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  1. Article ; Online: AMARL: An Attention-Based Multiagent Reinforcement Learning Approach to the Min-Max Multiple Traveling Salesmen Problem.

    Gao, Hao / Zhou, Xing / Xu, Xin / Lan, Yixing / Xiao, Yongqian

    IEEE transactions on neural networks and learning systems

    2023  Volume PP

    Abstract: ... learning (AMARL) approach, which is based on the gated transformer feature representations for min-max ... transferred across tasks with different numbers of agents and cities. Extensive experiments on min-max ...

    Abstract In recent years, the multiple traveling salesmen problem (MTSP or multiple TSP) has received increasing research interest and one of its main applications is coordinated multirobot mission planning, such as cooperative search and rescue tasks. However, it is still challenging to solve MTSP with improved inference efficiency as well as solution quality in varying situations, e.g., different city positions, different numbers of cities, or agents. In this article, we propose an attention-based multiagent reinforcement learning (AMARL) approach, which is based on the gated transformer feature representations for min-max multiple TSPs. The state feature extraction network in our proposed approach adopts the gated transformer architecture with reordering layer normalization (LN) and a new gate mechanism. It aggregates fixed-dimensional attention-based state features irrespective of the number of agents and cities. The action space of our proposed approach is designed to decouple the interaction of agents' simultaneous decision-making. At each time step, only one agent is assigned to a non-zero action so that the action selection strategy can be transferred across tasks with different numbers of agents and cities. Extensive experiments on min-max multiple TSPs were conducted to illustrate the effectiveness and advantages of the proposed approach. Compared with six representative algorithms, our proposed approach achieves state-of-the-art performance in solution quality and inference efficiency. In particular, the proposed approach is suitable for tasks with different numbers of agents or cities without extra learning, and experimental results demonstrate that the proposed approach realizes powerful transfer capability across tasks.
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2023.3236629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Transcriptomics yields valuable information regarding the response mechanisms of Chinese Min pigs infected with PEDV.

    Li, Huihui / Zhou, Chunxiang / Zhang, Meimei / Yuan, Na / Huang, Xiaoyu / Xiang, Jiaojiao / Wang, Lixian / Shi, Lijun

    Frontiers in veterinary science

    2023  Volume 10, Page(s) 1295723

    Abstract: ... and immune responses of pigs infected with PEDV.In this study, 12 Min pigs were randomly selected ... sections, and transcriptomics. The phenotypes of Min piglets infected with PEDV showed that the viral copy ...

    Abstract Porcine epidemic diarrhea virus (PEDV) causes porcine epidemic diarrhea (PED), a highly infectious disease, which has resulted in huge economic losses for the pig industry. To date, the pathogenic and immune response mechanism was not particularly clear. The purpose of this study was to investigate the pathogenic and immune responses of pigs infected with PEDV.In this study, 12 Min pigs were randomly selected without taking colostrum. At 3 days old, eight piglets were infected with 1 mL of PEDV solution (10 TCID50/ml), and the remaining four piglets were handled by 1 mL of 0.9% normal saline. Within the age of 7 days old, four piglets died and were considered as the death group. Correspondingly, four alive individuals were classified into the resistance group. Tissues of the duodenum, jejunum, ileum, colon, cecum, and rectum of piglets in the three groups were collected to measure the PEDV content. Additionally, the jejunum was used for the measurements and analyses of Hematoxylin-eosinstaining (HE), immunohistochemical sections, and transcriptomics. The phenotypes of Min piglets infected with PEDV showed that the viral copy numbers and jejunal damage had significant differences between the death and resistance groups. We also observed the transcriptome of the jejunum, and the differentially expressed (DE) analysis observed 6,585 DE protein-coding genes (PCGs), 3,188 DE long non-coding RNAs (lncRNAs), and 350 DE microRNAs (miRNAs), which were mainly involved in immune response and metabolic pathways. Furthermore, the specific expressed molecules for each group were identified, and 97 PCGs,108 lncRNAs, and 51 miRNAs were included in the ceRNA-regulated networks. By weighted gene co-expression network analysis (WGCNA) and transcription factor (TF) prediction, 27 significant modules and 32 significant motifs (
    Language English
    Publishing date 2023-12-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2023.1295723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A New Smart 2-Min Mobile Alerting Method for Mild Cognitive Impairment Due to Alzheimer's Disease in the Community.

    Wang, Yujia / Chen, Tong / Wang, Chen / Ogihara, Atsushi / Ma, Xiaowen / Huang, Shouqiang / Zhou, Siyu / Li, Shuwu / Liu, Jiakang / Li, Kai

    Brain sciences

    2023  Volume 13, Issue 2

    Abstract: ... According to this, we designed a new smart 2-min mobile alerting method for MCI due to AD, for community ...

    Abstract The early identification of mild cognitive impairment (MCI) due to Alzheimer's disease (AD), in an early stage of AD can expand the AD warning window. We propose a new capability index evaluating the spatial execution process (SEP), which can dynamically evaluate the execution process in the space navigation task. The hypothesis is proposed that there are neurobehavioral differences between normal cognitive (NC) elderly and AD patients with MCI reflected in digital biomarkers captured during SEP. According to this, we designed a new smart 2-min mobile alerting method for MCI due to AD, for community screening. Two digital biomarkers, total mission execution distance (METRtotal) and execution distance above the transverse obstacle (EDabove), were selected by step-up regression analysis. For the participants with more than 9 years of education, the alerting efficiency of the combination of the two digital biomarkers for MCI due to AD could reach 0.83. This method has the advantages of fast speed, high alerting efficiency, low cost and high intelligence and thus has a high application value for community screening in developing countries. It also provides a new intelligent alerting approach based on the human-computer interaction (HCI) paradigm for MCI due to AD in community screening.
    Language English
    Publishing date 2023-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13020244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Analysis of hydrological regime evolution and ecological response in the Min River, China

    Hongxiang Wang / Baoliang Wang / Huan Yang / Haotong Zhou / Hao Chen / Wenxian Guo

    Journal of Water and Climate Change, Vol 14, Iss 10, Pp 3596-

    2023  Volume 3616

    Abstract: ... Given the shortcomings of previous studies on hydrological regime change and the ecological response of the Min River ... response mechanisms. The results showed the following: (1) The hydrological regime in the Min River basin ... reduction in Min River runoff, with human activities contributing 54.20% of the change in the mean annual ...

    Abstract Natural fluctuation of the hydrological regime is the key to maintaining river ecosystem function. Given the shortcomings of previous studies on hydrological regime change and the ecological response of the Min River, this study combined two change degree evaluation methods and Budyko theory to quantify the degree of ecohydrological change and its driving factors. Ecological significance indicators (ecosurplus and ecodeficit) and the Shannon index (SI) were used to identify the characteristics of ecohydrological variation and ecological response mechanisms. The results showed the following: (1) The hydrological regime in the Min River basin had an abrupt change in 1993, with the overall alteration degree reaching 44%, which further led to a decrease in ecological surplus and an increase in the ecological deficit in ecological indicators. (2) Budyko's theoretical results show that climate change and human activities together lead to an 83.83 mm reduction in Min River runoff, with human activities contributing 54.20% of the change in the mean annual runoff, while rainfall and evapotranspiration contribute 43.88 and 1.92%, respectively. (3) The SI index indicates a decreasing trend in Min flow biodiversity. The results of the study can provide a reference for enhancing ecological protection and restoration in the Min River basin. HIGHLIGHTS Quantitative assessment of the overall degree of change in the hydrological situation of the Min River.; Quantitative assessment of the hydrological situation of the Min River using ecohydrological indicators (ecosurplus, ecodeficit).; Quantitative analysis of the contribution of climate change and human activities to the hydrological changes of the Min River.;
    Keywords attribution analysis ; budyko ; ecological response ; ecosurplus and ecodeficit ; iha-rva method ; min river ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350
    Subject code 333 ; 550
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher IWA Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Rapid Detection of SARS-CoV-2 in Clinical and Environmental Samples via a Resonant Cavity SERS Platform within 20 min.

    Huang, Jinglin / Wang, Conghui / Wang, Pingshi / Mo, Wenbo / Zhou, Minjie / Le, Wei / Qi, Daojian / Wei, Lai / Fan, Quanping / Yang, Yue / Ni, Shuang / Wu, Yan / Feng, Yuliang / Wang, Xiang / Zhao, Zongqing / He, Zhibing / Zhang, Haijun / Xue, Peili / Ren, Bin /
    Ren, Lili / Pan, Ming / Du, Kai

    ACS applied materials & interfaces

    2023  

    Abstract: ... and rapid detection of SARS-CoV-2 antigen within 20 min by the combination of a highly consistent SERS ...

    Abstract The coronavirus disease 2019 (COVID-19) epidemic has given a warning that it is important to explore the rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in clinical specimens or environmental samples for public health strategies and future variants. The surface-enhanced Raman spectroscopy (SERS) technique was demonstrated to achieve this goal. However, the consistency of signals originating from the poor compatibility of virions with SERS hotspots remains a key scientific challenge for the practical applications of SERS. Herein, we develop a SERS platform for the ultrasensitive and rapid detection of SARS-CoV-2 antigen within 20 min by the combination of a highly consistent SERS substrate and a supervised deep learning algorithm. A V-shaped resonant cavity array (VRC) substrate was fabricated to trap SARS-CoV-2 virions in the periodic V cavity array and stimulate the integral SERS signal of the virus via a resonance coupling effect. Benefiting from the unique architecture of the VRC substrate, we were able to directly detect the SARS-CoV-2 virus with high sensitivity and high consistency. These excellent performances enabled us to identify five different kinds of SARS-CoV-2 variants and detect SARS-CoV-2 from clinical and environmental samples with high accuracies.
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c08819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Power-duration relationship comparison in competition sprint cyclists from 1-s to 20-min. Sprint performance is more than just peak power.

    Ferguson, Hamish / Harnish, Chris / Klich, Sebastian / Michalik, Kamil / Dunst, Anna Katharina / Zhou, Tony / Chase, J Geoffrey

    PloS one

    2023  Volume 18, Issue 5, Page(s) e0280658

    Abstract: ... only peak power, but power out to 20-min. There is also a belief where maximal efforts of longer ... female) provided maximal power for durations from 1-s to 20-min. Peak power values are compared to assess ... and durations from 1-s to 20-min remained high (R2 ≥ 0.83). Despite current assumptions around 1-s ...

    Abstract Current convention place peak power as the main determinant of sprint cycling performance. This study challenges that notion and compares two common durations of sprint cycling performance with not only peak power, but power out to 20-min. There is also a belief where maximal efforts of longer durations will be detrimental to sprint cycling performance. 56 data sets from 27 cyclists (21 male, 6 female) provided maximal power for durations from 1-s to 20-min. Peak power values are compared to assess the strength of correlation (R2), and any relationship (slope) across every level. R2 between 15-s- 30-s power and durations from 1-s to 20-min remained high (R2 ≥ 0.83). Despite current assumptions around 1-s power, our data shows this relationship is stronger around competition durations, and 1-s power also still shared strong relationships with longer durations out to 20-min. Slopes for relationships at shorter durations were closer to a 1:1 relationship than longer durations, but closer to long-duration slopes than to a 1:1 line. The present analyses contradicts both well-accepted hypotheses that peak power is the main driver of sprint cycling performance and that maximal efforts of longer durations out to 20-min will hinder sprint cycling. This study shows the importance and potential of training durations from 1-s to 20-min over a preparation period to improve competition sprint cycling performance.
    MeSH term(s) Male ; Humans ; Female ; Bicycling ; Time Factors ; Athletic Performance
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0280658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Assessment of walkability and walkable routes of a 15-min city for heat adaptation: Development of a dynamic attenuation model of heat stress.

    Wang, Yu / He, Bao-Jie / Kang, Chong / Yan, Li / Chen, Xueke / Yin, Mingqiang / Liu, Xiao / Zhou, Tiejun

    Frontiers in public health

    2022  Volume 10, Page(s) 1011391

    Abstract: Actively addressing urban heat challenges is an urgent task for numerous cities. Existing studies have primarily developed heat mitigation strategies and analyzed their cooling performance, while the adaptation strategies are far from comprehensive to ... ...

    Abstract Actively addressing urban heat challenges is an urgent task for numerous cities. Existing studies have primarily developed heat mitigation strategies and analyzed their cooling performance, while the adaptation strategies are far from comprehensive to protect citizens from heat-related illnesses and deaths. To address this research gap, this paper aims to enhance people's adaptation capacity by investigating walkability within fifteen-minute cities (FMC). Taking cognizance of thermal comfort, health, and safety, this paper developed a dynamic attenuation model (DAM) of heat stress, along with heat stress aggravation, continuance, and alleviation. An indicator of remaining tolerant heat discomfort (
    MeSH term(s) Humans ; Cities ; Environment Design ; Thermotolerance ; Residence Characteristics ; Walking
    Language English
    Publishing date 2022-11-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.1011391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Assessment of walkability and walkable routes of a 15-min city for heat adaptation

    Yu Wang / Bao-Jie He / Chong Kang / Li Yan / Xueke Chen / Mingqiang Yin / Xiao Liu / Tiejun Zhou

    Frontiers in Public Health, Vol

    Development of a dynamic attenuation model of heat stress

    2022  Volume 10

    Abstract: ... the maximum tolerant heat discomfort was determined to be 60 min. Furthermore, the DAM was applied to an FMC ... the street was generally walkable with an Rt ranging between 15 and 30 min, after walking for 900 m ... for walking with an Rtof 45–46 min, and the perpetual areas were also walkable with an Rtof 15–30 min. Based ...

    Abstract Actively addressing urban heat challenges is an urgent task for numerous cities. Existing studies have primarily developed heat mitigation strategies and analyzed their cooling performance, while the adaptation strategies are far from comprehensive to protect citizens from heat-related illnesses and deaths. To address this research gap, this paper aims to enhance people's adaptation capacity by investigating walkability within fifteen-minute cities (FMC). Taking cognizance of thermal comfort, health, and safety, this paper developed a dynamic attenuation model (DAM) of heat stress, along with heat stress aggravation, continuance, and alleviation. An indicator of remaining tolerant heat discomfort (Rt) was proposed with the integration of the Universal Thermal Climate Index (UTCI) to assess heat-related walkability. Following an empirical study among 128 residents in Mianyang, China, and assessing four levels of heat stress, the maximum tolerant heat discomfort was determined to be 60 min. Furthermore, the DAM was applied to an FMC with 12 neighborhoods in Fucheng, Mianyang, China. The results indicate that for each neighborhood, the street was generally walkable with an Rt ranging between 15 and 30 min, after walking for 900 m. A population-based FMC walkability was further determined, finding that the core area of the FMC was favorable for walking with an Rtof 45–46 min, and the perpetual areas were also walkable with an Rtof 15–30 min. Based on these results, suggestions on the frequency of public services (frequently used, often used, and occasionally used) planning were presented. Overall, this paper provides a theoretical model for analyzing walkability and outlines meaningful implications for planning heat adaptation in resilient, safe, comfortable, and livable FMCs.
    Keywords extreme heat ; 15-min city ; thermal comfort ; dynamic attenuation model ; UTCI ; ENVI-met ; Public aspects of medicine ; RA1-1270
    Subject code 690
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: In Vivo Metabolite Profiling of DMU-212 in Apc Min/+ Mice Using UHPLC-Q/Orbitrap/LTQ MS

    Jing Li / Xinghua Li / Xiaohang Zhou / Le Yang / Hui Sun / Ling Kong / Guangli Yan / Ying Han / Xijun Wang

    Molecules, Vol 28, Iss 3828, p

    2023  Volume 3828

    Abstract: ... profiling of DMU-212 after oral administration in Apc Min/+ mice based on the effectiveness of the medicine ... of 240mg/kg for 3 weeks in the colorectal adenoma (CRA) spontaneous model Apc Min/+ mice. A total of 63 ... metabolites of DMU-212 were tentatively identified, including 48, 48, 34 and 28 metabolites in the Apc Min ...

    Abstract 3,4,5,4’-Trans-tetramethoxystilbene (Synonyms: DMU-212) is a resveratrol analogue with stronger antiproliferative activity and more bioavailability. However, the metabolite characterization of this component remains insufficient. An efficient strategy was proposed for the comprehensive in vivo metabolite profiling of DMU-212 after oral administration in Apc Min/+ mice based on the effectiveness of the medicine. Ultra-high performance liquid chromatography-quadrupole/orbitrap/linear ion trap mass spectrometry (UHPLC-Q/Orbitrap/LTQ MS) in the AcquireX TM intelligent data acquisition mode, combining the exact mass and structural information, was established for the profiling and identification of the metabolites of DMU-212 in vivo, and the possible metabolic pathways were subsequently proposed after the oral dose of 240mg/kg for 3 weeks in the colorectal adenoma (CRA) spontaneous model Apc Min/+ mice. A total of 63 metabolites of DMU-212 were tentatively identified, including 48, 48, 34 and 28 metabolites in the Apc Min/+ mice’s intestinal contents, liver, serum, and colorectal tissues, respectively. The metabolic pathways, including demethylation, oxidation, desaturation, methylation, acetylation, glucuronide and cysteine conjugation were involved in the metabolism. Additionally, further verification of the representative active metabolites was employed using molecular docking analysis. This study provides important information for the further investigation of the active constituents of DMU-212 and its action mechanisms for CRA prevention.
    Keywords DMU-212 ; colorectal adenoma ; UHPLC-Q/Orbitrap/LTQ MS ; metabolites ; Organic chemistry ; QD241-441
    Subject code 333
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Transcriptomics yields valuable information regarding the response mechanisms of Chinese Min pigs infected with PEDV

    Huihui Li / Chunxiang Zhou / Meimei Zhang / Na Yuan / Xiaoyu Huang / Jiaojiao Xiang / Lixian Wang / Lijun Shi

    Frontiers in Veterinary Science, Vol

    2023  Volume 10

    Abstract: ... and immune responses of pigs infected with PEDV.In this study, 12 Min pigs were randomly selected ... sections, and transcriptomics. The phenotypes of Min piglets infected with PEDV showed that the viral copy ...

    Abstract Porcine epidemic diarrhea virus (PEDV) causes porcine epidemic diarrhea (PED), a highly infectious disease, which has resulted in huge economic losses for the pig industry. To date, the pathogenic and immune response mechanism was not particularly clear. The purpose of this study was to investigate the pathogenic and immune responses of pigs infected with PEDV.In this study, 12 Min pigs were randomly selected without taking colostrum. At 3 days old, eight piglets were infected with 1 mL of PEDV solution (10 TCID50/ml), and the remaining four piglets were handled by 1 mL of 0.9% normal saline. Within the age of 7 days old, four piglets died and were considered as the death group. Correspondingly, four alive individuals were classified into the resistance group. Tissues of the duodenum, jejunum, ileum, colon, cecum, and rectum of piglets in the three groups were collected to measure the PEDV content. Additionally, the jejunum was used for the measurements and analyses of Hematoxylin-eosinstaining (HE), immunohistochemical sections, and transcriptomics. The phenotypes of Min piglets infected with PEDV showed that the viral copy numbers and jejunal damage had significant differences between the death and resistance groups. We also observed the transcriptome of the jejunum, and the differentially expressed (DE) analysis observed 6,585 DE protein-coding genes (PCGs), 3,188 DE long non-coding RNAs (lncRNAs), and 350 DE microRNAs (miRNAs), which were mainly involved in immune response and metabolic pathways. Furthermore, the specific expressed molecules for each group were identified, and 97 PCGs,108 lncRNAs, and 51 miRNAs were included in the ceRNA-regulated networks. By weighted gene co-expression network analysis (WGCNA) and transcription factor (TF) prediction, 27 significant modules and 32 significant motifs (E-value < 0.05) annotated with 519 TFs were detected. Of these TFs, 53 were DE PCGs. In summary, the promising key PCGs, lncRNAs, and miRNAs related to the pathogenic and immunological response of pigs ...
    Keywords Min pigs ; PEDV ; transcriptome ; WGCNA ; transcript factor ; Veterinary medicine ; SF600-1100
    Subject code 630
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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