence intervals of those parameters measured in healthy subjects. As heart size varies according to sex, there are sex-related differences in the ...

    Abstract In general, the reference values of diagnostic test parameters are specified based on the values of 95% confidence intervals of those parameters measured in healthy subjects. As heart size varies according to sex, there are sex-related differences in the reference values of echocardiographic parameters. There have been attempts to minimize the variability in the reference values of echocardiographic parameters worldwide by correcting for age-related, sex-related, and body size-related differences. This short review describes the current status and issues regarding the reference values of echocardiographic parameters and discusses the findings of research aimed at resolving these issues.
    MeSH term(s) Echocardiography ; Healthy Volunteers ; Humans ; Reference Values
    Language English
    Publishing date 2021-06-29
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1396630-3
    ISSN 1613-2254 ; 0287-0592 ; 1346-4523
    ISSN (online) 1613-2254
    ISSN 0287-0592 ; 1346-4523
    DOI 10.1007/s10396-021-01108-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Case report: A family of atypical hemolytic uremic syndrome involving a

    Tasaki, Yuko / Tsujimoto, Hiroshi / Yokoyama, Tadafumi / Sugimoto, Naotoshi / Kitajima, Shinji / Fujii, Hiroshi / Hidaka, Yoshihiko / Kato, Noritoshi / Maruyama, Shoichi / Inoue, Norimitsu / Wada, Taizo

    Frontiers in immunology

    2024  Volume 15, Page(s) 1360855

    Abstract: Mutations in the complement factor H ( ...

    Abstract Mutations in the complement factor H (
    MeSH term(s) Humans ; Female ; Infant ; Complement Factor H/genetics ; Atypical Hemolytic Uremic Syndrome/diagnosis ; Atypical Hemolytic Uremic Syndrome/genetics ; Gene Duplication ; Complement System Proteins/genetics ; Mutation ; Blood Proteins/genetics ; Complement C3b Inactivator Proteins/genetics
    Chemical Substances Complement Factor H (80295-65-4) ; Complement System Proteins (9007-36-7) ; CFHR3 protein, human ; Blood Proteins ; CFHR1 protein, human ; Complement C3b Inactivator Proteins
    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1360855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of Tweet Content on the Number of Retweets - "Tweet the Meeting 2022".

    Suzuki, Takahiro / Mizuno, Atsushi / Kishi, Takuya / Rewley, Jeffrey / Matsumoto, Chisa / Sahashi, Yuki / Ishida, Mari / Sanada, Shoji / Fukuda, Memori / Sugimoto, Tadafumi / Hirano, Miki / Node, Koichi

    Circulation reports

    2023  Volume 5, Issue 7, Page(s) 306–310

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-06-06
    Publishing country Japan
    Document type Journal Article
    ISSN 2434-0790
    ISSN (online) 2434-0790
    DOI 10.1253/circrep.CR-23-0043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cardiovascular Hospitalizations and Hospitalization Costs in Japan During the COVID-19 Pandemic.

    Sugimoto, Tadafumi / Mizuno, Atsushi / Yoneoka, Daisuke / Matsumoto, Shingo / Matsumoto, Chisa / Matsue, Yuya / Ishida, Mari / Nakai, Michikazu / Iwanaga, Yoshitaka / Miyamoto, Yoshihiro / Node, Koichi

    Circulation reports

    2023  Volume 5, Issue 10, Page(s) 381–391

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-09-16
    Publishing country Japan
    Document type Journal Article
    ISSN 2434-0790
    ISSN (online) 2434-0790
    DOI 10.1253/circrep.CR-23-0072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: An evidence review project for food with function claims ~Challenges of the Japan society for vascular failure for the promotion of adequate evidences for food with function claims.

    Matsumoto, Chisa / Tomiyama, Hirofumi / Takahashi, Osamu / Maruhashi, Tatsuya / Matsuzawa, Yasushi / Masaki, Nobuyuki / Muraki, Isao / Yano, Yuichiro / Sugimoto, Tadafumi / Kabutoya, Tomoyuki / Sawami, Kosuke / Tanaka, Atsushi / Arima, Hisatomi / Sata, Masataka / Node, Koichi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 47, Issue 2, Page(s) 533–536

    MeSH term(s) Japan ; Food ; Health Promotion ; Food Labeling
    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Editorial
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01485-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Novel non-pharmacological therapy to modulate the autonomic tone in patients with heart failure with pulmonary hypertension.

    Martinez, Christophe / Sugimoto, Tadafumi / Tsugu, Toshimitsu / Oury, Cécile / Lancellotti, Patrizio

    Journal of thoracic disease

    2019  Volume 11, Issue Suppl 9, Page(s) S1325–S1328

    Language English
    Publishing date 2019-06-05
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2019.04.23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Skeletal Muscle-Derived Irisin Enhances Gemcitabine Sensitivity and Suppresses Migration Ability in Pancreatic Ductal Adenocarcinoma.

    Sugimoto, Tomoki / Iwagami, Yoshifumi / Kobayashi, Shogo / Yamanaka, Chihiro / Sasaki, Kazuki / Yamada, Daisaku / Tomimaru, Yoshito / Asaoka, Tadafumi / Noda, Takehiro / Takahashi, Hidenori / Shimizu, Junzo / Doki, Yuichiro / Eguchi, Hidetoshi

    Annals of surgical oncology

    2024  

    Abstract: Background: High skeletal muscle mass might be a prognostic factor for patients with pancreatic ductal adenocarcinoma (PDAC); however, the underlying reason is unclear. We hypothesized that myokines, which are cytokines secreted by the skeletal muscle, ... ...

    Abstract Background: High skeletal muscle mass might be a prognostic factor for patients with pancreatic ductal adenocarcinoma (PDAC); however, the underlying reason is unclear. We hypothesized that myokines, which are cytokines secreted by the skeletal muscle, function as suppressors of PDAC. We specifically examined irisin, a myokine, which plays a critical role in the modulation of metabolism, to clarify the anticancer mechanisms.
    Methods: First, the effect of the conditioned medium (CM) from skeletal muscle cells and from irisin-knockdown skeletal muscle cells on PDAC cell lines was evaluated. We then investigated the effects and anticancer mechanism of irisin in PDAC cells, and evaluated the anticancer effect of recombinant irisin in a PDAC xenograft mouse model. Finally, patients undergoing pancreatic resection for PDAC were divided into two groups based on their serum irisin level, and the long-term outcomes were evaluated.
    Results: The CM enhanced gemcitabine sensitivity by inducing apoptosis and decreasing cell migration by inhibiting epithelial-mesenchymal transition (EMT) in PDAC cell lines. The CM derived from irisin-knockdown skeletal muscle cells did not affect the PDAC cell lines. The addition of recombinant irisin to PDAC cell lines facilitated sensitivity to gemcitabine by inhibiting the mitogen-activated protein kinase (MAPK) pathway, and decreased migration by inhibiting EMT via the transforming growth factor-β/SMAD pathway. Xenografts injected with gemcitabine and recombinant irisin grew slower than the xenografts injected with gemcitabine alone. The overall survival was prolonged in the high-irisin group compared with that in the low-irisin group.
    Conclusions: Skeletal muscle-derived irisin may affect PDAC by enhancing its sensitivity to gemcitabine and suppressing EMT.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-024-15118-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Clinical characteristics and the risk of hospitalization of patients with coronavirus disease 2019 quarantined in a designated hotel in Japan.

    Ito, Hiromasa / Sugimoto, Tadafumi / Ogihara, Yoshito / Kurita, Tairo / Tanabe, Masaki / Hirayama, Masahiro / Isaji, Shuji / Dohi, Kaoru

    PloS one

    2023  Volume 18, Issue 1, Page(s) e0280291

    Abstract: The aim was to investigate the clinical characteristics of coronavirus disease 2019 (COVID-19) patients who were admitted to a designated hotel, and to clarify the risk factors for hospitalization of such patients with clinical deterioration. The medical ...

    Abstract The aim was to investigate the clinical characteristics of coronavirus disease 2019 (COVID-19) patients who were admitted to a designated hotel, and to clarify the risk factors for hospitalization of such patients with clinical deterioration. The medical records of COVID-19 patients who were admitted to the designated hotel in Mie Prefecture, Japan, between August 2020 and September 2021 were reviewed retrospectively. Of the 1,087 COVID-19 patients who were admitted to the designated hotel, 936 patients (32.1± 12.8 years, 61.3% male) were recruited after excluding patients under the age of 15 years (n = 33), those admitted from the hospital (n = 111, 10.2%), COVID-19 vaccinated patients (n = 4, 0.4%), and those who were discharged to their own home due to social disorders (n = 3). During the study period, 884 patients (94.4%) were discharged to their own home with improving symptoms, whereas 52 patients (5.6%) were hospitalized for a deteriorating clinical condition. The logistic regression analyses showed that older age (≥ 40 years), higher body mass index (≥ 25 kg/m2), hypertension were the risk factors for hospitalization. As the new risk scale score based on the results of the odds ratios increased, the hospitalization rate increased significantly: 2.0% at 0-1 points, 9.7% at 2-3 points, and 28.8% at 4-5 points (p < 0.001). None of the 52 hospitalized patients died, and none developed serious complications from COVID-19 after hospitalization. In conclusion, the designated accommodation program for COVID-19 patients was safe, especially for those with a low risk for hospitalization.
    MeSH term(s) Humans ; Male ; Adolescent ; Female ; COVID-19/epidemiology ; Retrospective Studies ; Japan/epidemiology ; SARS-CoV-2 ; Hospitalization ; Risk Factors
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0280291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hospitalizations for Cardiovascular Diseases During the Early Stage of the COVID-19 Pandemic in Japan.

    Sugimoto, Tadafumi / Mizuno, Atsushi / Yoneoka, Daisuke / Matsumoto, Shingo / Matsumoto, Chisa / Matsue, Yuya / Ishida, Mari / Nakai, Michikazu / Iwanaga, Yoshitaka / Miyamoto, Yoshihiro / Node, Koichi

    Circulation reports

    2022  Volume 4, Issue 8, Page(s) 353–362

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-07-01
    Publishing country Japan
    Document type Journal Article
    ISSN 2434-0790
    ISSN (online) 2434-0790
    DOI 10.1253/circrep.CR-22-0058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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