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  1. Book ; Online ; Conference proceedings ; E-Book: Computational advances in bio and medical sciences

    Jha, Sumit Kumar

    10th international conference, ICCABS 2020, virtual event, December 10-12, 2020, revised selected papers

    (Lecture Notes in Computer Science ; v.12686)

    2021  

    Author's details edited by Sumit Kumar Jha [and three others]
    Series title Lecture Notes in Computer Science ; v.12686
    Keywords Computers, Special purpose ; Medical informatics ; Bioinformatics
    Subject code 570.285
    Language English
    Size 1 online resource (149 pages)
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; Conference proceedings ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-79290-0 ; 3-030-79289-7 ; 978-3-030-79290-9 ; 978-3-030-79289-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book: Surgery of brachial plexus

    Mahapatra, Ashok Kumar / Midha, Rajiv / Sinha, Sumit

    2019  

    Author's details A. K. Mahapatra, Rajiv Midha, Sumit Sinha
    Keywords Brachial Plexus Surgery ; Peripheral Nerve Surgery ; Brachial Plexus Injuries ; Shoulder Surgery ; 810 ; Armplexusverletzung ; Operationstechnik
    Subject Operative Technik ; Chirurgisches Verfahren ; Operationsverfahren ; Plexus brachialis
    Subject code 610
    Language English
    Size xviii, 209 Seiten, Illustrationen, 21.6 cm x 27.9 cm
    Publisher Indian Society of Peripheral Nerve Surgery ; Thieme
    Publishing place Gurgaon ; Delhi
    Publishing country India
    Document type Book
    HBZ-ID HT020192863
    ISBN 978-93-85062-49-0 ; 93-85062-49-2 ; 9789385062506 ; 9385062506
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 1016 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Curcumin as a potential multiple-target inhibitor against SARS-CoV-2 infection

    Kumar Sumit

    Journal of the Serbian Chemical Society, Vol 88, Iss 4, Pp 381-

    A detailed interaction study using quantum chemical calculations

    2023  Volume 394

    Abstract: Curcumin is one of the important naturally occurring compounds having several medicinal properties such as: antiviral, antioxidant, antifibrotic, antineoplastic as well as anti-inflammatory. SARS-CoV-2 has emerged as infectious virus, which severely ... ...

    Abstract Curcumin is one of the important naturally occurring compounds having several medicinal properties such as: antiviral, antioxidant, antifibrotic, antineoplastic as well as anti-inflammatory. SARS-CoV-2 has emerged as infectious virus, which severely infected a large number of people all over the world. Many efforts have been made to prepare novel antiviral compound, but it is still challenging. Naturally occurring compound, curcumin, can be used as an alternative to antiviral compound against SARS-CoV-2. Its effect against SARS-CoV-2 is already highlighted in the literature. But the quantitative study of its interaction with various precursors of SARS-CoV-2 is not reported till date. This paper reports the interaction of curcumin with angiotensin-converting enzyme2, transmembrane serine protease 2, 3-chymotrypsin-like protease and papain-like protease through molecular docking and quantum chemistry calculations to achieve quantitative understanding of underlying interactions. Here the conformational flexibility of curcumin is also highlighted, which helps it to accommodate in the four different docking sites. The study has been performed using calculations of geometrical parameter, atomic charge, electron density, Laplacian of electron density, dipole moment and the energy gap between highest occupied and lowest unoccupied molecular orbitals. The non- -covalent interaction (NCI) analysis is performed to visualize the weak interaction present in the active sites. Combinedly molecular docking and detailed quantum chemistry calculations revealed that curcumin can be adopted as a potential multiple-target inhibitor against SARS-CoV-2.
    Keywords antiviral drug ; non-covalent interaction ; charge density analysis ; atom-in-molecule calculation ; angiotensin-converting enzyme2 ; transmembrane serine protease 2 ; Chemistry ; QD1-999
    Subject code 541
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Serbian Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Profile of type 2 diabetes mellitus patients attending family medicine clinic in a rural tribal locality in India.

    Kumar, Sumit

    Journal of family medicine and primary care

    2023  Volume 12, Issue 12, Page(s) 3242–3248

    Abstract: Objective: Diabetes prevalence has been predicted to reach 578 million worldwide in 2030 and is estimated to increase by 51% (700 million) in 2045. Type 2 diabetes mellitus (T2DM) is frequently associated with various cardiovascular (CV) risk factors ... ...

    Abstract Objective: Diabetes prevalence has been predicted to reach 578 million worldwide in 2030 and is estimated to increase by 51% (700 million) in 2045. Type 2 diabetes mellitus (T2DM) is frequently associated with various cardiovascular (CV) risk factors secondary to associated dyslipidemias and good glycemic control is key for the prevention of long-term CV complications; this study was conducted to assess present glycemic status and lipid profile of the population residing in a rural tribal locality of Jharkhand (India).
    Materials and methods: This cross-sectional study was conducted as a project for Fellowship in diabetes course by the Department of Endocrinology, DEDU, CMC Vellore. Whole blood and sera were analyzed for fasting blood sugar (FBS), glycated-hemoglobin (HbA1c), total cholesterol (CH), triglycerides (TGs), high-density-lipoprotein-cholesterol (HDL-C), low-density-lipoprotein-cholesterol (LDL-C), and very-low-density-lipoprotein-cholesterol (VLDL-C). A correlation test of HbA1c with lipid ratios and individual lipid indexes was done.
    Results: The mean Hb1Ac level was uncontrolled as 7.24 ± 1.80 and, interestingly, was marginally higher [7.31 ± 1.92 Vs 6.92 ± 1.16] in patients with T2DM <5 years as compared to those with T2DM >5 years. Mixed dyslipidemias were common with abnormal TG, LDL, VLDL, HDL, and total CH values. Hb1Ac levels showed a significant positive correlation with serum CH, TG, LDL, and VLDL levels, while a significant negative correlation with HDL levels in the study.
    Conclusion: Apart from being a reliable indicator of long-term glycemic control, HbA1c can also be used as a surrogate marker of dyslipidemia, and thus early diagnosis and treatment of dyslipidemia can prevent life-threatening cardiovascular complications that can be particularly useful in resource-poor rural tribal locality settings.
    Language English
    Publishing date 2023-12-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_2114_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Influence of atmosphere and austenitic stainless steel on the solar salt corrosivity.

    Kumar, Sumit / Hanke, Andrea / Bonk, Alexander / Bauer, Thomas

    Heliyon

    2024  Volume 10, Issue 4, Page(s) e25966

    Abstract: The utilization of the Solar Salt (60 wt% ... ...

    Abstract The utilization of the Solar Salt (60 wt%NaNO
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e25966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Palpitations in a young man after heavy work.

    Thakur, Abhishek / Kumar, Sumit

    Heart (British Cardiac Society)

    2023  Volume 109, Issue 18, Page(s) 1356–1418

    MeSH term(s) Humans ; Male ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/etiology
    Language English
    Publishing date 2023-08-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2023-322604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 112: Show issues

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  7. Article ; Online: Numerical Analysis of Non-Fourier Model-Based Bio-Heat Transfer in the Laser-irradiated Axisymmetric Living Tissue.

    Kishore, Pankaj / Kumar, Sumit

    Journal of biomechanical engineering

    2024  , Page(s) 1–33

    Abstract: The current work is related to the numerical investigation of non-Fourier heat transfer inside the short-pulsed laser-irradiated axisymmetric soft tissue phantom. It utilizes the modified discrete ordinate method to solve the transient radiative transfer ...

    Abstract The current work is related to the numerical investigation of non-Fourier heat transfer inside the short-pulsed laser-irradiated axisymmetric soft tissue phantom. It utilizes the modified discrete ordinate method to solve the transient radiative transfer equation (TRTE) for determining the intensity field. The laser energy absorbed by the soft tissue phantom behaves like a source in the Fourier/non-Fourier heat conduction model based-bio-heat transfer equation (BHTE), which is solved by employing the finite volume method (FVM) to determine the temperature distribution. Despite the prevalent use of non-Fourier BHTE for this purpose, a second law analysis is considered crucial to detect any potential anomalies. Equilibrium entropy production rates (EPR) are initially computed based on classical irreversible thermodynamics (CIT), which may yield negative values, possibly contravening the second law. Consequently, the EPR based on CIT is adjusted using the extended irreversible thermodynamics (EIT) hypothesis to ensure positivity. After that, the current research findings are compared with the results from the literature, and found good agreement between them. Then, the independent study is performed to select the optimum grid size, control angle size, and time step. A comparative analysis of results between the traditional Fourier and non-Fourier models has been performed. The impact of different parameters on the temperature fields and EPRs, is discussed. The effect of the optical properties of the inhomogeneity on the temperature distribution has been investigated. This study may help to enhance the effectiveness of the laser-based photo-thermal therapy.
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 243094-0
    ISSN 1528-8951 ; 0148-0731
    ISSN (online) 1528-8951
    ISSN 0148-0731
    DOI 10.1115/1.4065400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2672: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: H

    Kumar, Sumit / Padala, Kishor / Maiti, Barnali

    ACS omega

    2023  Volume 8, Issue 36, Page(s) 33058–33068

    Abstract: A quinazolin-4( ... ...

    Abstract A quinazolin-4(3
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c05162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Insight on the evaporation dynamics in reducing the COVID-19 infection triggered by respiratory droplets.

    Kumar, Sumit

    Physics of fluids (Woodbury, N.Y. : 1994)

    2021  Volume 33, Issue 7, Page(s) 72004

    Abstract: In this paper, the lifetime of coronavirus infected droplets under a stick-slip evaporation mode has been investigated, which may play a pivotal role in reducing the spread of COVID-19 infection. It is showed that the survival time of the virus can be ... ...

    Abstract In this paper, the lifetime of coronavirus infected droplets under a stick-slip evaporation mode has been investigated, which may play a pivotal role in reducing the spread of COVID-19 infection. It is showed that the survival time of the virus can be reduced by increasing the receding contact angle or by reducing the initial contact angle of a drop deposited on a solid surface. It has been found that the lifetime of the virus increases almost five times under highly humid conditions as compared to dry conditions. It is further observed that the normalized lifetime does not depend upon thermo-physical properties, ambient temperature, relative humidity, and initial drop volume. A model has been proposed to estimate the shear stress acting on a virus taking into account the effect of a Marangoni flow. The presented model unveils that the magnitude of computed shear stress is not enough to obliterate the virus. The findings of the present model have been discussed in the context of reducing the COVID-19 infection, but the model can also be applied for coughed/sneezed droplets of other infectious diseases. Moreover, this physical understanding of evaporation dynamics on solid surfaces with a stick-slip mode may help in better design of a face mask, PPE kit, and other protective equipment used in public places in order to minimize the chances of infection and tackle the current pandemic. However, the reported model for estimating the survival time of the virus does not consider the effect of the thermo-capillary convection (the Marangoni effect).
    Language English
    Publishing date 2021-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1472743-2
    ISSN 1089-7666 ; 1070-6631
    ISSN (online) 1089-7666
    ISSN 1070-6631
    DOI 10.1063/5.0057045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Unlocking Opportunities for

    Shyam, Mousumi / Kumar, Sumit / Singh, Vinayak

    ACS infectious diseases

    2024  Volume 10, Issue 2, Page(s) 251–269

    Abstract: In the recent decade, scientific communities have toiled to tackle the emerging burden of drug-resistant tuberculosis (DR-TB) and rapidly growing opportunistic nontuberculous mycobacteria (NTM). Among these, two neglected mycobacteria species of the ... ...

    Abstract In the recent decade, scientific communities have toiled to tackle the emerging burden of drug-resistant tuberculosis (DR-TB) and rapidly growing opportunistic nontuberculous mycobacteria (NTM). Among these, two neglected mycobacteria species of the Acinetobacter family,
    MeSH term(s) Humans ; Mycobacterium ulcerans ; Mycobacterium leprae ; Buruli Ulcer/drug therapy ; Buruli Ulcer/microbiology ; Buruli Ulcer/pathology ; Mycobacterium
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.3c00371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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