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Article ; Online: Biosensor approach for electrochemical quantitative assessment and qualitative characterization of the effect of fusaric acid on a culture-receptor.

Emelyanova, Elena V / Antipova, Tatiana V

2022 Volume 357, Page(s) 1–8

Abstract: Fusaric acid (FA) is a secondary fungal metabolite, which is widespread on corn and corn-based feed and food; FA has non-specific toxicity. Biosensor method is an express and easy-to-use method for quantitative and qualitative assessment of FA effect. ... ...

Abstract	Fusaric acid (FA) is a secondary fungal metabolite, which is widespread on corn and corn-based feed and food; FA has non-specific toxicity. Biosensor method is an express and easy-to-use method for quantitative and qualitative assessment of FA effect. Search for cultures has been performed for the formation of laboratory models of FA biosensor with the Clark-type oxygen electrode as transducer: respiration intensity of chosen cultures changed in the presence of FA. Resting cells of Fusarium oxysporum f. sp. vasinfectum and Bacillus subtilis were used as receptors of the amperometric biosensor for FA determination in aqueous solution. To enhance the sensitivity of detection, induction by substrate was performed for Bacillus subtilis. Response-concentration linear dependencies were obtained in a range of 0.5-500 FA mg/L. Biosensor models were applied to characterize influence of FA on microbial cells and investigate some features of FA transport. The dependences of the cells' response to FA on FA concentration were obtained; the kinetic parameters S
MeSH term(s)	Bacillus subtilis/metabolism ; Biosensing Techniques ; Fusaric Acid/metabolism ; Fusaric Acid/pharmacology ; Fusarium ; Plant Diseases/microbiology ; Zea mays/microbiology
Chemical Substances	Fusaric Acid (JWJ963070N)
Language	English
Publishing date	2022-08-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	843647-2
ISSN	1873-4863 ; 0168-1656 ; 1389-0352
ISSN (online)	1873-4863
ISSN	0168-1656 ; 1389-0352
DOI	10.1016/j.jbiotec.2022.08.004
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Article ; Online: Coronavirus Pandemic as Black Swan Event

Antipova, Tatiana

Integrated Science in Digital Age 2020

Abstract: Nowadays coronavirus is the hottest break news around the world. This paper aims to study why coronavirus became so meaningful for worldwide life. On one side many countries closed their boarders to prevent coronavirus spreading. On another side some ... ...

Abstract	Nowadays coronavirus is the hottest break news around the world. This paper aims to study why coronavirus became so meaningful for worldwide life. On one side many countries closed their boarders to prevent coronavirus spreading. On another side some people said that coronavirus is no scared than simple influence. Where is true? The health effects and mortality of coronavirus and influenza were compared. Situation Reports of World Health Organization have been analyzed and signs of Black Swan event considered. Total confirmed cases, total, deaths, and Rate of coronavirus distribution was calculated based on Situation Reports of the World Health Organization. To conclude this paper Coronavirus Pandemic recognized as Black Swan event according to considered figures and facts from recent references.
Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1007/978-3-030-49264-9_32
Database	COVID19

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Article ; Online: Rituximab-induced interstitial pneumonitis in patient with non-Hodgkin lymphoma

Nikolai A. Ognerubov / Tatiana S. Antipova

Consilium Medicum, Vol 24, Iss 6, Pp 408-

a clinical case

2022 Volume 411

Abstract: Rituximab is a chimeric monoclonal antibody against CD20+ lymphocytes used to treat non-Hodgkin lymphoma, hematological and autoimmune diseases rheumatoid arthritis, systemic lupus erythematosus, thrombocytopenic purpura, hemolytic anemia, multiple ... ...

Abstract	Rituximab is a chimeric monoclonal antibody against CD20+ lymphocytes used to treat non-Hodgkin lymphoma, hematological and autoimmune diseases rheumatoid arthritis, systemic lupus erythematosus, thrombocytopenic purpura, hemolytic anemia, multiple sclerosis. The safety of the drug is critical to the choice of treatment. Rituximab-associated interstitial lung disease is rare. Objective. To describe a case of interstitial pneumonitis induced by rituximab in monotherapy at the end of maintenance therapy. Materials and methods. We describe a case of a 37-year-old patient with stage IIB non-Hodgkin lymphoma involving palatine tonsils and cervical and submandibular lymph nodes on both sides. Histologically, this tumor was a diffuse large B-cell lymphoma. Results. A patient received six R-CHOP courses of chemotherapy and immunotherapy for stage IIB diffuse large B-cell lymphoma. After the therapy, a complete clinical and metabolic response was achieved. Rituximab maintenance therapy was administered at a dose of 375 mg/m2 every 2 months for 2 years. At this treatment stage, combined positron emission tomography and 18F-fluorodeoxyglucose computed tomography (PET/CT with 18F-FDG) was performed at 45 months intervals. No radiological signs of pulmonary diseases were detected. Seven weeks after the last dose of rituximab (24 months), another PET/CT with 18F-FDG showed radiological changes that were considered to be interstitial pneumonitis, with no respiratory signs of the disease. No signs of tumor progression were found. Conclusion. Rituximab may contribute to late pulmonary toxicity presented as interstitial pneumonitis in non-Hodgkin lymphoma patients at a young age after maintenance therapy for 24 months. PET/CT with 18F-FDG is the primary method of diagnosing pulmonary toxicity.
Keywords	non-hodgkin lymphoma ; rituximab ; interstitial pneumonitis ; pet/ct ; Medicine (General) ; R5-920 ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	Russian
Publishing date	2022-08-01T00:00:00Z
Publisher	ZAO "Consilium Medicum"
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of red-colored carotenoids in yeasts by the biomass color.

Delegan, Yanina / Yachkula, Alena / Antipova, Tatiana / Vainshtein, Mikhail

Folia microbiologica

2021 Volume 66, Issue 4, Page(s) 615–622

Abstract: Production of carotenoids with red yeasts is a promising area of industrial biotechnology. All spectrophotometrical ("classic") analyses of carotenoids are based on preliminary extraction of the water-insoluble carotenoids; thus, these analyses are ... ...

Abstract	Production of carotenoids with red yeasts is a promising area of industrial biotechnology. All spectrophotometrical ("classic") analyses of carotenoids are based on preliminary extraction of the water-insoluble carotenoids; thus, these analyses are precise but complicated and time consuming. This paper presents a simple method to evaluate the red-colored carotenoids in yeast biomass by its color, without extraction. The method is based on digital characteristics of the biomass whole coloring, and it has already been successfully applied in other areas of biology: to compare plant and animal objects. In contrast to spectrophotometry measuring the amount of light that can pass through a solution, the biomass photo is a reflected color of the insoluble compounds. Application of this method to microorganisms permitted to compare the yeast strains and the effects of substrates or culturing regimes for any change in the red-colored pigments. The proposed rapid method was compared with the classic analyses of the carotenoids and showed that evaluation of red-colored carotenoids by the whole coloring of biomass can be used to discover changes in the yeast carotenoid production. In whole, the paper contributes method which is new for pigmented microorganisms and has a potential application in biotechnology.
MeSH term(s)	Biomass ; Biotechnology/trends ; Carotenoids/analysis ; Carotenoids/chemistry ; Photography ; Spectrophotometry ; Yeasts/chemistry
Chemical Substances	Carotenoids (36-88-4)
Language	English
Publishing date	2021-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	240503-9
ISSN	1874-9356 ; 0015-5632
ISSN (online)	1874-9356
ISSN	0015-5632
DOI	10.1007/s12223-021-00871-3
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Article ; Online: Сhronically Administered BDNF Dipeptide Mimetic GSB-106 Prevents the Depressive-like Behavior and Memory Impairments after Transient Middle Cerebral Artery Occlusion in Rats.

Povarnina, Polina Y / Antipova, Tatyana A / Logvinov, Ilya O / Gudasheva, Tatiana A / Seredenin, Sergey B

Current pharmaceutical design

2023 Volume 29, Issue 2, Page(s) 126–132

Abstract: Background: A dipeptide mimetic of the BDNF loop 4, bis (N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide, GSB-106, was designed and synthesized by V.V. Zakusov Research Institute of Pharmacology. The compound activated in vitro TrkB, MAPK/ERK, ... ...

Abstract	Background: A dipeptide mimetic of the BDNF loop 4, bis (N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide, GSB-106, was designed and synthesized by V.V. Zakusov Research Institute of Pharmacology. The compound activated in vitro TrkB, MAPK/ERK, PI3K/AKT, and PLCγ, like full-length BDNF. In vivo, GSB-106 exhibited antidepressant-like, neuroprotective and neuroregenerative properties. The aim of this work was to study the effects of GSB-106 on depressive-like behavior, cognitive impairments, as well as on hippocampal neuroplasticity in an experimental model of ischemic stroke. Methods: Male Wistar rats were subjected to 60 minutes of transient middle cerebral artery occlusion (MCAO). Dipeptide GSB-106 was administered intraperitoneally at a dose of 0.1 mg/kg/day for 21 days after surgery. 30-40 days after MCAO, the depressive-like state in the forced swimming test and memory impairment in the novel object recognition test were assessed. Then, the content of CREB, as a neuroplasticity marker, was assessed in the ipsilateral hippocampus. Results: Rats in MCAO group showed depression-like behavior (increase in immobility time in the forced swimming test by 22% compared to sham group), impairments in short-term and long-term memory (decrease in the discrimination index in the novel object recognition test by 70% and 50%, respectively), and a decrease in immunoreactivity to CREB (cAMP response element-binding protein) in the hippocampus by 36% as compared with the sham group. GSB-106 completely prevented the behavior impairments and counteracted the reduction of immunoreactivity to CREB in the hippocampus. Conclusion: The BDNF dipeptide mimetic GSB-106 is promising for further development as a drug for the treatment of poststroke neuropsychiatric disorders.
MeSH term(s)	Rats ; Male ; Animals ; Rats, Wistar ; Brain-Derived Neurotrophic Factor/metabolism ; Infarction, Middle Cerebral Artery ; Phosphatidylinositol 3-Kinases/metabolism ; Hippocampus ; Dipeptides/pharmacology ; Dipeptides/therapeutic use ; Dipeptides/chemistry ; Memory Disorders
Chemical Substances	bis-(N-monosuccinyl-l-seryl-l-lysine)hexamethylenediamide ; Brain-Derived Neurotrophic Factor ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Dipeptides
Language	English
Publishing date	2023-01-04
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612829666230103161824
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Article ; Online: Formation of Azaphilone Pigments and Monasnicotinic Acid by the Fungus

Antipova, Tatiana V / Zhelifonova, Valentina / Zaitsev, Kirill V / Zherebker, Alexander / Baskunov, Boris / Oprunenko, Yuri F

Journal of agricultural and food chemistry

2022 Volume 70, Issue 23, Page(s) 7122–7129

Abstract: Due to the ever-increasing demand for healthy and safe food, much attention has been gained by natural food colorants. This study showed the culture fluid extract of the ... ...

Abstract	Due to the ever-increasing demand for healthy and safe food, much attention has been gained by natural food colorants. This study showed the culture fluid extract of the fungus
MeSH term(s)	Aspergillus ; Benzopyrans ; Fungi ; Pigments, Biological/chemistry ; Pigments, Biological/pharmacology ; Plant Extracts
Chemical Substances	Benzopyrans ; Pigments, Biological ; Plant Extracts ; azaphilone
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.2c01952
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Article: Biosensor approach for electrochemical quantitative assessment and qualitative characterization of the effect of fusaric acid on a culture-receptor

Emelyanova, Elena V. / Antipova, Tatiana V.

Journal of biotechnology. 2022 Sept. 20, v. 357

2022

Abstract	Fusaric acid (FA) is a secondary fungal metabolite, which is widespread on corn and corn-based feed and food; FA has non-specific toxicity. Biosensor method is an express and easy-to-use method for quantitative and qualitative assessment of FA effect. Search for cultures has been performed for the formation of laboratory models of FA biosensor with the Clark-type oxygen electrode as transducer: respiration intensity of chosen cultures changed in the presence of FA. Resting cells of Fusarium oxysporum f. sp. vasinfectum and Bacillus subtilis were used as receptors of the amperometric biosensor for FA determination in aqueous solution. To enhance the sensitivity of detection, induction by substrate was performed for Bacillus subtilis. Response-concentration linear dependencies were obtained in a range of 0.5–500 FA mg/L. Biosensor models were applied to characterize influence of FA on microbial cells and investigate some features of FA transport. The dependences of the cells’ response to FA on FA concentration were obtained; the kinetic parameters S₀.₅ and Vₘₐₓ were determined for each culture. Inhibition-threshold FA (Sⁱᵗ) concentrations were similar for both studied cultures. At concentrations lower than Sⁱᵗ, the process of simple diffusion governed FA transport into cells and caused the cells’ response to FA for non-induced culture.
Keywords	Bacillus subtilis ; Fusarium oxysporum f. sp. vasinfectum ; aqueous solutions ; biosensors ; biotechnology ; corn ; electrochemistry ; electrodes ; fungi ; fusaric acid ; metabolites ; oxygen ; toxicity
Language	English
Dates of publication	2022-0920
Size	p. 1-8.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	843647-2
ISSN	1873-4863 ; 0168-1656 ; 1389-0352
ISSN (online)	1873-4863
ISSN	0168-1656 ; 1389-0352
DOI	10.1016/j.jbiotec.2022.08.004
Database	NAL-Catalogue (AGRICOLA)

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Article: The Nitro Group Reshapes the Effects of Pyrido[3,4-

Borisevich, Sophia S / Aksinina, Tatiana E / Ilyina, Margarita G / Shender, Victoria O / Anufrieva, Ksenia S / Arapidi, Georgij P / Antipova, Nadezhda V / Anizon, Fabrice / Esvan, Yannick J / Giraud, Francis / Tatarskiy, Victor V / Moreau, Pascale / Shakhparonov, Mikhail I / Pavlyukov, Marat S / Shtil, Alexander A

Cancers

2024 Volume 16, Issue 4

Abstract: Serine-threonine protein kinases of the DYRK and CLK families regulate a variety of vital cellular functions. In particular, these enzymes phosphorylate proteins involved in pre-mRNA splicing. Targeting splicing with pharmacological DYRK/CLK inhibitors ... ...

Abstract	Serine-threonine protein kinases of the DYRK and CLK families regulate a variety of vital cellular functions. In particular, these enzymes phosphorylate proteins involved in pre-mRNA splicing. Targeting splicing with pharmacological DYRK/CLK inhibitors emerged as a promising anticancer strategy. Investigation of the pyrido[3,4-
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16040834
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Article: Formation of Azaphilone Pigments and Monasnicotinic Acid by the Fungus Aspergillus cavernicola

Antipova, Tatiana V. / Zhelifonova, Valentina / Zaitsev, Kirill V. / Zherebker, Alexander / Baskunov, Boris / Oprunenko, Yuri F.

Journal of agricultural and food chemistry. 2022 June 01, v. 70, no. 23

2022

Abstract: Due to the ever-increasing demand for healthy and safe food, much attention has been gained by natural food colorants. This study showed the culture fluid extract of the fungus Aspergillus cavernicola VKM F-906 to contain red pigment and monasnicotinic ... ...

Abstract	Due to the ever-increasing demand for healthy and safe food, much attention has been gained by natural food colorants. This study showed the culture fluid extract of the fungus Aspergillus cavernicola VKM F-906 to contain red pigment and monasnicotinic acid (MNA) in predominant amounts. The structure of the pigment corresponded to cis-cavernamine (red pigment, RP). Two tautomers, NH and OH forms, in rapid equilibrium were present in a solution of RP. The critical factors for RP to form were the presence of NH₄⁺ salt and pH 6.3–6.5. In vitro experiments showed that MNA was synthesized from RP as a result of chemical transformations without the participation of enzymes. In this case, the main influence on the reaction rate is exerted by the pH of the medium, which is associated with the keto–enol tautomerism of RP in solution. The culture broth extract and MNA exhibited antifungal activity against Fusarium fungi.
Keywords	Aspergillus ; Fusarium ; antifungal properties ; culture media ; food chemistry ; fungi ; pH ; tautomerization ; tautomers
Language	English
Dates of publication	2022-0601
Size	p. 7122-7129.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.2c01952
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Potential of Arctic Pseudogymnoascus Fungi in the Biosynthesis of Natural Products

Antipova, Tatiana V. / Zaitsev, Kirill V. / Zhelifonova, Valentina P. / Tarlachkov, Sergey V. / Grishin, Yuri K. / Kochkina, Galina A. / Vainshtein, Mikhail B.

Fermentation. 2023 July 26, v. 9, no. 8

2023

Abstract: Scarce research into the secondary metabolites of the fungi Pseudogymnoascus spp. has shown a hidden biosynthetic potential for biologically active compounds. This work investigated the biosynthesis of secondary metabolites by two Pseudogymnoascus fungal ...

Abstract	Scarce research into the secondary metabolites of the fungi Pseudogymnoascus spp. has shown a hidden biosynthetic potential for biologically active compounds. This work investigated the biosynthesis of secondary metabolites by two Pseudogymnoascus fungal strains, VKM F-4518 and VKM F-4519, isolated from the surface soil layer of the Kolyma Lowland, Russia, in the Arctic. In these strains, 16-membered trilactone macrolides, (+)-macrosphelides A and B, were identified using 1D and 2D NMR, UHRMS, and optical rotation data. In the fungi of this genus, these metabolites were found for the first time. The studied strains are highly active producers of macrosphelide A, which is being considered as a promising agent for the cure of cancer. Using the antiSMASH secondary metabolite analysis tool, we found that the genome of strain VKM F-4518 contained 32 of the biosynthetic clusters of the secondary metabolite genes (BGC) and that of VKM F-4519 had 17 BGCs. Based on the comparison of the cluster of macrotriolide genes from the fungus Paraphaeosphaeria sporulosa, we found the complete supposed cluster BGCs of macrosphelides in the genomes of two Pseudogymnoascus strains using the BLAST+ program.
Keywords	Paraphaeosphaeria ; Pseudogymnoascus ; Russia ; biosynthesis ; fermentation ; fungi ; genome ; macrolides ; secondary metabolites ; soil ; Arctic region
Language	English
Dates of publication	2023-0726
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2813985-9
ISSN	2311-5637
ISSN	2311-5637
DOI	10.3390/fermentation9080702
Database	NAL-Catalogue (AGRICOLA)

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