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Article ; Online: NRF-2/HO-1 Pathway-Mediated SHOX2 Activation Is a Key Switch for Heart Rate Acceleration by Yixin-Fumai Granules.

Zhang, Heng / Chen, Chen / Liu, Yue / Ren, Lu / Qi, Jing / Yang, Yang / Chen, Wei / Yao, Yingjia / Cai, Xintong / Liu, Zhuang / Hao, Miao / Li, Lingkang / Deng, Zisu / Sun, Mingyu / Lu, Yongping / Chen, Keyan / Hou, Ping

Oxidative medicine and cellular longevity

2022 Volume 2022, Page(s) 8488269

Abstract: ... and safe medical therapy has been reported thus far. Yixin-Fumai granules (YXFMs), a Chinese medicine ...

Abstract	Population aging has led to increased sick sinus syndrome (SSS) incidence; however, no effective and safe medical therapy has been reported thus far. Yixin-Fumai granules (YXFMs), a Chinese medicine granule designed for bradyarrhythmia treatment, can effectively increase SSS patients' heart rate. Senescence-induced sinoatrial node (SAN) degeneration is an important part of SSS pathogenesis, and older people often show high levels of oxidative stress; reactive oxygen species (ROS) accumulation in the SAN causes abnormal SAN pacing or conduction functions. The current study observed the protective effects of YXFMs on senescent SAN and explored the relationship between the NRF-2/HO-1 pathway, SHOX2, and T-type calcium channels. We selected naturally senescent C57BL/6 mice with bradycardia to simulate SSS; electrocardiography, Masson's trichrome staining, and DHE staining were used to assess SAN function and tissue damage. Immunofluorescence staining and Western blotting were used to assay related proteins.
MeSH term(s)	Acceleration ; Aged ; Animals ; Calcium Channels, T-Type ; Galactose ; Heart Rate ; Heme Oxygenase-1/metabolism ; Homeodomain Proteins/metabolism ; Humans ; Medicine, Chinese Traditional ; Mibefradil ; Mice ; Mice, Inbred C57BL ; Molecular Docking Simulation ; NF-E2-Related Factor 2/metabolism ; Reactive Oxygen Species/metabolism ; Transcription Factors/metabolism
Chemical Substances	Cacna1g protein, mouse ; Calcium Channels, T-Type ; Homeodomain Proteins ; NF-E2-Related Factor 2 ; Reactive Oxygen Species ; SHOX2 protein, human ; Shox2 protein, mouse ; Transcription Factors ; Mibefradil (27B90X776A) ; Heme Oxygenase-1 (EC 1.14.14.18) ; Galactose (X2RN3Q8DNE)
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2022/8488269
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Article ; Online: Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome.

Zhang, Heng / Li, Lingkang / Hao, Miao / Chen, Keyan / Lu, Yongping / Qi, Jing / Chen, Wei / Ren, Lu / Cai, Xintong / Chen, Chen / Liu, Zhuang / Zhao, Bin / Li, Zhishuang / Hou, Ping

Journal of ethnopharmacology

2021 Volume 277, Page(s) 114254

Abstract: Ethnopharmacological relevance: Yixin-Fumai granules (YXFMs)-composed of Ginseng quinquefolium (L ...

Abstract	Ethnopharmacological relevance: Yixin-Fumai granules (YXFMs)-composed of Ginseng quinquefolium (L.) Alph. Wood, Ophiopogon japonicus (Thunb.) Ker Gawl, Schisandra arisanensis Hayata, Astragalus aaronsohnianus Eig, Salvia cryptantha Montbret & Aucher ex Benth, and Ligusticum striatum DC-are compound granules used in traditional Chinese medicine to increase heart rate and thus treat bradyarrhythmia. It may be effective in treating sick sinus syndrome (SSS). Aim: To observe the effect of YXFMs on aging-induced SSS in mice and explore whether this effect is related to the Nrf-2/HO-1 signaling pathway. Materials and methods: Mice with a significant decrease in the heart rate due to natural aging were selected to construct an SSS model. After the mice were administered YXFMs, the damage to their sinoartrial node (SAN) was assessed through electrocardiography, Masson's trichrome staining, and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL). Dihydroethidium staining and immunofluorescence staining were used to assay reactive oxygen species (ROS) content and HCN4, respectively. Moreover, to observe the effects of YXFMs in vitro, the HL-1 cell line, derived from mouse atrial myocytes, was used to simulate SAN pacemaker cells, with H Results: In our in vivo experiments, YXFMs significantly inhibited aging-induced SSS, shortened the R-R interval, increased heart rate, alleviated fibrosis, reduced apoptosis rate and ROS content, and promote HCN4 expression in the SAN. In our in vitro experiments, YXFMs significantly inhibited H Conclusion: Here, we elaborated on the relationship between aging-induced SSS and the Nrf-2/HO-1 pathway for the first time and proposed that YXFMs improve SSS via the Nrf-2/HO-1 axis. Specifically, YXFMs promoted Nrf-2 activation and plasma-nuclear transfer to enhance HO-1 expression via the Nrf-2/HO-1 axis. This inhibited OS and reduced ROS accumulation in the SAN, and then, through the ROS/HDAC4 axis, reduced HDAC4 expression and plasma-nuclear transfer. Thereby, the OS-induced HCN4 loss in the SAN was inhibited-improving the function of I
MeSH term(s)	Aging ; Animals ; Apoptosis/drug effects ; Drugs, Chinese Herbal/pharmacology ; Female ; Heme Oxygenase-1/metabolism ; Male ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism ; Sick Sinus Syndrome/drug therapy ; Sick Sinus Syndrome/physiopathology ; Signal Transduction/drug effects
Chemical Substances	Drugs, Chinese Herbal ; Membrane Proteins ; NF-E2-Related Factor 2 ; Nfe2l2 protein, mouse ; Reactive Oxygen Species ; Heme Oxygenase-1 (EC 1.14.14.18) ; Hmox1 protein, mouse (EC 1.14.14.18)
Language	English
Publishing date	2021-05-29
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114254
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Article: Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome

Zhang, Heng / Li, Lingkang / Hao, Miao / Chen, Keyan / Lu, Yongping / Qi, Jing / Chen, Wei / Ren, Lu / Cai, Xintong / Chen, Chen / Liu, Zhuang / Zhao, Bin / Li, Zhishuang / Hou, Ping

Journal of ethnopharmacology. 2021 Sept. 15, v. 277

2021

Abstract: Yixin-Fumai granules (YXFMs)—composed of Ginseng quinquefolium (L.) Alph. Wood ...

Abstract	Yixin-Fumai granules (YXFMs)—composed of Ginseng quinquefolium (L.) Alph. Wood, Ophiopogon japonicus (Thunb.) Ker Gawl, Schisandra arisanensis Hayata, Astragalus aaronsohnianus Eig, Salvia cryptantha Montbret & Aucher ex Benth, and Ligusticum striatum DC—are compound granules used in traditional Chinese medicine to increase heart rate and thus treat bradyarrhythmia. It may be effective in treating sick sinus syndrome (SSS).To observe the effect of YXFMs on aging-induced SSS in mice and explore whether this effect is related to the Nrf-2/HO-1 signaling pathway.Mice with a significant decrease in the heart rate due to natural aging were selected to construct an SSS model. After the mice were administered YXFMs, the damage to their sinoartrial node (SAN) was assessed through electrocardiography, Masson's trichrome staining, and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL). Dihydroethidium staining and immunofluorescence staining were used to assay reactive oxygen species (ROS) content and HCN4, respectively. Moreover, to observe the effects of YXFMs in vitro, the HL-1 cell line, derived from mouse atrial myocytes, was used to simulate SAN pacemaker cells, with H₂O₂ used as the cellular oxidative stress (OS) inducer. 2,7-Dichlorodihydrofluorescein diacetate staining was used to assay ROS content, whereas immunofluorescence staining and Western blotting were used to elucidate the related protein expression. Finally, mice were injected the Nrf-2 inhibitor ML385 to reversely verify the effects of YXFMs.In our in vivo experiments, YXFMs significantly inhibited aging-induced SSS, shortened the R-R interval, increased heart rate, alleviated fibrosis, reduced apoptosis rate and ROS content, and promote HCN4 expression in the SAN. In our in vitro experiments, YXFMs significantly inhibited H₂O₂-induced cell peroxidation damage, promoted Nrf-2 activation and nuclear metastasis, increased HO-1 expression— thereby inhibiting ROS accumulation—and finally, upregulated HCN4 expression through the inhibition of histone deacetylase 4 (HDAC4) expression and its nuclear metastasis. Finally, injection of the Nrf-2 inhibitor ML385 after YXFMs administration inhibited their protective effect in the mice.Here, we elaborated on the relationship between aging-induced SSS and the Nrf-2/HO-1 pathway for the first time and proposed that YXFMs improve SSS via the Nrf-2/HO-1 axis. Specifically, YXFMs promoted Nrf-2 activation and plasma–nuclear transfer to enhance HO-1 expression via the Nrf-2/HO-1 axis. This inhibited OS and reduced ROS accumulation in the SAN, and then, through the ROS/HDAC4 axis, reduced HDAC4 expression and plasma–nuclear transfer. Thereby, the OS-induced HCN4 loss in the SAN was inhibited—improving the function of If channel and thus producing SAN protection effect against SSS and improving the heart rate and R-R interval. In the future, we plan to use bioinformatics analysis technology to execute the next step of our research, namely to determine the effect of isolated, purified components of YXFMs in SSS, to increase its efficiency and reduce the toxicity of YXFMs.
Keywords	Astragalus ; Ophiopogon japonicus ; Oreocome striata ; Oriental traditional medicine ; Panax ; Salvia absconditiflora ; Schisandra ; apoptosis ; bioinformatics ; cell lines ; dihydroethidium ; electrocardiography ; fibrosis ; fluorescent antibody technique ; heart rate ; histone deacetylase ; metastasis ; mice ; models ; myocytes ; nucleotidyltransferases ; oxidative stress ; peroxidation ; protective effect ; protein synthesis ; toxicity ; wood
Language	English
Dates of publication	2021-0915
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114254
Database	NAL-Catalogue (AGRICOLA)

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Article: Effects of yixin jiangya capsules on insulin resistance and timor necrosis factor-alpha in cases of primary hypertension with left ventricular hypertrophy.

Duan, Xuezhong / Zhong, Shenqing / Sun, Xiqing / Cai, Xinji

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

2007 Volume 27, Issue 2, Page(s) 96–99

Abstract: Objectives: To observe the effects of yixin jiangya Capsules ([Chinese characters: see text ... a treatment group of 62 cases taking Enalapril and yixin jiangya Capsules.: Results: Fasting serum insulin ... influencing each other are involved in the generation and development of hypertension. Yixin jiangya Capsules ...

Abstract	Objectives: To observe the effects of yixin jiangya Capsules ([Chinese characters: see text] capsules for nourishing the heart and lowering blood pressure) on insulin resistance (IR) and tumor necrosis factor-alpha (TNF-alpha) in patients with primary hypertension with left ventricular hypertrophy (LVH). Methods: Totally 93 cases were randomly divided into a control group of 31 cases taking Enalapril and a treatment group of 62 cases taking Enalapril and yixin jiangya Capsules. Results: Fasting serum insulin (FSI) and TNF-alpha obviously increased and insulin sensitive index (ISI) significantly decreased in both groups before treatment as compared to those of a healthy group. After treatment, FSI, TNF-alpha and fasting blood glucose (FBG) obviously decreased and ISI remarkably increased in the treatment group, while ISI significantly increased and TNF-alpha obviously decreased in the control group. The curative effect in the treatment group was remarkably superior to that in the control group. FSI was positively related to TNF-a before treatment in both groups. Conclusion: FSI and TNF-alpha obviously increase and ISI significantly decreases in patients with primary hypertension with LVH. FSI and TNF-alpha influencing each other are involved in the generation and development of hypertension. Yixin jiangya Capsules can improve IR and decrease TNF-alpha.
MeSH term(s)	Aged ; Capsules/therapeutic use ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Hypertension/drug therapy ; Hypertension/etiology ; Hypertrophy, Left Ventricular/complications ; Insulin/blood ; Insulin Resistance ; Male ; Middle Aged ; Tumor Necrosis Factor-alpha/blood
Chemical Substances	Capsules ; Drugs, Chinese Herbal ; Insulin ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2007-06
Publishing country	China
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	603186-9
ISSN	0254-6272 ; 0255-2922
ISSN (online)	0254-6272
ISSN	0255-2922
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Article ; Online: Multi-branch myocardial infarction detection and localization framework based on multi-instance learning and domain knowledge.

Li, Xinyue / Huang, Yangcheng / Ning, Yixin / Wang, Mingjie / Cai, Wenjie

Physiological measurement

2024 Volume 45, Issue 4

Abstract: ... ...

Abstract	Objective
MeSH term(s)	Myocardial Infarction/diagnosis ; Humans ; Electrocardiography ; Signal Processing, Computer-Assisted ; Machine Learning ; Algorithms ; Databases, Factual
Language	English
Publishing date	2024-04-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1149545-5
ISSN	1361-6579 ; 0967-3334
ISSN (online)	1361-6579
ISSN	0967-3334
DOI	10.1088/1361-6579/ad3d25
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Article: The applications of internet of things in smart healthcare sectors: a bibliometric and deep study.

Ziwei, Hai / Dongni, Zhang / Man, Zhang / Yixin, Du / Shuanghui, Zheng / Chao, Yang / Chunfeng, Cai

Heliyon

2024 Volume 10, Issue 3, Page(s) e25392

Abstract: The recent attention garnered by Internet of Things (IoT) technology for its potential to alleviate challenges faced by healthcare systems, such as those resulting from an aging population and the rise in chronic illnesses, has underscored the ... ...

Abstract	The recent attention garnered by Internet of Things (IoT) technology for its potential to alleviate challenges faced by healthcare systems, such as those resulting from an aging population and the rise in chronic illnesses, has underscored the significance of smart healthcare. Surprisingly, no bibliometric study has been conducted on this subject to date. Consequently, this investigation aims to provide a comprehensive overview of the longitudinal state and knowledge structure of IoT in smart healthcare. To achieve this, a content analysis tool is employed for academic research, facilitating the identification of key study themes, the growth trajectory of the research topic, the top journal sources, and the distribution of nations based on subject areas. The bibliometric evaluation encompasses 614 publications published in 14 journals spanning the period from 2016 to 2022. Employing bibliographic coupling analysis, the latest developments in IoT have been uncovered within the domain of smart healthcare. The findings reveal 11 primary research topic areas that have been the focus of scholarly discourse during this period. This study highlights that the computing paradigm and network connectivity emerge as the most prominent topics within this research domain. Blockchain-based security in healthcare closely follows as the second-largest topic discussed by scholars. Additionally, the analysis indicates a significant increase in total publications for the most popular topic, peaking around 2018.
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e25392
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Article ; Online: HMOX1 as a therapeutic target associated with diabetic foot ulcers based on single-cell analysis and machine learning.

Chen, Yiqi / Zhang, Yixin / Jiang, Ming / Ma, Hong / Cai, Yuhui

International wound journal

2024 Volume 21, Issue 3, Page(s) e14815

Abstract: Diabetic foot ulcers (DFUs) are a serious chronic complication of diabetes mellitus and a leading cause of disability and death in diabetic patients. However, current treatments remain unsatisfactory. Although macrophages are associated with DFU, their ... ...

Abstract	Diabetic foot ulcers (DFUs) are a serious chronic complication of diabetes mellitus and a leading cause of disability and death in diabetic patients. However, current treatments remain unsatisfactory. Although macrophages are associated with DFU, their exact role in this disease remains uncertain. This study sought to detect macrophage-related genes in DFU and identify possible therapeutic targets. Single-cell datasets (GSE223964) and RNA-seq datasets (GSM68183, GSE80178, GSE134431 and GSE147890) associated with DFU were retrieved from the gene expression omnibus (GEO) database for this study. Analysis of the provided single-cell data revealed the distribution of macrophage subpopulations in the DFU. Four independent RNA-seq datasets were merged into a single DFU cohort and further analysed using bioinformatics. This included differential expression (DEG) analysis, multiple machine learning algorithms to identify biomarkers and enrichment analysis. Finally, key results were validated using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Western bolt. Finally, the findings were validated using RT-qPCR and western blot. We obtained 802 macrophage-related genes in single-cell analysis. Differential expression analysis yielded 743 DEGs. Thirty-seven macrophage-associated DEGs were identified by cross-analysis of marker genes with macrophage-associated DEGs. Thirty-seven intersections were screened and cross-analysed using four machine learning algorithms. Finally, HMOX1 was identified as a potentially valuable biomarker. HMOX1 was significantly associated with biological pathways such as the insulin signalling pathway. The results showed that HMOX1 was significantly overexpressed in DFU samples. In conclusion, the analytical results of this study identified HMOX1 as a potentially valuable biomarker associated with macrophages in DFU. The results of our analysis improve our understanding of the mechanism of macrophage action in this disease and may be useful in developing targeted therapies for DFU.
MeSH term(s)	Humans ; Diabetic Foot/genetics ; Diabetic Foot/therapy ; Diabetes Mellitus ; Macrophages/metabolism ; Biomarkers ; Single-Cell Analysis ; Heme Oxygenase-1/genetics
Chemical Substances	Biomarkers ; HMOX1 protein, human (EC 1.14.14.18) ; Heme Oxygenase-1 (EC 1.14.14.18)
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.14815
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Article: Analysis of the Curative Effect of Curved Angle Vertebroplasty in the Treatment of Osteoporotic Vertebral Compression Fracture.

Yao, Gong / Shen, Yixin / Cai, Bing / Li, Min

Indian journal of orthopaedics

2023 Volume 57, Issue 3, Page(s) 481–489

Abstract: Objective: To evaluate the clinical efficacy of Percutaneous curved vertebroplasty (PCVP) for osteoporotic vertebral compression fracture of the thoracolumbar spine.: Methods: Retrospective analysis of 113 patients with osteoporotic vertebral ... ...

Abstract	Objective: To evaluate the clinical efficacy of Percutaneous curved vertebroplasty (PCVP) for osteoporotic vertebral compression fracture of the thoracolumbar spine. Methods: Retrospective analysis of 113 patients with osteoporotic vertebral compressive fractures (OVCFs) in our hospital from January 2017 to January 2020, a total of 120 diseased vertebrae, were divided into PCVP group (35 cases, 37 sections) and bilateral PVP(BVP) group (78 cases, 83 sections). To compare the distribution of baseline clinical data, pain relief (Visual Analog Scale, VAS), ODI (Oswestry Dability Index, ODI), operation time, intraoperative fluoroscopy, postoperative vertebral body re-fracture, and comparison of bone, and to compare the volume of cement penetration and the leakage rate of bone cement, etc. Results: There was no significant difference in VAS and ODI before operation between the two groups ( Conclusion: Both PCVP and bilateral PVP are safe and effective methods for the treatment of osteoporotic vertebral compression fractures, but PCVP has a short operation time, fewer fluoroscopy times, and a low bone cement leakage rate.
Language	English
Publishing date	2023-02-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	603194-8
ISSN	0019-5413
ISSN	0019-5413
DOI	10.1007/s43465-023-00830-9
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Article ; Online: Harnessing strategies for enhancing diabetic wound healing from the perspective of spatial inflammation patterns.

Cai, Yixin / Chen, Kangli / Liu, Changsheng / Qu, Xue

Bioactive materials

2023 Volume 28, Page(s) 243–254

Abstract: Diabetic wound is a great threat to patient's health and lives. The refractory diabetic wound shows spatial inflammation patterns, in which the early-wound pattern depicts a deprived acute inflammatory response, and the long-term non-healing wound ... ...

Abstract	Diabetic wound is a great threat to patient's health and lives. The refractory diabetic wound shows spatial inflammation patterns, in which the early-wound pattern depicts a deprived acute inflammatory response, and the long-term non-healing wound pattern delineates an excessive and persistent inflammation due to the delayed immune cell infiltration in a positive feedback loop. In this work, we give points to some strategies to normalize the dysregulated immune process based on the spatial inflammation pattern differences in diabetic wound healing. First of all, inhibiting inflammatory response to avoid subsequent persistent and excessive immune infiltration for the early diabetic wound is proposed. However, diabetic wounds are unperceptive trauma that makes patients miss the best treatment time. Therefore, we also introduce two strategies for the long-term non-healing diabetic wound. One strategy is about changing chronic wounds to acute ones, which aims to rejuvenate M1 macrophages in diabetic wounds and make spontaneous M2 polarization possible. To activate the controllable proinflammatory response, western medicine delivers proinflammatory molecules while traditional Chinese medicine develops "wound-pus promoting granulation tissue growth theory". Another strategy to solve long-term non-healing wounds is seeking switches that target M1/M2 transition directly. These investigations draw a map that delineates strategies for enhancing diabetic wound healing from the perspective of spatial inflammation patterns systematically.
Language	English
Publishing date	2023-05-31
Publishing country	China
Document type	Journal Article ; Review
ISSN	2452-199X
ISSN (online)	2452-199X
DOI	10.1016/j.bioactmat.2023.04.019
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Article ; Online: Harnessing strategies for enhancing diabetic wound healing from the perspective of spatial inflammation patterns

Yixin Cai / Kangli Chen / Changsheng Liu / Xue Qu

Bioactive Materials, Vol 28, Iss , Pp 243-

2023 Volume 254

Abstract	Diabetic wound is a great threat to patient's health and lives. The refractory diabetic wound shows spatial inflammation patterns, in which the early-wound pattern depicts a deprived acute inflammatory response, and the long-term non-healing wound pattern delineates an excessive and persistent inflammation due to the delayed immune cell infiltration in a positive feedback loop. In this work, we give points to some strategies to normalize the dysregulated immune process based on the spatial inflammation pattern differences in diabetic wound healing. First of all, inhibiting inflammatory response to avoid subsequent persistent and excessive immune infiltration for the early diabetic wound is proposed. However, diabetic wounds are unperceptive trauma that makes patients miss the best treatment time. Therefore, we also introduce two strategies for the long-term non-healing diabetic wound. One strategy is about changing chronic wounds to acute ones, which aims to rejuvenate M1 macrophages in diabetic wounds and make spontaneous M2 polarization possible. To activate the controllable proinflammatory response, western medicine delivers proinflammatory molecules while traditional Chinese medicine develops “wound-pus promoting granulation tissue growth theory”. Another strategy to solve long-term non-healing wounds is seeking switches that target M1/M2 transition directly. These investigations draw a map that delineates strategies for enhancing diabetic wound healing from the perspective of spatial inflammation patterns systematically.
Keywords	Diabetic wound ; Spatial inflammation pattern ; M1/M2 transition ; Biomaterials ; Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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