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  1. Article: Monkeypox: A review of data essential in primary care.

    Ng, Ying Ying / Azidah, Abdul Kadir

    Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia

    2023  Volume 18, Page(s) 9

    Abstract: Monkeypox is known to be endemic in Africa, but recently, the unusually increasing number of cases of monkeypox in non-endemic countries has caught the attention of the world. The World Health Organization has declared the monkeypox outbreak a public ... ...

    Abstract Monkeypox is known to be endemic in Africa, but recently, the unusually increasing number of cases of monkeypox in non-endemic countries has caught the attention of the world. The World Health Organization has declared the monkeypox outbreak a public health emergency. The spread pattern is unlikely associated with the previous outbreak outside of Africa, which is related to travelling or contact with exotic animals. The current outbreak is linked to sexual history and presents with atypical localised genital eruptions with an unpredictable onset of viral prodromal symptoms. Although the monkeypox virus is not easily transmittable compared with severe acute respiratory syndrome coronavirus 2, anyone who has been in close contact with a patient with monkeypox is at risk. Most patients will present to a primary care centre for assessment and treatment; therefore, it is important to increase awareness of the infection among primary care providers for early recognition of monkeypox, containment of the outbreak and prevention of healthcare-associated infection. A physician who suspects any patient with monkeypox should notify local or state health authorities immediately.
    Language English
    Publishing date 2023-02-19
    Publishing country Malaysia
    Document type Journal Article ; Review
    ZDB-ID 2265769-1
    ISSN 1985-207X
    ISSN 1985-207X
    DOI 10.51866/rv.213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sucrose Gradient Analysis of Human Mitochondrial Ribosomes and RNA.

    Ng, Kah Ying / Battersby, Brendan J

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2661, Page(s) 101–117

    Abstract: Faithful expression of the mitochondrial genome is required for the synthesis of the oxidative phosphorylation complexes and cell fitness. In humans, mitochondrial DNA (mtDNA) encodes 13 essential subunits of four oxidative phosphorylation complexes ... ...

    Abstract Faithful expression of the mitochondrial genome is required for the synthesis of the oxidative phosphorylation complexes and cell fitness. In humans, mitochondrial DNA (mtDNA) encodes 13 essential subunits of four oxidative phosphorylation complexes along with tRNAs and rRNAs needed for the translation of these proteins. Protein synthesis occurs on unique ribosomes within the organelle. Over the last decade, the revolution in genetic diagnostics has identified disruptions to the faithful synthesis of these 13 mitochondrial proteins as the largest group of inherited human mitochondrial pathologies. All of the molecular steps required for mitochondrial protein synthesis can be affected, from the genome to protein, including cotranslational quality control. Here, we describe methodologies for the biochemical separation of mitochondrial ribosomes from cultured human cells for RNA and protein analysis. Our method has been optimized to facilitate analysis for low-level sample material and thus does not require prior organelle enrichment.
    MeSH term(s) Humans ; RNA/genetics ; RNA/metabolism ; Mitochondrial Ribosomes/metabolism ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Mitochondria/genetics ; Mitochondria/metabolism ; Protein Biosynthesis ; Oxidative Phosphorylation ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism
    Chemical Substances RNA (63231-63-0) ; DNA, Mitochondrial ; Mitochondrial Proteins
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3171-3_7
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  3. Article ; Online: Sexual dysfunction among six months postpartum women in north-eastern Malaysia.

    Ng, Ying Ying / Muhamad, Rosediani / Ahmad, Imran

    PloS one

    2023  Volume 18, Issue 4, Page(s) e0284014

    Abstract: Female sexual dysfunction (FSD) is a common problem among postpartum women. However, little is known about this topic in Malaysia. This study aimed to determine the prevalence of sexual dysfunction and its associated factors in postpartum women in ... ...

    Abstract Female sexual dysfunction (FSD) is a common problem among postpartum women. However, little is known about this topic in Malaysia. This study aimed to determine the prevalence of sexual dysfunction and its associated factors in postpartum women in Kelantan, Malaysia. In this cross-sectional study, we recruited 452 sexually active women at six months postpartum from four primary care clinics in Kota Bharu, Kelantan, Malaysia. The participants were asked to fill in questionnaires consisting of sociodemographic information and the Malay Version of the Female Sexual Function Index-6. The data were analyzed using bivariate and multivariate logistic regression analyses. With a 95% response rate, the prevalence of sexual dysfunction among sexually active, six months postpartum women was 52.4% (n = 225). FSD was significantly associated with the older husband's age (p = 0.034) and lower frequency of sexual intercourse (p<0.001). Therefore, the prevalence of postpartum sexual dysfunction in women is relatively high in Kota Bharu, Kelantan, Malaysia. Efforts should be made to raise awareness among healthcare providers about screening for FSD in postpartum women and for their counseling and early treatment.
    MeSH term(s) Female ; Humans ; Malaysia/epidemiology ; Cross-Sectional Studies ; Sexual Dysfunction, Physiological/epidemiology ; Surveys and Questionnaires ; Postpartum Period
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0284014
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  4. Article ; Online: Management of stenosing flexor tenosynovitis in primary care.

    Ng, Natalie Yu Yi / Sirisena, Renita / Chua, Ying Xian

    Singapore medical journal

    2023  Volume 64, Issue 4, Page(s) 255–261

    MeSH term(s) Humans ; Tenosynovitis/diagnosis ; Tenosynovitis/therapy ; Tendons ; Constriction, Pathologic ; Primary Health Care
    Language English
    Publishing date 2023-03-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 604319-7
    ISSN 2737-5935 ; 0037-5675
    ISSN (online) 2737-5935
    ISSN 0037-5675
    DOI 10.4103/SINGAPOREMEDJ.SMJ-2021-262
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  5. Article ; Online: Monkeypox

    Ying Ying Ng / Azidah Abdul Kadir

    Malaysian Family Physician, Vol 18, p

    A review of data essential in primary care

    2023  Volume 9

    Abstract: Monkeypox is known to be endemic in Africa, but recently, the unusually increasing number of cases of monkeypox in non-endemic countries has caught the attention of the world. The World Health Organization has declared the monkeypox outbreak a public ... ...

    Abstract Monkeypox is known to be endemic in Africa, but recently, the unusually increasing number of cases of monkeypox in non-endemic countries has caught the attention of the world. The World Health Organization has declared the monkeypox outbreak a public health emergency. The spread pattern is unlikely associated with the previous outbreak outside of Africa, which is related to travelling or contact with exotic animals. The current outbreak is linked to sexual history and presents with atypical localised genital eruptions with an unpredictable onset of viral prodromal symptoms. Although the monkeypox virus is not easily transmittable compared with severe acute respiratory syndrome coronavirus 2, anyone who has been in close contact with a patient with monkeypox is at risk. Most patients will present to a primary care centre for assessment and treatment; therefore, it is important to increase awareness of the infection among primary care providers for early recognition of monkeypox, containment of the outbreak and prevention of healthcare-associated infection. A physician who suspects any patient with monkeypox should notify local or state health authorities immediately.
    Keywords monkeypox ; disease outbreaks ; primary health care ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Academy of Family Physicians of Malaysia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Sexual dysfunction among six months postpartum women in north-eastern Malaysia.

    Ying Ying Ng / Rosediani Muhamad / Imran Ahmad

    PLoS ONE, Vol 18, Iss 4, p e

    2023  Volume 0284014

    Abstract: Female sexual dysfunction (FSD) is a common problem among postpartum women. However, little is known about this topic in Malaysia. This study aimed to determine the prevalence of sexual dysfunction and its associated factors in postpartum women in ... ...

    Abstract Female sexual dysfunction (FSD) is a common problem among postpartum women. However, little is known about this topic in Malaysia. This study aimed to determine the prevalence of sexual dysfunction and its associated factors in postpartum women in Kelantan, Malaysia. In this cross-sectional study, we recruited 452 sexually active women at six months postpartum from four primary care clinics in Kota Bharu, Kelantan, Malaysia. The participants were asked to fill in questionnaires consisting of sociodemographic information and the Malay Version of the Female Sexual Function Index-6. The data were analyzed using bivariate and multivariate logistic regression analyses. With a 95% response rate, the prevalence of sexual dysfunction among sexually active, six months postpartum women was 52.4% (n = 225). FSD was significantly associated with the older husband's age (p = 0.034) and lower frequency of sexual intercourse (p<0.001). Therefore, the prevalence of postpartum sexual dysfunction in women is relatively high in Kota Bharu, Kelantan, Malaysia. Efforts should be made to raise awareness among healthcare providers about screening for FSD in postpartum women and for their counseling and early treatment.
    Keywords Medicine ; R ; Science ; Q
    Subject code 360
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Alternative lengthening of telomeres is seen in a proportion of oligodendrogliomas and is associated with a worse prognosis.

    Shi, Zhi-Feng / Li, Kay Ka-Wai / Chan, Danny Tat-Ming / Mao, Ying / Ng, Ho-Keung

    Neuro-oncology advances

    2024  Volume 6, Issue 1, Page(s) vdae006

    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 3009682-0
    ISSN 2632-2498 ; 2632-2498
    ISSN (online) 2632-2498
    ISSN 2632-2498
    DOI 10.1093/noajnl/vdae006
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  8. Article: Gingival Necrosis Related to Sepsis-Induced Agranulocytosis Due to

    Tan, Jia Ying / Teo, Guo Nian / Ng, Ethan / Tay, Andrew Ban Guan / Tay, John Rong Hao

    Journal of clinical medicine

    2024  Volume 13, Issue 5

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-02-24
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13051285
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  9. Article ; Online: A facile method to fabricate versatile keratin cryogels for tissue engineering applications.

    Zhao, Zhitong / Chua, Huei Min / Lai, Hui Ying / Ng, Kee Woei

    Biomedical materials (Bristol, England)

    2024  Volume 19, Issue 2

    Abstract: Human hair keratin (HHK) has been extensively explored as a biomaterial for soft tissue regeneration due to their excellent bioactivity and biocompatibility. The possibility to fabricate HHK into three-dimensional (3D) hydrogels with physical properties ... ...

    Abstract Human hair keratin (HHK) has been extensively explored as a biomaterial for soft tissue regeneration due to their excellent bioactivity and biocompatibility. The possibility to fabricate HHK into three-dimensional (3D) hydrogels with physical properties resembling soft tissues has been well demonstrated. However, conventional keratin hydrogels often exhibit a dense architecture that could hinder cell filtration. In the present study, HHK-based cryogels were fabricated using a freeze-thaw (FT) method, where oxidized dopamine (ODA) was employed to covalently crosslink thiol/amine rich-keratin molecules at sub-zero temperatures. The obtained HHK-ODA cryogels have micron-sized pores ranging between 100 and 200 μm and mechanical properties that can be tuned by varying the crosslinking density between ODA and HHK. Through optimization of the weight content of ODA and the number of FT cycles, the compressive strengths and stiffnesses of these cryogels achieved 15-fold increments from ∼1.5 kPa to ∼22 kPa and ∼300 Pa to ∼5000 Pa, respectively. The HHK-ODA cryogels competently supported human dermal fibroblast spreading and proliferation. Overall, this study exhibited a facile method to fabricate mechanically superior keratin-based cryogels with cell compatible microarchitecture, circumventing the need for complicated chemical modifications and the use of cytotoxic crosslinkers.
    MeSH term(s) Humans ; Tissue Engineering/methods ; Cryogels/chemistry ; Tissue Scaffolds/chemistry ; Keratins ; Biocompatible Materials/chemistry
    Chemical Substances Cryogels ; Keratins (68238-35-7) ; Biocompatible Materials
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2265222-X
    ISSN 1748-605X ; 1748-6041
    ISSN (online) 1748-605X
    ISSN 1748-6041
    DOI 10.1088/1748-605X/ad2a3f
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  10. Article ; Online: Hyperpolarized Carbon-13 Magnetic Resonance Imaging: Technical Considerations and Clinical Applications.

    Lai, Ying-Chieh / Hsieh, Ching-Yi / Juan, Yu-Hsiang / Lu, Kuan-Ying / Lee, Hsien-Ju / Ng, Shu-Hang / Wan, Yung-Liang / Lin, Gigin

    Korean journal of radiology

    2024  Volume 25, Issue 5, Page(s) 459–472

    Abstract: Hyperpolarized (HP) carbon-13 ( ...

    Abstract Hyperpolarized (HP) carbon-13 (
    MeSH term(s) Humans ; Magnetic Resonance Imaging/methods ; Carbon Isotopes ; Male ; Muscle, Skeletal/diagnostic imaging ; Brain/diagnostic imaging ; Brain/metabolism ; Female ; Pyruvic Acid ; Liver/diagnostic imaging
    Chemical Substances Carbon Isotopes ; Carbon-13 (FDJ0A8596D) ; Pyruvic Acid (8558G7RUTR)
    Language English
    Publishing date 2024-04-29
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2046981-0
    ISSN 2005-8330 ; 1229-6929
    ISSN (online) 2005-8330
    ISSN 1229-6929
    DOI 10.3348/kjr.2024.0069
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