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Article ; Online: Treatment failure in scabies: a single-centre 5-year retrospective review.

Coleman, Harry / Sethi, Gulshan Cindy

2024 Volume 100, Issue 2, Page(s) 123–124

MeSH term(s)	Humans ; Scabies/drug therapy ; Retrospective Studies ; Treatment Failure
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Letter
ZDB-ID	1420303-0
ISSN	1472-3263 ; 1368-4973
ISSN (online)	1472-3263
ISSN	1368-4973
DOI	10.1136/sextrans-2023-055949
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Article ; Online: The risks associated with stopping injectable antiretroviral treatment in women who are trying to conceive: a case series.

Coleman, Harry / Fox, Julie / Chilton, Daniella

AIDS (London, England)

2022 Volume 36, Issue 8, Page(s) 1205–1206

MeSH term(s)	Anti-Retroviral Agents/therapeutic use ; Female ; Fertilization ; HIV Infections/drug therapy ; Humans
Chemical Substances	Anti-Retroviral Agents
Language	English
Publishing date	2022-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000003236
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Zs.A 2228: Show issues

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Article ; Online: Freesurfer Software Update Significantly Impacts Striatal Volumes in the Huntington's Disease Young Adult Study and Will Influence HD-ISS Staging.

Knights, Harry / Coleman, Annabelle / Hobbs, Nicola Z / Tabrizi, Sarah J / Scahill, Rachael I

Journal of Huntington's disease

2024 Volume 13, Issue 1, Page(s) 77–90

Abstract: Background: The Huntington's Disease Integrated Staging System (HD-ISS) defined disease onset using volumetric cut-offs for caudate and putamen derived from FreeSurfer 6 (FS6). The impact of the latest software update (FS7) on volumes remains unknown. ... ...

Abstract	Background: The Huntington's Disease Integrated Staging System (HD-ISS) defined disease onset using volumetric cut-offs for caudate and putamen derived from FreeSurfer 6 (FS6). The impact of the latest software update (FS7) on volumes remains unknown. The Huntington's Disease Young Adult Study (HD-YAS) is appropriately positioned to explore differences in FS bias when detecting early atrophy. Objective: Explore the relationships and differences between raw caudate and putamen volumes, calculated total intracranial volumes (cTICV), and adjusted caudate and putamen volumes, derived from FS6 and FS7, in HD-YAS. Methods: Images from 123 participants were segmented and quality controlled. Relationships and differences between volumes were explored using intraclass correlation (ICC) and Bland-Altman analysis. Results: Across the whole cohort, ICC for raw caudate and putamen was 0.99, cTICV 0.93, adjusted caudate 0.87, and adjusted putamen 0.86 (all p < 0.0005). Compared to FS6, FS7 calculated: i) larger raw caudate (+0.8%, p < 0.00005) and putamen (+1.9%, p < 0.00005), with greater difference for larger volumes; and ii) smaller cTICV (-5.1%, p < 0.00005), with greater difference for smaller volumes. The systematic and proportional difference in cTICV was greater than raw volumes. When raw volumes were adjusted for cTICV, these effects compounded (adjusted caudate +7.0%, p < 0.00005; adjusted putamen +8.2%, p < 0.00005), with greater difference for larger volumes. Conclusions: As new software is released, it is critical that biases are explored since differences have the potential to significantly alter the findings of HD trials. Until conversion factors are defined, the HD-ISS must be applied using FS6. This should be incorporated into the HD-ISS online calculator.
MeSH term(s)	Humans ; Young Adult ; Huntington Disease/diagnostic imaging ; Huntington Disease/pathology ; Caudate Nucleus/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Corpus Striatum ; Atrophy/pathology
Language	English
Publishing date	2024-03-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2673033-9
ISSN	1879-6400 ; 1879-6397
ISSN (online)	1879-6400
ISSN	1879-6397
DOI	10.3233/JHD-231512
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Article ; Online: SARS-CoV-2 antibody seroprevalence in a London HIV clinic cohort.

Sivaraj, Venkateshwaran / Coleman, Harry / Nebbia, Gaia / Douthwaite, Sam / Kulasegaram, Ranjababu

Sexually transmitted infections

2022 Volume 99, Issue 1, Page(s) 73–74

MeSH term(s)	Humans ; COVID-19/epidemiology ; London/epidemiology ; SARS-CoV-2 ; Seroepidemiologic Studies ; HIV Infections/epidemiology ; Antibodies, Viral
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2022-11-17
Publishing country	England
Document type	Letter
ZDB-ID	1420303-0
ISSN	1472-3263 ; 1368-4973
ISSN (online)	1472-3263
ISSN	1368-4973
DOI	10.1136/sextrans-2021-055306
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Article ; Online: Suicide attempts after bariatric surgery: comparison to a nonsurgical cohort of individuals with severe obesity.

Miller-Matero, Lisa R / Yeh, Hsueh-Han / Ahmedani, Brian K / Rossom, Rebecca C / Harry, Melissa L / Daida, Yihe G / Coleman, Karen J

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

2023 Volume 19, Issue 12, Page(s) 1458–1466

Abstract: Background: The rate of suicide is higher among individuals following bariatric surgery compared with the general population; however, it is not clear whether risk is associated with bariatric surgery beyond having severe obesity.: Objective: To ... ...

Abstract	Background: The rate of suicide is higher among individuals following bariatric surgery compared with the general population; however, it is not clear whether risk is associated with bariatric surgery beyond having severe obesity. Objective: To compare the risk of a suicide attempt among those who had bariatric surgery versus a nonsurgical cohort with severe obesity. Setting: Aggregate count data were collected from 5 healthcare systems. Methods: Individuals were identified in the surgical cohort if they underwent bariatric surgery between 2009 and 2017 (n = 35,522) and then were compared with a cohort of individuals with severe obesity who never had bariatric surgery (n = 691,752). Suicide attempts were identified after study enrollment date using International Classification of Diseases, Ninth and Tenth Editions (ICD-9 and ICD-10) diagnosis codes from 2009 to 2021. Results: The relative risk of a suicide attempt was 64% higher in the cohort with bariatric surgery than that of the nonsurgical cohort (2.2% versus 1.3%; relative risk = 1.64; 95% CI, 1.53-1.76). Within the cohort with bariatric surgery, suicide attempts were more common among the 18- to 39-year age group (P < .001), women (P = .002), Hawaiian-Pacific Islanders (P < .001), those with Medicaid insurance (P < .001), and those with a documented mental health condition at baseline (in the previous 2 years; P < .001). Conclusions: The relative risk of suicide attempts was higher among those who underwent bariatric surgery compared with a nonsurgical cohort, though absolute risk remained low. Providers should be aware of this increased risk. Screening for suicide risk after bariatric surgery may be useful to identify high-risk individuals.
MeSH term(s)	Humans ; Female ; Obesity, Morbid/complications ; Obesity, Morbid/surgery ; Obesity, Morbid/psychology ; Suicide, Attempted ; Obesity/surgery ; Bariatric Surgery/adverse effects ; Risk
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2274243-8
ISSN	1878-7533 ; 1550-7289
ISSN (online)	1878-7533
ISSN	1550-7289
DOI	10.1016/j.soard.2023.08.013
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Article ; Online: British association for sexual health and HIV national guideline for the management of anogenital warts in adults (2024).

Nugent, Diarmuid / Apoola, Ade / Coleman, Harry / Gilmour, Cindy / Lawton, Mark David / Nori, Achyuta / D C Ross, Jonathan / Whitlock, Gary / Yeend-Curd-Trimble, Hannah

International journal of STD & AIDS

2024 , Page(s) 9564624241233338

Abstract: This guideline offers recommendations on the diagnosis, treatment and health promotion principles needed for the effective management of human papillomavirus (HPV)-related warts at anogenital sites including the external genitals, vagina, cervix, urethra, ...

Abstract	This guideline offers recommendations on the diagnosis, treatment and health promotion principles needed for the effective management of human papillomavirus (HPV)-related warts at anogenital sites including the external genitals, vagina, cervix, urethra, perianus and anal canal. The guideline is aimed primarily at patients aged 16 years or older presenting to healthcare professionals working in level 3 sexual health services in the United Kingdom. However, the principles of the recommendations may be applied in other care settings, including in primary care, using locally adapted care pathways where appropriate. The management of HPV-related anogenital dysplasia or warts at other extragenital sites is outside the scope of this guideline.
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/09564624241233338
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Article ; Online: Acute cardiac autonomic and haemodynamic responses to leg and arm isometric exercise.

Swift, Harry T / O'Driscoll, Jamie M / Coleman, Damian D / Caux, Anthony De / Wiles, Jonathan D

European journal of applied physiology

2022 Volume 122, Issue 4, Page(s) 975–985

Abstract: Objectives: Acute cardiovascular responses following a single session of isometric exercise (IE) have been shown to predict chronic adaptations in blood pressure (BP) regulation. It was hypothesised that exercises which recruit more muscle mass induce ... ...

Abstract	Objectives: Acute cardiovascular responses following a single session of isometric exercise (IE) have been shown to predict chronic adaptations in blood pressure (BP) regulation. It was hypothesised that exercises which recruit more muscle mass induce greater reductions in BP compared to exercises using smaller muscle mass. To test this hypothesis, the current study aimed to compare the acute haemodynamic and autonomic responses to a single session of isometric wall squat (IWS) and isometric handgrip (IHG) training. Methods: Twenty-six sedentary participants performed a single IWS and IHG session in a randomised cross-over design, with training composed of 4 × 2-min contractions, with 2-min rest, at 95 HR Results: During IWS exercise, there was a significantly greater increase in systolic BP (P < 0.001), diastolic BP (P < 0.001), mean BP (P < 0.001), heart rate (P < 0.001), and cardiac output (P < 0.001), and a contrasting decrease in baroreflex effectiveness index (BEI) and cardiac baroreceptor sensitivity (cBRS). In the 10-min recovery period following IWS exercise, there was a significantly greater reduction in systolic BP (P = 0.005), diastolic BP (P = 0.006), mean BP (P = 0.003), total peripheral resistance (TPR) (P < 0.001), BEI (P = 0.003), and power spectral density (PSD-RRI) (P < 0.001). There were no differences in any variables between conditions 1-h post exercise. Conclusions: Isometric wall squat exercise involving larger muscle mass is associated with a significantly greater post-exercise hypotensive response during a 10-min recovery window compared to smaller muscle mass IHG exercise. The significantly greater reduction in TPR may be an important mechanism for the differences in BP response.
MeSH term(s)	Arm ; Blood Pressure ; Exercise/physiology ; Hand Strength/physiology ; Heart Rate/physiology ; Hemodynamics ; Humans ; Isometric Contraction/physiology ; Leg
Language	English
Publishing date	2022-01-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124793-1
ISSN	1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
ISSN (online)	1439-6327 ; 1432-1025
ISSN	0301-5548 ; 1439-6319
DOI	10.1007/s00421-022-04894-7
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Article ; Online: Restoration prioritization must be informed by marginalized people.

Fleischman, Forrest / Coleman, Eric / Fischer, Harry / Kashwan, Prakash / Pfeifer, Marion / Ramprasad, Vijay / Rodriguez Solorzano, Claudia / Veldman, Joseph W

Nature

2022 Volume 607, Issue 7918, Page(s) E5–E6

MeSH term(s)	Humans ; Social Marginalization
Language	English
Publishing date	2022-07-13
Publishing country	England
Document type	Letter ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-04733-x
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Article: Aligning the principles and practice of research integrity and research fairness in global health: a mixed-methods study.

Sempa, Joseph Bukulu / Patil, Rutuja / Mathewson, Jake D / Kabelka, Hannah / Yaghmaei, Nima / Coleman, Harry / Sohoni, Preeti / Straetemans, Masja / Gopalakrishna, Gowri / Wienia, Martijn / Kombe, Francis / Alba, Sandra

BMJ global health

2024 Volume 9, Issue 3

Abstract: Introduction: In the past decade, global health research has seen a growing emphasis on research integrity and fairness. The concept of research integrity emerged in response to the reproducibility crisis in science during the late 2000s. Research ... ...

Abstract	Introduction: In the past decade, global health research has seen a growing emphasis on research integrity and fairness. The concept of research integrity emerged in response to the reproducibility crisis in science during the late 2000s. Research fairness initiatives aim to enhance ownership and inclusivity in research involving partners with varying powers, decision-making roles and resource capacities, ultimately prioritising local health research needs. Despite extensive academic discussions, empirical data on these aspects, especially in the context of global health, remain limited. Methods: To address this gap, we conducted a mixed-methods study focusing on research integrity and fairness. The study included an online frequency survey and in-depth key informant interviews with researchers from international research networks. The dual objectives were to quantify the frequency of practices related to research integrity and fairness and explore the determinants influencing these practices in global health. Results: Out of 145 participants in the quantitative survey (8.4% response rate), findings indicate that global health researchers generally adhere to principles of research integrity and fairness, with variations in reported behaviours. The study identified structural, institutional and individual factors influencing these patterns, including donor landscape rigidity, institutional investments in relationship building, guidelines, mentoring and power differentials among researchers. Conclusion: This research highlights that, despite some variations, there is a substantial alignment between research integrity and fairness, with both sharing similar determinants and the overarching goal of enhancing research quality and societal benefits. The study emphasises the potential to explicitly recognise and leverage these synergies, aligning both agendas to further advance global health research.
MeSH term(s)	Humans ; Global Health ; Reproducibility of Results
Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Journal Article
ISSN	2059-7908
ISSN	2059-7908
DOI	10.1136/bmjgh-2023-013917
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Article ; Online: Racial Differences in Psychiatric Symptoms, Maladaptive Eating, and Lifestyle Behaviors After Bariatric Surgery.

Haley, Erin N / Loree, Amy M / Maye, Melissa / Coleman, Karen J / Braciszewski, Jordan M / Snodgrass, Maunda / Harry, Melissa L / Carlin, Arthur M / Miller-Matero, Lisa R

Journal of racial and ethnic health disparities

2023

Abstract: There are several psychological and behavioral factors associated with poorer outcomes following bariatric surgery, yet it is unknown whether and how these factors may differ by race. In this cross-sectional study, individuals who underwent bariatric ... ...

Abstract	There are several psychological and behavioral factors associated with poorer outcomes following bariatric surgery, yet it is unknown whether and how these factors may differ by race. In this cross-sectional study, individuals who underwent bariatric surgery from 2018 to 2021 and up to 4 years post-surgery were invited to complete an online survey. Psychiatric symptoms, maladaptive eating patterns, self-monitoring behaviors, and exercise frequency were examined. Participants (N = 733) were 87% women, 63% White, with a mean age of 44 years. Analyses of covariance demonstrated that White individuals endorsed greater anxiety symptoms (p =.01) and emotional eating due to depression (p = .01), whereas Black individuals endorsed greater depression severity (p = .02). Logistic regression analyses demonstrated that White individuals were more likely to experience loss of control eating (OR= 1.7, p = .002), grazing (OR= 2.53, p <.001), and regular self-weighing (OR= 1.41, p <.001) than Black individuals, and were less likely to skip meals (OR= .61, p = .04), or partake in nighttime eating (OR= .40, p <.001). There were no racial differences in binge eating, emotional eating due to anxiety or frustration, use of a food diary, or exercise. Thus, depressive symptoms, skipping meals, and nighttime eating may be important, modifiable intervention targets to optimize the benefits of bariatric surgery and promote equitable outcomes.
Language	English
Publishing date	2023-10-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2760524-3
ISSN	2196-8837 ; 2197-3792
ISSN (online)	2196-8837
ISSN	2197-3792
DOI	10.1007/s40615-023-01835-8
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