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  1. Article ; Online: Coronavirus Receptors as Immune Modulators.

    Devarakonda, Charan Kumar V / Meredith, Emily / Ghosh, Mallika / Shapiro, Linda H

    Journal of immunology (Baltimore, Md. : 1950)

    2020  Volume 206, Issue 5, Page(s) 923–929

    Abstract: The Coronaviridae family includes the seven known human coronaviruses (CoV) that cause mild to moderate respiratory infections (HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV-HKU1) as well as severe illness and death (MERS-CoV, SARS-CoV, SARS-CoV-2). Severe ... ...

    Abstract The Coronaviridae family includes the seven known human coronaviruses (CoV) that cause mild to moderate respiratory infections (HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV-HKU1) as well as severe illness and death (MERS-CoV, SARS-CoV, SARS-CoV-2). Severe infections induce hyperinflammatory responses that are often intensified by host adaptive immune pathways to profoundly advance disease severity. Proinflammatory responses are triggered by CoV entry mediated by host cell surface receptors. Interestingly, five of the seven strains use three cell surface metallopeptidases (CD13, CD26, and ACE2) as receptors, whereas the others employ
    MeSH term(s) Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Betacoronavirus/classification ; Betacoronavirus/immunology ; Betacoronavirus/metabolism ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/virology ; Humans ; Immunity ; Immunomodulation ; Interleukin-6/immunology ; Metalloproteases/immunology ; Receptors, Cell Surface/immunology ; Receptors, Coronavirus/immunology ; Virus Internalization
    Chemical Substances IL6 protein, human ; Interleukin-6 ; Receptors, Cell Surface ; Receptors, Coronavirus ; Metalloproteases (EC 3.4.-) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2020-12-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2001062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A novel urinary biomarker protein panel to identify children with ureteropelvic junction obstruction - A pilot study.

    Devarakonda, Charan Kumar V / Shearier, Emily R / Hu, Chaoran / Grady, James / Balsbaugh, Jeremy L / Makari, John H / Ferrer, Fernando A / Shapiro, Linda H

    Journal of pediatric urology

    2020  Volume 16, Issue 4, Page(s) 466.e1–466.e9

    Abstract: Introduction and objective: Reliable urinary biomarker proteins would be invaluable in identifying children with ureteropelvic junction obstruction (UPJO) as the existing biomarker proteins are inconsistent in their predictive ability. Therefore, the ... ...

    Abstract Introduction and objective: Reliable urinary biomarker proteins would be invaluable in identifying children with ureteropelvic junction obstruction (UPJO) as the existing biomarker proteins are inconsistent in their predictive ability. Therefore, the aim of this study was to identify consistent and reliable urinary biomarker proteins in children with UPJO.
    Methods: To identify candidate biomarker proteins, total protein from age-restricted (<2 years) and sex-matched (males) control (n = 22) and UPJO (n = 21) urine samples was analyzed by mass spectrometry. Proteins that were preferentially identified in UPJO samples were selected (2-step process) and ranked according to their diagnostic odds ratio value. The top ten proteins with highest odds ratio values were selected and tested individually by ELISA. The total amount of each protein was normalized to urine creatinine and the median with interquartile ranges for control and UPJO samples was determined. Additionally, fold change (UPJO/Control) of medians of the final panel of 5 proteins was also determined. Finally, we calculated the average + 3(SD) and average + 4(SD) values of each of the 5 proteins in the control samples and used it as an arbitrary cutoff to classify individual control and UPJO samples.
    Results: In the first step of our selection process, we identified 171 proteins in UPJO samples that were not detected in the majority of the control samples (16/22 samples, or 72.7%). Of the 171 proteins, only 50 proteins were detected in at least 11/21 (52.4%) of the UPJO samples and hence were selected in the second step. Subsequently, these 50 proteins were ranked according to the odds ratio value and the top 10 ranked proteins were validated by ELISA. Five of the 10 proteins - prostaglandin-reductase-1, ficolin-2, nicotinate-nucleotide pyrophosphorylase [carboxylating], immunoglobulin superfamily-containing leucine-rich-repeat-protein and vascular cell adhesion molecule-1 were present at higher levels in the UPJO samples (fold-change of the median protein concentrations ranging from 2.9 to 9.4) and emerged as a panel of biomarkers to identify obstructive uropathy. Finally, the order of prevalence of the 5 proteins in UPJO samples is PTGR1>FCN2>QPRT>ISLR>VCAM1.
    Conclusion: In summary, this unique screening strategy led to the identification of previously unknown biomarker proteins that when screened collectively, may reliably distinguish between obstructed vs. non-obstructed infants and may prove useful in identifying informative biomarker panels for biological samples from many diseases.
    MeSH term(s) Biomarkers ; Child ; Child, Preschool ; Humans ; Infant ; Kidney Pelvis ; Lipocalin-2 ; Male ; Pilot Projects ; Ureteral Obstruction/diagnosis ; Urinalysis
    Chemical Substances Biomarkers ; Lipocalin-2
    Language English
    Publishing date 2020-06-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2237683-5
    ISSN 1873-4898 ; 1477-5131
    ISSN (online) 1873-4898
    ISSN 1477-5131
    DOI 10.1016/j.jpurol.2020.05.163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6387: Show issues Location:
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