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Article ; Online: Coronavirus disease 2019-The principles of the curve, explained simply.

Jozaghi, Yelda

2020 Volume 42, Issue 7, Page(s) 1539–1542

Abstract: In the setting of the coronavirus disease 2019 pandemic, the concept of the disease curve has become ubiquitous in medicine and across society. Nevertheless, even among medical specialists, there are common misconception about the curve and how it ... ...

Abstract	In the setting of the coronavirus disease 2019 pandemic, the concept of the disease curve has become ubiquitous in medicine and across society. Nevertheless, even among medical specialists, there are common misconception about the curve and how it affects population outcomes. This article provides a simple review of the various population dynamics at play. Principles such as the area under the curve and the threshold of capacity are discussed and simply conceptualized. Understanding the fundamental characteristics of a problem can allow us to see it with more clarity. By the end of the article, the reader will gain an effortless a sense of insight on this topic.
MeSH term(s)	Area Under Curve ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Epidemiologic Measurements ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Surge Capacity
Keywords	covid19
Language	English
Publishing date	2020-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.26289
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Article: Coronavirus disease 2019-The principles of the curve, explained simply

Jozaghi, Yelda

Head Neck

Abstract	In the setting of the coronavirus disease 2019 pandemic, the concept of the disease curve has become ubiquitous in medicine and across society. Nevertheless, even among medical specialists, there are common misconception about the curve and how it affects population outcomes. This article provides a simple review of the various population dynamics at play. Principles such as the area under the curve and the threshold of capacity are discussed and simply conceptualized. Understanding the fundamental characteristics of a problem can allow us to see it with more clarity. By the end of the article, the reader will gain an effortless a sense of insight on this topic.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #457356
Database	COVID19

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Article ; Online: Functional Outcomes and Quality of Life in Patients with Sinonasal, Nasopharyngeal, and Anterior Skull Base Tumors.

Jozaghi, Yelda / Phan, Jack / Hanna, Ehab Y / Kupferman, Michael E / Su, Shirley Y

Current oncology reports

2022 Volume 24, Issue 6, Page(s) 775–781

Abstract: Purpose of review: This article will review functional and QOL outcomes among patients treated predominantly for sinonasal and nasopharyngeal malignancies.: Recent findings: Treatment advances and interdisciplinary supportive care help to lessen the ... ...

Abstract	Purpose of review: This article will review functional and QOL outcomes among patients treated predominantly for sinonasal and nasopharyngeal malignancies. Recent findings: Treatment advances and interdisciplinary supportive care help to lessen the functional impairments and the reduction in quality of life (QOL) that were once accepted as inevitable tradeoffs for cure. Recent progress in QOL and Patient-Reported Outcome (PRO) instruments for this population will be covered. Sinonasal and nasopharyngeal tumors affect patients' quality of life, appearance, and critical functions. Tumors arise in proximity of vital structures including the orbit, cranial nerves, carotid artery, brain, cervical spine, and pituitary gland. Surgical morbidity, along with acute and late effects of systemic therapy and radiotherapy on normal tissues in this functionally critical region, may result in wide-ranging symptoms. Patients with skull base tumors report a high symptom burden at presentation, prior to treatment, relative to other malignancies in the head and neck region.
MeSH term(s)	Endoscopy ; Humans ; Nasopharyngeal Neoplasms/therapy ; Quality of Life ; Skull Base Neoplasms/radiotherapy ; Treatment Outcome
Language	English
Publishing date	2022-03-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057359-5
ISSN	1534-6269 ; 1523-3790
ISSN (online)	1534-6269
ISSN	1523-3790
DOI	10.1007/s11912-022-01214-2
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Article ; Online: Simultaneous Scalp, Skull, Kidney, and Pancreas Transplant from a Single Donor: Insights from a 5-Year Follow-Up.

Jozaghi, Yelda / Chang, Edward I / Clemens, Mark W / Hanasono, Matthew M / Klebuc, Michael / Yu, Peirong / Gaber, A Osama / Selber, Jesse C

Plastic and reconstructive surgery

2023 Volume 151, Issue 6, Page(s) 1318–1321

Abstract: Summary: This report provides a 5-year follow-up on the first reported simultaneous scalp, calvarium, kidney, and pancreas transplant. The previously published case report represented both the first composite calvarial-scalp transplant and combination ... ...

Abstract	Summary: This report provides a 5-year follow-up on the first reported simultaneous scalp, calvarium, kidney, and pancreas transplant. The previously published case report represented both the first composite calvarial-scalp transplant and combination of a vascularized composite allotransplantation with double organ transplantation. Over the ensuing 5 years, the patient underwent a single episode of acute scalp rejection successfully managed with intravenous Solu-Medrol, one resection of a basal cell carcinoma on the native scalp, hardware removal, and bony contouring. In addition, the patient developed seizures secondary to delayed, postirradiation cerebral necrosis requiring craniotomy and resection. His seizures were ultimately controlled. Currently, more than 5 years after his multiorgan transplant, the patient continues to have excellent allograft function and a very satisfactory aesthetic outcome, demonstrating that in certain cases, combined vascularized composite allotransplantation with solid organ transplantation can be performed safely without compromising the solid organ transplantation.
MeSH term(s)	Humans ; Scalp/surgery ; Pancreas Transplantation ; Follow-Up Studies ; Skull ; Kidney ; Graft Rejection/pathology
Language	English
Publishing date	2023-05-24
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000010103
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Article ; Online: Establishing Orbital Floor Symmetry to Support Mirror Imaging in Computer-Aided Reconstruction of the Orbital Floor.

Jozaghi, Yelda / Chan, Harley H L / Davies, Joel C / Irish, Jonathan C

The Journal of craniofacial surgery

2019 Volume 30, Issue 6, Page(s) 1888–1890

Abstract: Background: Surgical precision in the reconstruction of the orbital floor is crucial to functional visual and aesthetic outcomes. Increasingly, computer-aided design is being utilized to aid in precise preoperative planning by using the mirror images of ...

Abstract	Background: Surgical precision in the reconstruction of the orbital floor is crucial to functional visual and aesthetic outcomes. Increasingly, computer-aided design is being utilized to aid in precise preoperative planning by using the mirror images of the unaffected side. The authors aim to use 3-dimensional (3D) quantitative analysis to establish whether the native orbital floor topography is sufficiently symmetric to support this practice. Methods: Ten high resolution head and neck computed tomography scans of patients without periorbital pathology were obtained. These were imported into a 3D medical image processing software and segmented to isolate bilateral orbital floors. Each native orbital floor was compared to the mirror image of the contralateral side by conformance map computation. Data collection included measures of 25% and 75% quartile, median, mean, standard deviation, and root-mean-square (RMS). Results: The topographic analysis demonstrated a high degree of topographic conformance with a mean RMS of 0.58 ± 0.37 mm. Further volumetric analysis comparing the total orbital volume between each side also demonstrates a high degree of volumetric symmetry with a mean difference of 0.55 mL (P = 0.30). Conclusion: Comparison of the native orbital floor and the mirror image of the contralateral side by conformance map computation and volumetric analysis demonstrated a high degree of morphologic similarity. The native orbital floor topography provides optimal symmetry to support mirror imaging techniques used in orbital floor reconstruction.
MeSH term(s)	Computer-Aided Design ; Humans ; Image Processing, Computer-Assisted/methods ; Imaging, Three-Dimensional/methods ; Orbit/diagnostic imaging ; Orbit/surgery ; Reconstructive Surgical Procedures/methods ; Software ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2019-11-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000005368
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Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 175: Show issues

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Article ; Online: Ultrasound-guided maxillary nerve block: an anatomical study using the suprazygomatic approach.

Echaniz, Gaston / Chan, Vincent / Maynes, Jason T / Jozaghi, Yelda / Agur, Anne

Canadian journal of anaesthesia = Journal canadien d'anesthesie

2019 Volume 67, Issue 2, Page(s) 186–193

Abstract: Purpose: Although a maxillary nerve (MN) block reportedly provides satisfactory analgesia for midface surgery and chronic maxillofacial pain syndromes, a safe and reliable MN block technique has not been reported. The goal of this anatomical study was ... ...

Title translation	Bloc du nerf maxillaire échoguidé : une étude anatomique de l’approche supra-zygomatique.
Abstract	Purpose: Although a maxillary nerve (MN) block reportedly provides satisfactory analgesia for midface surgery and chronic maxillofacial pain syndromes, a safe and reliable MN block technique has not been reported. The goal of this anatomical study was to quantify the various angles and depth of the block needle, as well as to evaluate the impact of volume on the extent of injectate spread that might influence anesthetic coverage and block-related complications. Methods: Following an ultrasound-guided suprazygomatic MN block with dye injection, a dissection was performed in the pterygopalatine fossa (PPF) of four lightly embalmed cadaveric specimens. Half of the specimens were injected with 5 mL of dye, and the other half with 1 mL of dye. The needle depth was measured from the ultrasound images and using rubber markers. Following injection, dissection was performed to map the area of dye spread. Results: The median [interquartile range (IQR)] distance from the skin to the PPF was 37 [36-43] mm and 47 [40-50] mm by ultrasound and rubber marker methods, respectively. The median [IQR] needle orientation was 14 [11-32] degrees inferiorly and 15 [10-17] degrees posteriorly. The PPF was consistently dyed in the 5 mL group, but sporadically dyed in the 1 mL group. In the 5 mL group, spread outside of the PPF was seen. Conclusions: We showed that 5 mL of injectate far exceeds the capacity of the PPF, leading to drug spread outside of the PPF. Moreover, we found that 1 mL of injectate largely covered the nerve, suggesting a more efficacious and safer block procedure. This finding will need confirmation in future clinical studies.
MeSH term(s)	Anesthesia, Conduction ; Cadaver ; Humans ; Maxillary Nerve/anatomy & histology ; Maxillary Nerve/diagnostic imaging ; Nerve Block ; Ultrasonography, Interventional
Language	English
Publishing date	2019-09-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	91002-8
ISSN	1496-8975 ; 0832-610X
ISSN (online)	1496-8975
ISSN	0832-610X
DOI	10.1007/s12630-019-01481-x
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Zs.A 109: Show issues

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Article ; Online: The combined profunda artery perforator-gracilis flap for immediate facial reanimation and resurfacing of the radical parotidectomy defect.

Yao, Christopher M K / Jozaghi, Yelda / Danker, Sara / Karami, Reem / Asaad, Malke / Lai, Stephen Y / Hanna, Ehab Y / Esmaeli, Bita / Gidley, Paul W / Chang, Edward I

Microsurgery

2022 Volume 43, Issue 4, Page(s) 309–315

Abstract: Background: A radical parotidectomy with facial nerve sacrifice results in facial nerve paralysis as well as a volume and often cutaneous defect. Prior experience with nerve grafting and static suspension has yielded suboptimal results. The present ... ...

Abstract	Background: A radical parotidectomy with facial nerve sacrifice results in facial nerve paralysis as well as a volume and often cutaneous defect. Prior experience with nerve grafting and static suspension has yielded suboptimal results. The present report aims to examine the feasibility and outcomes of a combined free gracilis and profunda artery perforator (PAP) flap from a single donor site can reconstruct these extensive defects and potentially restore dynamic facial reanimation even in the setting of adjuvant radiation. Patients and methods: A retrospective review of 10 patients (6 males and 4 females) was performed from 2016 to 2020 that underwent a combined PAP-gracilis reconstruction of a radical parotidectomy defect. All patients (mean age: 71.3 years; range: 52-83 years) received adjuvant radiation. A chimeric PAP-gracilis flap requiring a single microvascular anastomosis was performed in three patients while the remaining patients underwent a double free flap reconstruction. Results: The gracilis flap was innervated using the facial nerve stump, spinal accessory and massecteric nerve in three patients each. One patient's gracilis was innervated using the hypoglossal nerve. Three patients also underwent nerve grafting of the facial nerve. One patient was taken back to the operating room for a hematoma in the recipient site and there were not flap losses of either the PAP or gracilis flap. Two patients had delayed wound healing of the donor site that healed with conservative management. Average follow-up was 11.1 months (range: 8.1-19.5 months). Six patients were able to achieve dynamic animation while the others obtained a static reconstruction and did not have issues with drooling, eating, or speaking. Conclusions: Immediate functional muscle transfer can potentially restore dynamic facial reanimation even following radiation. Combining reconstruction using a PAP-gracilis flap addresses the soft tissue deficit and facial paralysis using a single donor site in a single operation.
MeSH term(s)	Male ; Female ; Humans ; Aged ; Plastic Surgery Procedures ; Facial Paralysis/surgery ; Perforator Flap/surgery ; Facial Nerve/surgery ; Arteries/surgery
Language	English
Publishing date	2022-12-21
Publishing country	United States
Document type	Case Reports
ZDB-ID	605524-2
ISSN	1098-2752 ; 0738-1085
ISSN (online)	1098-2752
ISSN	0738-1085
DOI	10.1002/micr.30997
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Article ; Online: Overview of COVID-19 testing and implications for otolaryngologists.

Vinh, Daniel B / Zhao, Xiao / Kiong, Kimberley L / Guo, Theresa / Jozaghi, Yelda / Yao, Chris / Kelley, James M / Hanna, Ehab Y

Head & neck

2020 Volume 42, Issue 7, Page(s) 1629–1633

Abstract: Background: Testing for SARS-CoV-2 is important for decision making prior to surgery in otolaryngology. An understanding of current and developing testing methods is important for interpreting test results.: Methods: We performed a literature review ... ...

Abstract	Background: Testing for SARS-CoV-2 is important for decision making prior to surgery in otolaryngology. An understanding of current and developing testing methods is important for interpreting test results. Methods: We performed a literature review of current evidence surrounding SARS-CoV-2 diagnostic testing highlighting its utility, limitations, and implications for otolaryngologists. Results: The currently accepted RT-PCR test for SARS-CoV-2 has varying sensitivity according to which subsite of the aerodigestive tract is sampled. Nasal swab sensitivities appear to be about 70%. Chest CT imaging for screening purposes is not currently recommended. Conclusion: Due to the current sensitivity of RT-PCR based testing for SARS-CoV-2, a negative test cannot rule out COVID-19. Full PPE should be worn during high-risk procedures such as aerosol generating procedures even if testing is negative. Patients who test positive during screening should have their surgeries postponed if possible until asymptomatic and have tested negative for SARS-CoV-2.
MeSH term(s)	Antibodies/blood ; Betacoronavirus/genetics ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Cough/virology ; Diarrhea/virology ; Dyspnea/virology ; Fatigue/virology ; Fever/virology ; Headache/virology ; Hemoptysis/virology ; Humans ; Immunoglobulin G/immunology ; Immunoglobulin M/immunology ; Lung/diagnostic imaging ; Myalgia/virology ; Nasopharynx/virology ; Otorhinolaryngologic Surgical Procedures ; Pandemics ; Pneumonia, Viral/diagnosis ; Preoperative Care ; Quarantine ; RNA, Viral/isolation & purification ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Sputum/virology ; Tomography, X-Ray Computed
Chemical Substances	Antibodies ; Immunoglobulin G ; Immunoglobulin M ; RNA, Viral
Keywords	covid19
Language	English
Publishing date	2020-05-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.26213
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Article ; Online: Overview of COVID ‐19 testing and implications for otolaryngologists

Vinh, Daniel B. / Zhao, Xiao / Kiong, Kimberley L. / Guo, Theresa / Jozaghi, Yelda / Yao, Chris / Kelley, James M. / Hanna, Ehab Y.

Head & Neck

2020 Volume 42, Issue 7, Page(s) 1629–1633

Keywords	Otorhinolaryngology ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ISSN	1043-3074
DOI	10.1002/hed.26213
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Article ; Online: Analysis of simulated mandibular reconstruction using a segmental mirroring technique.

Davies, Joel C / Chan, Harley H L / Jozaghi, Yelda / Goldstein, David P / Irish, Jonathan C

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

2018 Volume 47, Issue 3, Page(s) 468–472

Abstract: Purpose: When deforming pathology limits intraoperative plating of the mandible, three-dimensional (3D) models can be generated by digitally replacing the deformed segment of bone with an inverted segment from the contralateral unaffected mandible to ... ...

Abstract	Purpose: When deforming pathology limits intraoperative plating of the mandible, three-dimensional (3D) models can be generated by digitally replacing the deformed segment of bone with an inverted segment from the contralateral unaffected mandible to adapt a reconstruction plate. The purpose of this study was to use 3D conformance analysis to evaluate the degree of accuracy of this "segmental mirroring" technique. Methods: Using a pre-existing melanoma database (January 1, 2005-September 20, 2015), high-resolution computed tomography (CT) scans of the head and neck were obtained from patients without evidence of bony disease or defects involving the mandible. Using 3D software (Mimics, Materialise, Leuven, Belgium), each mandible was segmented based on four defect classes (Ic, II, IIc and III) of the Brown et al. (2016) classification system. An inverted, or "mirrored", image of each segment was digitally created and manually co-registered with the corresponding contralateral segment of the mandible. Conformance analysis was performed by calculating the root-mean-square (RMS) conformance distance and through evaluating 3D generated conformance maps. The primary outcome was degree of conformance. Data were analyzed using descriptive statistics and tests of statistical significance. The significance level was set at a p-value less than or equal to .05. Results: A high degree of conformance (mean RMS < 1 mm) was observed when comparing all classes of simulated reconstruction. The closest conformance was observed for class III simulated reconstructions (mean RMS: 0.4 ± 0.2 mm). Inclusion of the condyle resulted in a reduced mean RMS conformance (class II: 0.5 ± 0.3 mm vs class IIc: 0.7 ± 0.5 mm; p = 0.01). There was no significant difference between RMS conformance distances when comparing side of simulated reconstruction. Evaluation of 3D mapping demonstrated reduced conformance with simulated reconstruction of the condyle and coronoid process. Conclusion: The segmental mirroring technique can be used reliably to generate highly accurate three-dimensional models that may assist with mandibular reconstruction in circumstances where bony deformity limits intraoperative adaptation of a reconstruction plate. This technique is less accurate where pathology involves the mandibular condyle and, to a lesser degree, the coronoid process.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Bone Plates ; Computer Simulation ; Cross-Sectional Studies ; Dental Models ; Female ; Humans ; Imaging, Three-Dimensional ; Male ; Mandible/diagnostic imaging ; Mandible/surgery ; Mandibular Reconstruction/methods ; Middle Aged ; Retrospective Studies ; Software ; Tomography, X-Ray Computed
Language	English
Publishing date	2018-12-30
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	91267-0
ISSN	1878-4119 ; 1010-5182 ; 0301-0503
ISSN (online)	1878-4119
ISSN	1010-5182 ; 0301-0503
DOI	10.1016/j.jcms.2018.12.016
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