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  1. Article ; Online: Kawasaki disease in the COVID-19 era: a distinct clinical phenotype?

    Kam, Kai-Qian / Ong, Jacqueline S M / Lee, Jan Hau

    The Lancet. Child & adolescent health

    2020  Volume 4, Issue 9, Page(s) 642–643

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Mucocutaneous Lymph Node Syndrome ; Pandemics ; Phenotype ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-4650
    ISSN (online) 2352-4650
    DOI 10.1016/S2352-4642(20)30207-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Beyond Conventional Hemodynamic Monitoring-Monitoring to Improve Our Understanding of Disease Process and Interventions.

    Ramírez, Michelle / Mazwi, Mjaye L / Bronicki, Ronald A / Checchia, Paul A / Ong, Jacqueline S M

    Critical care clinics

    2022  Volume 39, Issue 2, Page(s) 243–254

    Abstract: Monitoring the hemodynamic state of patients is a hallmark of any intensive care environment. However, no single monitoring strategy can provide all the necessary data to paint the entire picture of the state of a patient; each monitor has strengths and ... ...

    Abstract Monitoring the hemodynamic state of patients is a hallmark of any intensive care environment. However, no single monitoring strategy can provide all the necessary data to paint the entire picture of the state of a patient; each monitor has strengths and weaknesses, advantages, and limitations. We review the currently available hemodynamic monitors used in pediatric critical care units using a clinical scenario. This provides the reader with a construct to understand the progression from basic to more advanced monitoring modalities and how they serve to inform the practitioner at the bedside.
    MeSH term(s) Child ; Humans ; Hemodynamic Monitoring ; Monitoring, Physiologic ; Hemodynamics ; Critical Care ; Cardiac Output
    Language English
    Publishing date 2022-12-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1006423-0
    ISSN 1557-8232 ; 0749-0704
    ISSN (online) 1557-8232
    ISSN 0749-0704
    DOI 10.1016/j.ccc.2022.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Kawasaki disease in the COVID-19 era

    Kam, Kai-Qian / Ong, Jacqueline S M / Lee, Jan Hau

    The Lancet Child & Adolescent Health

    a distinct clinical phenotype?

    2020  Volume 4, Issue 9, Page(s) 642–643

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2352-4642
    DOI 10.1016/s2352-4642(20)30207-8
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Treatment and long term safety outcomes of Peptide Receptor Radionuclide Therapy for metastatic neuroendocrine tumours: an Asian experience.

    Tham, Wei Ying / Huang, Hian Liang / Tai, David Wai Meng / Allen, John C / Hwang, Jacqueline S G / Loh, Lih Ming / Goh, Brian K P / Ong, Simon Y K / Kek, Peng Chin / Tan, Damien M Y / Ng, David C E / Loke, Kelvin S H

    Neuroendocrinology

    2024  

    Abstract: Peptide-receptor radionuclide therapy (PRRT) is a targeted molecular therapy used to treat neuroendocrine tumours (NET). It has been shown to be effective and well-tolerated in patients with metastatic neuroendocrine tumours in several centres in United ... ...

    Abstract Peptide-receptor radionuclide therapy (PRRT) is a targeted molecular therapy used to treat neuroendocrine tumours (NET). It has been shown to be effective and well-tolerated in patients with metastatic neuroendocrine tumours in several centres in United States (US), Europe and Australia. Tolerability and efficacy data emerging from Asian centres remain few. Epidemiological evidence suggests that there are differences in neuroendocrine neoplasms between the population groups. We aim to describe the treatment and safety outcomes of PRRT in the Asian population. Methods One hundred and seven (107) patients with metastatic neuroendocrine tumour who had undergone PRRT treatment from January 2012 to March 2019 were included in this retrospective study. The response rates using RECIST1.1 and qualitative analysis were examined. The overall and progression free survival curves were also evaluated. Results The median progression free survival was 49 months. Response assessment after completion of treatment showed that 33(37.9%) of 87 patients had partial or complete response. Subgroup analysis comparing high- and low-grade NET showed that there was a significant difference in the time to progression curves. Comparison of the number of cycles and progression free and overall survival also showed a significant difference. Ten patients (9%) had grade 3 or more haematological toxicities. Four patients (4%) had grade 3/4 hepatobiliary toxicities, although the presence of extensive liver metastases was a confounding factor. None of the patients had grade 3/4 acute kidney injury. Conclusion Our results show that PRRT is safe and effective in the treatment of metastatic neuroendocrine tumour in the Asian population. There was a significant difference in the progression free survival curves between low-grade and high-grade NET, and in the progression free and overall survival comparing the number of cycles received.
    Language English
    Publishing date 2024-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 123303-8
    ISSN 1423-0194 ; 0028-3835
    ISSN (online) 1423-0194
    ISSN 0028-3835
    DOI 10.1159/000538523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 531: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Sedation protocols in the pediatric intensive care unit: fact or fiction?

    Balit, Corrine R / LaRosa, Jessica M / Ong, Jacqueline S M / Kudchadkar, Sapna R

    Translational pediatrics

    2021  Volume 10, Issue 10, Page(s) 2814–2824

    Abstract: Comfort of the critically unwell pediatric patient is paramount to ensuring good outcomes. Analgesia-based, multimodal sedative approaches are the foundation for comfort, whereby pain is addressed first and then sedation titrated to a predefined target ... ...

    Abstract Comfort of the critically unwell pediatric patient is paramount to ensuring good outcomes. Analgesia-based, multimodal sedative approaches are the foundation for comfort, whereby pain is addressed first and then sedation titrated to a predefined target based on the goals of care. Given the heterogeneity of patients within the pediatric critical care population, the approach must be individualized based on the age and developmental stage of the child, physiologic status, and degree of invasive treatment required. In both the adult and pediatric intensive care unit (PICU), sedation titration is practiced as standard of care to meet therapeutic goals with a focus on facilitating early rehabilitation and extubation while avoiding under- and over-sedation. Sedation protocols have been developed as methods to reduce variability and optimize goal-directed therapy. Components of a sedation protocol include routine analgesia and sedation scoring with validated tools at specified intervals and a predefined algorithm that allows the titration of analgesia and sedation based on those assessments. Sedation protocols are designed to improve communication and documentation of sedation goals while also empowering the bedside team to respond rapidly to changes in a patient's clinical status. Previously it was thought that sedation protocols would consistently reduce duration of mechanical ventilation (MV) and length of stay (LOS) for patients in the PICU, however, this has not been the case. Nonetheless, introduction of sedation protocols has provided several benefits, including: (I) reduction in benzodiazepine usage; (II) improvements in interprofessional communication surrounding sedation goals and management of sedation goals; and (III) reductions in iatrogenic withdrawal symptoms. Successful implementation of sedation protocols requires passionate clinical champions and a robust implementation, education, and sustainability plan. Emerging evidence suggests that sedation protocols as part of a bundle of quality improvement initiatives will form the basis of future studies to improve short- and long-term outcomes after PICU discharge. In this review, we aim to define sedation protocols in the context of pediatric critical care and highlight important considerations for clinical practice and research.
    Language English
    Publishing date 2021-10-29
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2901309-4
    ISSN 2224-4344 ; 2224-4344 ; 2224-4336
    ISSN (online) 2224-4344
    ISSN 2224-4344 ; 2224-4336
    DOI 10.21037/tp-20-328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The authors reply.

    Ong, Jacqueline S M / Tosoni, Alvise / Kim, YaeJean / Kissoon, Niranjan / Murthy, Srinivas

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2020  Volume 21, Issue 11, Page(s) 1023

    MeSH term(s) Betacoronavirus ; COVID-19 ; Child ; Coronavirus ; Coronavirus Infections ; Critical Illness ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-12-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000002569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5600: Show issues Location:
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  8. Article: The authors reply.

    Ong, Jacqueline S M / Tosoni, Alvise / Kim, YaeJean / Kissoon, Niranjan / Murthy, Srinivas

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2020  Volume 21, Issue 8, Page(s) 783–784

    MeSH term(s) Betacoronavirus ; COVID-19 ; Child ; Coronavirus ; Coronavirus Infections ; Critical Illness ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000002464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5600: Show issues Location:
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  9. Article: Coronavirus Disease 2019 in Critically Ill Children: A Narrative Review of the Literature.

    Ong, Jacqueline S M / Tosoni, Alvise / Kim, YaeJean / Kissoon, Niranjan / Murthy, Srinivas

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2020  Volume 21, Issue 7, Page(s) 662–666

    Abstract: Coronavirus disease 2019 has spread around the world. In the 3 months since its emergence, we have learned a great deal about its clinical management and its relevance to the pediatric critical care provider. In this article, we review the available ... ...

    Abstract Coronavirus disease 2019 has spread around the world. In the 3 months since its emergence, we have learned a great deal about its clinical management and its relevance to the pediatric critical care provider. In this article, we review the available literature and provide valuable insight into the clinical management of this disease, as well as information on preparedness activities that every PICU should perform.
    MeSH term(s) Age Distribution ; Age Factors ; Betacoronavirus ; COVID-19 ; Child ; Child, Preschool ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Coronavirus Infections/transmission ; Critical Care/methods ; Global Health ; Humans ; Infant ; Intensive Care Units, Pediatric/organization & administration ; Intubation, Intratracheal/methods ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Severity of Illness Index
    Keywords covid19
    Language English
    Publishing date 2020-04-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000002376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Gender Equity and Diversity in Pediatric Critical Care Medicine: We Must Do Better

    Lanziotti, Vanessa Soares / Dewan, Maya / Behrens, Deanna / Bulut, Yonca / Miller, Jenna / Ong, Jacqueline S. M. / Kudchadkar, Sapna

    Journal of Pediatric Intensive Care

    2021  

    Language English
    Publishing date 2021-09-10
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2146-4626 ; 2146-4618
    ISSN (online) 2146-4626
    ISSN 2146-4618
    DOI 10.1055/s-0041-1735871
    Database Thieme publisher's database

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