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Article: Rathke's cleft cyst abscess from

Ashraf, Mohammad / Iqbal, Javed / Husnain, Ali / Hussain, Syed Shahzad / Ashraf, Naveed

Journal of neurosciences in rural practice

2023 Volume 14, Issue 2, Page(s) 358–360

Abstract: Pituitary abscesses are uncommon lesions accounting for <1% of all pituitary diseases. We report a case of a female microbiology technician with a rare congenital heart disease who developed an Rathke's Cleft Cyst abscess ... ...

Abstract	Pituitary abscesses are uncommon lesions accounting for <1% of all pituitary diseases. We report a case of a female microbiology technician with a rare congenital heart disease who developed an Rathke's Cleft Cyst abscess from
Language	English
Publishing date	2023-03-16
Publishing country	United States
Document type	Case Reports
ZDB-ID	2601242-X
ISSN	0976-3155 ; 0976-3147
ISSN (online)	0976-3155
ISSN	0976-3147
DOI	10.25259/JNRP_53_2023
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Article ; Online: Effects of

Kadhem, Ali Hakem / Gholizadeh, Ashraf / Khalaj-Kondori, Mohammad

The Journal of international medical research

2023 Volume 51, Issue 9, Page(s) 3000605231196837

Abstract: Objective: To identify the effects of metformin and kisspeptin structural polymorphism on the risk of polycystic ovary syndrome (PCOS) in Iraqi women.: Methods: Samples were collected at the family planning center of Al-Hassan Teaching Hospital ( ... ...

Abstract	Objective: To identify the effects of metformin and kisspeptin structural polymorphism on the risk of polycystic ovary syndrome (PCOS) in Iraqi women. Methods: Samples were collected at the family planning center of Al-Hassan Teaching Hospital (infertility clinic), Iraq. Hormonal and hematological parameters were measured. Kisspeptin structural polymorphisms were analyzed by polymerase chain reaction using a conventional thermal cycler and Phyre2 predictions. Kisspeptin concentrations were assessed by an enzyme-linked immunosorbent assay. Results: Follicle-stimulating hormone (FSH) was the only sex hormone that changed in women with PCOS after metformin treatment. FSH concentrations were significantly increased after therapy compared with before therapy (9.39 ± 2.1 vs 5.13 ± 1.53 IU/L). We found that a single nucleotide polymorphism substituting G to C was related to PCOS. The kisspeptin structural polymorphism showed that the C allele was related to low FSH concentrations after treatment (6.92 ± 2.2 IU/L to 5.34 ± 1.58 IU/L). Kisspeptin concentrations were significantly lower after metformin treatment than before metformin treatment (395.44 ± 67.83 vs 273.18 ± 42.98 ng/mL). Conclusion: A variation in the
MeSH term(s)	Humans ; Female ; Kisspeptins ; Iraq ; Polycystic Ovary Syndrome/drug therapy ; Polycystic Ovary Syndrome/genetics ; Follicle Stimulating Hormone, Human ; Polymorphism, Single Nucleotide/genetics ; Metformin/therapeutic use
Chemical Substances	Kisspeptins ; Follicle Stimulating Hormone, Human ; Metformin (9100L32L2N) ; KISS1 protein, human
Language	English
Publishing date	2023-09-13
Publishing country	England
Document type	Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605231196837
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Zs.A 925: Show issues

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Article ; Online: Prevalence of Postoperative Hypothermia in the Post-anesthesia Care Unit.

Ashoobi, Mohammad Taghi / Shakiba, Maryam / Keshavarzmotamed, Atoosa / Ashraf, Ali

Anesthesiology and pain medicine

2023 Volume 13, Issue 5, Page(s) e136730

Abstract: Background: Unwanted postoperative hypothermia is an unpleasant event that can cause various complications.: Objectives: As this serious complication and its provoking causes have not been investigated sufficiently, this study was designed and ... ...

Abstract	Background: Unwanted postoperative hypothermia is an unpleasant event that can cause various complications. Objectives: As this serious complication and its provoking causes have not been investigated sufficiently, this study was designed and conducted to determine the prevalence of hypothermia and its associated factors in the post-anesthesia care unit after elective surgery. Methods: Four hundred patients undergoing elective surgeries were enrolled in the present cross-sectional research after termination of surgery and at the time of arrival at the post-anesthesia care unit of Poursina Public University Hospital. The tympanic membrane temperature was measured and recorded at the time of arrival at the post-anesthesia care unit and every 30 minutes after arrival. The required data were collected in a researcher-made checklist and analyzed after entering the SPSS software version 25. Results: Considering the 5% error, it can be said that the prevalence of hypothermia in patients undergoing elective surgery ranges from 20 to 28% at the time of arrival at the post-anesthesia care unit and 18.5 to 26% 30 minutes after arrival. Conclusions: More than a quarter of patients experienced hypothermia following elective surgery. Therefore, appropriate treatment and control measures are necessary to manage this complication, particularly in patients with predisposing risk factors and comorbidities.
Language	English
Publishing date	2023-09-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3018888-X
ISSN	2228-7531 ; 2228-7523
ISSN (online)	2228-7531
ISSN	2228-7523
DOI	10.5812/aapm-136730
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Article ; Online: Oxadiazole Derivatives of Diclofenac as an Anti-proliferative Agent for B-cell Non-Hodgkin Lymphoma: An In vitro and In Silico Studies.

Qayyum, Shaista / Jabeen, Almas / Ashraf, Sajda / Seraj, Faiza / Mohammad Khan, Khalid / Siddiqui, Rafat Ali / Zaheer Ul-Haq

Medicinal chemistry (Shariqah (United Arab Emirates))

2024

Abstract: Background: Non-Hodgkin lymphoma of B cell origin is the common type of lymphoma- related malignancy with poor response rate with conventional front-line therapies.: Aim: The aim of the present study was to investigate the potential of new anti- ... ...

Abstract	Background: Non-Hodgkin lymphoma of B cell origin is the common type of lymphoma- related malignancy with poor response rate with conventional front-line therapies. Aim: The aim of the present study was to investigate the potential of new anti-inflammatory oxadiazole derivatives of Diclofenac as an anti-lymphoma agent through in vitro and in silico approaches. Method: The compound (II) showed anti-lymphoma activity against both follicular and Burkitt's lymphoma cells, whereas compound (V) inhibited follicular lymphoma cells only. The diclofenac (I) and derivatives (III, IV and VI) exhibited no anti-proliferative effects. The (II) significantly inhibited the expression of BCL-2, p-38 MAPK and TGF-β in both follicular and Burkitt's lymphoma cells and was non-toxic against normal human fibroblast cells (BJ). Result: The in silico studies against BCL-2 revealed that the unsubstituted Sulphur group in compound (II) is involved in the crucial interactions with the binding site residue. Conclusion: The compound (II) can be a potential therapeutic candidate for B-cell non-Hodgkin lymphoma and deserves further development as a novel anti-lymphoma agent.
Language	English
Publishing date	2024-01-25
Publishing country	Netherlands
Document type	Journal Article
ISSN	1875-6638
ISSN (online)	1875-6638
DOI	10.2174/0115734064290905231228110023
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Article: Epidemiology of Asthma in Patients with COVID-19: Investigation of Respiratory Allergy as a Risk Factor for COVID-19 Severity.

Moghtaderi, Mozhgan / Mostafavi, Sara / Hosseini Teshnizi, Saeed / Mostafavi, Ali / Ashraf, Mohammad Ali

Tanaffos

2023 Volume 21, Issue 2, Page(s) 186–192

Abstract: Background: The outcome of coronavirus disease 2019 (COVID-19) is complicated by various comorbidities; asthma, a common chronic disease, may be considered one of these conditions. This study aimed to investigate the effect of asthma as a potential ... ...

Abstract	Background: The outcome of coronavirus disease 2019 (COVID-19) is complicated by various comorbidities; asthma, a common chronic disease, may be considered one of these conditions. This study aimed to investigate the effect of asthma as a potential comorbid condition on the COVID-19 prognosis. Materials and methods: This retrospective study included all RT-PCR confirmed COVID-19 cases recorded on the Shiraz health department's electronic database from January to May 2020. A questionnaire was designed to collect information about patients' demographics, their history of asthma and other comorbidities, and the severity of COVID-19 by contacting them by phone. Results: Of 3163 COVID-19 patients, 109 (3.4%) had self-reported asthma with a mean age of 42.7 ± 19.1 years. Most patients (98%) had mild-to-moderate asthma, while 2% had severe disease. Among asthmatic patients, fourteen (12.8%) were admitted to the hospital, and five (4.6%) died. Univariate logistic regression results showed that asthma had no significant effect on hospitalization (OR 0.95, 95% CI: 0.54-1.63) and mortality (OR 1.18, 95% CI: 0.48-2.94) in patients with COVID-19. Compared living and deceased patients with COVID-19, the pooled OR was 18.2 (95% CI: 7.3-40.1) for cancer, 13.5 (95% CI: 8.2-22.5) for age 40-70 years, 3.1 (95% CI: 2-4.8) for hypertension, 3.1 (95% CI: 1.8-5.3) for cardiac disease and 2.1 (95% CI: 1.3-3.5) for diabetes mellitus. Conclusion: This study showed that asthma is not associated with an increased risk of hospitalization and mortality in patients with COVID-19. Further studies are needed to investigate the risk of different asthma phenotypes on the severity of COVID-19 disease.
Language	English
Publishing date	2023-01-18
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2233372-1
ISSN	1735-0344
ISSN	1735-0344
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Article ; Online: Letter to the Editor Regarding "The Challenges in Neurosurgery Training in a Third World Country".

Ashraf, Mohammad / Sultan, Kashif Ali / Hussain, Syed Shahzad

World neurosurgery

2021 Volume 154, Page(s) 176–179

MeSH term(s)	Developing Countries ; Humans ; Neurosurgery ; Neurosurgical Procedures
Language	English
Publishing date	2021-09-28
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2021.06.003
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Article ; Online: Clinical Research in Chronic Lymphocytic Leukemia in Pakistan; A Systematic Review.

Ammad Ud Din, Mohammad / Shahzad, Moazzam / Ashraf, Aqsa / Liaqat, Hania / Jaan, Ali / Anwer, Faiz

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 8

Abstract: ... ...

Abstract	Background
MeSH term(s)	Humans ; Pakistan/epidemiology ; Cross-Sectional Studies ; In Situ Hybridization, Fluorescence ; Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Disease Progression
Language	English
Publishing date	2023-08-17
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59081483
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Article ; Online: Emerging therapeutic options in the management of diabetes: recent trends, challenges and future directions.

Ansari, Mohammad Azam / Chauhan, Waseem / Shoaib, Shoaib / Alyahya, Sami A / Ali, Mubashshir / Ashraf, Hamid / Alomary, Mohammad N / Al-Suhaimi, Ebtesam A

International journal of obesity (2005)

2023 Volume 47, Issue 12, Page(s) 1179–1199

Abstract: Diabetes is a serious health issue that causes a progressive dysregulation of carbohydrate metabolism due to insufficient insulin hormone, leading to consistently high blood glucose levels. According to the epidemiological data, the prevalence of ... ...

Abstract	Diabetes is a serious health issue that causes a progressive dysregulation of carbohydrate metabolism due to insufficient insulin hormone, leading to consistently high blood glucose levels. According to the epidemiological data, the prevalence of diabetes has been increasing globally, affecting millions of individuals. It is a long-term condition that increases the risk of various diseases caused by damage to small and large blood vessels. There are two main subtypes of diabetes: type 1 and type 2, with type 2 being the most prevalent. Genetic and molecular studies have identified several genetic variants and metabolic pathways that contribute to the development and progression of diabetes. Current treatments include gene therapy, stem cell therapy, statin therapy, and other drugs. Moreover, recent advancements in therapeutics have also focused on developing novel drugs targeting these pathways, including incretin mimetics, SGLT2 inhibitors, and GLP-1 receptor agonists, which have shown promising results in improving glycemic control and reducing the risk of complications. However, these treatments are often expensive, inaccessible to patients in underdeveloped countries, and can have severe side effects. Peptides, such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), are being explored as a potential therapy for diabetes. These peptides are postprandial glucose-dependent pancreatic beta-cell insulin secretagogues and have received much attention as a possible treatment option. Despite these advances, diabetes remains a major health challenge, and further research is needed to develop effective treatments and prevent its complications. This review covers various aspects of diabetes, including epidemiology, genetic and molecular basis, and recent advancements in therapeutics including herbal and synthetic peptides.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/pharmacology ; Incretins/therapeutic use ; Incretins/metabolism ; Gastric Inhibitory Polypeptide ; Insulin/metabolism ; Peptides/therapeutic use ; Glucose/metabolism ; Blood Glucose/metabolism
Chemical Substances	Hypoglycemic Agents ; Incretins ; Gastric Inhibitory Polypeptide (59392-49-3) ; Insulin ; Peptides ; Glucose (IY9XDZ35W2) ; Blood Glucose
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	752409-2
ISSN	1476-5497 ; 0307-0565
ISSN (online)	1476-5497
ISSN	0307-0565
DOI	10.1038/s41366-023-01369-3
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Article ; Online: Bacillus mojavensis

Danish, Mohammad / Shahid, Mohammad / Zeyad, Mohammad Tarique / Bukhari, Najat A / Al-Khattaf, Fatimah S / Hatamleh, Ashraf Atef / Ali, Sajad

ACS omega

2022 Volume 7, Issue 16, Page(s) 13878–13893

Abstract: Discharge of nanoparticles (NPs) into aquatic and terrestrial ecosystems during manufacturing processes and from various commercial goods has become a significant ecotoxicological concern. After reaching soil systems, NPs cause deleterious effects on ... ...

Abstract	Discharge of nanoparticles (NPs) into aquatic and terrestrial ecosystems during manufacturing processes and from various commercial goods has become a significant ecotoxicological concern. After reaching soil systems, NPs cause deleterious effects on soil fertility, microbial activity, and crop productivity. Taking into consideration the medicinal importance of
Language	English
Publishing date	2022-04-17
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c00262
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Article ; Online: Long-term outcome of microvascular decompression for typical trigeminal neuralgia with autologous muscle: an analysis of 1025 patients from a developing country.

Ashraf, Mohammad / Sajjad, Fauzia / Hussain, Syed Shahzad / Cheema, Huzaifa Ahmad / Ali, Sundus / Umar, Hira / Gillespie, Conor S / Faiz, Umar / Shahid, Abia / Akmal, Muhammad / Ashraf, Naveed

Journal of neurosurgery

2024 , Page(s) 1–11

Abstract: Objective: The objective was to evaluate the long-term outcome of microvascular decompression (MVD) utilizing autologous muscle for trigeminal neuralgia (TGN).: Methods: A retrospective review was performed of all first-time MVD patients for typical ... ...

Abstract	Objective: The objective was to evaluate the long-term outcome of microvascular decompression (MVD) utilizing autologous muscle for trigeminal neuralgia (TGN). Methods: A retrospective review was performed of all first-time MVD patients for typical classic TGN without prior surgical intervention who were treated between 2000 and 2019 at a tertiary supraregional neurosurgery practice. Demographic characteristics, surgical findings, operative results, complications, and recurrence rates at 1 year, 5 years, and last follow-up were collected. Pain outcome was assessed using the Barrow Neurological Institute (BNI) pain score. The chi-square test with continuity correction was used to compare categorical variables, and Kaplan-Meier curves and Cox regression were used to identify factors associated with recurrence. Results: In total, 1025 patients were studied with a median (interquartile range [IQR]) (range) follow-up of 8 (5-13) (3-20) years. In the immediate postoperative period, 889 patients (86.7%) had complete pain relief and 106 (10.3%) had partial pain relief; neither group required medication, and 30 patients (2.9%) had no relief. One hundred forty-one recurrences (13.8%) occurred over a median (IQR) of 3 (2-6) years after surgery. The proportion of patients without recurrence was 97% at 1 year, 90% at 5 years, 85% at 10 years, 82% at 15 years, and 81% at 20 years. There was no significant difference in the probability of recurrence between patients with complete (114/907 [12.6%] recurrences) or partial (19/106 [17.9%] recurrences) postoperative pain relief (p = 0.124, log-rank test). Patients with venous compression (n = 322) had a significantly higher rate of MVD failure (n = 16 [5%]) compared to those with arterial compression (14/703 [2%]) (p = 0.015, chi-square test). In the Cox proportional hazards model, venous compression and lack of immediate postoperative pain relief had hazard ratios of 1.62 (95% CI 1.16-2.27) and 2.65 (95% CI 1.45-4.82) for recurrence, respectively. One hundred twenty-four (12.1%) complications were documented, including facial numbness (44 [4.3%]), facial nerve palsy (37 [3.6%]), CSF leak (13 [1.3%]), and diplopia (5 [0.5%]), which resolved in all patients. Conclusions: MVD with autologous muscle provides long-lasting pain relief in TGN patients with vascular compression with minimum morbidity and is a viable alternative to synthetic materials.
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2023.9.JNS231473
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