LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 208

Search options

  1. Article ; Online: Interview with Amr H Sawalha: epigenetics and autoimmunity.

    Sawalha, Amr H

    Epigenomics

    2017  Volume 9, Issue 4, Page(s) 379–382

    Abstract: Amr H Sawalha is Professor of Internal Medicine and Marvin and Betty Danto Research Professor ...

    Abstract Amr H Sawalha is Professor of Internal Medicine and Marvin and Betty Danto Research Professor of Connective Tissue Research at the University of Michigan, Department of Internal Medicine, Division of Rheumatology. He also holds faculty appointments at the Center for Computational Medicine and Bioinformatics and the Graduate Program in Immunology at the University of Michigan. He was recently appointed as Guest Professor at Central South University in Changsha, China. He received his medical degree from Jordan University of Science and Technology and completed his residency training in internal medicine at the University of Oklahoma Health Sciences Center, and his fellowship in rheumatology at the University of Michigan. His research focus is the genetics and epigenetics of complex autoimmune and inflammatory diseases, including lupus and systemic vasculitis. He has authored over 100 peer-reviewed manuscripts, book chapters and review articles, and is on the editorial board of several journals in his field. He has been elected as a member of the American Society for Clinical Investigation, and has received numerous awards, including the Edmund L Dubois, MD, Memorial Lectureship Award from the American College of Rheumatology in recognition for his work in lupus. He is Chair of the Lupus Foundation of America research subcommittee and is a member of the Vasculitis Foundation Medical and Scientific Advisory Board. He also provides clinical care and teaching in the rheumatology outpatient and inpatient services, and he is the director of the NIH-funded rheumatology training grant at the University of Michigan.
    MeSH term(s) Autoimmune Diseases/diagnosis ; Autoimmune Diseases/genetics ; Autoimmune Diseases/history ; Autoimmune Diseases/therapy ; Autoimmunity ; Computational Biology ; Epigenesis, Genetic ; Epigenomics/trends ; History, 20th Century ; History, 21st Century ; Humans ; United States
    Language English
    Publishing date 2017-04
    Publishing country England
    Document type Biography ; Historical Article ; Interview
    ISSN 1750-192X
    ISSN (online) 1750-192X
    DOI 10.2217/epi-2017-0005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: Pediatric rheumatology: A special issue from the European Journal of Rheumatology.

    Sawalha, Amr H

    European journal of rheumatology

    2022  Volume 7, Issue Suppl1, Page(s) S1–S2

    Language English
    Publishing date 2022-07-29
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2873727-1
    ISSN 2148-4279 ; 2147-9720
    ISSN (online) 2148-4279
    ISSN 2147-9720
    DOI 10.5152/eurjrheum.2020.090120
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Behçet's Disease: From Bench To Bedside.

    Sawalha, Amr H / Direskeneli, Haner

    Clinical immunology (Orlando, Fla.)

    2023  Volume 254, Page(s) 109711

    MeSH term(s) Humans ; Behcet Syndrome
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2023.109711
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Patients with lupus are not protected from COVID-19.

    Sawalha, Amr H

    Annals of the rheumatic diseases

    2020  Volume 80, Issue 2, Page(s) e21

    MeSH term(s) COVID-19 ; Humans ; Hydroxychloroquine ; Immunosuppressive Agents ; SARS-CoV-2
    Chemical Substances Immunosuppressive Agents ; Hydroxychloroquine (4QWG6N8QKH)
    Keywords covid19
    Language English
    Publishing date 2020-04-24
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-217656
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Intestinal permeability correlates with disease activity and DNA methylation changes in lupus patients.

    Bowes, Mckenna M / Casares-Marfil, Desiré / Sawalha, Amr H

    Clinical immunology (Orlando, Fla.)

    2024  Volume 262, Page(s) 110173

    Abstract: Objective: Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease that can involve various organ systems. Several studies have suggested that increased intestinal permeability may play a role in the pathogenesis of lupus. The aim of ...

    Abstract Objective: Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease that can involve various organ systems. Several studies have suggested that increased intestinal permeability may play a role in the pathogenesis of lupus. The aim of this study was to elucidate the relationship between intestinal permeability, disease activity, and epigenetic changes in lupus patients.
    Methods: A total of 25 female lupus patients were included in this study. Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores were used as indicator of disease activity. Plasma zonulin levels were measured, using an ELISA, as a marker of intestinal permeability. Genome-wide DNA methylation patterns were assessed in neutrophils for 19 of the lupus patients using the Infinium MethylationEPIC array. Linear regression and Pearson's correlation were used to evaluate the correlation between zonulin concentrations and SLEDAI scores. The relationship between DNA methylation levels and zonulin concentrations was assessed using beta regression, linear regression, and Pearson's correlation, adjusting for age and race.
    Results: Intestinal permeability positively correlated with disease activity in lupus patients (p-value = 7.60 × 10
    Conclusion: Our data suggest a correlation between increased intestinal permeability and disease activity in lupus patients. Further, increased intestinal permeability might be associated with epigenetic changes that could play a role in the pathogenesis of lupus.
    MeSH term(s) Humans ; Female ; DNA Methylation ; Intestinal Barrier Function ; Epigenesis, Genetic ; Lupus Erythematosus, Systemic/genetics ; Case-Control Studies
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2024.110173
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Medical Licensure: It Is Time to Eliminate Practice Borders Within the United States.

    Sawalha, Amr H

    The American journal of medicine

    2020  Volume 133, Issue 10, Page(s) 1120–1121

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Federal Government ; Humans ; Licensure ; Licensure, Medical/legislation & jurisprudence ; National Institutes of Health (U.S.) ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; State Government ; United States ; United States Department of Veterans Affairs ; United States Indian Health Service ; Veterans Health Services
    Keywords covid19
    Language English
    Publishing date 2020-05-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2020.04.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: The Role of Oxidative Stress in Epigenetic Changes Underlying Autoimmunity.

    Zheng, Xiaoqing / Sawalha, Amr H

    Antioxidants & redox signaling

    2022  Volume 36, Issue 7-9, Page(s) 423–440

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Animals ; Autoimmune Diseases/genetics ; Autoimmune Diseases/metabolism ; Autoimmunity/genetics ; DNA Methylation ; Epigenesis, Genetic ; Oxidative Stress/genetics
    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2021.0066
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Reply.

    Sawalha, Amr H

    Arthritis & rheumatology (Hoboken, N.J.)

    2019  Volume 72, Issue 2, Page(s) 373–374

    MeSH term(s) Animals ; Mice ; Mice, Inbred MRL lpr
    Language English
    Publishing date 2019-12-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.41132
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: BCL-6 and EZH2 cooperate to epigenetically repress anti-inflammatory miR-142-3p/5p in lupus CD4+T cells.

    Sawalha, Amr H

    Cellular & molecular immunology

    2019  Volume 18, Issue 2, Page(s) 504–505

    MeSH term(s) Antagomirs ; Anti-Inflammatory Agents ; Lymphocyte Activation ; MicroRNAs/genetics
    Chemical Substances Antagomirs ; Anti-Inflammatory Agents ; MicroRNAs
    Language English
    Publishing date 2019-09-11
    Publishing country China
    Document type Journal Article ; Comment
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-019-0288-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top