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  1. Article ; Online: Clinical trials in hepatitis D virus: Measuring success.

    Da, Ben L

    Hepatology (Baltimore, Md.)

    2022  Volume 77, Issue 6, Page(s) 2147–2157

    Abstract: Chronic hepatitis D infection results in the most severe form of chronic viral hepatitis but currently lacks effective treatment options. Therapy with pegylated interferon alpha is recommended for finite treatment duration by major liver societies. Still, ...

    Abstract Chronic hepatitis D infection results in the most severe form of chronic viral hepatitis but currently lacks effective treatment options. Therapy with pegylated interferon alpha is recommended for finite treatment duration by major liver societies. Still, it is plagued by low rates of sustained virologic response (SVR) and frequent relapses even if SVR is achieved. Recently, a wave of investigational therapies has come under evaluation, including bulevirtide, lonafarnib, pegylated interferon lambda, and REP-2139 creating excitement with this viral infection. However, there has been significant variability in the endpoints used to evaluate these therapeutics. One of the recently introduced endpoints is characterized by a decline in HDV RNA by 2 logs, with or without achieving an undetectable serum hepatitis D virus (HDV) RNA, as a marker of virologic response. Furthermore, this measure has been combined with alanine aminotransferase normalization, also known as a biochemical response, to formulate the primary endpoint of several late-stage studies. Per recent guidance by the US Food and Drug Administration, these should be surrogate endpoints that will ultimately portend long-term clinical benefits. These clinical benefits may include reducing the risk of progression to cirrhosis, hepatic decompensation, hepatocellular carcinoma, liver transplantation, and mortality. However, the optimal way to measure success in HDV clinical trials remains unknown and will continue to evolve.
    MeSH term(s) Humans ; Hepatitis Delta Virus ; Antiviral Agents ; Neoplasm Recurrence, Local ; Hepatitis D ; Hepatitis D, Chronic/drug therapy ; Polyethylene Glycols/therapeutic use ; RNA
    Chemical Substances Antiviral Agents ; Polyethylene Glycols (3WJQ0SDW1A) ; RNA (63231-63-0)
    Language English
    Publishing date 2022-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.32732
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    Zs.A 1660: Show issues Location:
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  2. Article ; Online: Letter to the editor: A reminder to screen for varices! Atezolizumab/bevacizumab for HCC.

    Suchman, Kelly / Da, Ben L

    Hepatology (Baltimore, Md.)

    2022  Volume 76, Issue 4, Page(s) E78–E79

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Antineoplastic Combined Chemotherapy Protocols ; Bevacizumab/therapeutic use ; Carcinoma, Hepatocellular/drug therapy ; Humans ; Liver Neoplasms/drug therapy ; Varicose Veins
    Chemical Substances Antibodies, Monoclonal, Humanized ; Bevacizumab (2S9ZZM9Q9V) ; atezolizumab (52CMI0WC3Y)
    Language English
    Publishing date 2022-05-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.32556
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  3. Article ; Online: Hepatorenal Syndrome: Definitions, Diagnosis, and Management.

    Buccheri, Sebastiano / Da, Ben L

    Clinics in liver disease

    2022  Volume 26, Issue 2, Page(s) 181–201

    Abstract: Hepatorenal syndrome (HRS) is a hemodynamically driven process mediated by renal dysregulation and inflammatory response. Albumin, antibiotics, and β-blockers are among therapies that have been studied in HRS prevention. There are no Food and Drug ... ...

    Abstract Hepatorenal syndrome (HRS) is a hemodynamically driven process mediated by renal dysregulation and inflammatory response. Albumin, antibiotics, and β-blockers are among therapies that have been studied in HRS prevention. There are no Food and Drug Administration-approved treatments for HRS although multiple liver societies have recommended terlipressin as first-line pharmacotherapy. Renal replacement therapy is the primary modality used to bridge to definitive therapy with orthotopic liver transplant or simultaneous liver-kidney transplant. Advances in our understanding of HRS pathophysiology and emerging therapeutic modalities are needed to change outcomes for this vulnerable population.
    MeSH term(s) Albumins/therapeutic use ; Female ; Hepatorenal Syndrome/diagnosis ; Hepatorenal Syndrome/etiology ; Hepatorenal Syndrome/therapy ; Humans ; Kidney Transplantation ; Liver Transplantation ; Male ; Terlipressin/therapeutic use
    Chemical Substances Albumins ; Terlipressin (7Z5X49W53P)
    Language English
    Publishing date 2022-04-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1472315-3
    ISSN 1557-8224 ; 1089-3261
    ISSN (online) 1557-8224
    ISSN 1089-3261
    DOI 10.1016/j.cld.2022.01.002
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  4. Article ; Online: Semaglutide or Placebo for Nonalcoholic Steatohepatitis.

    Da, Ben L / Satapathy, Sanjaya K

    The New England journal of medicine

    2021  Volume 385, Issue 2, Page(s) e6

    MeSH term(s) Glucagon-Like Peptides/therapeutic use ; Humans ; Hypoglycemic Agents/therapeutic use ; Non-alcoholic Fatty Liver Disease/drug therapy
    Chemical Substances Hypoglycemic Agents ; semaglutide (53AXN4NNHX) ; Glucagon-Like Peptides (62340-29-8)
    Language English
    Publishing date 2021-07-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2106921
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  5. Article ; Online: Letter to the editor: l-ornithine l-aspartate in acute treatment of severe hepatic encephalopathy: A double-blind randomized controlled trial.

    Kovalic, Alexander J / Lee, Tai-Ping / Da, Ben L

    Hepatology (Baltimore, Md.)

    2022  Volume 76, Issue 5, Page(s) E108–E109

    MeSH term(s) Humans ; Hepatic Encephalopathy/drug therapy ; Aspartic Acid ; Dipeptides/therapeutic use ; Ornithine ; Double-Blind Method ; Ammonia
    Chemical Substances Aspartic Acid (30KYC7MIAI) ; Dipeptides ; Ornithine (E524N2IXA3) ; Ammonia (7664-41-7)
    Language English
    Publishing date 2022-07-12
    Publishing country United States
    Document type Randomized Controlled Trial ; Letter ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.32643
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  6. Article ; Online: Treating Portopulmonary Hypertension With Macitentan: Smoking Gun or Magic Bullet?

    Satapathy, Sanjaya K / Da, Ben L

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2020  Volume 26, Issue 7, Page(s) 863–865

    MeSH term(s) Humans ; Hypertension ; Liver Transplantation ; Pyrimidines/adverse effects ; Sulfonamides/adverse effects
    Chemical Substances Pyrimidines ; Sulfonamides ; macitentan (Z9K9Y9WMVL)
    Language English
    Publishing date 2020-05-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.25797
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  7. Article ; Online: ABSTRACTS CONGRÈS STCCCV 2022.

    Allouche, Emna / Lachter, Ghassen / Aissa, Mohamed Selmen / Ben Jemaa, Hakim / Boudiche, Feten / Ben Ahmed, Habib / Ouechtati, Wejden / Bezdah, Leila / Bousnina, Sabrine / Antit, Saoussen / Ben Kaab, Badreddine / Boussabah, Elhem / Zakhama, Lilia / Brahmi, Hanen / Ammar, Fares / Belkhiria, Houda / Dali, Alaeddine / Daassa, Chayma / Jamel, Ahmed /
    Ben Halima, Nejeh / Hamdani, A / Ajra, Z / Bayar, M F / Gheni, R / Rashikou, L / Ben Hmida, R / Ounissi, T / Ibn Elhadj, Zied / Chelbi, Hazem / Fekih, Ridha / Boufares, Amine / Thameur, Moez / Abdelhedi, Marwa / Neji, S / Boudiche, Faten / Chetoui, Ahmed / Ouechtati, Wejdene / Cherif, Nour / Mekki, Nouha / Slim, Mehdi / Ouannes, Sami / Ghardallou, Houda / Neffati, Elies / Kadardar, Fateh / Hachani, Mouna / Iddir, Skander / Marzouki, Yassine / Dardour, Syrine / Mejber, Wassim / Ben Slima, Hédi / Lassoued, Taha / Chamtouri, Ikram / Jomaa, Walid / Ben Hamda, Khaldoun / Maatouk, Faouzi / Hakim, Kaouther / Ben Othmen, Rihab / Msaad, Hela / Ouarda, Fatma / Ben Gandoura, Asma / Ben Halima, Afef / Taktak, Imen / Draoui, Yasmine / Yaakoubi, Wael / Tamallah, Karima / Chourabi, Chedia / Oussema, Mejri / Haggui, Abdeyem / Hajlaoui, Nadhem / Fehri, Wafa / Ben Romdhane, Rim / Tlili, Rami / Azaiez, Fares / Bachraoui, Kaouther / Drissa, Meriem / Ben Youssef, Ameur / Fatou, A W / Khadra, H / Diouf, M T / Ba, S / Diouf, D / Sarr, M N / Mingou, J S / Sarr, S A / Dioum, M / Ngaide, A A / Beye, S M / Manga, S / Affangla, D A / Diouf, Y / Diop, K H / Bodian, M / Leye, M M C Bo / Ndiaye, M B / Mbaye, A / Kane, A D / Diao, M / Kane, A / Ben Ghorbel, Chaima / Soudani, Sabrine / Gribaa, Rim / Leye, M / Ismael Ibouroi, M H / Ba, E H M / Ba, D M / Diagne Diallo, A / Fall, A L / Saidane, S / Mzoughi, K / Bouzidi, Hela / Khannouch, Ahlem / Ben Mrad, Intinene / Kamoun, Sofiene / Zairi, Ihsen / Kraiem, Sondos / Guesmi, Anwar / Mestiri, Brahim

    La Tunisie medicale

    2023  Volume 100, Issue 11, Page(s) 809–818

    Language English
    Publishing date 2023-08-08
    Publishing country Tunisia
    Document type Journal Article
    ZDB-ID 128627-4
    ISSN 2724-7031 ; 0041-4131
    ISSN (online) 2724-7031
    ISSN 0041-4131
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    Zs.B 223: Show issues Location:
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  8. Article: Cadmium and copper stresses affect germination and enzymatic activities in chickpea (Cicer arietinum L.)

    Larbi, S. / Ben Kaâb, S. / Teixeira da Silva, J. A. / Bettaieb Ben Kaâb, L.

    Agrochimica

    2020  Volume 64, Issue 2, Page(s) 191

    Language English ; Italian ; French
    Document type Article
    ZDB-ID 820197-3
    ISSN 0002-1857
    Database Current Contents Nutrition, Environment, Agriculture

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  9. Article ; Online: American Association for the Surgery of Trauma/American College of Surgeons-Committee on Trauma Clinical Consensus-Driven Protocol for glucose management in the post-resuscitation intensive care unit adult trauma patient.

    Jacovides, Christina L / Skeete, Dionne A / Werner, Nicole L / Toschlog, Eric A / Agarwal, Suresh / Coopwood, Ben / Crandall, Marie / Tominaga, Gail T

    The journal of trauma and acute care surgery

    2023  Volume 95, Issue 6, Page(s) 951–958

    MeSH term(s) Humans ; Adult ; United States ; Consensus ; Traumatology ; Trauma Centers ; Intensive Care Units ; Surgeons
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000004124
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  10. Article ; Online: Reply.

    Da, Ben L / Koh, Christopher / Heller, Theo

    Hepatology (Baltimore, Md.)

    2019  Volume 71, Issue 1, Page(s) 397–398

    MeSH term(s) Humans ; Hypertension, Portal ; Portal Pressure
    Language English
    Publishing date 2019-12-24
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.30955
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