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  1. Article ; Online: Life-Threatening Wunderlich Syndrome Associated with Apixaban and the Complexity of Anticoagulation Management in Bleeding Patients: A Case Report.

    Maltês, Sérgio / Carvalho Gouveia, Cristina / Serrazina, Filipa / Rebelo, Marta

    Acta medica portuguesa

    2022  Volume 36, Issue 3, Page(s) 206–209

    Abstract: Wunderlich syndrome is a rare and possibly life-threatening haemorrhagic syndrome presenting as spontaneous nontraumatic renal rupture with subcapsular and perinephric haemorrhage. Apixaban, a direct oral anticoagulant recommended in patients with atrial ...

    Abstract Wunderlich syndrome is a rare and possibly life-threatening haemorrhagic syndrome presenting as spontaneous nontraumatic renal rupture with subcapsular and perinephric haemorrhage. Apixaban, a direct oral anticoagulant recommended in patients with atrial fibrillation, has previously been associated with atraumatic solid organ rupture but, to date, no case of apixaban-related Wunderlich syndrome has been reported. We report a rare case of Wunderlich syndrome associated with apixaban while addressing the difficulties face by clinicians when managing anticoagulation in bleeding patients.
    MeSH term(s) Humans ; Anticoagulants/therapeutic use ; Hemorrhage ; Pyrazoles/therapeutic use ; Pyridones/therapeutic use ; Atrial Fibrillation/complications ; Kidney Diseases/complications ; Stroke/complications ; Administration, Oral
    Chemical Substances Anticoagulants ; apixaban (3Z9Y7UWC1J) ; Pyrazoles ; Pyridones
    Language English
    Publishing date 2022-07-08
    Publishing country Portugal
    Document type Case Reports ; Journal Article
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.16941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Coronavirus Disease 2019: Clinical Review.

    Gouveia, Cristina Carvalho / Campos, Luís

    Acta medica portuguesa

    2020  Volume 33, Issue 7-8, Page(s) 505–511

    Abstract: Introduction: In December 2019, an outbreak of pneumonia caused by a novel coronavirus occurred in Wuhan, the capital of Central China's Hubei Province and has been declared a public health emergency of international concern by the World Health ... ...

    Abstract Introduction: In December 2019, an outbreak of pneumonia caused by a novel coronavirus occurred in Wuhan, the capital of Central China's Hubei Province and has been declared a public health emergency of international concern by the World Health Organization since January 2020.
    Material and methods: A comprehensive search using the PubMed database was carried out to summarize the latest published information about the epidemiology, definition, pathogenesis, clinical characteristics, treatment options, prognosis and prevention of coronavirus disease 2019.
    Discussion: This new strain of coronavirus, named severe acute respiratory syndrome coronavirus 2, enters human cells that express angiotensin-converting enzyme II receptors, which exist in the respiratory, gastrointestinal and genitourinary tracts and heart, causing coronavirus disease. Transmission occurs essentially through the respiratory tract and the main symptoms are fever, cough and dyspnea. Diagnosis is based on epidemiological, clinical and imaging features and confirmed by nucleic acid testing.
    Conclusion: Despite intensive research, the exact origin of the virus and pathophysiology of coronavirus disease is not yet completely known, and clinically approved vaccines and drugs that target severe acute respiratory syndrome coronavirus 2 are lacking.
    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Amides/therapeutic use ; Animals ; Antiviral Agents/therapeutic use ; Azithromycin/therapeutic use ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; Blood Coagulation Disorders/prevention & control ; COVID-19 ; China/epidemiology ; Chiroptera/virology ; Chloroquine/therapeutic use ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Glucocorticoids/therapeutic use ; Humans ; Hydroxychloroquine/therapeutic use ; Infectious Disease Incubation Period ; Lopinavir/therapeutic use ; Lung/diagnostic imaging ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Prognosis ; Pyrazines/therapeutic use ; Radiography, Thoracic ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Symptom Assessment
    Chemical Substances Amides ; Antiviral Agents ; Glucocorticoids ; Pyrazines ; Lopinavir (2494G1JF75) ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5) ; Chloroquine (886U3H6UFF) ; favipiravir (EW5GL2X7E0) ; Alanine (OF5P57N2ZX)
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country Portugal
    Document type Journal Article ; Review
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.13957
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Coronavirus Disease 2019

    Cristina Carvalho Gouveia / Luís Campos

    Acta Médica Portuguesa, Vol 33, Iss 7-8, Pp 505-

    Clinical Review

    2020  Volume 511

    Abstract: Introduction: In December 2019, an outbreak of pneumonia caused by a novel coronavirus occurred in Wuhan, the capital of Central China’s Hubei Province and has been declared a public health emergency of international concern by the World Health ... ...

    Abstract Introduction: In December 2019, an outbreak of pneumonia caused by a novel coronavirus occurred in Wuhan, the capital of Central China’s Hubei Province and has been declared a public health emergency of international concern by the World Health Organization since January 2020. Material and Methods: A comprehensive search using the PubMed database was carried out to summarize the latest published information about the epidemiology, definition, pathogenesis, clinical characteristics, treatment options, prognosis and prevention of coronavirus disease 2019. Discussion: This new strain of coronavirus, named severe acute respiratory syndrome coronavirus 2, enters human cells that express angiotensin-converting enzyme II receptors, which exist in the respiratory, gastrointestinal and genitourinary tracts and heart, causing coronavirus disease. Transmission occurs essentially through the respiratory tract and the main symptoms are fever, cough and dyspnea. Diagnosis is based on epidemiological, clinical and imaging features and confirmed by nucleic acid testing. Conclusion: Despite intensive research, the exact origin of the virus and pathophysiology of coronavirus disease is not yet completely known, and clinically approved vaccines and drugs that target severe acute respiratory syndrome coronavirus 2 are lacking.
    Keywords coronavirus infections ; covid-19 ; severe acute respiratory syndrome ; Medicine ; R ; Medicine (General) ; R5-920 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Ordem dos Médicos
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article: Mitral Valve Infective Endocarditis Complicated With Coronary Artery Embolization.

    Carvalho Gouveia, Cristina / Pimenta, Inês / Fernandes, Marco / Chambino, Beatriz / Côrte-Real, Hugo

    Cureus

    2022  Volume 14, Issue 1, Page(s) e21459

    Abstract: Infective endocarditis is a multisystem and potentially fatal disease. Systemic embolization is a relatively common complication, the spleen and central nervous system being the most frequent sites for septic emboli formation. Coronary artery septic ... ...

    Abstract Infective endocarditis is a multisystem and potentially fatal disease. Systemic embolization is a relatively common complication, the spleen and central nervous system being the most frequent sites for septic emboli formation. Coronary artery septic embolization is extremely uncommon and its management remains controversial. We present the case of a 50-year-old male diagnosed with mitral valve infective endocarditis complicated with spleen and central nervous system embolization, who developed acute myocardial infarction two weeks after disease onset. The patient was successfully treated with combined mitral valve replacement and coronary artery bypass grafting.
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.21459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Life-Threatening Wunderlich Syndrome Associated with Apixaban and the Complexity of Anticoagulation Management in Bleeding Patients

    Sérgio Maltês / Cristina Carvalho Gouveia / Filipa Serrazina / Marta Rebelo

    Acta Médica Portuguesa, Vol 36, Iss 3, Pp 206-

    A Case Report

    2022  Volume 209

    Abstract: Wunderlich syndrome is a rare and possibly life-threatening haemorrhagic syndrome presenting as spontaneous nontraumatic renal rupture with subcapsular and perinephric haemorrhage. Apixaban, a direct oral anticoagulant recommended in patients with atrial ...

    Abstract Wunderlich syndrome is a rare and possibly life-threatening haemorrhagic syndrome presenting as spontaneous nontraumatic renal rupture with subcapsular and perinephric haemorrhage. Apixaban, a direct oral anticoagulant recommended in patients with atrial fibrillation, has previously been associated with atraumatic solid organ rupture but, to date, no case of apixaban-related Wunderlich syndrome has been reported. We report a rare case of Wunderlich syndrome associated with apixaban while addressing the difficulties face by clinicians when managing anticoagulation in bleeding patients.
    Keywords acute kidney injury ; anticoagulants/adverse effects ; hemorrage ; kidney diseases/chemically induced ; rupture ; spontaneous ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Ordem dos Médicos
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  6. Article: An Unusual Cause of Knee Mass: Osseous Hydatidosis.

    Carvalho Gouveia, Cristina / Morais, Margarida / Correia, Maria João / Marques, Tiago / Pereira, Álvaro

    Cureus

    2021  Volume 13, Issue 10, Page(s) e18556

    Abstract: Hydatid disease (hydatidosis) is a zoonotic infection caused by the larval stage of the parasitic ... ...

    Abstract Hydatid disease (hydatidosis) is a zoonotic infection caused by the larval stage of the parasitic tapeworm
    Language English
    Publishing date 2021-10-06
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.18556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A New Perspective for Vineyard Terroir Identity: Looking for Microbial Indicator Species by Long Read Nanopore Sequencing.

    Cruz-Silva, Ana / Laureano, Gonçalo / Pereira, Marcelo / Dias, Ricardo / Silva, José Moreira da / Oliveira, Nuno / Gouveia, Catarina / Cruz, Cristina / Gama-Carvalho, Margarida / Alagna, Fiammetta / Duarte, Bernardo / Figueiredo, Andreia

    Microorganisms

    2023  Volume 11, Issue 3

    Abstract: Grapevine is one of the most important fruit crops worldwide, being Portugal one of the top wine producers. It is well established that wine sensory characteristics from a particular region are defined by the physiological responses of the grapevine to ... ...

    Abstract Grapevine is one of the most important fruit crops worldwide, being Portugal one of the top wine producers. It is well established that wine sensory characteristics from a particular region are defined by the physiological responses of the grapevine to its environment and thus, the concept of terroir in viticulture was established. Among all the factors that contribute to terroir definition, soil microorganisms play a major role from nutrient recycling to a drastic influence on plant fitness (growth and protection) and of course wine production. Soil microbiome from four different terroirs in Quinta dos Murças vineyard was analysed through long-read Oxford Nanopore sequencing. We have developed an analytical pipeline that allows the identification of function, ecologies, and indicator species based on long read sequencing data. The Douro vineyard was used as a case study, and we were able to establish microbiome signatures of each terroir.
    Language English
    Publishing date 2023-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11030672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Coronavirus Disease 2019: Clinical Review

    Gouveia, Cristina Carvalho / Campos, Luís

    Acta Med Port

    Abstract: INTRODUCTION: In December 2019, an outbreak of pneumonia caused by a novel coronavirus occurred in Wuhan, the capital of Central China's Hubei Province and has been declared a public health emergency of international concern by the World Health ... ...

    Abstract INTRODUCTION: In December 2019, an outbreak of pneumonia caused by a novel coronavirus occurred in Wuhan, the capital of Central China's Hubei Province and has been declared a public health emergency of international concern by the World Health Organization since January 2020. MATERIAL AND METHODS: A comprehensive search using the PubMed database was carried out to summarize the latest published information about the epidemiology, definition, pathogenesis, clinical characteristics, treatment options, prognosis and prevention of coronavirus disease 2019. DISCUSSION: This new strain of coronavirus, named severe acute respiratory syndrome coronavirus 2, enters human cells that express angiotensin-converting enzyme II receptors, which exist in the respiratory, gastrointestinal and genitourinary tracts and heart, causing coronavirus disease. Transmission occurs essentially through the respiratory tract and the main symptoms are fever, cough and dyspnea. Diagnosis is based on epidemiological, clinical and imaging features and confirmed by nucleic acid testing. CONCLUSION: Despite intensive research, the exact origin of the virus and pathophysiology of coronavirus disease is not yet completely known, and clinically approved vaccines and drugs that target severe acute respiratory syndrome coronavirus 2 are lacking.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #844091
    Database COVID19

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  9. Article ; Online: Scenarios of environmental deterioration in the Paraopeba River, in the three years after the breach of B1 tailings dam in Brumadinho (Minas Gerais, Brazil).

    Mendes, Rafaella Gouveia / do Valle Junior, Renato Farias / de Melo Silva, Maytê Maria Abreu Pires / de Morais Fernandes, Gabriel Henrique / Fernandes, Luís Filipe Sanches / Pissarra, Teresa Cristina Tarlé / de Melo, Marília Carvalho / Valera, Carlos Alberto / Pacheco, Fernando António Leal

    The Science of the total environment

    2023  Volume 891, Page(s) 164426

    Abstract: The collapse of B1 dam at the Córrego do Feijão mine of Vale, S.A., located in the Ferro-Carvão stream watershed (Brazil), released 11.7 ... ...

    Abstract The collapse of B1 dam at the Córrego do Feijão mine of Vale, S.A., located in the Ferro-Carvão stream watershed (Brazil), released 11.7 Mm
    Language English
    Publishing date 2023-05-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.164426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers.

    Rodrigues, Fernanda Guedes / Ormanji, Milene Subtil / Pietrobom, Igor Gouveia / Matos, Ana Cristina Carvalho de / De Borst, Martin H / Heilberg, Ita Pfeferman

    Journal of clinical medicine

    2023  Volume 12, Issue 15

    Abstract: Background: Sclerostin plays an important role in bone metabolism and adipose tissue. Animal studies suggest that sclerostin influences urinary calcium (UCa), but this relationship has not been evaluated in stone formers (SFs). We aimed to investigate ... ...

    Abstract Background: Sclerostin plays an important role in bone metabolism and adipose tissue. Animal studies suggest that sclerostin influences urinary calcium (UCa), but this relationship has not been evaluated in stone formers (SFs). We aimed to investigate the association of UCa with serum sclerostin, bone mineral density (BMD), and body composition among SFs.
    Methods: Clinical and laboratorial data were retrieved from medical records. Determinants of UCa were studied using linear regression.
    Results: A total of 107 SFs (35.8 ± 9.3 years, 54% male) with eGFR 99.8 ± 14.5 mL/min/1.73 were studied. Subjects were split by sex and grouped into tertiles of UCa levels. Men in the highest UCa tertile had higher body mass index (BMI) and serum sclerostin, lower lean mass, and a trend towards higher fat mass. Women in the highest tertile had higher BMI and a trend towards higher serum sclerostin. Hypertension and metabolic syndrome, but not lower BMD, were more prevalent in the highest UCa tertile for both sexes. Sclerostin was positively correlated with fat mass and inversely correlated with lean mass among men, but not among women. BMD corrected for BMI at lumbar spine was inversely associated with UCa in a univariate analysis, but only serum sclerostin, hypertension, and NaCl intake were independent determinants of UCa in the multivariate model.
    Conclusion: The present findings disclose that in addition to hypertension and salt intake, serum sclerostin is associated with urinary calcium in stone formers, suggesting that in addition to the hormones traditionally thought to alter calcium reabsorption in the kidney, sclerostin may play a significant additional role, warranting further investigation.
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12155027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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