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Article ; Online: Honoring a legend: Celebrating the life and legacy of Professor Heng Li.

Guo, Hui-Jun / Huang, Jin-Ling / Ji, Yun-Heng / Li, Rong / Long, Chun-Lin / Yang, Qin-Er / Yang, Yong-Ping / Yi, Ting-Shuang

Plant diversity

2023 Volume 45, Issue 3, Page(s) 239–240

Language	English
Publishing date	2023-03-17
Publishing country	China
Document type	Editorial
ZDB-ID	2873411-7
ISSN	2468-2659 ; 2095-0845
ISSN (online)	2468-2659
ISSN	2095-0845
DOI	10.1016/j.pld.2023.03.003
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Article ; Online: Exploring the potential mechanism of Heng-Gu-Gu-Shang-Yu-He-Ji therapy for osteoporosis based on network pharmacology and transcriptomics.

Xie, Linbi / Song, Xu / Lei, Ling / Chen, Chu / Zhao, Huan / Hu, Jingyi / Yu, Yue / Bai, Xiaolu / Wu, Xia / Li, Xiangfeng / Yang, Xiao / Yuan, Bo / Li, Dongxiao / Zhu, Xiangdong / Zhang, Xingdong

Journal of ethnopharmacology

2023 Volume 321, Page(s) 117480

Abstract: Ethnopharmacological relevance: Heng-Gu-Gu-Shang-Yu-He-Ji (Osteoking, OK) is a well-known formula ...

Abstract	Ethnopharmacological relevance: Heng-Gu-Gu-Shang-Yu-He-Ji (Osteoking, OK) is a well-known formula for fracture therapy. In clinic, OK is effective in treating fractures while alleviating osteoporosis (OP) symptoms. However, active components of OK and the associated molecular mechanisms remain not fully elucidated. Aim of the study: This study aims to systematically evaluate the anti-osteoporosis efficacy of OK and for the first time combine network pharmacology with high-throughput whole gene transcriptome sequencing to study its underlying mechanism. Materials and methods: In this study, the osteoporosis model was established by the castration of both ovaries. The level of serum bone turnover factor was detected by enzyme-linked immunosorbent assay. Micro-CT and HE staining were used to observe the changes of bone histopathology, and nano-indentation technique was used to detect the biomechanical properties of rat bone. The main active Chemical components of OK were identified using UPLC-DAD. Efficacy verification and mechanism exploration were conducted by network pharmacology, molecular docking, whole gene transcriptomics and in vivo experiments. Results: In our study, OK significantly improved bone microarchitecture and bone biomechanical parameters in OVX rats, reduced osteoclast indexes such as C-telopeptide of type I collage (CTX-I) and increased Osteoprotegerin (OPG)/Receptor activator of NF-κB ligand (RANKL) levels. Mechanistically, PI3K/AKT pathway was a common pathway for genome enrichment analysis (KEGG) of both network pharmacology and RNA-seq studies. G protein-β-like protein (GβL), Ribosomal-protein S6 kinase homolog 2 (S6K2), and Phosphoinositide 3-kinase (PI3K) appeared differentially expression in the PI3K-AKT signaling pathway. These results were also confirmed by qRT-PCR and immunohistochemistry. Conclusions: OK may be used to treat osteoporosis, at least partly by activating PI3K/AKT/mTORC1 signaling pathway.
MeSH term(s)	Rats ; Animals ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Network Pharmacology ; Molecular Docking Simulation ; Rats, Sprague-Dawley ; Osteoprotegerin/genetics ; Osteoprotegerin/metabolism ; Osteoporosis/metabolism ; Gene Expression Profiling ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Osteoprotegerin ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-11-22
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117480
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Article: Chemical characteristics of freezing rain observed at Mount Heng in southern China

Li, Xingyu / Lyu, Yixuan / Pan, Yuepeng / Sun, Qian / Zhu, Xiaying / Hu, Jiabao / Liu, Jin / Cao, Jing / Gu, Mengna / Zhang, Mengshen / Stewart, Ronald E.

Atmospheric environment. 2022 July 15, v. 281

2022

Abstract: ... rain/snow) samples on Mt. Heng in southern China for 7 years in the winters between 2015 and 2021 ... The winter precipitation collected at Mt. Heng was mostly acidic with pH values lower than 5. Acidity ...

Abstract	Freezing rain usually occurs when snow falls into an above-freezing layer aloft where it melts before reaching the sub-freezing surface as supercooled water. Although the occurrence of freezing rain is uncommon, it can produce extremely costly impacts. To date, field chemical observations of supercooled drops that form freezing rain are lacking. In this study, we collected 101 precipitation (freezing rain/rain/snow) samples on Mt. Heng in southern China for 7 years in the winters between 2015 and 2021. The winter precipitation collected at Mt. Heng was mostly acidic with pH values lower than 5. Acidity, contributed from NO₃⁻ and SO₄²⁻, was neutralized by NH₄⁺ and Ca²⁺, indicating the additional contribution from organic acids. The major ions were NH₄⁺, Ca²⁺, SO₄²⁻ and NO₃⁻, with concentrations of 135.7, 86.3, 72.5 and 61.8 μeq L⁻¹, respectively. In general, the total ionic concentrations of freezing rain were, in comparison with mountain-based observations elsewhere, lower than those in cloud water but higher than those in rain. The higher concentrations of major ions in freezing rain would depress the freezing point of supercooled water drops and act to reduce the likelihood of freezing with effects increasing with concentration. This process would be countered by the presence of ice nuclei that is acting to freeze supercooled drops. These opposing processes complicate the understanding of the onset of freezing and consequently the occurrence of freezing rain. This study highlighted that additional model simulations and laboratory experiments are needed to validate the relationship between air pollution and freezing rain.
Keywords	acidity ; air pollution ; calcium ; environment ; ice ; laboratory experimentation ; pH ; rain ; simulation models ; snow ; China
Language	English
Dates of publication	2022-0715
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	216368-8
ISSN	0004-6981 ; 1352-2310
ISSN	0004-6981 ; 1352-2310
DOI	10.1016/j.atmosenv.2022.119140
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Article ; Online: A 230-Year Summer Precipitation Variations Recorded by Tree-Ring δ 18 O in Heng Mountains, North China

Yu Liu / Wenxin Shi / Qiang Li / Wentai Liu / Qiufang Cai

Forests, Vol 13, Iss 10, p

2022 Volume 1654

Abstract: ... on Heng Mountain, a 230-year June–July precipitation sequence from 1784 to 2013 AD was reconstructed ...

Abstract	To explore the history of the changes in monsoon precipitation and their driving mechanisms in the context of global warming, climatology studies using tree-ring stable oxygen isotopes (δ 18 O) were carried out in Shanxi Province, China. Based on a tree-ring δ 18 O series from Pinus tabulaeformis Carr . on Heng Mountain, a 230-year June–July precipitation sequence from 1784 to 2013 AD was reconstructed that explained 45% of the total variance (44% after adjusting the degrees of freedom). The reconstructed sequence captured the characteristics of the variations in precipitation. Periods of drought occurred mainly in 1820–1840 AD, 1855–1865 AD, 1895–1910 AD, 1925–1930 AD, and 1970–1995 AD, and wet periods occurred mainly in 1880–1895 AD, 1910–1925 AD, and 1935–1960 AD. The dry and wet years in the precipitation reconstruction corresponded well to the years in which disaster events were documented in historical records. A spatial correlation analysis with Climatic Research Unit (CRU)-gridded precipitation data indicated that the reconstructed precipitation provided good regional representation and reflected large-scale June–July precipitation changes in northern China. In addition, the reconstructed precipitation sequence was also significantly correlated with the dry and wet index (DWI) and other tree-ring dry/wet reconstructions from the surrounding areas. The correlation between the reconstructed precipitation and the Asian monsoon index showed that the precipitation can indicate the intensity of the Asian summer monsoon. Moreover, a significant negative correlation was found between the El Niño–Southern Oscillation (ENSO) and the reconstructed precipitation. At the decadal scale, the negative phase of the Pacific Decadal Oscillation (PDO) and the positive phase of the Atlantic Multidecadal Oscillation (AMO) may co-promote summer precipitation in the study area.
Keywords	Heng Mountain ; northern China ; tree-ring δ 18 O ; precipitation ; reconstruction ; Asian monsoon ; Plant ecology ; QK900-989
Subject code	910
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reply to Adam G. Sowalsky, Stephen R. Plymate, Michael C. Haffner, Johann S. de Bono, and Adam Sharp's Letter to the Editor re: Heng Li, Yucong Zhang, Dong Li, et al. Androgen Receptor Splice Variant 7 Predicts Shorter Response in Patients with Metastatic Hormone-sensitive Prostate Cancer Receiving Androgen Deprivation Therapy. Eur Urol 2021;79:879-86: AR-V7 is Rare in Hormone-sensitive Prostate Cancer.

Li, Heng / Zhang, Yucong / Xu, Hua

European urology

2022 Volume 82, Issue 5, Page(s) e137–e138

MeSH term(s)	Androgen Antagonists/therapeutic use ; Androgens/therapeutic use ; Hormone Replacement Therapy ; Humans ; Male ; Prostatic Neoplasms, Castration-Resistant/pathology ; Receptors, Androgen/genetics
Chemical Substances	Androgen Antagonists ; Androgens ; Receptors, Androgen
Language	English
Publishing date	2022-09-07
Publishing country	Switzerland
Document type	Letter ; Comment
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2022.08.013
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Article: Effects of Slaughter Age on Muscle Characteristics and Meat Quality Traits of Da-Heng Meat Type Birds.

Li, Jingjing / Yang, Chaowu / Peng, Han / Yin, Huadong / Wang, Yan / Hu, Yaodong / Yu, Chunlin / Jiang, Xiaosong / Du, Huarui / Li, Qingyun / Liu, Yiping

Animals : an open access journal from MDPI

2019 Volume 10, Issue 1

Abstract: ... groups of 200 male Da-Heng meat type birds were reared until slaughter age of 60, 90, 120, 150, 180 days ...

Abstract	Due to the increasing demand for producing chickens with high meat quality, there is a need to determine its mode of action on chicken meat quality traits across a wider age spectrum. In this study, five groups of 200 male Da-Heng meat type birds were reared until slaughter age of 60, 90, 120, 150, 180 days old and breast muscle performance, meat quality traits, and myofiber characteristics were evaluated. The larger body weight and breast weight of chicken are based on larger myofiber diameter and area, less myofiber density for the older birds than younger birds. There was an age effect on all meat quality traits of chicken breast muscle (
Language	English
Publishing date	2019-12-30
Publishing country	Switzerland
Document type	Journal Article
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani10010069
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Article ; Online: Study on safe usage of agricultural land in karst and non-karst areas based on soil Cd and prediction of Cd in rice: A case study of Heng County, Guangxi.

Li, Cheng / Yang, Zhongfang / Yu, Tao / Hou, Qingye / Liu, Xu / Wang, Jue / Zhang, Qizuan / Wu, Tiansheng

Ecotoxicology and environmental safety

2020 Volume 208, Page(s) 111505

Abstract: ... and rice samples, and in comparison with the different soil parent materials in Heng County, it was ...

Abstract	It is well-known that Cd concentration in the soil, Cd bioavailability, and Cd bioaccumulation in rice (Oryza sativa L.) grains vary greatly in different soil parent materials. Therefore, the classification of agricultural land environmental quality and agricultural land safe usage based on the Cd content in the soil has a wide deviation. By the application of systematic sampling and analysis of soil and rice samples, and in comparison with the different soil parent materials in Heng County, it was found that soil derived from carbonate rocks has higher total Cd and lower mobile Cd proportion than soil from the non-karst areas. This result indicated that soil carbonates raised soil pH and the adsorption of Fe/Mn oxide/hydroxide on Cd significantly reduced the bioavailability of Cd in karst areas. In contrast, acidic soils with relatively lower CaO, TFe
MeSH term(s)	Agriculture/methods ; Biological Availability ; Cadmium/analysis ; Cadmium/pharmacokinetics ; Carbonates/analysis ; China ; Edible Grain/metabolism ; Models, Theoretical ; Oryza/metabolism ; Soil/chemistry ; Soil Pollutants/analysis ; Soil Pollutants/pharmacokinetics
Chemical Substances	Carbonates ; Soil ; Soil Pollutants ; Cadmium (00BH33GNGH)
Language	English
Publishing date	2020-10-28
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2020.111505
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Article: Effects of Slaughter Age on Muscle Characteristics and Meat Quality Traits of Da-Heng Meat Type Birds

Li, Jingjing / Yang, Chaowu / Peng, Han / Yin, Huadong / Wang, Yan / Hu, Yaodong / Yu, Chunlin / Jiang, Xiaosong / Du, Huarui / Li, Qingyun / Liu, Yiping

Animals. 2019 Dec. 30, v. 10, no. 1

2019

Abstract: ... groups of 200 male Da-Heng meat type birds were reared until slaughter age of 60, 90, 120, 150, 180 days ...

Abstract	Due to the increasing demand for producing chickens with high meat quality, there is a need to determine its mode of action on chicken meat quality traits across a wider age spectrum. In this study, five groups of 200 male Da-Heng meat type birds were reared until slaughter age of 60, 90, 120, 150, 180 days old and breast muscle performance, meat quality traits, and myofiber characteristics were evaluated. The larger body weight and breast weight of chicken are based on larger myofiber diameter and area, less myofiber density for the older birds than younger birds. There was an age effect on all meat quality traits of chicken breast muscle (p < 0.05). Older chickens often presented a higher pH, lower drip loss, higher shear force, darker, and redder breast meat. The correlation coefficients showed that myofiber characteristics played an important role in breast pH values, drip loss, and meat color (p < 0.05). Besides, significant correlations were also found between meat quality traits (p < 0.05). Further studies are needed to explore the biochemical character and potential molecular mechanism of chicken breast muscle to determine the factors that causes these age-related differences in meat quality in the current study.
Keywords	age at slaughter ; body weight ; breast meat ; breast muscle ; breasts ; chicken meat ; chickens ; color ; drip loss ; males ; meat quality ; mechanism of action ; pH
Language	English
Dates of publication	2019-1230
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ISSN	2076-2615
DOI	10.3390/ani10010069
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effects of Slaughter Age on Muscle Characteristics and Meat Quality Traits of Da-Heng Meat Type Birds

Jingjing Li / Chaowu Yang / Han Peng / Huadong Yin / Yan Wang / Yaodong Hu / Chunlin Yu / Xiaosong Jiang / Huarui Du / Qingyun Li / Yiping Liu

Animals, Vol 10, Iss 1, p

2019 Volume 69

Abstract: ... groups of 200 male Da-Heng meat type birds were reared until slaughter age of 60, 90, 120, 150, 180 days ...

Abstract	Due to the increasing demand for producing chickens with high meat quality, there is a need to determine its mode of action on chicken meat quality traits across a wider age spectrum. In this study, five groups of 200 male Da-Heng meat type birds were reared until slaughter age of 60, 90, 120, 150, 180 days old and breast muscle performance, meat quality traits, and myofiber characteristics were evaluated. The larger body weight and breast weight of chicken are based on larger myofiber diameter and area, less myofiber density for the older birds than younger birds. There was an age effect on all meat quality traits of chicken breast muscle ( p < 0.05). Older chickens often presented a higher pH, lower drip loss, higher shear force, darker, and redder breast meat. The correlation coefficients showed that myofiber characteristics played an important role in breast pH values, drip loss, and meat color ( p < 0.05). Besides, significant correlations were also found between meat quality traits ( p < 0.05). Further studies are needed to explore the biochemical character and potential molecular mechanism of chicken breast muscle to determine the factors that causes these age-related differences in meat quality in the current study.
Keywords	chicken ; slaughter age ; myofiber ; meat quality ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A New Hybrid Model Using an Autoregressive Integrated Moving Average and a Generalized Regression Neural Network for the Incidence of Tuberculosis in Heng County, China.

Wei, Wudi / Jiang, Junjun / Gao, Lian / Liang, Bingyu / Huang, Jiegang / Zang, Ning / Ning, Chuanyi / Liao, Yanyan / Lai, Jingzhen / Yu, Jun / Qin, Fengxiang / Chen, Hui / Su, Jinming / Ye, Li / Liang, Hao

The American journal of tropical medicine and hygiene

2017 Volume 97, Issue 3, Page(s) 799–805

Abstract: It is a daunting task to eradicate tuberculosis completely in Heng County due to a large transient ... GRNN model may be more suitable for forecasting the tuberculosis incidence in Heng County ...

Abstract	It is a daunting task to eradicate tuberculosis completely in Heng County due to a large transient population, human immunodeficiency virus/tuberculosis coinfection, and latent infection. Thus, a high-precision forecasting model can be used for the prevention and control of tuberculosis. In this study, four models including a basic autoregressive integrated moving average (ARIMA) model, a traditional ARIMA-generalized regression neural network (GRNN) model, a basic GRNN model, and a new ARIMA-GRNN hybrid model were used to fit and predict the incidence of tuberculosis. Parameters including mean absolute error (MAE), mean absolute percentage error (MAPE), and mean square error (MSE) were used to evaluate and compare the performance of these models for fitting historical and prospective data. The new ARIMA-GRNN model had superior fit relative to both the traditional ARIMA-GRNN model and basic ARIMA model when applied to historical data and when used as a predictive model for forecasting incidence during the subsequent 6 months. Our results suggest that the new ARIMA-GRNN model may be more suitable for forecasting the tuberculosis incidence in Heng County than traditional models.
MeSH term(s)	China/epidemiology ; Computer Simulation ; Humans ; Incidence ; Models, Biological ; Models, Statistical ; Neural Networks, Computer ; Tuberculosis/epidemiology
Language	English
Publishing date	2017-08-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.16-0648
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