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  1. Book ; Online: Good emergency management practice: the essentials

    Gary, François / Clauss, Mathilde / Bonbon, Etienne / Myers, Lee

    a guide to preparing for animal health emergencies

    (FAO animal production and health manual ; 25)

    2021  

    Institution FAO
    Author's details authors: François Gary, Mathilde Clauss, Etienne Bonbon, Lee Myers ; Food and Agriculture Organization of the United Nations
    Series title FAO animal production and health manual ; 25
    Collection
    Language English
    Size 1 Online-Ressource (xiii, 80 Seiten), Diagramme
    Edition third edition
    Publisher Food and Agriculture Organization of the United Nations
    Publishing place Rome
    Publishing country Italy
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT020990642
    ISBN 978-92-5-134127-8 ; 92-5-134127-3
    DOI 10.4060/cb3833en
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book ; Online: Global rinderpest action plan

    Myers, Lee / Metwally, Samia / Marrana, Mariana / Stoffel, Carla / Ismayilova, Gunel / Brand, Tianna

    post-eradication

    2018  

    Institution FAO
    Author's details authors: Lee Myers, Samia Metwally, Mariana Marrana, Carla Stoffel, Gunel Ismayilova, Tianna Brand ; Food and Agriculture Organization of the United Nations; oie, World Organisation for Animal Health
    Language English
    Size 1 Online-Ressource (vii, 75 Seiten), Diagramme
    Publisher Food and Agriculture Organizaton of the United Nations
    Publishing place Rome, Italy
    Publishing country Italy
    Document type Book ; Online
    HBZ-ID HT019936997
    ISBN 9789251310335 ; 9251310335
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  3. Article: An integrated mechanistic and data-driven computational model predicts cell responses to high- and low-affinity EGFR ligands.

    Myers, Paul J / Lee, Sung Hyun / Lazzara, Matthew J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The biophysical properties of ligand binding heavily influence the ability of receptors to specify cell fates. Understanding the rules by which ligand binding kinetics impact cell phenotype is challenging, however, because of the coupled information ... ...

    Abstract The biophysical properties of ligand binding heavily influence the ability of receptors to specify cell fates. Understanding the rules by which ligand binding kinetics impact cell phenotype is challenging, however, because of the coupled information transfers that occur from receptors to downstream signaling effectors and from effectors to phenotypes. Here, we address that issue by developing an integrated mechanistic and data-driven computational modeling platform to predict cell responses to different ligands for the epidermal growth factor receptor (EGFR). Experimental data for model training and validation were generated using MCF7 human breast cancer cells treated with the high- and low-affinity ligands epidermal growth factor (EGF) and epiregulin (EREG), respectively. The integrated model captures the unintuitive, concentration-dependent abilities of EGF and EREG to drive signals and phenotypes differently, even at similar levels of receptor occupancy. For example, the model correctly predicts the dominance of EREG over EGF in driving a cell differentiation phenotype through AKT signaling at intermediate and saturating ligand concentrations and the ability of EGF and EREG to drive a broadly concentration-sensitive migration phenotype through cooperative ERK and AKT signaling. Parameter sensitivity analysis identifies EGFR endocytosis, which is differentially regulated by EGF and EREG, as one of the most important determinants of the alternative phenotypes driven by different ligands. The integrated model provides a new platform to predict how phenotypes are controlled by the earliest biophysical rate processes in signal transduction and may eventually be leveraged to understand receptor signaling system performance depends on cell context.
    One-sentence summary: Integrated kinetic and data-driven EGFR signaling model identifies the specific signaling mechanisms that dictate cell responses to EGFR activation by different ligands.
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.25.543329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tobacco Use, Quitting, and Service Access for Northern California Arab Americans: A Participatory Study.

    Lee, Juliet P / Salam, Lina / Abdelhalim, Gamila / Lipton, Robert / Myers, Mark / Alnahari, Sarah / Hamud-Ahmed, Walid

    Progress in community health partnerships : research, education, and action

    2024  Volume 17, Issue 3, Page(s) e3

    MeSH term(s) Humans ; Community-Based Participatory Research ; California/epidemiology ; Arabs ; Female ; Health Services Accessibility ; Male ; Smoking Cessation/ethnology ; Adult ; Middle Aged ; Tobacco Use/prevention & control ; Young Adult
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2275483-0
    ISSN 1557-055X ; 1557-0541
    ISSN (online) 1557-055X
    ISSN 1557-0541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Integrated budget impact model to estimate the impact of introducing selpercatinib as a tumor-agnostic treatment option for patients with

    Bhandari, Naleen Raj / Gilligan, Adrienne M / Myers, Julie / Ale-Ali, Amine / Smolen, Lee

    Journal of medical economics

    2024  Volume 27, Issue 1, Page(s) 348–358

    Abstract: Objective: To estimate the potential budget impact on US third party payers (commercial or Medicare) associated with addition of selpercatinib as a tumor-agnostic treatment for patients with Rearranged during Transfection (: Methods: An : Results: ...

    Abstract Objective: To estimate the potential budget impact on US third party payers (commercial or Medicare) associated with addition of selpercatinib as a tumor-agnostic treatment for patients with Rearranged during Transfection (
    Methods: An
    Results: Commercial perspective estimated 11.68 patients/million with
    Conclusions: Three-year incremental PMPM cost estimates suggest a modest impact on payer-budgets associated with introduction of tumor-agnostic selpercatinib treatment.
    MeSH term(s) Aged ; Humans ; United States ; Medicare ; Neoplasms/drug therapy ; Drug Costs ; Budgets ; Proto-Oncogene Proteins c-ret ; Pyrazoles ; Pyridines
    Chemical Substances selpercatinib (CEGM9YBNGD) ; RET protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-ret (EC 2.7.10.1) ; Pyrazoles ; Pyridines
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2270945-9
    ISSN 1941-837X ; 1369-6998
    ISSN (online) 1941-837X
    ISSN 1369-6998
    DOI 10.1080/13696998.2024.2317120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6450: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Perspective on Intradiscal Therapies for Lumbar Discogenic Pain: State of the Science, Knowledge Gaps, and Imperatives for Clinical Adoption.

    Lorio, Morgan P / Tate, Jordan Lee / Myers, Thomas J / Block, Jon E / Beall, Douglas P

    Journal of pain research

    2024  Volume 17, Page(s) 1171–1182

    Abstract: Specific clinical diagnostic criteria have established a consensus for defining patients with lumbar discogenic pain. However, if conservative medical management fails, these patients have few treatment options short of surgery involving discectomy often ...

    Abstract Specific clinical diagnostic criteria have established a consensus for defining patients with lumbar discogenic pain. However, if conservative medical management fails, these patients have few treatment options short of surgery involving discectomy often coupled with fusion or arthroplasty. There is a rapidly-emerging research effort to fill this treatment gap with intradiscal therapies that can be delivered minimally-invasively via fluoroscopically guided injection without altering the normal anatomy of the affected vertebral motion segment. Viable candidate products to date have included mesenchymal stromal cells, platelet-rich plasma, nucleus pulposus structural allograft, and other cell-based compositions. The objective of these products is to repair, supplement, and restore the damaged intervertebral disc as well as retard further degeneration. In doing so, the intervention is meant to eliminate the source of discogenic pain and avoid surgery. Methodologically rigorous studies are rare, however, and based on the best clinical evidence, the safety as well as the magnitude and duration of clinical efficacy remain difficult to estimate. Further, we summarize the US Food and Drug Administration's (FDA) guidance regarding the interpretation of the minimal manipulation and homologous use criteria, which is central to designating these products as a tissue or as a drug/device/biologic. We also provide perspectives on the core evidence and knowledge gaps associated with intradiscal therapies, propose imperatives for evaluating effectiveness of these treatments and highlight several new technologies on the horizon.
    Language English
    Publishing date 2024-03-18
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495284-9
    ISSN 1178-7090
    ISSN 1178-7090
    DOI 10.2147/JPR.S441180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Dimensionality reduction methods for extracting functional networks from large-scale CRISPR screens.

    Zernab Hassan, Arshia / Ward, Henry N / Rahman, Mahfuzur / Billmann, Maximilian / Lee, Yoonkyu / Myers, Chad L

    bioRxiv : the preprint server for biology

    2023  

    Abstract: CRISPR-Cas9 screens facilitate the discovery of gene functional relationships and phenotype-specific dependencies. The Cancer Dependency Map (DepMap) is the largest compendium of whole-genome CRISPR screens aimed at identifying cancer-specific genetic ... ...

    Abstract CRISPR-Cas9 screens facilitate the discovery of gene functional relationships and phenotype-specific dependencies. The Cancer Dependency Map (DepMap) is the largest compendium of whole-genome CRISPR screens aimed at identifying cancer-specific genetic dependencies across human cell lines. A mitochondria-associated bias has been previously reported to mask signals for genes involved in other functions, and thus, methods for normalizing this dominant signal to improve co-essentiality networks are of interest. In this study, we explore three unsupervised dimensionality reduction methods - autoencoders, robust, and classical principal component analyses (PCA) - for normalizing the DepMap to improve functional networks extracted from these data. We propose a novel "onion" normalization technique to combine several normalized data layers into a single network. Benchmarking analyses reveal that robust PCA combined with onion normalization outperforms existing methods for normalizing the DepMap. Our work demonstrates the value of removing low-dimensional signals from the DepMap before constructing functional gene networks and provides generalizable dimensionality reduction-based normalization tools.
    Language English
    Publishing date 2023-03-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.22.529573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Physical activity self-efficacy online intervention for adults with obesity: protocol for a feasibility study.

    Lee, Seungmin / Lahoda, Kevin / Myers, Nicholas D / Horowitz, Andrew / Chiu, Kenneth / Begdache, Lina / Einav, Eldad

    Pilot and feasibility studies

    2024  Volume 10, Issue 1, Page(s) 40

    Abstract: Background: Even without weight loss, adults with obesity can greatly benefit from regular physical activity. The Physical Activity Self-efficacy (PAS) intervention is an online behavioral intervention newly developed to promote physical activity in ... ...

    Abstract Background: Even without weight loss, adults with obesity can greatly benefit from regular physical activity. The Physical Activity Self-efficacy (PAS) intervention is an online behavioral intervention newly developed to promote physical activity in adults with obesity by providing capability-enhancing learning opportunities. The objective of this manuscript is to describe the protocol for a feasibility study designed to investigate the feasibility and acceptability of implementing the PAS online intervention for adults with obesity recruited from a local weight management center in the United States of America (USA).
    Methods: The study design is a prospective, double-blind, parallel-group individual randomized pilot trial. Thirty participants will be randomly assigned to the PAS group or usual care group to achieve a 1:1 group assignment. Recruitment of participants is scheduled to begin on 1 March 2024 at a local weight management center within a private healthcare system in the USA. There are six eligibility criteria for participation in this study (e.g., a body mass index ≥ 25.00 kg/m
    Discussion: Results are intended to inform the preparation of a future definitive randomized controlled trial.
    Trial registration: ClinicalTrials.gov, NCT05935111, registered 7 July 2023.
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2809935-7
    ISSN 2055-5784
    ISSN 2055-5784
    DOI 10.1186/s40814-024-01468-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Weight Loss in Short-Term Interventions for Physical Activity and Nutrition Among Adults With Overweight or Obesity: A Systematic Review and Meta-Analysis.

    Rotunda, Wendi / Rains, Caroline / Jacobs, Sara R / Ng, Valerie / Lee, Rachael / Rutledge, Stephanie / Jackson, Matt C / Myers, Kristopher

    Preventing chronic disease

    2024  Volume 21, Page(s) E21

    Abstract: Introduction: Reaching, enrolling, and retaining participants in lengthy lifestyle change interventions for weight loss is a major challenge. The objective of our meta-analysis was to investigate whether lifestyle interventions addressing nutrition and ... ...

    Abstract Introduction: Reaching, enrolling, and retaining participants in lengthy lifestyle change interventions for weight loss is a major challenge. The objective of our meta-analysis was to investigate whether lifestyle interventions addressing nutrition and physical activity lasting 6 months or less are effective for weight loss.
    Methods: We searched for peer-reviewed studies on lifestyle change interventions of 6 months or less published from 2012 through 2023. Studies were screened based on inclusion criteria, including randomized controlled trials (RCTs) for adults with overweight or obesity. We used a random-effects model to pool the mean difference in weight loss between intervention and control groups. We also performed subgroup analyses by intervention length and control type.
    Results: Fourteen RCTs were identified and included in our review. Half had interventions lasting less than 13 weeks, and half lasted from 13 to 26 weeks. Seven were delivered remotely, 4 were delivered in person, and 3 used combined methods. The pooled mean difference in weight change was -2.59 kg (95% CI, -3.47 to -1.72). The pooled mean difference measured at the end of the intervention was -2.70 kg (95% CI, -3.69 to -1.71) among interventions lasting less than 13 weeks and -2.40 kg (95% CI, -4.44 to -0.37) among interventions of 13 to 26 weeks.
    Conclusion: Short-term multicomponent interventions involving physical activity and nutrition can achieve weight loss for adults with overweight or obesity. Offering short-term interventions as alternatives to long-term ones may reach people who otherwise would be unwilling or unable to enroll in or complete longer programs.
    MeSH term(s) Adult ; Humans ; Overweight/therapy ; Obesity/therapy ; Exercise ; Weight Loss ; Life Style
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2135684-1
    ISSN 1545-1151 ; 1545-1151
    ISSN (online) 1545-1151
    ISSN 1545-1151
    DOI 10.5888/pcd21.230347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Dimensionality reduction methods for extracting functional networks from large-scale CRISPR screens.

    Hassan, Arshia Zernab / Ward, Henry N / Rahman, Mahfuzur / Billmann, Maximilian / Lee, Yoonkyu / Myers, Chad L

    Molecular systems biology

    2023  Volume 19, Issue 11, Page(s) e11657

    Abstract: CRISPR-Cas9 screens facilitate the discovery of gene functional relationships and phenotype-specific dependencies. The Cancer Dependency Map (DepMap) is the largest compendium of whole-genome CRISPR screens aimed at identifying cancer-specific genetic ... ...

    Abstract CRISPR-Cas9 screens facilitate the discovery of gene functional relationships and phenotype-specific dependencies. The Cancer Dependency Map (DepMap) is the largest compendium of whole-genome CRISPR screens aimed at identifying cancer-specific genetic dependencies across human cell lines. A mitochondria-associated bias has been previously reported to mask signals for genes involved in other functions, and thus, methods for normalizing this dominant signal to improve co-essentiality networks are of interest. In this study, we explore three unsupervised dimensionality reduction methods-autoencoders, robust, and classical principal component analyses (PCA)-for normalizing the DepMap to improve functional networks extracted from these data. We propose a novel "onion" normalization technique to combine several normalized data layers into a single network. Benchmarking analyses reveal that robust PCA combined with onion normalization outperforms existing methods for normalizing the DepMap. Our work demonstrates the value of removing low-dimensional signals from the DepMap before constructing functional gene networks and provides generalizable dimensionality reduction-based normalization tools.
    MeSH term(s) Humans ; Cell Line, Tumor ; Oncogenes ; Gene Regulatory Networks ; CRISPR-Cas Systems/genetics
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2193510-5
    ISSN 1744-4292 ; 1744-4292
    ISSN (online) 1744-4292
    ISSN 1744-4292
    DOI 10.15252/msb.202311657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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