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Article ; Online: Regulation of hippo signaling mediated apoptosis by Rauvolfia tetraphylla in triple-negative breast cancer.

Balavaishnavi, B / Kamaraj, M / Nithya, T G / Santhosh, P / GokilaLakshmi, S / Shaik, Mohammed Rafi

Medical oncology (Northwood, London, England)

2024 Volume 41, Issue 5, Page(s) 103

Abstract: Rauvolfia tetraphylla is an essential medicinal plant that has been widely used in traditional medicine for various disease treatments. However, the tumor suppressor activity of R. tetraphylla and its phytocompounds were not explored against triple- ... ...

Abstract	Rauvolfia tetraphylla is an essential medicinal plant that has been widely used in traditional medicine for various disease treatments. However, the tumor suppressor activity of R. tetraphylla and its phytocompounds were not explored against triple-negative breast cancer. The current research investigated the impact of R. tetraphylla methanolic extract (RTE) and its isolated compounds Ajmaline (RTC1) and Reserpine (RTC2) on triple-negative breast cancer cell line (MDA-MB-231) focusing on anti-proliferative effects. Our study imparts that RTE and RTC2 showed promising cytotoxic effects compared to RTC1. So further experiments have proceeded with RTE and RTC2, to evaluate its proliferation, migration, and apoptotic effect. The result shows around 80% of cells were observed in the G0/G1 phase in cell cycle analysis indicating the cell cycle inhibition and duel staining clearly showed the apoptotic effect. The migration of cells after the scratch was 60.45% observed in control and 90% in treated cells showing the inhibition of migration. ROS distribution was intense compared to control indicating the increased ROS stress in treated cells. Both RTE and RTC2-treated cells showed the potential to suppress proliferation and induce apoptotic change by upregulating BAX and MST-1 and suppressing Bcl2, LATS-1, and YAP, proving that deregulation of YAP resulting in the blockage of TEAD-YAP complex and inhibit proliferation. Therefore, R. tetraphylla extract and its isolated compounds were demonstrated to find its ability to act against MDA-MB-231 and these findings will help adjudicate it as a therapeutic drug against experimental triple-negative breast cancer.
MeSH term(s)	Humans ; Female ; Rauwolfia/metabolism ; Hippo Signaling Pathway ; Reactive Oxygen Species/metabolism ; Triple Negative Breast Neoplasms/metabolism ; Breast Neoplasms ; Cell Line, Tumor ; Apoptosis ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Cell Proliferation
Chemical Substances	Reactive Oxygen Species ; Plant Extracts
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-024-02341-5
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Article ; Online: Knowledge, Attitudes, and Practices Regarding Ticks, Tick-Borne Diseases, and Ethnomedicine Among an at-Risk Population in Kerala.

Sidhik, Sahina / Santhosh, Sithalakshmi / Rathinam, Balasubramanian

Vector borne and zoonotic diseases (Larchmont, N.Y.)

2023 Volume 24, Issue 2, Page(s) 86–94

Abstract: Tick and tick-borne diseases (TBDs) are increasing annually, and the study of ticks has gained importance after the outbreak of Kyasanur Forest disease (KFD) in the South Western Ghats of India. Wayanad district of Kerala, with the highest tribal ... ...

Abstract	Tick and tick-borne diseases (TBDs) are increasing annually, and the study of ticks has gained importance after the outbreak of Kyasanur Forest disease (KFD) in the South Western Ghats of India. Wayanad district of Kerala, with the highest tribal population in South India, is a KFD endemic state, owing to the lack of knowledge, attitude, and practice studies on TBDs and ethnomedicines against ticks. This study was carried out to assess their baseline knowledge, attitude, and ethnomedicinal practice against ticks. A structured questionnaire was used to conduct a survey of 499 tribal members living in forest fringe areas. Logistic regression analysis was performed to identify the factors that influence the knowledge, attitude, and practice of tribes on TBDs. More than 70% of the population visit the forests on a regular basis, with 65.7% of the population regularly exposed to tick bites; however, only 47.7% were aware of TBDs. About 47.4% of the respondents took precautions like therapeutics and natural remedies to avoid tick bites. Ten species of medicinal plant belonging to eight different families have been identified from the survey. The tribal population use these plants to repel ticks as well as treat tick bites. From the study, we concluded that the limited in-depth knowledge displayed by the tribes can be strengthened by conducting community programs such as awareness classes on TBD and its control measures. The ethnobotanicals identified can be used to formulate novel tick repellents in the future.
MeSH term(s)	Humans ; Animals ; Ticks ; Tick Bites/veterinary ; Health Knowledge, Attitudes, Practice ; Tick-Borne Diseases/epidemiology ; Tick-Borne Diseases/prevention & control ; Tick-Borne Diseases/veterinary ; Kyasanur Forest Disease/epidemiology ; Kyasanur Forest Disease/veterinary ; Medicine, Traditional
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2047199-3
ISSN	1557-7759 ; 1530-3667
ISSN (online)	1557-7759
ISSN	1530-3667
DOI	10.1089/vbz.2023.0040
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Article: Machine Learning Enabled P300 Classifier for Autism Spectrum Disorder Using Adaptive Signal Decomposition.

Peketi, Santhosh / Dhok, Sanjay B

Brain sciences

2023 Volume 13, Issue 2

Abstract: Joint attention skills deficiency in Autism spectrum disorder (ASD) hinders individuals from communicating effectively. The P300 Electroencephalogram (EEG) signal-based brain-computer interface (BCI) helps these individuals in neurorehabilitation ... ...

Abstract	Joint attention skills deficiency in Autism spectrum disorder (ASD) hinders individuals from communicating effectively. The P300 Electroencephalogram (EEG) signal-based brain-computer interface (BCI) helps these individuals in neurorehabilitation training to overcome this deficiency. The detection of the P300 signal is more challenging in ASD as it is noisy, has less amplitude, and has a higher latency than in other individuals. This paper presents a novel application of the variational mode decomposition (VMD) technique in a BCI system involving ASD subjects for P300 signal identification. The EEG signal is decomposed into five modes using VMD. Thirty linear and non-linear time and frequency domain features are extracted for each mode. Synthetic minority oversampling technique data augmentation is performed to overcome the class imbalance problem in the chosen dataset. Then, a comparative analysis of three popular machine learning classifiers is performed for this application. VMD's fifth mode with a support vector machine (fine Gaussian kernel) classifier gave the best performance parameters, namely accuracy, F1-score, and the area under the curve, as 91.12%, 91.18%, and 96.6%, respectively. These results are better when compared to other state-of-the-art methods.
Language	English
Publishing date	2023-02-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13020315
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Article: Biochemical and

Magwaza, Buka / Amobonye, Ayodeji / Bhagwat, Prashant / Pillai, Santhosh

Heliyon

2024 Volume 10, Issue 7, Page(s) e28667

Abstract: β-glucosidase hydrolyses the glycosidic bonds in cellobiose and cello-oligosaccharides, a critical step in the saccharification for biofuel production. Hence, the aim of this study was to gain insights into the biochemical and structural properties of a ... ...

Abstract	β-glucosidase hydrolyses the glycosidic bonds in cellobiose and cello-oligosaccharides, a critical step in the saccharification for biofuel production. Hence, the aim of this study was to gain insights into the biochemical and structural properties of a β-glucosidase from
Language	English
Publishing date	2024-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28667
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Article ; Online: Impact of a Multidisciplinary Post-COVID-19 Clinic on Hospital Admissions and ED Visits.

Levan, Sophia / Mourad, Michelle / Block, Brian / Shah, Rupal / Santhosh, Lekshmi

Chest

2023 Volume 164, Issue 1, Page(s) 199–202

MeSH term(s)	Humans ; COVID-19 ; Hospitalization ; Patient Admission ; Ambulatory Care Facilities ; Hospitals ; Emergency Service, Hospital ; Retrospective Studies
Language	English
Publishing date	2023-01-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2022.12.031
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Article: Immune Thrombocytopenic Purpura (ITP) Following Natural COVID-19 Infection.

Santhosh, Sisira / Malik, Bilal / Kalantary, Atefeh / Kunadi, Arvind

Cureus

2022 Volume 14, Issue 7, Page(s) e26582

Abstract: Immune thrombocytopenic purpura (ITP) has been linked to the COVID-19 vaccine series as a rare adverse event but has recently emerged in the literature as a sequela of natural COVID-19 infection. ITP is a diagnosis of exclusion where a diagnosis is made ... ...

Abstract	Immune thrombocytopenic purpura (ITP) has been linked to the COVID-19 vaccine series as a rare adverse event but has recently emerged in the literature as a sequela of natural COVID-19 infection. ITP is a diagnosis of exclusion where a diagnosis is made by having isolated thrombocytopenia (platelet count <100,000/μL) and no other identifiable etiology for the thrombocytopenia. We share the case of a young male without any history of hematological or immunological disorders presenting with severe, symptomatic thrombocytopenia following a natural COVID-19 infection. Patients should be made aware of the potential risk of adverse events with not only vaccination but also even mild cases of natural infection with COVID-19. An emphasis should be placed on the fact that the benefits of vaccination continue to outweigh the potential risks of adverse events, even in those with a pre-existing diagnosis of ITP.
Language	English
Publishing date	2022-07-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.26582
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Article ; Online: HLA allele frequency of HLA-A, -B, -C, -DRB1 and -DQB1 in Indian recurrent implantation failure and recurrent pregnancy loss couples - A retrospective study.

Shetty, Sachin / Santhosh, Ashly / S Pillai, Sree Parvathi / Gunasheela, Devika / Nayak, Rajsekhar / Shetty, Swathi

Journal of reproductive immunology

2024 Volume 163, Page(s) 104225

Abstract: The maternal-fetal interaction has been hypothesized to involve the human leucocyte antigen (HLA). It has been suggested that excessive HLA antigen sharing between spouses is a mechanism causing maternal hyporesponsiveness to paternal antigens ... ...

Abstract	The maternal-fetal interaction has been hypothesized to involve the human leucocyte antigen (HLA). It has been suggested that excessive HLA antigen sharing between spouses is a mechanism causing maternal hyporesponsiveness to paternal antigens encountered during pregnancy and thus leading to a miscarriage. Participants in this retrospective study are RIF and RPL couples who visited Gunasheela Surgical and Maternity Hospital, Bangalore, India from November 2019 to September 2022. A total of 40 couples with RIF and 195 couples with RPL are included in the study. We observed that the DQB102:01:01 allele is associated with an increase in risk of both RIF and RPL, while the C12:02:01 allele increases risk of only RPL. On the contrary, DQB102:02:01 and DQB106:03 alleles appear to be protective against both RPL and RIF. In addition, the C07:02:01 allele was observed to be protective against RPL. In conclusion, C12:02:01 and DQB102:01:01 could play a major role in RPL which is consistent with other studies, while DQB102:01:01 is the risk allele in our RIF group. The protective alleles C07:02:01 in the RPL group, DQB102:02:01, and DQB1*06:03 in both RIF and RPL, were discovered for the first time. Allele frequencies will vary in population-based studies depending on the ethnicities of the cohort. Meta-analysis and antibody testing will provide additional insights on whether and how this data can be adopted into clinical practices.
Language	English
Publishing date	2024-03-03
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	424421-7
ISSN	1872-7603 ; 0165-0378
ISSN (online)	1872-7603
ISSN	0165-0378
DOI	10.1016/j.jri.2024.104225
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Article ; Online: First discovery of the Neotropical species Brachymeria trinidadensis (Hymenoptera: Chalcididae, Brachymeriinae) in India.

Binoy, C / Santhosh, S / Nasser, M

Zootaxa

2022 Volume 5092, Issue 4, Page(s) 429–441

Abstract: ... holotype of B. trinidadensis are both illustrated with colour photographs. Brachymeria trinidadensis is ... Type material of the long tailed species B. grisselli (Narendran Varghese), B. kraussi (Narendran ... Varghese), B. aculeata (Walker) and B. producta (Olivier) are illustrated by photographs. Variation of B ...

Abstract	Brachymeria trinidadensis (Narendran Varghese) (Hymenoptera: Chalcididae), described originally from Trinidad, West Indies, is newly reported from the state of Kerala, India, as a likely accidental introduction. A possible parasitoid association with an unidentified Bembix (Hymenoptera: Crabronidae) larva feeding on an unidentified species of Tabanidae (Diptera) is suggested based on collection of the female near the Bembix tunnel. The species is redescribed based on the Kerala female and it and the female holotype of B. trinidadensis are both illustrated with colour photographs. Brachymeria trinidadensis is considered a long tailed species of Brachymeria based on females of the species having a conspicuously elongate syntergum, but is removed from the subconica species group of Brachymeria based on the head lacking a transverse carina across the vertex posterior of the median ocellus. Brachymeria laetiliae Burks is also removed from the subconica species group based on the head lacking the transverse carina. Type material of the long tailed species B. grisselli (Narendran Varghese), B. kraussi (Narendran Varghese), B. aculeata (Walker) and B. producta (Olivier) are illustrated by photographs. Variation of B. trinidadensis from other long tailed (syntergum) congeners is also provided.
MeSH term(s)	Animals ; Female ; Hymenoptera ; India ; Larva ; Lepidoptera
Language	English
Publishing date	2022-01-21
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5092.4.2
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Article ; Online: Histomorphological evaluation of stromal collagen in canine mammary tumours

Keerthana Santhosh / S.S. Devi / K.S. Prasanna / B. Dhanush Krishna / Laiju M. Philip

Journal of Veterinary and Animal Sciences, Vol 54, Iss 3, Pp 699-

A study using picrosirius red stain and polarizing microscopy

2023 Volume 705

Abstract: Mammary gland tumours are considered as the most common neoplasms in sexually intact female dogs. Incidence of mammary tumours, especially the malignant ones are found to be rare in dogs younger than five years of age. Latest reports indicate that more ... ...

Abstract	Mammary gland tumours are considered as the most common neoplasms in sexually intact female dogs. Incidence of mammary tumours, especially the malignant ones are found to be rare in dogs younger than five years of age. Latest reports indicate that more than 75 per cent of canine mammary tumours (CMTs) are of malignant type. Recent research has demonstrated that in breast cancer, apart from changes in the parenchyma, major modifications also occur in the stroma or tumour microenvironment, which surrounds the neoplastic cells and these changes are now understood to be crucial factors in the onset and progression of tumour. The tumour microenvironment consists of multiple cell types such as fibroblasts, leukocytes, adipocytes, myoepithelial cells, endothelial cells and the extra cellular matrix (ECM). Numerous studies have indicated that the primary protein in the ECM, collagen, has the potential to give physical, biochemical, and biomechanical impulses to both tumour and non-tumour cells, thus regulating the growth and spread of cancer. The current study employed special staining using picrosirius red to demonstrate the stromal collagen in CMTs and utilised polarised microscopy to analyse the birefringence of collagen fibres in tumours. Picrosirius red staining for evaluation of alterations in stromal collagen fibres was identified to be highly efficient in determining the prognosis of CMTs.
Keywords	collagen ; canine mammary tumour ; picrosirius red ; polarised microscopy ; Animal biochemistry ; QP501-801 ; Science (General) ; Q1-390
Subject code	610
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Director of Academics and Research, Kerala Veterinary and Animal Sciences University
Document type	Article ; Online
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Article ; Online: Sustainable consideration for traditional textile handloom cluster/village in pollution abatement - A case study.

Kopperi, Harishankar / Hemalatha, Manupati / Ravi Kiran, Boda / Santhosh, J / Venkata Mohan, S

Environmental pollution (Barking, Essex : 1987)

2023 Volume 324, Page(s) 121320

Abstract: Decentralized handlooms are being traditionally practised throughout India. Siripuram village known for traditional Pochampally/Ikat work was considered as a case study for detailed investigation towards providing a sustainable solution. Nearly 65% of ... ...

Abstract	Decentralized handlooms are being traditionally practised throughout India. Siripuram village known for traditional Pochampally/Ikat work was considered as a case study for detailed investigation towards providing a sustainable solution. Nearly 65% of village population solely depend on weaving and dyeing works as primary occupation based on the household survey and generated wash water of 127 KLD on an average from the dyeing operations. Initially, a topographical survey (Aerial drone; PHANTOM 4 RTK UAV) was carried out to understand the drainage pattern, elevations, contours and interlinked with domestic and dyeing functions. The characteristics of combined wastewater and dye wash water were studied at lab scale using sequential batch (SBR) operation under aerobic (SBRAe) and aerobic-anoxic (SBRAex) microenvironments. SBRAex microenvironment showed effective organic and nutrients removal due to infused anoxic microenvironment. Treatment studies depicted 76.2% of organic fraction, 73.3% of phosphate, and 81.6% of nitrate removal. Based on the lab scale studies a closed-loop decentralized effluent treatment system was designed to ensure zero-liquid discharge (ZLD).
MeSH term(s)	Waste Disposal, Fluid ; Wastewater ; Organic Chemicals ; Textiles ; Coloring Agents ; Water ; Water Pollutants, Chemical/analysis
Chemical Substances	Wastewater ; Organic Chemicals ; Coloring Agents ; Water (059QF0KO0R) ; Water Pollutants, Chemical
Language	English
Publishing date	2023-02-18
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.121320
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