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  1. Article ; Online: Impact of Moderate Hyperchloremia on Clinical Outcomes in Intracerebral Hemorrhage Patients. Is There Still Room for Continuous Infusion of 3% Hypertonic Saline?

    Poignant, Simon / Laffon, Marc

    Critical care medicine

    2018  Volume 46, Issue 2, Page(s) e178–e179

    MeSH term(s) Cerebral Hemorrhage ; Humans ; Pilot Projects ; Saline Solution, Hypertonic ; Water-Electrolyte Imbalance
    Chemical Substances Saline Solution, Hypertonic
    Language English
    Publishing date 2018-02-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000002794
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  2. Article ; Online: Coronavirus Disease 2019: Challenges in the Pacific Islands.

    Poignant, Simon / Baudouin, Laure / Vinclair, Marc / Mons, Sandrine

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 72, Issue 4, Page(s) 722–723

    MeSH term(s) COVID-19 ; Humans ; New Caledonia ; Pacific Islands/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa746
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  3. Article ; Online: Comparison of Rainbow Pleth Variability Index and Pleth Variability Index in mechanically ventilated patients under general anaesthesia.

    Berger, Simon / Poignant, Elizabeth / Jacquet-Lagrèze, Matthias / Fellahi, Jean-Luc

    Anaesthesia, critical care & pain medicine

    2020  Volume 40, Issue 1, Page(s) 100735

    MeSH term(s) Anesthesia, General ; Fluid Therapy ; Humans ; Respiration, Artificial
    Language English
    Publishing date 2020-09-17
    Publishing country France
    Document type Letter ; Research Support, Non-U.S. Gov't
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2020.06.018
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  5. Article ; Online: Heart transplantation in Danon disease: A single family displaying diverse phenotypes.

    Poignant, Simon / Bourguignon, Thierry / Espitalier, Fabien

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2017  

    Language English
    Publishing date 2017-11-04
    Publishing country United States
    Document type Letter
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2017.10.027
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    Zs.A 2056: Show issues Location:
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  6. Article ; Online: Streptococcus pyogenes subdural empyema and pre-eclampsia.

    Poignant, Simon / Pigache, Pascaline / Fournier, Eric / Elaroussi, Djilali / Laffon, Marc

    The Lancet. Infectious diseases

    2018  Volume 18, Issue 4, Page(s) 473

    MeSH term(s) Adult ; Empyema, Subdural/complications ; Empyema, Subdural/diagnostic imaging ; Empyema, Subdural/etiology ; Empyema, Subdural/pathology ; Female ; Head/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/pathology ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/pathology ; Streptococcal Infections/complications ; Streptococcal Infections/diagnosis ; Streptococcal Infections/pathology ; Streptococcus pyogenes/isolation & purification
    Language English
    Publishing date 2018-03-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(18)30096-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5743: Show issues Location:
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  7. Article ; Online: Bacterial Pneumonia in Brain-Dead Patients: Clinical Features and Impact on Lung Suitability for Donation.

    Poignant, Simon / Boutrot, Maxime / Ehrmann, Stephan / Remerand, Francis / Venhard, Jean-Christophe / Wolf, Manuel / Boulain, Thierry / Barbier, François

    Critical care medicine

    2020  Volume 48, Issue 12, Page(s) 1760–1770

    Abstract: Objectives: To appraise the epidemiological features of bacterial pneumonia and its impact on lung suitability for donation in brain-dead patients managed with protective ventilatory settings.: Design: Retrospective observational study.: Setting: ... ...

    Abstract Objectives: To appraise the epidemiological features of bacterial pneumonia and its impact on lung suitability for donation in brain-dead patients managed with protective ventilatory settings.
    Design: Retrospective observational study.
    Setting: Six ICUs from two university-affiliated hospitals.
    Patients: Brain-dead adult patients managed in the participating ICUs over a 4-year period.
    Interventions: None.
    Measurements and main results: Among the 231 included patients, 145 (62.8%) were classified as ideal or extended-criteria potential lung donors at ICU admission and the remaining 86 patients having baseline contraindication for donation. Culture-proven aspiration pneumonia and early-onset ventilator-associated pneumonia occurred in 54 patients (23.4%) and 15 patients (6.5%), respectively (overall pneumonia incidence, 29.9%). Staphylococcus aureus and Enterobacterales were the most common pathogens. Using mixed-effects Cox proportional hazard models, age (adjusted hazard ratio, 0.98; 95% CI [0.96-0.99]), anoxic brain injury (3.55 [1.2-10.5]), aspiration (2.29 [1.22-4.29]), and not receiving antimicrobial agents at day 1 (3.56 [1.94-6.53]) were identified as independent predictors of pneumonia occurrence in the whole study population. Analyses restricted to potential lung donors yielded similar results. Pneumonia was associated with a postadmission decrease in the PaO2/FIO2 ratio and lower values at brain death, in the whole study population (estimated marginal mean, 294 [264-323] vs 365 [346-385] mm Hg in uninfected patients; p = 0.0005) as in potential lung donors (299 [248-350] vs 379 [350-408] mm Hg; p = 0.04; linear mixed models). Lungs were eventually retrieved in 31 patients (34.4%) among the 90 potential lung donors with at least one other organ harvested (pneumonia prevalence in lung donors (9.7%) vs nondonors (49.2%); p = 0.0002).
    Conclusions: Pneumonia occurs in one-third of brain-dead patients and appears as the main reason for lung nonharvesting in those presenting as potential lung donors. The initiation of antimicrobial prophylaxis upon the first day of the ICU stay in comatose patients with severe brain injury could enlarge the pool of actual lung donors.
    MeSH term(s) Aged ; Brain Death/pathology ; Humans ; Lung/pathology ; Lung Transplantation ; Male ; Middle Aged ; Pneumonia, Bacterial/complications ; Pneumonia, Bacterial/pathology ; Retrospective Studies ; Tissue Donors
    Language English
    Publishing date 2020-09-30
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000004631
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    Zs.A 1261: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: A One-Day Prospective National Observational Study on Sedation-Analgesia of Patients with Brain Injury in French Intensive Care Units: The SEDA-BIP-ICU (Sedation-Analgesia in Brain Injury Patient in ICU) Study.

    Poignant, Simon / Vigué, Bernard / Balram, Patricia / Biais, Mathieu / Carillon, Romain / Cottenceau, Vincent / Dahyot-Fizelier, Claire / Degos, Vincent / Geeraerts, Thomas / Jeanjean, Patrick / Vega, Emmanuel / Lasocki, Sigismond / Espitalier, Fabien / Laffon, Marc

    Neurocritical care

    2021  Volume 36, Issue 1, Page(s) 266–278

    Abstract: Background: Sedation/analgesia is a daily challenge faced by intensivists managing patients with brain injury (BI) in intensive care units (ICUs). The optimization of sedation in patients with BI presents particular challenges. A choice must be made ... ...

    Abstract Background: Sedation/analgesia is a daily challenge faced by intensivists managing patients with brain injury (BI) in intensive care units (ICUs). The optimization of sedation in patients with BI presents particular challenges. A choice must be made between the potential benefit of a rapid clinical evaluation and the potential exacerbation of intracranial hypertension in patients with impaired cerebral compliance. In the ICU, a pragmatic approach to the use of sedation/analgesia, including the optimal titration, management of multiple drugs, and use of any type of brain monitor, is needed. Our research question was as follows: the aim of the study is to identify what is the current daily practice regarding sedation/analgesia in the management of patients with BI in the ICU in France?
    Methods: This study was composed of two parts. The first part was a descriptive survey of sedation practices and characteristics in 30 French ICUs and 27 academic hospitals specializing in care for patients with BI. This first step validates ICU participation in data collection regarding sedation-analgesia practices. The second part was a 1-day prospective cross-sectional snapshot of all characteristics and prescriptions of patients with BI.
    Results: On the study day, among the 246 patients with BI, 106 (43%) had a brain monitoring device and 74 patients (30%) were sedated. Thirty-nine of the sedated patients (53%) suffered from intracranial hypertension, 14 patients (19%) suffered from agitation and delirium, and 7 patients (9%) were sedated because of respiratory failure. Fourteen patients (19%) no longer had a formal indication for sedation. In 60% of the sedated patients, the sedatives were titrated by nurses based on sedation scales. The Richmond Agitation Sedation Scale was used in 80% of the patients, and the Behavioral Pain Scale was used in 92%. The common sedatives and opioids used were midazolam (58.1%), propofol (40.5%), and sufentanil (67.5%). The cerebral monitoring devices available in the participating ICUs were transcranial Doppler ultrasound (100%), intracranial and intraventricular pressure monitoring (93.3%), and brain tissue oxygenation (60%). Cerebral monitoring by one or more monitoring devices was performed in 62% of the sedated patients. This proportion increased to 74% in the subgroup of patients with intracranial hypertension, with multimodal cerebral monitoring in 43.6%. The doses of midazolam and sufentanil were lower in sedated patients managed based on a sedation/analgesia scale.
    Conclusions: Midazolam and sufentanil are frequently used, often in combination, in French ICUs instead of alternative drugs. In our study, cerebral monitoring was performed in more than 60% of the sedated patients, although that proportion is still insufficient. Future efforts should stress the use of multiple monitoring modes and adherence to the indications for sedation to improve care of patients with BI. Our study suggests that the use of sedation and analgesia scales by nurses involved in the management of patients with BI could decrease the dosages of midazolam and sufentanil administered. Updated guidelines are needed for the management of sedation/analgesia in patients with BI.
    MeSH term(s) Analgesia ; Brain Injuries ; Cross-Sectional Studies ; Humans ; Hypnotics and Sedatives ; Intensive Care Units ; Pain ; Prospective Studies ; Respiration, Artificial
    Chemical Substances Hypnotics and Sedatives
    Language English
    Publishing date 2021-07-30
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-021-01298-x
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  9. Article ; Online: Acute Tetraplegia Caused by Rat Bite Fever in Snake Keeper and Transmission of Streptobacillus moniliformis.

    Eisenberg, Tobias / Poignant, Simon / Jouan, Youenn / Fawzy, Ahmad / Nicklas, Werner / Ewers, Christa / Mereghetti, Laurent / Guillon, Antoine

    Emerging infectious diseases

    2017  Volume 23, Issue 4, Page(s) 719–721

    Abstract: We report acute tetraplegia caused by rat bite fever in a 59-year old man (snake keeper) and transmission of Streptobacillus moniliformis. We found an identical characteristic bacterial pattern in rat and human samples, which validated genotyping-based ... ...

    Abstract We report acute tetraplegia caused by rat bite fever in a 59-year old man (snake keeper) and transmission of Streptobacillus moniliformis. We found an identical characteristic bacterial pattern in rat and human samples, which validated genotyping-based evidence for infection with the same strain, and identified diagnostic difficulties concerning infection with this microorganism.
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2304.161987
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  10. Article ; Online: Acute Tetraplegia Caused by Rat Bite Fever in Snake Keeper and Transmission of Streptobacillus moniliformis

    Tobias Eisenberg / Simon Poignant / Youenn Jouan / Ahmad Fawzy / Werner Nicklas / Christa Ewers / Laurent Mereghetti / Antoine Guillon

    Emerging Infectious Diseases, Vol 23, Iss 4, Pp 719-

    2017  Volume 721

    Abstract: We report acute tetraplegia caused by rat bite fever in a 59-year old man (snake keeper) and transmission of Streptobacillus moniliformis. We found an identical characteristic bacterial pattern in rat and human samples, which validated genotyping-based ... ...

    Abstract We report acute tetraplegia caused by rat bite fever in a 59-year old man (snake keeper) and transmission of Streptobacillus moniliformis. We found an identical characteristic bacterial pattern in rat and human samples, which validated genotyping-based evidence for infection with the same strain, and identified diagnostic difficulties concerning infection with this microorganism.
    Keywords acute tetraplegia ; rat bite fever ; snake keeper ; transmission ; Streptobacillus moniliformis ; bacteria ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2017-04-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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