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Article ; Online: Racial Bias in Pulse Oximetry Measurement: Considerations in Patients With Heart Failure.

Ketcham, Scott W / Konerman, Matthew C / Marshall, Vincent D / Adie, Sarah K

Circulation. Cardiovascular quality and outcomes

2024 Volume 17, Issue 3, Page(s) e010390

MeSH term(s)	Humans ; Racism ; Oximetry ; Heart Failure/diagnosis
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Letter
ZDB-ID	2483197-9
ISSN	1941-7705 ; 1941-7713
ISSN (online)	1941-7705
ISSN	1941-7713
DOI	10.1161/CIRCOUTCOMES.123.010390
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Article ; Online: Impact of Delirium Among Patients Receiving Temporary Mechanical Circulatory Support.

Ketcham, Scott W / Konerman, Matthew C / Marshall, Vincent D / Adie, Sarah K

Chest

2023 Volume 164, Issue 2, Page(s) 414–417

MeSH term(s)	Humans ; Heart Failure/therapy ; Heart-Assist Devices/adverse effects ; Delirium/etiology ; Shock, Cardiogenic
Language	English
Publishing date	2023-04-11
Publishing country	United States
Document type	Letter
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2023.04.005
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Article ; Online: The association of glucose control on in-hospital mortality in the cardiac intensive care unit.

Adie, Sarah K / Ketcham, Scott W / Marshall, Vincent D / Farina, Nicholas / Sukul, Devraj

Journal of diabetes and its complications

2023 Volume 37, Issue 4, Page(s) 108453

Abstract: Background: Current guidelines recommend maintaining serum blood glucose (BG) levels between 150 and 180 mg/dL for patients admitted to the intensive care unit (ICU); however, these recommendations are based on randomized controlled trials among general ...

Abstract	Background: Current guidelines recommend maintaining serum blood glucose (BG) levels between 150 and 180 mg/dL for patients admitted to the intensive care unit (ICU); however, these recommendations are based on randomized controlled trials among general ICU patients and observational studies among specific subgroups. Little is known about the impact of glucose control among patients cared for in the cardiac intensive care unit (CICU). Methods: This was a retrospective cohort analysis of patients >18 years of age admitted to the University of Michigan CICU from December 2016 through December 2020 with at least one BG measurement during CICU admission. The primary outcome was in-hospital mortality. The secondary outcome was CICU length of stay. Results: A total of 3217 patients were included. When analyzed based on quartiles of mean CICU BG, there were significant differences in in-hospital mortality across BG quartiles for those with diabetes mellitus (DM) and those without DM. In multivariable logistic regression, age, Elixhauser comorbidity score, use of mechanical ventilation, any hypoglycemic event, and any BG value >180 mg/dL were significant predictors for in-hospital mortality in both patients with and without DM, yet average BG was only predictive of in-hospital mortality in patients without DM. Conclusions: This study highlights the importance of glucose control in critically ill adult patients admitted to the CICU. The trends in mortality based on quartiles and deciles of average BG suggest a difference in optimal blood glucose levels in those with and without DM. However, regardless of diabetes status, mortality increases with higher average BG.
MeSH term(s)	Adult ; Humans ; Blood Glucose/analysis ; Retrospective Studies ; Hospital Mortality ; Intensive Care Units ; Diabetes Mellitus ; Hyperglycemia/prevention & control
Chemical Substances	Blood Glucose
Language	English
Publishing date	2023-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1105840-7
ISSN	1873-460X ; 1056-8727
ISSN (online)	1873-460X
ISSN	1056-8727
DOI	10.1016/j.jdiacomp.2023.108453
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Zs.A 2225: Show issues

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Article: Emergency Department Management of Patients With Alcohol Intoxication, Alcohol Withdrawal, and Alcohol Use Disorder: A White Paper Prepared for the American Academy of Emergency Medicine.

Strayer, Reuben J / Friedman, Benjamin W / Haroz, Rachel / Ketcham, Eric / Klein, Lauren / LaPietra, Alexis M / Motov, Sergey / Repanshek, Zachary / Taylor, Scott / Weiner, Scott G / Nelson, Lewis S

The Journal of emergency medicine

2023 Volume 64, Issue 4, Page(s) 517–540

MeSH term(s)	Humans ; Alcoholism/complications ; Alcoholism/therapy ; Substance Withdrawal Syndrome/therapy ; Alcoholic Intoxication/complications ; Alcoholic Intoxication/therapy ; Alcohol Drinking ; Emergency Service, Hospital
Language	English
Publishing date	2023-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	605559-x
ISSN	0736-4679
ISSN	0736-4679
DOI	10.1016/j.jemermed.2023.01.010
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Article ; Online: Implementation of a Nurse-Driven Spontaneous Awakening Trial Protocol in a Cardiac Intensive Care Unit.

Ketcham, Scott W / Adie, Sarah K / Brummel, Kent / Walker, Emily / Prescott, Hallie C / Thomas, Michael P

Critical care nurse

2022 Volume 42, Issue 2, Page(s) 56–61

Abstract: Background: In patients receiving mechanical ventilation, spontaneous awakening trials reduce morbidity and mortality when paired with spontaneous breathing trials. However, spontaneous awakening trials are not performed every day they are indicated and ...

Abstract	Background: In patients receiving mechanical ventilation, spontaneous awakening trials reduce morbidity and mortality when paired with spontaneous breathing trials. However, spontaneous awakening trials are not performed every day they are indicated and little is known about spontaneous awakening trial protocol use in cardiac intensive care units. Local problem: Spontaneous awakening trial completion rate at the study institution was low and no trial protocol was regularly used. Methods: A preintervention-postintervention retrospective cohort study was performed in adult patients with at least 24 hours of invasive mechanical ventilation in Michigan Medicine's cardiac intensive care unit. Patients with SARS-CoV-2 infection were excluded. Data included demographics, sedation, mechanical ventilation duration, and in-hospital mortality. A nurse-driven spontaneous awakening trial protocol modified for the cardiac intensive care unit was implemented in October 2020. Results: Compared with the preintervention cohort (n = 29, May through July 2020), the postintervention cohort (n = 27, October 2020 through February 2021) had a higher ratio of number of trials performed to number of days eligible for trial (0.91 vs 0.52; P < .01). Median continuous sedative infusion duration was shorter after intervention (2.3 vs 3.6 days; P = .02). Median mechanical ventilation duration (3.8 vs 4.7 days; P = .18) and mortality (41% vs 41%; P = .95) were similar between groups. Conclusions: Spontaneous awakening trial protocol implementation led to a higher trial completion rate and a shorter duration of continuous sedative infusion. Larger studies are needed to assess the impact of protocolized spontaneous awakening trials on cardiac intensive care unit patient outcomes.
MeSH term(s)	Adult ; COVID-19 ; Humans ; Intensive Care Units ; Retrospective Studies ; SARS-CoV-2 ; Ventilator Weaning
Language	English
Publishing date	2022-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	632663-8
ISSN	1940-8250 ; 0279-5442
ISSN (online)	1940-8250
ISSN	0279-5442
DOI	10.4037/ccn2022114
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Zs.A 2102: Show issues

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Article ; Online: Considerations for Inotrope and Vasopressor Use in Critically Ill Patients With Pulmonary Arterial Hypertension.

Adie, Sarah K / Abdul-Aziz, Ahmad A / Ketcham, Scott W / Moles, Victor M

Journal of cardiovascular pharmacology

2021 Volume 79, Issue 1, Page(s) e11–e17

Abstract: Abstract: Pulmonary arterial hypertension (PAH) is a rare and progressive cardiopulmonary disease, characterized by pulmonary vasculopathy. The disease can lead to increase pulmonary arterial pressures and eventual right ventricle failure due to ... ...

Abstract	Abstract: Pulmonary arterial hypertension (PAH) is a rare and progressive cardiopulmonary disease, characterized by pulmonary vasculopathy. The disease can lead to increase pulmonary arterial pressures and eventual right ventricle failure due to elevated afterload. The prevalence of PAH in patients admitted to the intensive care unit (ICU) is unknown, and pulmonary hypertension (PH) in the ICU is more commonly the result of left heart disease or hypoxic lung injury (PH due to left heart disease and PH due to lung diseases and/or hypoxia, respectively), as opposed to PAH. Management of patients with PAH in the ICU is complex as it requires a careful balance to maintain perfusion while optimizing right-sided heart function. A comprehensive understanding of the underlying physiology and underlying hemodynamics is crucial for the management of this population. In this review, we summarized the evidence for use of vasopressors and inotropes in the management of PH and extrapolated the data to patients with PAH. We strongly believe that the understanding of the hemodynamic consequences of inotropes and vasopressors, especially from data in the PH population, can lead to better management of this complex patient population.
MeSH term(s)	Animals ; Arterial Pressure/drug effects ; Cardiotonic Agents/adverse effects ; Cardiotonic Agents/therapeutic use ; Critical Illness ; Heart Failure/diagnostic imaging ; Heart Failure/drug therapy ; Heart Failure/epidemiology ; Heart Failure/physiopathology ; Humans ; Pulmonary Arterial Hypertension/diagnosis ; Pulmonary Arterial Hypertension/drug therapy ; Pulmonary Arterial Hypertension/epidemiology ; Pulmonary Arterial Hypertension/physiopathology ; Pulmonary Artery/drug effects ; Pulmonary Artery/physiopathology ; Treatment Outcome ; Vasoconstrictor Agents/adverse effects ; Vasoconstrictor Agents/therapeutic use ; Ventricular Dysfunction, Right/diagnosis ; Ventricular Dysfunction, Right/drug therapy ; Ventricular Dysfunction, Right/epidemiology ; Ventricular Dysfunction, Right/physiopathology ; Ventricular Function, Right/drug effects
Chemical Substances	Cardiotonic Agents ; Vasoconstrictor Agents
Language	English
Publishing date	2021-10-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0000000000001155
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Zs.A 1471: Show issues

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Article ; Online: Characteristics of Heart Failure Patients With or Without Hypotension When Transitioning From Nitroprusside to Sacubitril-Valsartan.

Adie, Sarah K / Ketcham, Scott W / Abdul-Aziz, Ahmad A / Thomas, Michael P / Konerman, Matthew C

Journal of cardiovascular pharmacology

2021 Volume 78, Issue 3, Page(s) 403–406

Abstract: Background: Sacubitril-valsartan is an angiotensin receptor-neprilysin inhibitor indicated for the treatment of patients with symptomatic heart failure with reduced ejection fraction (HFrEF). Little is known about outcomes of HFrEF patients transitioned ...

Abstract	Background: Sacubitril-valsartan is an angiotensin receptor-neprilysin inhibitor indicated for the treatment of patients with symptomatic heart failure with reduced ejection fraction (HFrEF). Little is known about outcomes of HFrEF patients transitioned from sodium nitroprusside (SNP) to sacubitril-valsartan during an admission for acute decompensated heart failure. We sought to describe characteristics of patients initiated on sacubitril-valsartan while receiving SNP and, in particular, those patients who did and did not experience hypotension requiring interruption or discontinuation of sacubitril-valsartan. Methods: We performed a retrospective case series of adult patients (>18 years) with HFrEF (left ventricular ejection fraction ≤40%) admitted to the University of Michigan cardiac intensive care unit between July 2018 to September 2020 who received sacubitril-valsartan while on SNP. Results: A total of 15 patients with acute decompensated heart failure were initiated on sacubitril-valsartan while on SNP. The mean age was 57 ± 15.9 years. Seven (46.7%) patients experienced hypotension. The patients in the cohort who experienced hypotension were numerically older (60 ± 17 vs. 55 ± 15.5), and the majority were white (86%). Patients with hypotension had a numerically lower left ventricular ejection fraction (13 ± 4.2 vs. 18 ± 8.2) and higher serum creatinine (1.4 ± 0.54 vs. 0.88 ± 0.25). Seven (100%) patients received a diuretic on the day of sacubitril-valsartan initiation in those who experienced hypotension compared with 2 (25%) in those who did not experience hypotension. Conclusions: In almost half of patients admitted to the cardiac intensive care unit with acutely decompensated HFrEF, significant hypotension was seen when initiating sacubitril-valsartan while on SNP. Future studies should evaluate appropriate patients for this transition and delineate appropriate titration parameters.
MeSH term(s)	Adult ; Aged ; Aminobutyrates/adverse effects ; Angiotensin II Type 1 Receptor Blockers/adverse effects ; Biphenyl Compounds/adverse effects ; Blood Pressure/drug effects ; Coronary Care Units ; Diuretics/adverse effects ; Drug Combinations ; Female ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Heart Failure/physiopathology ; Humans ; Hypotension/chemically induced ; Hypotension/diagnosis ; Hypotension/physiopathology ; Male ; Middle Aged ; Neprilysin/antagonists & inhibitors ; Nitroprusside/adverse effects ; Protease Inhibitors/adverse effects ; Retrospective Studies ; Risk Factors ; Treatment Outcome ; Valsartan/adverse effects ; Vasodilator Agents/adverse effects
Chemical Substances	Aminobutyrates ; Angiotensin II Type 1 Receptor Blockers ; Biphenyl Compounds ; Diuretics ; Drug Combinations ; Protease Inhibitors ; Vasodilator Agents ; Nitroprusside (169D1260KM) ; Valsartan (80M03YXJ7I) ; Neprilysin (EC 3.4.24.11) ; sacubitril and valsartan sodium hydrate drug combination (WB8FT61183)
Language	English
Publishing date	2021-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0000000000001091
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Article ; Online: Causes and Circumstances of Death among Patients Hospitalized with COVID-19: A Retrospective Cohort Study.

Ketcham, Scott W / Bolig, Thomas C / Molling, Daniel J / Sjoding, Michael W / Flanders, Scott A / Prescott, Hallie C

Annals of the American Thoracic Society

2020 Volume 18, Issue 6, Page(s) 1076–1079

MeSH term(s)	Aged ; Aged, 80 and over ; COVID-19/mortality ; Cause of Death ; Cohort Studies ; Coinfection/epidemiology ; Female ; Heart Failure/epidemiology ; Heart Failure/mortality ; Hospitalization ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Multiple Organ Failure/epidemiology ; Multiple Organ Failure/mortality ; Nervous System Diseases/epidemiology ; Nervous System Diseases/mortality ; Patient Care Planning ; Patients' Rooms ; Renal Insufficiency/epidemiology ; Respiratory Insufficiency/mortality ; Retrospective Studies ; SARS-CoV-2 ; Shock, Septic/epidemiology ; Shock, Septic/mortality ; Terminal Care/statistics & numerical data ; United States/epidemiology ; Withholding Treatment/statistics & numerical data
Language	English
Publishing date	2020-12-13
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202011-1381RL
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Zs.A 5828: Show issues

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Article ; Online: Validating Measures of Disease Severity in Acute Respiratory Distress Syndrome.

Sedhai, Yub Raj / Yuan, Mengdan / Ketcham, Scott W / Co, Ivan / Claar, Dru D / McSparron, Jakob I / Prescott, Hallie C / Sjoding, Michael W

Annals of the American Thoracic Society

2020 Volume 18, Issue 7, Page(s) 1211–1218

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Extracorporeal Membrane Oxygenation ; Hospital Mortality ; Humans ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/therapy ; Retrospective Studies ; Severity of Illness Index
Language	English
Publishing date	2020-12-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202007-772OC
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Article ; Online: Noncardiac Organ System Dysfunction and Cause of Death Common Among Patients Admitted to the Cardiac Intensive Care Unit.

Ketcham, Scott W / Ice, Erin / Molling, Daniel J / Thompson, Andrea D / Sukul, Devraj / Thomas, Michael P / Prescott, Hallie C

Circulation. Cardiovascular quality and outcomes

2020 Volume 13, Issue 11, Page(s) e007147

MeSH term(s)	Aged ; Cause of Death ; Comorbidity ; Coronary Care Units ; Female ; Heart Diseases/diagnosis ; Heart Diseases/mortality ; Heart Diseases/therapy ; Hospital Mortality ; Humans ; Lung Diseases/diagnosis ; Lung Diseases/mortality ; Lung Diseases/therapy ; Male ; Michigan/epidemiology ; Multiple Organ Failure/diagnosis ; Multiple Organ Failure/mortality ; Multiple Organ Failure/therapy ; Patient Admission ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Sepsis/diagnosis ; Sepsis/mortality ; Sepsis/therapy ; Time Factors
Language	English
Publishing date	2020-11-12
Publishing country	United States
Document type	Comparative Study ; Letter ; Research Support, N.I.H., Extramural
ZDB-ID	2483197-9
ISSN	1941-7705 ; 1941-7713
ISSN (online)	1941-7705
ISSN	1941-7713
DOI	10.1161/CIRCOUTCOMES.120.007147
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