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Article ; Online: Editorial for "Incremental Effect of Mitral Regurgitation on Left Atrial Dysfunction and Atrioventricular Interaction in Hypertensive Patients by MRI".

Brieger, Daniel / Rye, Eleanor E / Hungerford, Sara L

Journal of magnetic resonance imaging : JMRI

2023 Volume 58, Issue 4, Page(s) 1137–1138

MeSH term(s)	Humans ; Mitral Valve Insufficiency/diagnostic imaging ; Atrial Fibrillation ; Heart Atria/diagnostic imaging ; Mitral Valve ; Magnetic Resonance Imaging ; Ventricular Function, Left
Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.28639
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Article ; Online: Editorial for "Risk Stratification and Outcomes in Patients with Pulmonary Hypertension: Insights into Right Ventricular Strain by MRI Feature-Tracking".

Brieger, Daniel / Rye, Eleanor E / Hungerford, Sara L

Journal of magnetic resonance imaging : JMRI

2022 Volume 57, Issue 2, Page(s) 557–558

MeSH term(s)	Humans ; Hypertension, Pulmonary/diagnostic imaging ; Magnetic Resonance Imaging ; Heart Ventricles/diagnostic imaging ; Risk Assessment ; Magnetic Resonance Imaging, Cine ; Ventricular Function, Right ; Ventricular Dysfunction, Right/diagnostic imaging
Language	English
Publishing date	2022-06-14
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.28289
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Article ; Online: Coronavirus disease (COVID-19) - impact on vaccine preventable diseases.

Hungerford, Daniel / Cunliffe, Nigel A

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2020 Volume 25, Issue 18

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Immunization ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Vaccination ; Vaccine-Preventable Diseases
Keywords	covid19
Language	English
Publishing date	2020-05-12
Publishing country	Sweden
Document type	Letter ; Comment
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2020.25.18.2000756
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Article ; Online: Socioeconomic and ethnic inequalities in incidence and severity of enteric fever in England 2015-2019: analysis of a national enhanced surveillance system.

Buczkowska, Matylda / Jenkins, Claire / Hawker, Jeremy / Hungerford, Daniel / Katwa, Parisha / Kirkbride, Hilary / Byrne, Lisa

Epidemiology and infection

2023 Volume 151, Page(s) e29

Abstract: There is limited research on whether inequalities exist among individuals from different ethnicities and deprivation status among enteric fever cases. The aim of the study was to investigate the association between the enteric fever incidence rates, ... ...

Abstract	There is limited research on whether inequalities exist among individuals from different ethnicities and deprivation status among enteric fever cases. The aim of the study was to investigate the association between the enteric fever incidence rates, ethnicity and deprivation for enteric fever cases in England. Additionally, it was assessed if ethnicity and deprivation were associated with symptom severity, hospital admission and absence from school/work using logistic regression models. Incidence rates were higher in the two most deprived index of multiple deprivation quintiles and those of Pakistani ethnicity (9.89, 95% CI 9.08-10.75) followed by Indian (7.81, 95% CI 7.18-8.49) and Bangladeshi (5.68, 95% CI 4.74-6.76) groups: the incidence rate in the White group was 0.07 (95% CI 0.06-0.08). Individuals representing Pakistani (3.00, 95% CI 1.66-5.43), Indian (2.05, 95% CI 1.18-3.54) and Other/Other Asian (3.51, 95% CI 1.52-8.14) ethnicities had significantly higher odds of hospital admission than individuals representing White (British/Other) ethnicity, although all three groups had statistically significantly lower symptom severity scores. Our results show that there are significant ethnic and socioeconomic inequalities in enteric fever incidence that should inform prevention and treatment strategies. Targeted, community-specific public health interventions are needed to impact on overall burden.
MeSH term(s)	Humans ; Incidence ; Typhoid Fever/epidemiology ; Socioeconomic Factors ; Ethnicity ; England/epidemiology
Language	English
Publishing date	2023-02-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632982-2
ISSN	1469-4409 ; 0950-2688
ISSN (online)	1469-4409
ISSN	0950-2688
DOI	10.1017/S0950268822001959
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Article ; Online: Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK.

Flatt, Aidan / Inns, Thomas / Fleming, Kate M / Iturriza-Gómara, Miren / Hungerford, Daniel

Epidemiology and infection

2023 Volume 151, Page(s) e103

Abstract: In the UK, the incidence and prevalence of inflammatory bowel disease (IBD) is increasing in paediatric populations. Environmental factors including acute gastroenteritis episodes (AGE) may impact IBD development. Infant rotavirus vaccination has been ... ...

Abstract	In the UK, the incidence and prevalence of inflammatory bowel disease (IBD) is increasing in paediatric populations. Environmental factors including acute gastroenteritis episodes (AGE) may impact IBD development. Infant rotavirus vaccination has been shown to significantly reduce AGE. This study aims to explore the association between vaccination with live oral rotavirus vaccines and IBD development. A population-based cohort study was used, analysing primary care data from the Clinical Practice Research Datalink Aurum. Participants included children born in the UK from 2010 to 2015, followed from a minimum of 6 months old to a maximum of 7 years old. The primary outcome was IBD, and the primary exposure was rotavirus vaccination. Cox regression analysis with random intercepts for general practices was undertaken, with adjustment for potential confounding factors. In a cohort of 907,477 children, IBD was recorded for 96 participants with an incidence rate of 2.1 per 100,000 person-years at risk. The univariable analysis hazard ratio (HR) for rotavirus vaccination was 1.45 (95% confidence interval (CI) 0.93-2.28). Adjustment in the multivariable model attenuated the HR to 1.19 (95% CI 0.53-2.69). This study shows no statistically significant association between rotavirus vaccination and development of IBD. However, it provides further evidence for the safety of live rotavirus vaccination.
MeSH term(s)	Child ; Humans ; Infant ; Cohort Studies ; Gastroenteritis/epidemiology ; Gastroenteritis/prevention & control ; Inflammatory Bowel Diseases/epidemiology ; Rotavirus ; Rotavirus Vaccines/administration & dosage ; United Kingdom/epidemiology ; Vaccination ; Viral Vaccines ; Survival Analysis
Chemical Substances	Rotavirus Vaccines ; Viral Vaccines
Language	English
Publishing date	2023-06-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632982-2
ISSN	1469-4409 ; 0950-2688
ISSN (online)	1469-4409
ISSN	0950-2688
DOI	10.1017/S0950268823000936
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Article ; Online: Evaluating the impacts of tiered restrictions introduced in England in December 2020 on covid-19 hospitalisations: a synthetic control study.

Zhang, Xingna / Hungerford, Daniel / Green, Mark / Garcia-Finana, Marta / Buchan, Iain / Barr, Ben

medRxiv

Abstract: Objectives To assess the impact of Tier 3 covid-19 restrictions implemented in December 2020 in England on covid-19 hospital admissions compared to Tier 2 restrictions, and its potential variations by neighbourhood deprivation levels and the prevalence ... ...

Abstract	Objectives To assess the impact of Tier 3 covid-19 restrictions implemented in December 2020 in England on covid-19 hospital admissions compared to Tier 2 restrictions, and its potential variations by neighbourhood deprivation levels and the prevalence of the Alpha variant (B.1.1.7). Design Observational study utilising a synthetic control approach. Comparison of changes in weekly hospitalisation rates in Tier 3 areas to a synthetic control group derived from Tier 2 areas. Setting England between 4th October 2020 and 21st February 2021. Participants 23 million people under Tier 3 restrictions, compared to a synthetic control group derived from 29 million people under Tier 2 restrictions. Interventions Implementation of Tier 3 covid-19 restrictions in designated areas on 7th December 2020, with additional constraints on indoor and outdoor meetings and the hospitality sector compared to less stringent Tier 2 restrictions. Main Outcome Measures Weekly covid-19 related hospital admissions for neighbourhoods in England over a 12-week period following the interventions. Results The introduction of Tier 3 restrictions was associated with a 17% average reduction in hospital admissions compared to Tier 2 areas (95% CI 13% to 21%; 8158 (6286 to 9981) in total)). The effects were similar across different levels of neighbourhood deprivation and prevalence of the Alpha variant (B.1.1.7). Conclusions Regionally targeted Tier 3 restrictions in England had a moderate but significant effect on reducing hospitalisations. The impact did not exacerbate socioeconomic inequalities during the pandemic. Our findings suggest that regionally targeted restrictions can be effective in managing infectious diseases.
Keywords	covid19
Language	English
Publishing date	2024-02-29
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2024.02.28.24303487
Database	COVID19

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Article: Coronavirus disease (COVID-19) - impact on vaccine preventable diseases

Hungerford, Daniel / Cunliffe, Nigel A

Euro surveill

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #197025
Database	COVID19

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Article ; Online: Pregnant women's attitudes and behaviours towards antenatal vaccination against Influenza and COVID-19 in the Liverpool City Region, United Kingdom: cross-sectional survey

Kilada, Samantha / French, Neil / Perkins, Elizabeth / Hungerford, Daniel

medRxiv

Abstract: Objectives Influenza poses a serious health risk to pregnant women and their babies. Despite this risk, influenza vaccine uptake in pregnant women in the UK is less than 50%. Little is known about how COVID-19 affects pregnant women, but its management ... ...

Abstract	Objectives Influenza poses a serious health risk to pregnant women and their babies. Despite this risk, influenza vaccine uptake in pregnant women in the UK is less than 50%. Little is known about how COVID-19 affects pregnant women, but its management may affect attitudes and behaviours towards vaccination in pregnancy. The study objectives were to establish attitudes and knowledge of pregnant women towards influenza disease and influenza vaccination and to compare these to attitudes and knowledge about COVID-19 and COVID-19 vaccination. Design A cross-sectional survey was conducted using an online questionnaire distributed through local advertisement and social media outlets. Information was sought on attitudes and knowledge of influenza and COVID-19 and their respective vaccines. Participants and setting Pregnant women residing in Liverpool City Region, UK Results Of the 237 respondents, 73.8% reported receiving an influenza vaccine. Over half (56.5%) perceived themselves to be at risk from influenza, 70.5% believed that if they got influenza, their baby would get ill, and 64.6% believed getting influenza could hurt their baby, 60.3% believed that the influenza vaccine would prevent their baby from getting ill, and 70.8% believed it would protect their baby. Only 32.9% of respondents stated they would receive the COVID-19 vaccine if it were available to them. However, 80.2% stated they would receive a COVID-19 vaccine if they were not pregnant. Most of the women stated that they would accept a vaccine if recommended to them by healthcare professionals. Conclusions Acceptance of the influenza and COVID-19 vaccines during pregnancy seems to be more related to the safety of the baby rather than the mother. Women perceived their child to be more at risk than themselves. Information about influenza and COVID-19 vaccine safety as well as healthcare provider recommendations play an important role in vaccine uptake in pregnant women.
Keywords	covid19
Language	English
Publishing date	2022-09-14
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2022.09.13.22279846
Database	COVID19

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Article ; Online: Paediatric rotavirus vaccination, coeliac disease and type 1 diabetes in children: a population-based cohort study.

Inns, Thomas / Fleming, Kate M / Iturriza-Gomara, Miren / Hungerford, Daniel

BMC medicine

2021 Volume 19, Issue 1, Page(s) 147

Abstract: Background: Rotavirus infection has been proposed as a risk factor for coeliac disease (CD) and type 1 diabetes (T1D). The UK introduced infant rotavirus vaccination in 2013. We have previously shown that rotavirus vaccination can have beneficial off- ... ...

Abstract	Background: Rotavirus infection has been proposed as a risk factor for coeliac disease (CD) and type 1 diabetes (T1D). The UK introduced infant rotavirus vaccination in 2013. We have previously shown that rotavirus vaccination can have beneficial off-target effects on syndromes, such as hospitalised seizures. We therefore investigated whether rotavirus vaccination prevents CD and T1D in the UK. Methods: A cohort study of children born between 2010 and 2015 was conducted using primary care records from the Clinical Practice Research Datalink. Children were followed up from 6 months to 7 years old, with censoring for outcome, death or leaving the practice. CD was defined as diagnosis of CD or the prescription of gluten-free goods. T1D was defined as a T1D diagnosis. The exposure was rotavirus vaccination, defined as one or more doses. Mixed-effects Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CIs). Models were adjusted for potential confounders and included random intercepts for general practices. Results: There were 880,629 children in the cohort (48.8% female). A total of 343,113 (39.0%) participants received rotavirus vaccine; among those born after the introduction of rotavirus vaccination, 93.4% were vaccinated. Study participants contributed 4,388,355 person-years, with median follow-up 5.66 person-years. There were 1657 CD cases, an incidence of 38.0 cases per 100,000 person-years. Compared with unvaccinated children, the adjusted HR for a CD was 1.05 (95% CI 0.86-1.28) for vaccinated children. Females had a 40% higher hazard than males. T1D was recorded for 733 participants, an incidence of 17.1 cases per 100,000 person-years. In adjusted analysis, rotavirus vaccination was not associated with risk of T1D (HR = 0.89, 95% CI 0.68-1.19). Conclusions: Rotavirus vaccination has reduced diarrhoeal disease morbidity and mortality substantial since licencing in 2006. Our finding from this large cohort study did not provide evidence that rotavirus vaccination prevents CD or T1D, nor is it associated with increased risk, delivering further evidence of rotavirus vaccine safety.
MeSH term(s)	Celiac Disease/epidemiology ; Celiac Disease/prevention & control ; Child ; Cohort Studies ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 1/prevention & control ; Female ; Humans ; Infant ; Male ; Rotavirus ; Rotavirus Infections/epidemiology ; Rotavirus Infections/prevention & control ; Rotavirus Vaccines ; Vaccination
Chemical Substances	Rotavirus Vaccines
Language	English
Publishing date	2021-06-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2131669-7
ISSN	1741-7015 ; 1741-7015
ISSN (online)	1741-7015
ISSN	1741-7015
DOI	10.1186/s12916-021-02017-1
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Article ; Online: A Systematic Review of the Prevalence of Persistent Gastrointestinal Symptoms and Incidence of New Gastrointestinal Illness after Acute SARS-CoV-2 Infection.

Hawkings, Michael J / Vaselli, Natasha Marcella / Charalampopoulos, Dimitrios / Brierley, Liam / Elliot, Alex J / Buchan, Iain / Hungerford, Daniel

Viruses

2023 Volume 15, Issue 8

Abstract: It is known that SARS-CoV-2 infection can result in gastrointestinal symptoms. For some, these symptoms may persist beyond acute infection, in what is known as 'post-COVID syndrome'. We conducted a systematic review to examine the prevalence of ... ...

Abstract	It is known that SARS-CoV-2 infection can result in gastrointestinal symptoms. For some, these symptoms may persist beyond acute infection, in what is known as 'post-COVID syndrome'. We conducted a systematic review to examine the prevalence of persistent gastrointestinal symptoms and the incidence of new gastrointestinal illnesses following acute SARS-CoV-2 infection. We searched the scientific literature using MedLine, SCOPUS, Europe PubMed Central and medRxiv from December 2019 to July 2023. Two reviewers independently identified 45 eligible articles, which followed participants for various gastrointestinal outcomes after acute SARS-CoV-2 infection. The study quality was assessed using the Joanna Briggs Institute Critical Appraisal Tools. The weighted pooled prevalence for persistent gastrointestinal symptoms of any nature and duration was 10.8% compared with 4.9% in healthy controls. For seven studies at low risk of methodological bias, the symptom prevalence ranged from 0.2% to 24.1%, with a median follow-up time of 18 weeks. We also identified a higher risk for future illnesses such as irritable bowel syndrome, dyspepsia, hepatic and biliary disease, liver disease and autoimmune-mediated illnesses such as inflammatory bowel disease and coeliac disease in historically SARS-CoV-2-exposed individuals. Our review has shown that, from a limited pool of mostly low-quality studies, previous SARS-CoV-2 exposure may be associated with ongoing gastrointestinal symptoms and the development of functional gastrointestinal illness. Furthermore, we show the need for high-quality research to better understand the SARS-CoV-2 association with gastrointestinal illness, particularly as population exposure to enteric infections returns to pre-COVID-19-restriction levels.
MeSH term(s)	Humans ; Incidence ; COVID-19/complications ; COVID-19/epidemiology ; Prevalence ; SARS-CoV-2 ; Inflammatory Bowel Diseases
Language	English
Publishing date	2023-07-26
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15081625
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