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Article ; Online: Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson's disease through anti-oxidant capacities.

Anjum, Rabia / Raza, Chand / Faheem, Mehwish / Ullah, Arif / Chaudhry, Maham

2024 Volume 19, Issue 4, Page(s) e0302102

Abstract: ... The expression of genes related to dopamine, anti-oxidant potential and synapses were modulated in M. piperita ...

Abstract	Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Neurodegeneration of the substantia nigra (SN) and diminished release of dopamine are prominent causes of this progressive disease. The current study aims to evaluate the protective potential of ethanolic extract of Mentha piperita (EthMP) against rotenone-mediated PD features, dopaminergic neuronal degeneration, oxidative stress and neuronal survival in a mouse model. Swiss albino male mice were assigned to five groups: control (2.5% DMSO vehicle), PD (rotenone 2.5 mg/kg), EthMP and rotenone (200mg/kg and 2.5mg/kg, respectively), EthMP (200 mg/kg), and Sinemet, reference treatment containing levodopa and carbidopa (20 mg/kg and rotenone 2.5mg/kg). Behavioral tests for motor functional deficit analysis were performed. Anti-oxidant capacity was estimated using standard antioxidant markers. Histopathology of the mid-brain for neurodegeneration estimation was performed. HPLC based dopamine level analysis and modulation of gene expression using quantitative real-time polymerase chain reaction was performed for the selected genes. EthMP administration significantly prevented the rotenone-mediated motor dysfunctions compared to PD group as assessed through open field, beam walk, pole climb down, stepping, tail suspension, and stride length tests. EthMP administration modulated the lipid peroxidation (LPO), reduced glutathione (GSH), and superoxide dismutase (SOD) levels, as well as glutathione-s-transferase (GST) and catalase (CAT) activities in mouse brain. EthMP extract prevented neurodegeneration in the SN of mice and partially maintained dopamine levels. The expression of genes related to dopamine, anti-oxidant potential and synapses were modulated in M. piperita (MP) extract treated mice brains. Current data suggest therapeutic capacities of MP extract and neuroprotective capacities, possibly through antioxidant capacities. Therefore, it may have potential clinical applications for PD management.
MeSH term(s)	Animals ; Parkinson Disease/drug therapy ; Parkinson Disease/prevention & control ; Parkinson Disease/metabolism ; Antioxidants/metabolism ; Mentha piperita/metabolism ; Rotenone/pharmacology ; Dopamine/metabolism ; Neurodegenerative Diseases ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Oxidative Stress ; Disease Models, Animal
Chemical Substances	Antioxidants ; Rotenone (03L9OT429T) ; Dopamine (VTD58H1Z2X) ; Neuroprotective Agents
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0302102
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An efficient approach to study multi-polar fuzzy ideals of semirings.

Bashir, Shahida / Alharbi, Talal / Mazhar, Rabia / Khalid, Issra / Ul Hassan Afzal, Muneeb / Riaz Chaudhry, Nauman

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2446

Abstract: The multi polar fuzzy (m-PF) set has an extensive range of implementations in real world problems ... innovative extensions to algebraic structures. We present the definitions and some important results of m ... polar fuzzy subsemirings (m-PFSSs), m-polar fuzzy ideals (m-PFIs), m-polar fuzzy generalized bi-ideals ...

Abstract	The multi polar fuzzy (m-PF) set has an extensive range of implementations in real world problems related to the multi-polar information, multi-index and multi-attributes data. This paper introduces innovative extensions to algebraic structures. We present the definitions and some important results of m-polar fuzzy subsemirings (m-PFSSs), m-polar fuzzy ideals (m-PFIs), m-polar fuzzy generalized bi-ideals (m-PFGBIs), m-polar fuzzy bi-ideals (m-PFBIs) and m-polar fuzzy quasi-ideals (m-PFQIs) in semirings. The main contributions of the paper include the derivation and proof of key theorems that shed light on the algebraic interplay and computational aspects of m-polar fuzzy ideals (m-PFIs), m-polar fuzzy generalized bi-ideals (m-PFGBIs), m-polar fuzzy bi-ideals (m-PFBIs) and m-polar fuzzy quasi-ideals (m-PFQIs) in semirings along with examples. Moreover, this paper deals with several important properties of m-PFIs and characterizes regular and intra-regular semirings by the properties of these ideals.
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-49395-5
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Article ; Online: Mature Orbital Teratoma.

Chaudhry, Rabia / Qamar, M Nasar / Riaz, Areej

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2021 Volume 31, Issue 5, Page(s) 596–598

Abstract: Orbital teratoma is a rare tumour that is composed of tissues derived from all three germ cell layers. It presents, in otherwise, healthy neonates with unilateral proptosis that progresses rapidly, threatening vision through optic nerve compromise or ... ...

Abstract	Orbital teratoma is a rare tumour that is composed of tissues derived from all three germ cell layers. It presents, in otherwise, healthy neonates with unilateral proptosis that progresses rapidly, threatening vision through optic nerve compromise or exposure keratopathy. Globe conservation may be difficult too in advanced cases. Mature teratomas are benign, but the immature ones can sometimes become malignant. We report a case of a six-month female infant who presented with mature orbital teratoma since birth. Vision could not be salvaged; but following complete surgical excision, good cosmesis was achieved. Key Words: Mature teratoma, Orbit, Congenital tumour, Surger.
MeSH term(s)	Dermoid Cyst ; Exophthalmos/etiology ; Female ; Humans ; Infant ; Infant, Newborn ; Orbit ; Orbital Neoplasms/diagnosis ; Orbital Neoplasms/surgery ; Teratoma/surgery
Language	English
Publishing date	2021-05-20
Publishing country	Pakistan
Document type	Case Reports
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2021.05.596
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Article: COVID-19 Testing Trend: A Retrospective Analysis of the Three Major Pandemic Waves in Punjab, Pakistan.

Chaudhry, Rabia M / Minhas, Sadia / Khan, Mehroz A / Nargus, Shumaila / Nawadat, Kanza / Khan, Muhammad Athar / Kashif, Muhammad

Cureus

2024 Volume 16, Issue 1, Page(s) e52309

Abstract: Background/objectives: There is some evidence in the literature of under-testing of COVID-19 cases in Pakistan. This study aims to explore COVID-19 testing trends and the factors affecting them in a lower middle-income country for future infectious ... ...

Abstract	Background/objectives: There is some evidence in the literature of under-testing of COVID-19 cases in Pakistan. This study aims to explore COVID-19 testing trends and the factors affecting them in a lower middle-income country for future infectious disease policy-making and intervention strategies. Methodology: The study was conducted as a serial cross-sectional study during the three major peaks from March 2020 to June 2021 on 1616 participants in Punjab, Pakistan. This is the first study to explore COVID-19 testing trends in association with flu-like symptoms (FLS) and the factors affecting all three major waves in Pakistan. Results: The results show that in all three waves, only 18.8% reported COVID-19 tested despite that 86.7% thought they had already had COVID-19, with 51.3% reporting having FLS and 35.6% with exposure to FLS from their families and 19.8% of positive testing rate among their family members. Out of the survey participants, 66% received vaccination, and over 80% had their eligible family members immunized. Fear of contracting COVID-19 was 69.7% in all three waves. Factors positively associated with the uptake of testing were the age group of 31-40 years with an adjusted odds ratio of 3.27 (95% confidence interval (CI): 2.09-5.12) for the second wave and an adjusted odds ratio of 13.75 (95% CI: 9.43-20.01) for the third wave and traveling abroad with odds of 3.08 times when the reference was inland traveling. The adjusted odds ratio to test for FLS was 1.62 (95% CI: 1.21-2.16). Conclusion: In this study, there is convincing evidence of COVID-19 under-testing and thus under-reporting. This study also suggests that fear-based interventions may be counterproductive; however, economic factors such as education, employment, and traveling are significant in guiding the behavior for infectious disease prevention and management.
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52309
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Article ; Online: Ecological and human health hazards; integrated risk assessment of organochlorine pesticides (OCPs) from the Chenab River, Pakistan.

Siddique, Sidra / Chaudhry, M Nawaz / Ahmad, Sajid Rashid / Nazir, Rabia / Zhao, Zhen / Javed, Rimsha / Alghamdi, Huda Ahmed / Mahmood, Adeel

The Science of the total environment

2023 Volume 882, Page(s) 163504

Abstract: Carcinogenic hazards to human health were investigated through oral and dermal exposure to organochlorine pesticides (OCPs) from water samples (n = 120) of River Chenab, Pakistan. The Pioneering study aimed to employ an integrated geographic information ... ...

Abstract	Carcinogenic hazards to human health were investigated through oral and dermal exposure to organochlorine pesticides (OCPs) from water samples (n = 120) of River Chenab, Pakistan. The Pioneering study aimed to employ an integrated geographic information system (GIS) based geostatistical method for the determination of pollution load by GC-ECD from water of River Chenab. The residual levels of OCPs detected from water samples ranged from 0.54 to 122 ng L
MeSH term(s)	Humans ; Pakistan ; Water Pollutants, Chemical/analysis ; Environmental Monitoring ; Pesticides/analysis ; Hydrocarbons, Chlorinated/analysis ; Risk Assessment ; Heptachlor ; Water Quality ; China
Chemical Substances	alpha-hexachlorocyclohexane (319-84-6) ; Water Pollutants, Chemical ; Pesticides ; Hydrocarbons, Chlorinated ; Heptachlor (7GLS9ACN3L)
Language	English
Publishing date	2023-04-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.163504
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Article ; Online: Risk surveillance with spatial distribution of Organochlorine Pesticides (OCPs) from sedimentary samples of Chenab River.

Siddique, Sidra / Chaudhry, M Nawaz / Ahmad, Sajid Rashid / Nazir, Rabia / Javed, Rimsha / Hafeez, Muhammad Rashid / Alraey, Yasser / Sivasamugham, Lalita Ambigai / Mahmood, Adeel

The Science of the total environment

2023 Volume 912, Page(s) 169256

Abstract: A pioneering study employed a holistic geostatistical approach to predict the spatial variability of a non sampled area in the Chenab River, Pakistan, using kriging interpolation for organochlorine pesticide (OCP)-polluted risk zones. The Present ... ...

Abstract	A pioneering study employed a holistic geostatistical approach to predict the spatial variability of a non sampled area in the Chenab River, Pakistan, using kriging interpolation for organochlorine pesticide (OCP)-polluted risk zones. The Present research intended to investigate the carcinogenic and non-carcinogenic human health risks, contamination levels, and spatial variation of OCPs in the Chenab River, Pakistan. The residual OCP content in sediment samples (n = 120) ranged from 0.056 to 32.14 ng/g. DDE and α-HCH were prevalent among all the samples analyzed, with mean concentrations of 15.84 ± 8.02 and 12.45 ± 6.72 ng/g, respectively. The order of magnitude of OCPs in sediment samples was DDTs > α-HCH > chlorothalonil > heptachlor > endosulfan > aldrin > dieldrin. The findings of the single (SPI) and Nemerow (Nel) pollution index of α-HCH, heptachlor, and aldrin depicted the Chenab River as a serious pollution risk zone. The outcomes of the Pearson correlation coefficient analysis represent the positive correlation among all OCPs, revealing the common origin. Distribution trends showed substantially higher (p < 0.05) contents of analyzed OCPs along the downstream zone. With regards to USEPA human health hazard assessment model, the estimated non-carcinogenic (ΣHI) and non-carcinogenic (ΣTCR) risk ranged from 1.1 × 10
MeSH term(s)	Humans ; Dieldrin/analysis ; Aldrin/analysis ; Environmental Monitoring ; Pesticides/analysis ; Hydrocarbons, Chlorinated/analysis ; Heptachlor/analysis ; Neoplasms ; Water Pollutants, Chemical/analysis ; China ; Hexachlorocyclohexane
Chemical Substances	alpha-hexachlorocyclohexane (319-84-6) ; Dieldrin (I0246D2ZS0) ; Aldrin (OZE3CLY605) ; Pesticides ; Hydrocarbons, Chlorinated ; Heptachlor (7GLS9ACN3L) ; Water Pollutants, Chemical ; Hexachlorocyclohexane (59NEE7PCAB)
Language	English
Publishing date	2023-12-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.169256
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Article ; Online: Comprehensive GIS based risk surveillance of organochlorine pesticides (OCPs) in edible fish species of River Chenab, Pakistan.

Siddique, Sidra / Chaudhry, M Nawaz / Ahmad, Sajid Rashid / Javed, Rimsha / Nazir, Rabia / Mubarak, Shafaq / Alghamdi, Huda Ahmed / Mahmood, Adeel

The Science of the total environment

2023 Volume 871, Page(s) 162084

Abstract: The present study was conducted to evaluate Carcinogenic (TR) and non-carcinogenic (THQ) human health risk of organochlorine pesticides (OCPs) in three edible fish species (Labeo boga, Channa marulius and Wallago attu) of River Chenab, Pakistan using ... ...

Abstract	The present study was conducted to evaluate Carcinogenic (TR) and non-carcinogenic (THQ) human health risk of organochlorine pesticides (OCPs) in three edible fish species (Labeo boga, Channa marulius and Wallago attu) of River Chenab, Pakistan using USEPA human health risk assessment model. Holistic GIS (Geographic information system) based Geo-Statistical approach has been employed for the first time in River Chenab, Pakistan to categorize contaminated risk zones of OCPs based on single pollution index. The ∑OCPs concentrations in fish species were ranged from 5.09 to 414 ng/g with the prevalence of dieldrin. Results of single pollution index of DDE, aldrin, dieldrin and ∑endosulfan revealed River Chenab as polluted and risk zone area. Distribution pattern assessed significantly higher (p < 0.05) concentrations of OCPs in downstream area suggesting substantial pollution of surrounded industrial region. The human health risk assessment depicted no harmful non-carcinogenic (THQ) risk except for ΣOCPs concentration of C. marulius. Significant carcinogenic (TR) health risk exhibited by all examined OCPs from maximum of the studied sites. Therefore, the high carcinogenic human health risk had highlighted an immediate removal of continuous disposal of OCPs in the River Chenab.
MeSH term(s)	Animals ; Humans ; Geographic Information Systems ; Dieldrin ; Pakistan ; Water Pollutants, Chemical/analysis ; Pesticides/analysis ; Hydrocarbons, Chlorinated/analysis ; Cyprinidae ; Carcinogens ; Risk Assessment ; Environmental Monitoring/methods
Chemical Substances	Dieldrin (I0246D2ZS0) ; Water Pollutants, Chemical ; Pesticides ; Hydrocarbons, Chlorinated ; Carcinogens
Language	English
Publishing date	2023-02-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.162084
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Article ; Online: Synthesis and Evaluation of 1,3,5-Triaryl-2-Pyrazoline Derivatives as Potent Dual Inhibitors of Urease and α-Glucosidase Together with Their Cytotoxic, Molecular Modeling and Drug-Likeness Studies.

Mehmood, Rabia / Sadiq, Amina / Alsantali, Reem I / Mughal, Ehsan Ullah / Alsharif, Meshari A / Naeem, Nafeesa / Javid, Asif / Al-Rooqi, Munirah M / Chaudhry, Gul-E-Saba / Ahmed, Saleh A

ACS omega

2022 Volume 7, Issue 4, Page(s) 3775–3795

Abstract: In the present work, a concise library of 1,3,5-triaryl-2-pyrazolines ( ...

Abstract	In the present work, a concise library of 1,3,5-triaryl-2-pyrazolines (
Language	English
Publishing date	2022-01-20
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.1c06694
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Article ; Online: Comprehensive GIS based risk surveillance of organochlorine pesticides (OCPs) in edible fish species of River Chenab, Pakistan

Siddique, Sidra / Chaudhry, M. Nawaz / Ahmad, Sajid Rashid / Javed, Rimsha / Nazir, Rabia / Mubarak, Shafaq / Alghamdi, Huda Ahmed / Mahmood, Adeel

Science of the Total Environment. 2023 May, v. 871 p.162084-

2023

Abstract	The present study was conducted to evaluate Carcinogenic (TR) and non-carcinogenic (THQ) human health risk of organochlorine pesticides (OCPs) in three edible fish species (Labeo boga, Channa marulius and Wallago attu) of River Chenab, Pakistan using USEPA human health risk assessment model. Holistic GIS (Geographic information system) based Geo-Statistical approach has been employed for the first time in River Chenab, Pakistan to categorize contaminated risk zones of OCPs based on single pollution index. The ∑OCPs concentrations in fish species were ranged from 5.09 to 414 ng/g with the prevalence of dieldrin. Results of single pollution index of DDE, aldrin, dieldrin and ∑endosulfan revealed River Chenab as polluted and risk zone area. Distribution pattern assessed significantly higher (p < 0.05) concentrations of OCPs in downstream area suggesting substantial pollution of surrounded industrial region. The human health risk assessment depicted no harmful non-carcinogenic (THQ) risk except for ΣOCPs concentration of C. marulius. Significant carcinogenic (TR) health risk exhibited by all examined OCPs from maximum of the studied sites. Therefore, the high carcinogenic human health risk had highlighted an immediate removal of continuous disposal of OCPs in the River Chenab.
Keywords	Channa ; Labeo boga ; United States Environmental Protection Agency ; Wallago attu ; aldrin ; carcinogenicity ; chlorinated hydrocarbons ; dieldrin ; environment ; fish ; geographic information systems ; health effects assessments ; human health ; models ; monitoring ; pollution ; risk ; rivers ; Pakistan ; River Chenab ; Geo-statistical ; Pollution index ; Bio-indicator human health risk assessment
Language	English
Dates of publication	2023-05
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.162084
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Ecological and human health hazards; integrated risk assessment of organochlorine pesticides (OCPs) from the Chenab River, Pakistan

Siddique, Sidra / Chaudhry, M. Nawaz / Ahmad, Sajid Rashid / Nazir, Rabia / Zhao, Zhen / Javed, Rimsha / Alghamdi, Huda Ahmed / Mahmood, Adeel

Science of the Total Environment. 2023 July, v. 882 p.163504-

2023

Abstract	Carcinogenic hazards to human health were investigated through oral and dermal exposure to organochlorine pesticides (OCPs) from water samples (n = 120) of River Chenab, Pakistan. The Pioneering study aimed to employ an integrated geographic information system (GIS) based geostatistical method for the determination of pollution load by GC-ECD from water of River Chenab. The residual levels of OCPs detected from water samples ranged from 0.54 to 122 ng L⁻¹ with significant prevalence of DDE and α-HCH. Results of the Nemerrow pollution index (NeI), single pollution index (SPI), and comprehensive pollution index (CPI) reflected the downstream zone a stern pollution risk zone. The spatial distribution pattern through geostatistical approaches also revealed significantly higher (p < 0.05) OCP levels in the downstream zone. Risk quotient (RQCCC) of surface water quality with respect to heptachlor epitomized a high level of risk (RQCCC > 1). Non-carcinogenic human health risk (Σ HQ) assessment ranged from 8.39 × 10⁻⁹ to 1.7 × 10⁻³, which represented a marginal risk through oral and dermal exposure. However, carcinogenic risks by oral exposure route were ranged from 3.57 × 10⁻¹¹ to 4.46 × 10⁻⁶. Estimated cancer risk (ΣCR) exhibited a considerable carcinogenic risk posed by heptachlor, α-HCH and dieldrin. It is suggested to employ an immediate mitigation strategy for the constant discharge of OCPs in the studied area.
Keywords	carcinogenicity ; chlorinated hydrocarbons ; dermal exposure ; dieldrin ; environment ; geographic information systems ; geostatistics ; heptachlor ; human health ; oral exposure ; pollution load ; relative risk ; risk assessment ; rivers ; surface water ; water quality ; Pakistan ; Chenab River ; GIS modeling ; Geo-statistical techniques ; Ecological risk ; Human hazard
Language	English
Dates of publication	2023-07
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.163504
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