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Article: A Comprehensive Review of Electromagnetic Interference Shielding Composite Materials.

Zecchi, Silvia / Cristoforo, Giovanni / Bartoli, Mattia / Tagliaferro, Alberto / Torsello, Daniele / Rosso, Carlo / Boccaccio, Marco / Acerra, Francesco

Micromachines

2024 Volume 15, Issue 2

Abstract: The interaction between matter and microwaves assumes critical significance due to the ubiquity of wireless communication technology. The selective shielding of microwaves represents the only way to achieve the control on crucial technological sectors. ... ...

Abstract	The interaction between matter and microwaves assumes critical significance due to the ubiquity of wireless communication technology. The selective shielding of microwaves represents the only way to achieve the control on crucial technological sectors. The implementation of microwave shielding ensures the proper functioning of electronic devices. By preventing electromagnetic pollution, shielding safeguards the integrity and optimal performances of devices, contributing to the reliability and efficiency of technological systems in various sectors and allowing the further step forwards in a safe and secure society. Nevertheless, the microwave shielding research is vast and can be quite hard to approach due to the large number and variety of studies regarding both theory and experiments. In this review, we focused our attention on the comprehensive discussion of the current state of the art of materials used for the production of electromagnetic interference shielding composites, with the aim of providing a solid reference point to explore this research field.
Language	English
Publishing date	2024-01-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi15020187
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Coronavirus-Infected International Business Transactions: A Preliminary Diagnosis

Torsello, Marco / Winkler, Matteo M.

European Journal of Risk Regulation

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #832241
Database	COVID19

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Article: Prokineticin 2 and Cytokine Content in the Synovial Fluid of Knee Osteoarthritis and Traumatic Meniscal Tear Patients: Preliminary Results.

Turati, Marco / Franchi, Silvia / Crippa, Marco / Rizzi, Laura / Rigamonti, Luca / Sacerdote, Paola / Gatti, Simone Daniel / Piatti, Massimiliano / Galimberti, Giulia / Munegato, Daniele / Amodeo, Giada / Omeljaniuk, Robert J / Zatti, Giovanni / Torsello, Antonio / Bigoni, Marco

Journal of clinical medicine

2023 Volume 12, Issue 13

Abstract: Knee osteoarthritis (OA) is a chronic degenerative inflammatory-based condition caused by a cascade of different intra-articular molecules including several cytokines. Among the cytokines, prokineticins (PKs) have recently been identified as important ... ...

Abstract	Knee osteoarthritis (OA) is a chronic degenerative inflammatory-based condition caused by a cascade of different intra-articular molecules including several cytokines. Among the cytokines, prokineticins (PKs) have recently been identified as important mediators of inflammation and pain. This observational study examined the potential involvement of PK2 in degenerative or traumatic knee disease. Fifteen patients presenting knee osteoarthritis (OA group) and 15 patients presenting a traumatic meniscal tear (TM group) were studied. Synovial fluid samples from affected knees were assessed for PK2, IL-10, and TNF-α using the ELISA method. At a long-term follow-up (minimum 5 years, mean = 6.1 years), patients in the TM group underwent clinical re-evaluation with PROMs (Tegner Activity Scale, IKDC, Lysholm, SKV); in addition, X-ray visualization was used to assess the presence of secondary OA. PK2 was detected in synovial fluids of both TM and OA patients and the levels were comparable between the two groups, while IL-10 levels were significantly greater in the OA group than those in TM patients. PK2 levels correlated with those of IL-10. PK2 levels were greater in blood effusions compared to clear samples, did not differ significantly between sexes, nor were they related to differences in weight, height, or injury (meniscal laterality, time since dosing). No correlation was found between PROMs and radiological classifications in patients in the TM group at final follow-up. These data are the first observations of PK2 in synovial fluid following traumatic meniscus injury. These findings suggest possible further prognostic indices and therapeutic targets to limit the development of secondary OA.
Language	English
Publishing date	2023-06-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12134330
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Article ; Online: Preliminary Clinical and Radiologic Outcome of Matched Patients with Thoracoabdominal Aortic Aneurysms Treated by Low-Profile vs Standard Profile Branched Aortic Endografts.

Puta, Besjona / Fazzini, Stefano / Torsello, Giovanni / Pipitone, Marco Damiano / Austermann, Martin / Beropoulis, Efthymios / Torsello, Giovanni Federico

Annals of vascular surgery

2021 Volume 75, Page(s) 397–405

Abstract: Background: Durability of low-profile branched aortic stent-grafts (LPSG) in the treatment of patients with thoracoabdominal aortic aneurysms (TAAA) remains unclear. Objective of this study is to compare the outcomes of LPSG with standard profile ... ...

Abstract	Background: Durability of low-profile branched aortic stent-grafts (LPSG) in the treatment of patients with thoracoabdominal aortic aneurysms (TAAA) remains unclear. Objective of this study is to compare the outcomes of LPSG with standard profile branched aortic stent-grafts (SPSG). Methods: Between January 2016 and January 2020, 225 consecutive patients with TAAA were treated by branched endovascular aortic repair (BEVAR). Twenty-four patients who were treated with a LPSG were compared to 24 patients who received SPSG as a control group. Control patients were selected according to aneurysm size (maximum aneurysm diameter) and extension (Crawford classification) as well as availability of adequate preoperative and postoperative CT-angiograms at 24 months. The primary endpoint was ongoing clinical success defined as successful implantation and freedom from aneurysm- or procedure-related death, secondary intervention, type I or III endoleak, infection, thrombosis, aneurysm expansion or rupture and conversion. Secondary endpoints were radiological changes of the branched endograft (migration, shortening, scoliosis, lordosis, and fracture). Results: After a median follow-up of 22.6 (LPSG) and 26.2 months (SPSG), no significant difference was found in terms of technical success (100% in both groups), late mortality (4.2% vs 0%), aneurysm diameter increase (4.2% in both groups) and reinterventions (25% vs 37.5%). Infection, thrombosis, aneurysm expansion or rupture and conversion were not observed. Radiological analysis of aortic graft remodeling showed no fracture and no significant migration, shortening, scoliosis and lordosis of the LPSG (6.1 mm, 7.5 mm, 12.8° and 6.1°) compared to SPSG (3.9 mm, 5.1 mm, 7.9° and 5.6°) after 2 years. Conclusion: The clinical and radiological findings of the present study showed no increased mortality and complications for the matched patients who underwent treatment with low-profile vs standard-profile BEVAR. This study provides preliminary evidence of safety and efficacy of low-profile branched endografts in patients with demanding iliac access vessels.
MeSH term(s)	Aged ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/mortality ; Aortic Aneurysm, Thoracic/surgery ; Aortography ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/adverse effects ; Blood Vessel Prosthesis Implantation/instrumentation ; Blood Vessel Prosthesis Implantation/mortality ; Computed Tomography Angiography ; Endovascular Procedures/adverse effects ; Endovascular Procedures/instrumentation ; Endovascular Procedures/mortality ; Female ; Humans ; Male ; Middle Aged ; Postoperative Complications/diagnostic imaging ; Predictive Value of Tests ; Prosthesis Design ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Stents ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2021-02-05
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2021.01.095
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Article ; Online: The PROTAGORAS 2.0 Study to Identify Sizing and Planning Predictors for Optimal Outcomes in Abdominal Chimney Endovascular Procedures.

Fazzini, Stefano / Martinelli, Ombretta / Torsello, Giovanni / Austermann, Martin / Pipitone, Marco D / Torsello, Giovanni F / Irace, Luigi / Donas, Konstantinos P

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2021 Volume 61, Issue 4, Page(s) 591–602

Abstract: Objective: The aim was to identify predictors of adequate pre-operative sizing and planning for chimney endovascular aortic repair (ChEVAR) in order to reduce the incidence of persistent type Ia endoleaks (IaELs) without influencing chimney graft (CG) ... ...

Abstract	Objective: The aim was to identify predictors of adequate pre-operative sizing and planning for chimney endovascular aortic repair (ChEVAR) in order to reduce the incidence of persistent type Ia endoleaks (IaELs) without influencing chimney graft (CG) patency. Methods: Consecutive patients who underwent ChEVAR between January 2009 and December 2017 at a single centre were evaluated retrospectively. Included were patients treated with one device combination (Medtronic Endurant mated with Getinge Advanta V12/iCast) and placement of single or double CG. The freedom from IaEL related re-interventions and primary CG patency was estimated by measuring aortic stent graft oversizing (OS), total neck length (TNL), and a composite parameter (L-OS: TNL [mm] + OS [%]). Results: Seventy-three patients who underwent placement of 101 CGs (45 single, 28 double) met the inclusion criteria. The median radiological follow up was 25.5 (interquartile range [IQR] 12-48) months. Freedom from IaEL related re-intervention was achieved in 94.6% with a median OS of 38.5% (IQR 30%-44%, p = .004), TNL 19 mm (16-25 mm, p = .62), and L-OS 59 (51-65, p = .018). Primary CG patency was achieved in 95% of the cases with a median OS of 36% (29%-42%, p = .008), TNL 19 mm (15.5-26 mm, p = .91), and L-OS 57 (50-64, p = .005). By using the receiver operating characteristic curve, an optimal cut off to prevent IaEL related re-interventions was identified by an OS of 30% (p < .001; L-OS 55, p = .006) and to avoid CG stenosis/occlusions by OS 42% (p < .001; L-OS 65, p < .001). In multivariable analysis, aortic endograft OS was the only independent parameter preventive for IaEL related re-intervention (odds ratio, 0.78; 95% confidence interval, 0.61-0.99). Conclusion: With the Endurant-Advanta V12/iCast combination, an aortic stent graft OS of at least 30% (range 30%-42%) should be used to avoid type Ia endoleaks and likewise to ensure CG patency.
MeSH term(s)	Aged ; Aged, 80 and over ; Aorta, Abdominal/diagnostic imaging ; Aorta, Abdominal/physiopathology ; Aorta, Abdominal/surgery ; Aortic Aneurysm, Abdominal/diagnostic imaging ; Aortic Aneurysm, Abdominal/physiopathology ; Aortic Aneurysm, Abdominal/surgery ; Aortography ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/adverse effects ; Blood Vessel Prosthesis Implantation/instrumentation ; Computed Tomography Angiography ; Databases, Factual ; Endoleak/etiology ; Endoleak/prevention & control ; Endovascular Procedures/adverse effects ; Endovascular Procedures/instrumentation ; Female ; Graft Occlusion, Vascular/etiology ; Graft Occlusion, Vascular/prevention & control ; Humans ; Male ; Prosthesis Design ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Stents ; Time Factors ; Treatment Outcome ; Vascular Patency
Language	English
Publishing date	2021-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1225869-6
ISSN	1532-2165 ; 1078-5884
ISSN (online)	1532-2165
ISSN	1078-5884
DOI	10.1016/j.ejvs.2020.11.019
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Zs.MO 381: Show issues

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Article ; Online: Time and space resolved modelling of the heating induced by synchrotron X-ray nanobeams.

Bonino, Valentina / Torsello, Daniele / Prestipino, Carmelo / Mino, Lorenzo / Truccato, Marco

Journal of synchrotron radiation

2020 Volume 27, Issue Pt 6, Page(s) 1662–1673

Abstract: X-ray synchrotron sources, possessing high power density, nanometric spot size and short pulse duration, are extending their application frontiers up to the exploration of direct matter modification. In this field, the use of atomistic and continuum ... ...

Abstract	X-ray synchrotron sources, possessing high power density, nanometric spot size and short pulse duration, are extending their application frontiers up to the exploration of direct matter modification. In this field, the use of atomistic and continuum models is now becoming fundamental in the simulation of the photoinduced excitation states and eventually in the phase transition triggered by intense X-rays. In this work, the X-ray heating phenomenon is studied by coupling the Monte Carlo method (MC) with the Fourier heat equation, to first calculate the distribution of the energy absorbed by the systems and finally to predict the heating distribution and evolution. The results of the proposed model are also compared with those obtained removing the explicit definition of the energy distribution, as calculated by the MC. A good approximation of experimental thermal measurements produced irradiating a millimetric glass bead is found for both of the proposed models. A further step towards more complex systems is carried out, including in the models the different time patterns of the source, as determined by the filling modes of the synchrotron storage ring. The two models are applied in three prediction cases, in which the heating produced in Bi
Language	English
Publishing date	2020-09-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2021413-3
ISSN	1600-5775 ; 0909-0495
ISSN (online)	1600-5775
ISSN	0909-0495
DOI	10.1107/S1600577520010553
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Article ; Online: Prokineticin 2 and Cytokine Content in the Synovial Fluid of Knee Osteoarthritis and Traumatic Meniscal Tear Patients

Marco Turati / Silvia Franchi / Marco Crippa / Laura Rizzi / Luca Rigamonti / Paola Sacerdote / Simone Daniel Gatti / Massimiliano Piatti / Giulia Galimberti / Daniele Munegato / Giada Amodeo / Robert J. Omeljaniuk / Giovanni Zatti / Antonio Torsello / Marco Bigoni

Journal of Clinical Medicine, Vol 12, Iss 4330, p

Preliminary Results

2023 Volume 4330

Abstract	Knee osteoarthritis (OA) is a chronic degenerative inflammatory-based condition caused by a cascade of different intra-articular molecules including several cytokines. Among the cytokines, prokineticins (PKs) have recently been identified as important mediators of inflammation and pain. This observational study examined the potential involvement of PK2 in degenerative or traumatic knee disease. Fifteen patients presenting knee osteoarthritis (OA group) and 15 patients presenting a traumatic meniscal tear (TM group) were studied. Synovial fluid samples from affected knees were assessed for PK2, IL-10, and TNF-α using the ELISA method. At a long-term follow-up (minimum 5 years, mean = 6.1 years), patients in the TM group underwent clinical re-evaluation with PROMs (Tegner Activity Scale, IKDC, Lysholm, SKV); in addition, X-ray visualization was used to assess the presence of secondary OA. PK2 was detected in synovial fluids of both TM and OA patients and the levels were comparable between the two groups, while IL-10 levels were significantly greater in the OA group than those in TM patients. PK2 levels correlated with those of IL-10. PK2 levels were greater in blood effusions compared to clear samples, did not differ significantly between sexes, nor were they related to differences in weight, height, or injury (meniscal laterality, time since dosing). No correlation was found between PROMs and radiological classifications in patients in the TM group at final follow-up. These data are the first observations of PK2 in synovial fluid following traumatic meniscus injury. These findings suggest possible further prognostic indices and therapeutic targets to limit the development of secondary OA.
Keywords	meniscus ; osteoarthritis ; cytokines ; knee ; prokineticins ; synovial ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High glucose induces an activated state of partial epithelial-mesenchymal transition in human primary tubular cell cultures.

Torsello, Barbara / De Marco, Sofia / Bombelli, Silvia / Cifola, Ingrid / Morabito, Ivana / Invernizzi, Lara / Meregalli, Chiara / Zucchini, Nicola / Strada, Guido / Perego, Roberto A / Bianchi, Cristina

PloS one

2023 Volume 18, Issue 2, Page(s) e0279655

Abstract: Tubulointerstitial fibrosis is observed in diabetic nephropathy. It is still debated whether tubular cells, undergoing epithelial-mesenchymal transition (EMT) in high glucose (HG) conditions, may contribute to interstitial fibrosis development. In this ... ...

Abstract	Tubulointerstitial fibrosis is observed in diabetic nephropathy. It is still debated whether tubular cells, undergoing epithelial-mesenchymal transition (EMT) in high glucose (HG) conditions, may contribute to interstitial fibrosis development. In this study, we investigated the phenotypic and molecular EMT-like changes and the alteration of inflammatory and fibrogenic secretome induced by HG in human primary tubular cell cultures. Taking advantage of this in vitro cell model composed of proximal and distal tubular cells, we showed that HG-treated tubular cells acquired a fibroblast-like morphology with increased cytoplasmic stress fibers, maintaining the expression of the epithelial markers specific of proximal and distal tubular cells. HG increased Snail1, miRNA210 and Vimentin mesenchymal markers, decreased N-cadherin expression and migration ability of primary tubular cells, while E-cadherin expression and focal adhesion distribution were not affected. Furthermore, HG treatment of tubular cells altered the inflammatory cytokine secretion creating a secretome able to enhance the proliferation and migration of fibroblasts. Our findings show that HG promotes an activated state of partial EMT in human tubular primary cells and induces a pro-inflammatory and pro-fibrogenic microenvironment, supporting the active role of tubular cells in diabetic nephropathy onset.
MeSH term(s)	Humans ; Diabetic Nephropathies/metabolism ; Epithelial-Mesenchymal Transition ; Epithelial Cells/metabolism ; Glucose/metabolism ; Fibrosis ; Cell Culture Techniques
Chemical Substances	Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0279655
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Book ; Online: GNN-LoFI

Bicciato, Alessandro / Cosmo, Luca / Minello, Giorgia / Rossi, Luca / Torsello, Andrea

a Novel Graph Neural Network through Localized Feature-based Histogram Intersection

2024

Abstract: Graph neural networks are increasingly becoming the framework of choice for graph-based ...

Abstract	Graph neural networks are increasingly becoming the framework of choice for graph-based machine learning. In this paper, we propose a new graph neural network architecture that substitutes classical message passing with an analysis of the local distribution of node features. To this end, we extract the distribution of features in the egonet for each local neighbourhood and compare them against a set of learned label distributions by taking the histogram intersection kernel. The similarity information is then propagated to other nodes in the network, effectively creating a message passing-like mechanism where the message is determined by the ensemble of the features. We perform an ablation study to evaluate the network's performance under different choices of its hyper-parameters. Finally, we test our model on standard graph classification and regression benchmarks, and we find that it outperforms widely used alternative approaches, including both graph kernels and graph neural networks.
Keywords	Computer Science - Machine Learning
Subject code	006
Publishing date	2024-01-17
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The cross‐talk between Abl2 tyrosine kinase and TGFβ1 signalling modulates the invasion of clear cell Renal Cell Carcinoma cells

De Marco, Sofia / Torsello, Barbara / Minutiello, Emanuela / Morabito, Ivana / Grasselli, Chiara / Bombelli, Silvia / Zucchini, Nicola / Lucarelli, Giuseppe / Strada, Guido / Perego, Roberto A. / Bianchi, Cristina

FEBS Letters. 2023 Apr., v. 597, no. 8 p.1098-1113

2023

Abstract: Clear cell Renal Cell Carcinoma (ccRCC) is the most common and metastatic urological cancer. Molecular players of ccRCC progression and metastasis are not completely known. Here, using primary cell cultures from patients' specimens, we found that TGFβ1/ ... ...

Abstract	Clear cell Renal Cell Carcinoma (ccRCC) is the most common and metastatic urological cancer. Molecular players of ccRCC progression and metastasis are not completely known. Here, using primary cell cultures from patients' specimens, we found that TGFβ1/Smad signalling is more activated in high versus low grade ccRCC and inversely correlates with Abl2 tyrosine kinase protein expression. TGFβ1 treatment increased ubiquitination and degradation of Abl2 protein in ccRCC cell lines by TGFβ1/Smad pathway activation and reactive oxygen species production. 3D invasion and matrix degradation assays showed that Abl2 promoted TGFβ1‐induced ccRCC cell invasion and maturation of invadopodia, a hallmark of tumour invasion and metastasis. Our findings define Abl2 as a new downstream molecule of TGFβ1 signalling and putative target to counteract advanced ccRCC.
Keywords	metastasis ; reactive oxygen species ; renal cell carcinoma ; tyrosine ; ubiquitination
Language	English
Dates of publication	2023-04
Size	p. 1098-1113.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1002/1873-3468.14531
Database	NAL-Catalogue (AGRICOLA)

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