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  1. Book: Identification and control of common weeds / Volume 3 / Zhenghao Xu ; Le Chang

    Xu, Zhenghao / Zhou, Guoning / Deng, Meihua / Chang, Le

    2017  

    Author's details Zhenghao Xu, Meihua Deng
    Collection Identification and control of common weeds
    Language English
    Size xix, 944 Seiten
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT019402628
    ISBN 978-981-10-5402-0 ; 9789811054037 ; 981-10-5402-9 ; 9811054037
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    178/589 available for loan (reading room) Freihandmagazin (U1)

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  2. Article ; Online: The effect of Le Fort III procedure in the treatment of obstructive sleep apnea in children with syndromic craniosynostosis.

    Chang, Yuan / Zhang, Wei / Li, Mengjie / Gao, Yinghui / Feng, Junjun / Yu, Yongbo / Han, Fang

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2024  

    Abstract: ... of ongoing debate. This study aimed to explore the efficacy of Le Fort III procedure in the management of OSA ... criteria were those who underwent Le Fort III surgery and had both baseline PSG and follow-up sleep studies ... Twenty-five received the Le Fort III procedure and follow-up sleep studies. The Le Fort III procedure ...

    Abstract Study objectives: Obstructive sleep apnea (OSA) is common in children with Syndromic Craniosynostosis (SC). The efficacy of Fort III procedure in managing OSA in children with SC remains a subject of ongoing debate. This study aimed to explore the efficacy of Le Fort III procedure in the management of OSA in children with SC.
    Methods: A retrospective study was performed in children with SC and OSA diagnosed by polysomnography (PSG), which was defined as an apnea and hypopnea index (AHI) ≥ 1. Patients meeting the inclusion criteria were those who underwent Le Fort III surgery and had both baseline PSG and follow-up sleep studies. Relevant clinical and demographic data were collected from all subjects who participated in the study.
    Results: Overall, forty-five OSA children with SC were identified, with a mean age of 6.8 ± 4.7 years. Twenty-five received the Le Fort III procedure and follow-up sleep studies. The Le Fort III procedure resulted in a significant reduction in AHI (6.0 [2.6, 10.1] versus 37.6 [20.9, 48.0] events/h;
    Conclusions: The Le Fort III procedure is efficacious in the treatment of OSA in children with SC. However, despite the observed improvement, residual OSA following treatment remains common.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.11144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6590: Show issues Location:
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  3. Article ; Online: Comparison study of the Le Fort I osteotomy using 2- and 4-plate fixation.

    Fujio, Masahito / Sayo, Akira / Ogisu, Kota / Chang, Qi / Tsuboi, Makoto / Hibi, Hideharu

    Nagoya journal of medical science

    2023  Volume 85, Issue 1, Page(s) 70–78

    Abstract: This study was conducted to evaluate the postsurgical stability of Le Fort I osteotomy using ... with maxillary retrognathia and mandibular prognathism underwent the Le Fort I osteotomy with a bilateral ... however, within the limitations of the study, the choice of the number of plates for osteosynthesis following Le ...

    Abstract This study was conducted to evaluate the postsurgical stability of Le Fort I osteotomy using zygomatic buttress internal fixation alone with no piriform aperture internal fixation. Patients with maxillary retrognathia and mandibular prognathism underwent the Le Fort I osteotomy with a bilateral sagittal split ramus osteotomy. In group I, fixation was accomplished using titanium plate and screws placed at the piriform aperture and the zygomatic buttress (4 plates). In group II, fixation was accomplished using titanium plate and screws placed at the zygomatic buttress (2 plates). Lateral cephalometric radiographs were taken preoperatively (T1), immediately after surgery (T2), and at 6 months to 1 year (T3) to evaluate skeletal movement. In total, 32 patients were included in this study. None of the patients had wound infection, dehiscence, bone fragment instability, and long-term malocclusion. Regarding point A and the posterior nasal spine (PNS), vertical and horizontal relapse in groups I and II did not differ significantly. In most hospitals, the maxilla was fixed using four plates (piriform aperture and zygomatic buttress); however, within the limitations of the study, the choice of the number of plates for osteosynthesis following Le Fort I osteotomy and repositioning of the maxilla can be left to the discretion of the surgeon without putting the patients at risk for increased relapse by careful intraoperative management.
    MeSH term(s) Humans ; Titanium ; Osteotomy, Le Fort ; Bone Plates ; Maxilla/diagnostic imaging ; Maxilla/surgery ; Recurrence
    Chemical Substances Titanium (D1JT611TNE)
    Language English
    Publishing date 2023-02-27
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 193148-9
    ISSN 2186-3326 ; 0027-7622
    ISSN (online) 2186-3326
    ISSN 0027-7622
    DOI 10.18999/nagjms.85.1.70
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Deciphering the Underlying Mechanisms of Formula Le-Cao-Shi Against Liver Injuries by Integrating Network Pharmacology, Metabonomics, and Experimental Validation.

    Zhao, Qing / Ren, Xia / Song, Shu-Yue / Yu, Ri-Lei / Li, Xin / Zhang, Peng / Shao, Chang-Lun / Wang, Chang-Yun

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 884480

    Abstract: Le-Cao-Shi (LCS) has long been used as a folk traditional Chinese medicine formula against liver ...

    Abstract Le-Cao-Shi (LCS) has long been used as a folk traditional Chinese medicine formula against liver injuries, whereas its pharmacological mechanisms remain elusive. Our study aims to investigate the underlying mechanism of LCS in treating liver injuries
    Language English
    Publishing date 2022-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.884480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The underlying mechanisms of anti-hepatitis B effects of formula Le-Cao-Shi and its single herbs by network pharmacology and gut microbiota analysis.

    Zhao, Qing / Song, Shu-Yue / Zhang, Yu-Qi / Ren, Xia / Zhang, Peng / Li, Xin / Fu, Xiu-Mei / Wang, Chang-Yun

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2022  Volume 148, Page(s) 112692

    Abstract: Formula Le-Cao-Shi (LCS), a traditional Chinese medicine (TCM), has been used as folk remedy ...

    Abstract Formula Le-Cao-Shi (LCS), a traditional Chinese medicine (TCM), has been used as folk remedy for treating hepatitis B for a long time. In our previous study, the anti-hepatitis B effects of LCS have been verified. In the present study, the anti-hepatitis B activities of LCS and its three single herbs were investigated in vitro by HepG2.2.15 cellular model, and the mechanisms against hepatitis B were deciphered via network pharmacology and gut microbiota analysis. By network pharmacology method, twelve key compounds that played a vital role in LCS were filtered from 213 ingredients. The targets RORA, CDK2, RELA, AKT1, IKBKG, PRKCβ and CASP3 were directly related to hepatitis B pathway, which indicated that LCS could exert anti-hepatitis B effect by co-regulating cell cycle and inflammatory pathways. The interactions between candidate compounds and target proteins that were directly involved in hepatitis B pathway were validated by molecular docking simulation and RT-PCR. By gut microbiota analysis, it was revealed that LCS could alter the disordered microbial composition in the infected ducks towards normal, especially the restoration of three key strains, namely Streptococcus alactolyticus, Enterococcus cecorum and Bacteroides fragilis. The above findings could provide a scientific basis for further development and utilization of LCS against hepatitis B.
    MeSH term(s) Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Gastrointestinal Microbiome ; Medicine, Chinese Traditional/methods ; Molecular Docking Simulation ; Network Pharmacology
    Chemical Substances Drugs, Chinese Herbal ; Le-Cao-Shi
    Language English
    Publishing date 2022-02-09
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2022.112692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.198: Show issues Location:
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  6. Article ; Online: Janus Metal-Organic Frameworks/Wood Aerogel Composites for Boosting Catalytic Performance by Le Châtelier's Principle.

    Wu, Ming-Bang / Zhang, Chao / Xie, Yi / Huang, Sheng / Liu, Chang / Wu, Jian / Xu, Zhi-Kang

    ACS applied materials & interfaces

    2021  Volume 13, Issue 43, Page(s) 51039–51047

    Abstract: ... Herein, we first report MOFs composites with Janus structures to boost catalytic performance by Le ...

    Abstract Elaborate design of metal-organic frameworks (MOFs) composites with enhanced properties is of fundamental interest and practical importance in the fields of catalysis. Typical strategies are usually focused on how to increase MOFs contents while lacking architecture design for performance improvements. Herein, we first report MOFs composites with Janus structures to boost catalytic performance by Le Châtelier's principle when using wood aerogel as a versatile platform. Janus structures mean that one part of the composite is still wood aerogel while the other part is decorated with MOFs. The underoil hydrophilicity of the wood aerogels endows the Janus composites with dehydration capacity for promoting the equilibrium movement so as to boost the catalytic performance. The catalytic performance of Janus composites for the Knoevenagel reaction increases more than 40% compared with those symmetric composites. Moreover, both the final conversion and the reaction rate are much better for the Janus composites than other state-of-the-art heterogeneous ZIF-8-based catalysts. Our design is general and paves the way to exploit composites with special architecture.
    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.1c15738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Application of Le Fort Ⅲ osteotomy with minimal invasive approach in the treatment of midfacial hypoplasia].

    Wang, Ruichen / Liu, Chunming / Gao, Quanwen / Hou, Min / Liang, Limin / Yao, Yusheng / Ma, Zuo / Jin, Zenggiang / Chang, Shimin

    Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery

    2018  Volume 32, Issue 2, Page(s) 93–97

    Abstract: Objective: To describe a minimal invasive approach in the Le Fort Ⅲ osteotomy procedure ... Methods: 33 cases with midfacial hypoplasia were treated by Le Fort Ⅲ osteotomy.Incisions were performed ... Conclusion: The Le Fort Ⅲ osteotomy procedure could be successfully performed through minimal approach ...

    Abstract Objective: To describe a minimal invasive approach in the Le Fort Ⅲ osteotomy procedure.
    Methods: 33 cases with midfacial hypoplasia were treated by Le Fort Ⅲ osteotomy.Incisions were performed with minimal invasive approach,through lower eyelid,intraoral and upper eyelid crease or medial part of eyebrow instead of coronal incision.After the completion of osteotomy,distraction osteogenesis or orthognathic procedures were followed.
    Results: The midfacial segments achieved enough advancement without obvious relapse.Bleeding and operative time were reduced compared with coronal approach.No obvious scar was left.
    Conclusion: The Le Fort Ⅲ osteotomy procedure could be successfully performed through minimal approach with steady results and minimal scars.
    Language Chinese
    Publishing date 2018-05-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 2019799-8
    ISSN 1009-4598 ; 1000-7806
    ISSN 1009-4598 ; 1000-7806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3058: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Deciphering the Underlying Mechanisms of Formula Le-Cao-Shi Against Liver Injuries by Integrating Network Pharmacology, Metabonomics, and Experimental Validation

    Qing Zhao / Xia Ren / Shu-Yue Song / Ri-Lei Yu / Xin Li / Peng Zhang / Chang-Lun Shao / Chang-Yun Wang

    Frontiers in Pharmacology, Vol

    2022  Volume 13

    Abstract: Le-Cao-Shi (LCS) has long been used as a folk traditional Chinese medicine formula against liver ...

    Abstract Le-Cao-Shi (LCS) has long been used as a folk traditional Chinese medicine formula against liver injuries, whereas its pharmacological mechanisms remain elusive. Our study aims to investigate the underlying mechanism of LCS in treating liver injuries via integrated network pharmacology, metabonomics, and experimental validation. By network pharmacology, 57 compounds were screened as candidate compounds based on ADME parameters from the LCS compound bank (213 compounds collected from the literature of three single herbs). According to online compound–target databases, the aforementioned candidate compounds were predicted to target 87 potential targets related to liver injuries. More than 15 pathways connected with these potential targets were considered vital pathways in collectively modulating liver injuries, which were found to be relevant to cancer, xenobiotic metabolism by cytochrome P450 enzymes, bile secretion, inflammation, and antioxidation. Metabonomics analysis by using the supernatant of the rat liver homogenate with UPLC-Q-TOF/MS demonstrated that 18 potential biomarkers could be regulated by LCS, which was closely related to linoleic acid metabolism, glutathione metabolism, cysteine and methionine metabolism, and glycerophospholipid metabolism pathways. Linoleic acid metabolism and glutathione metabolism pathways were two key common pathways in both network pharmacology and metabonomics analysis. In ELISA experiments with the CCl4-induced rat liver injury model, LCS was found to significantly reduce the levels of inflammatory parameters, decrease liver malondialdehyde (MDA) levels, and enhance the activities of hepatic antioxidant enzymes, which validated that LCS could inhibit liver injuries through anti-inflammatory property and by suppressing lipid peroxidation and improving the antioxidant defense system. Our work could provide new insights into the underlying pharmacological mechanisms of LCS against liver injuries, which is beneficial for its further investigation and modernization.
    Keywords traditional Chinese medicine ; formula Le-Cao-Shi ; liver injury ; network pharmacology ; metabonomics ; Therapeutics. Pharmacology ; RM1-950
    Subject code 500
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: The underlying mechanisms of anti-hepatitis B effects of formula Le-Cao-Shi and its single herbs by network pharmacology and gut microbiota analysis

    Qing Zhao / Shu-Yue Song / Yu-Qi Zhang / Xia Ren / Peng Zhang / Xin Li / Xiu-Mei Fu / Chang-Yun Wang

    Biomedicine & Pharmacotherapy, Vol 148, Iss , Pp 112692- (2022)

    2022  

    Abstract: Formula Le-Cao-Shi (LCS), a traditional Chinese medicine (TCM), has been used as folk remedy ...

    Abstract Formula Le-Cao-Shi (LCS), a traditional Chinese medicine (TCM), has been used as folk remedy for treating hepatitis B for a long time. In our previous study, the anti-hepatitis B effects of LCS have been verified. In the present study, the anti-hepatitis B activities of LCS and its three single herbs were investigated in vitro by HepG2.2.15 cellular model, and the mechanisms against hepatitis B were deciphered via network pharmacology and gut microbiota analysis. By network pharmacology method, twelve key compounds that played a vital role in LCS were filtered from 213 ingredients. The targets RORA, CDK2, RELA, AKT1, IKBKG, PRKCβ and CASP3 were directly related to hepatitis B pathway, which indicated that LCS could exert anti-hepatitis B effect by co-regulating cell cycle and inflammatory pathways. The interactions between candidate compounds and target proteins that were directly involved in hepatitis B pathway were validated by molecular docking simulation and RT-PCR. By gut microbiota analysis, it was revealed that LCS could alter the disordered microbial composition in the infected ducks towards normal, especially the restoration of three key strains, namely Streptococcus alactolyticus, Enterococcus cecorum and Bacteroides fragilis. The above findings could provide a scientific basis for further development and utilization of LCS against hepatitis B.
    Keywords Traditional Chinese medicine ; Formula Le-Cao-Shi ; Single herb ; Anti-hepatitis B effect ; Network pharmacology ; Gut microbiota ; Therapeutics. Pharmacology ; RM1-950
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: Effects of traditional Chinese medicine formula Le-Cao-Shi on hepatitis B: In vivo and in vitro studies.

    Zhao, Qing / Ren, Xia / Chen, Min / Yue, Shi-Jun / Zhang, Meng-Qi / Chen, Kai-Xian / Guo, Yue-Wei / Shao, Chang-Lun / Wang, Chang-Yun

    Journal of ethnopharmacology

    2019  Volume 244, Page(s) 112132

    Abstract: Ethnopharmacological relevance: Formula Le-Cao-Shi (LCS) is a traditional Chinese medicine (TCM ...

    Abstract Ethnopharmacological relevance: Formula Le-Cao-Shi (LCS) is a traditional Chinese medicine (TCM), which has long been used as a folk remedy against hepatitis B in China. The present study was conducted to evaluate the anti-hepatitis B effects of aqueous extract of LCS in vivo and in vitro.
    Materials and method: we investigated the anti-HBV effects of LCS in vivo and in vitro with duck hepatitis B model and HepG2.2.15 cell line model, respectively. The serologic and cellular biomarkers and the histopathological changes were examined.
    Results: By a duck hepatitis B model, the extract of LCS was found to restrain the expressions of duck hepatitis B surface antigen (DHBsAg), hepatitis B e antigen (DHBeAg), and HBV-DNA (DHBV-DNA). Moreover, LCS could decrease the levels of aspartate and alanine aminotransferases (AST and ALT) and ameliorate duck liver histological lesions. Correspondingly, in a HepG2.2.15 cellular model, LCS could also significantly inhibit the secretions of HBsAg and HBeAg.
    Conclusion: LCS exerted potent anti-hepatitis effects against the infection of HBV. The above results demonstrated the first-hand experimental evidences for the anti-hepatitis B efficiency of LCS. Our study provides a basis for further exploration and development of this promising compound prescription to treat hepatitis B disease.
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Cell Line, Tumor ; Cell Survival/drug effects ; DNA, Viral ; Drugs, Chinese Herbal/therapeutic use ; Ducks ; Hepatitis B/drug therapy ; Hepatitis B/immunology ; Hepatitis B/pathology ; Hepatitis B/virology ; Hepatitis B Surface Antigens/immunology ; Hepatitis B Virus, Duck/drug effects ; Hepatitis B Virus, Duck/genetics ; Hepatitis B Virus, Duck/immunology ; Hepatitis B e Antigens/immunology ; Hepatitis, Viral, Animal/drug therapy ; Hepatitis, Viral, Animal/immunology ; Hepatitis, Viral, Animal/pathology ; Hepatitis, Viral, Animal/virology ; Humans ; Liver/drug effects ; Liver/pathology ; Medicine, Chinese Traditional
    Chemical Substances Antiviral Agents ; DNA, Viral ; Drugs, Chinese Herbal ; Hepatitis B Surface Antigens ; Hepatitis B e Antigens ; Le-Cao-Shi
    Language English
    Publishing date 2019-08-02
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2019.112132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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