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  1. Book ; Online ; E-Book: Immunopharmacology and inflammation

    Riccardi, Carlo / Levi-Schaffer, Francesca / Tiligada, Ekaterini

    2018  

    Author's details Carlo Riccardi, Francesca Levi-Schaffer, Ekaterini Tiligada editors
    Language English
    Size 1 Online-Ressource (viii, 331 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019754596
    ISBN 978-3-319-77658-3 ; 9783319776576 ; 3-319-77658-4 ; 3319776576
    DOI 10.1007/978-3-319-77658-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Effect of the Israel-Hamas war on allergy and immunology care and research.

    Hershko, Alon Y / Levi-Schaffer, Francesca

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2024  

    Language English
    Publishing date 2024-02-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2024.02.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Antiallergic/adrenergic drugs from 80 years ago: Still relevant today?

    Zurlo, Marco / Nowak-Węgrzyn, Anna / Levi-Schaffer, Francesca

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2024  Volume 132, Issue 2, Page(s) 119–120

    MeSH term(s) Humans ; Anti-Allergic Agents ; Adrenergic Agents
    Chemical Substances Anti-Allergic Agents ; Adrenergic Agents
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2023.08.602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mast cell signaling and its role in urticaria.

    Puxeddu, Ilaria / Pistone, Francesca / Pisani, Francesco / Levi-Schaffer, Francesca

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2024  

    Abstract: Chronic urticaria (CU) is a mast cells (MC)-driven disease characterized by the development of itching wheals and/or angioedema. In the last decades, outstanding progress has been made in defining the mechanisms involved in MC activation, and novel ... ...

    Abstract Chronic urticaria (CU) is a mast cells (MC)-driven disease characterized by the development of itching wheals and/or angioedema. In the last decades, outstanding progress has been made in defining the mechanisms involved in MC activation, and novel activating and inhibitory receptors expressed in MC surface were identified and characterized. Besides an IgE-mediated activation via FcεRI-cross-linking, other activating receptors, including Mas-related G protein-coupled receptor-X2 (MRGPRX2), C5a receptor and protease-activated receptors (PAR1 and PAR2) are responsible for MC activation. This would partly explain why some subgroups of chronic spontaneous urticaria (CSU), the most frequent form of urticaria in the general population, do not respond to IgE target therapies, requiring other therapeutic approaches for improving the management of the disease. In this review we shed some light on the current knowledge of the immunological and non-immunological mechanisms regulating MC activation in CSU, taking in account the complex inflammatory scenario underlying CSU pathogenesis, and novel potential MC targeted therapies, including surface receptors and cytoplasmic signaling proteins.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2024.04.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: CD300a Regulates Mouse Macrophage Functionality in Allergic Inflammation.

    Puzzovio, Pier Giorgio / Levy, Bruce D / Levi-Schaffer, Francesca

    International archives of allergy and immunology

    2023  Volume 184, Issue 7, Page(s) 720–726

    Abstract: Background: CD300a is an inhibitory receptor (IR) expressed on several leukocytes, including mast cells (MCs) and macrophages (MΦ), important cells in allergic inflammation (AI). We have previously characterized CD300a role on MCs and in vivo in mouse ... ...

    Abstract Background: CD300a is an inhibitory receptor (IR) expressed on several leukocytes, including mast cells (MCs) and macrophages (MΦ), important cells in allergic inflammation (AI). We have previously characterized CD300a role on MCs and in vivo in mouse models of allergy, in which the absence of CD300a resulted in increased inflammatory features and delayed resolution. However, the exact mechanism of this delayed resolution is unclear. Our hypothesis is that MΦ, important players in resolution, might be impaired when CD300a is absent.
    Objectives: The aim of the study was to investigate CD300a-dependent functionality of mouse MΦ.
    Method: MΦ were purified from the peritoneum of wild-type (WT) and CD300a-/- mice naïve and 48 h and 96 h after challenge with ovalbumin/alum. Phenotype switching was analyzed via specific M1-M2 inducers and markers. MΦ phagocytotic ability was assessed via Staphylococcus aureus pHrodo-conjugated bioparticles. The influence of MCs on MΦ was investigated by incubating WT MΦ with supernatants from non-activated and IgE-activated bone marrow-derived MCs (BMMCs) and analyzing functional responses.
    Results: Naïve CD300a-/- MΦ presented with increased sensitivity to activation when treated with LPS. Absence of CD300a results in increased Arg1 expression and increased IL-6 release when MΦ are purified from allergic peritonitis-induced mice. Similar results were obtained when CD300a-/- MΦ were purified 96 h after challenge. On the other hand, CD300a absence did not affect phagocytosis. WT MΦ incubated with supernatants of non-activated and IgE-activated BMMCs presented with increased iNOS expression and decreased Arg1 levels.
    Conclusions: The IR CD300a controls the activation state of MΦ, and its absence could augment the inflammatory state seen in CD300a-/- mice. Moreover, MCs can also influence MΦ phenotype switching. This may partially explain the delayed AI resolution seen in these mice.
    MeSH term(s) Animals ; Mice ; Hypersensitivity ; Immunoglobulin E/metabolism ; Inflammation ; Macrophages/metabolism ; Phagocytosis
    Chemical Substances Immunoglobulin E (37341-29-0) ; LMIR1 protein, mouse
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1108932-5
    ISSN 1423-0097 ; 1018-2438
    ISSN (online) 1423-0097
    ISSN 1018-2438
    DOI 10.1159/000529606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Allergic Rhinitis: Pathophysiology and Treatment Focusing on Mast Cells.

    Zoabi, Yara / Levi-Schaffer, Francesca / Eliashar, Ron

    Biomedicines

    2022  Volume 10, Issue 10

    Abstract: Allergic rhinitis (AR) is a common rhinopathy that affects up to 30% of the adult population. It is defined as an inflammation of the nasal mucosa, develops in allergic individuals, and is detected mostly by a positive skin-prick test. AR is ... ...

    Abstract Allergic rhinitis (AR) is a common rhinopathy that affects up to 30% of the adult population. It is defined as an inflammation of the nasal mucosa, develops in allergic individuals, and is detected mostly by a positive skin-prick test. AR is characterized by a triad of nasal congestion,
    Language English
    Publishing date 2022-10-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10102486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Tezepelumab administration in moderate-to-severe uncontrolled asthma: Is it all about eosinophils?

    Puzzovio, Pier Giorgio / Eliashar, Ron / Levi-Schaffer, Francesca

    The Journal of allergy and clinical immunology

    2022  Volume 149, Issue 5, Page(s) 1582–1584

    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Asthma/drug therapy ; Cytokines ; Eosinophils ; Humans ; Leukocyte Count
    Chemical Substances Antibodies, Monoclonal, Humanized ; Cytokines ; tezepelumab (RJ1IW3B4QX)
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.01.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The allergic effector unit: From basic science to drug-targetable mast cell-eosinophil interactions in patients.

    Puzzovio, Pier Giorgio / Levi-Schaffer, Francesca

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 10, Page(s) 3845–3846

    MeSH term(s) Eosinophils ; Humans ; Hypersensitivity ; Mast Cells ; Pharmaceutical Preparations
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2021-10-09
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.07.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Omalizumab safety in pregnancy.

    Levi-Schaffer, Francesca / Mankuta, David

    The Journal of allergy and clinical immunology

    2019  Volume 145, Issue 2, Page(s) 481–483

    MeSH term(s) Cohort Studies ; Female ; Humans ; Omalizumab ; Pregnancy ; Pregnancy Outcome ; Premature Birth ; Registries
    Chemical Substances Omalizumab (2P471X1Z11)
    Language English
    Publishing date 2019-11-26
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2019.11.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Novel Immunopharmacological Drugs for the Treatment of Allergic Diseases.

    Tiligada, Ekaterini / Gafarov, Daria / Zaimi, Maria / Vitte, Joana / Levi-Schaffer, Francesca

    Annual review of pharmacology and toxicology

    2023  Volume 64, Page(s) 481–506

    Abstract: The exponential rise in the prevalence of allergic diseases since the mid-twentieth century has led to a genuine public health emergency and has also fostered major progress in research on the underlying mechanisms and potential treatments. The ... ...

    Abstract The exponential rise in the prevalence of allergic diseases since the mid-twentieth century has led to a genuine public health emergency and has also fostered major progress in research on the underlying mechanisms and potential treatments. The management of allergic diseases benefits from the biological revolution, with an array of novel immunomodulatory therapeutic and investigational tools targeting players of allergic inflammation at distinct pathophysiological steps. Prominent examples include therapeutic monoclonal antibodies against cytokines, alarmins, and their receptors, as well as small-molecule modifiers of signal transduction mainly mediated by Janus kinases and Bruton's tyrosine kinases. However, the first-line therapeutic options have yet to switch from symptomatic to disease-modifying interventions. Here we present an overview of available drugs in the context of our current understanding of allergy pathophysiology, identify potential therapeutic targets, and conclude by providing a selection of candidate immunopharmacological molecules under investigation for potential future use in allergic diseases.
    MeSH term(s) Humans ; Hypersensitivity/drug therapy ; Antibodies, Monoclonal ; Cytokines ; Inflammation ; Signal Transduction
    Chemical Substances Antibodies, Monoclonal ; Cytokines
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 196587-6
    ISSN 1545-4304 ; 0362-1642
    ISSN (online) 1545-4304
    ISSN 0362-1642
    DOI 10.1146/annurev-pharmtox-051623-091038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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