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Article: The Flavonoid Agathisflavone Directs Brain Microglia/Macrophages to a Neuroprotective Anti-Inflammatory and Antioxidant State via Regulation of NLRP3 Inflammasome.

Dos Santos, Balbino Lino / Dos Santos, Cleonice Creusa / Soares, Janaina R P / da Silva, Karina C / de Oliveira, Juciele Valeria R / Pereira, Gabriele S / de Araújo, Fillipe M / Costa, Maria de Fátima D / David, Jorge Mauricio / da Silva, Victor Diogenes A / Butt, Arthur Morgan / Costa, Silvia Lima

Pharmaceutics

2023 Volume 15, Issue 5

Abstract: Agathisflavone, purified ... ...

Abstract	Agathisflavone, purified from
Language	English
Publishing date	2023-05-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15051410
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Coronavirus disease 2019 pandemic and identifying insufflators with desufflation mode and surgical smoke evacuators for safe CO

da Costa, Karina M / Saxena, Amulya K

Asian journal of endoscopic surgery

2020 Volume 14, Issue 2, Page(s) 165–169

Abstract: Introduction: Given the propensity of severe acute respiratory syndrome coronavirus 2 to spread, it is imperative that those continuing to perform surgery take precautions to limit the potential generation of contaminated aerosols in smoke from energy- ... ...

Abstract	Introduction: Given the propensity of severe acute respiratory syndrome coronavirus 2 to spread, it is imperative that those continuing to perform surgery take precautions to limit the potential generation of contaminated aerosols in smoke from energy-based instruments. The aim of this study was to report current data regarding insufflators with desufflation mode and similar options to safely remove CO Methods: A non-systematic review of the scientific literature was conducted using the PubMed database, and the main companies that provide surgical devices were contacted for information. Results: Most commercially available smoke evacuators use a combination of suction and mechanical filtering. There are also electrostatic precipitators that charge surgical smoke and retain the particles via electrostatic attraction. The search identified three insufflators with desufflation mode, four modular smoke evacuators using mechanical filtration, and only one device using electrostatic precipitation. However, none of these devices has been tested with viruses. Conclusion: This review identified commercially available equipment that employs mechanical filtering and electrostatic attraction principles that can be used for pneumoperitoneum evacuation during the present coronavirus disease 2019 pandemic. This pandemic should assist in raising awareness regarding protection measures and the risk of occupational exposure in surgery.
MeSH term(s)	COVID-19/prevention & control ; COVID-19/transmission ; Carbon Dioxide ; Humans ; Infection Control ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Insufflation ; Laparoscopy ; Pandemics ; Pneumoperitoneum, Artificial ; Smoke/adverse effects ; Static Electricity
Chemical Substances	Smoke ; Carbon Dioxide (142M471B3J)
Keywords	covid19
Language	English
Publishing date	2020-07-26
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2503256-2
ISSN	1758-5910 ; 1758-5902
ISSN (online)	1758-5910
ISSN	1758-5902
DOI	10.1111/ases.12834
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Laparoscopic Ladd Procedure for Malrotation in Newborns and Infants.

da Costa, Karina M / Saxena, Amulya K

The American surgeon

2020 Volume 87, Issue 2, Page(s) 253–258

Abstract: Background: Laparoscopic approach for malrotation has become more popular for neonates and in cases with volvulus, but its safety and efficacy remains controversial. This study reviewed laparoscopy outcomes in neonate/infant malrotation.: Methods: ... ...

Abstract	Background: Laparoscopic approach for malrotation has become more popular for neonates and in cases with volvulus, but its safety and efficacy remains controversial. This study reviewed laparoscopy outcomes in neonate/infant malrotation. Methods: Medline/PubMed and Lilacs databases were reviewed. Data from studies published in English/Spanish between 1995 and 2019 were collected. Results are presented as percentages and means/medians; logistic regression was used to study possible associations. Results: Nineteen papers offered 99 neonates/infants with median age and weight of 10.5 days and 3.5 kg, respectively. Ladd's procedure was performed in 95 (96%) patients and bands' division in 4 (4%); appendectomy was not included in 16 (16.2%) patients, and cecopexy was not performed in all cases. Volvulus was reported in 39 (39.4%) patients. There were 11 conversions (11.1%) and 10 recurrences of symptoms (10.1%) that required reintervention. An association was found between volvulus and recurrence ( Discussion: Laparoscopic approach to malrotation is feasible and safe in hemodynamically stable neonates/infants without intestinal necrosis and is associated with 11% conversion rate and 10% reinterventions. The presence of volvulus is associated with recurrence and conversion. Laparoscopic Ladd's procedure with appendectomy and without cecopexy is the commonly practiced approach that is associated with minor complications.
MeSH term(s)	Conversion to Open Surgery/statistics & numerical data ; Humans ; Infant ; Infant, Newborn ; Intestines/abnormalities ; Intestines/surgery ; Laparoscopy/methods ; Reoperation/statistics & numerical data ; Treatment Outcome
Language	English
Publishing date	2020-09-15
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/0003134820951424
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Article ; Online: Assessment of macrobenthos diversity and a zoning proposal for Seixas coral reefs (northeastern Brazil).

Souza, Maria Cecilia Silva / Massei, Karina / Vianna, Pedro Costa Guedes / Santos, Celso Augusto Guimarães / Mishra, Manoranjan / Silva, Richarde Marques da

Marine pollution bulletin

2023 Volume 195, Page(s) 115443

Abstract: ... by analyzing 25 transects, each divided into 1 m ...

Abstract	Coral reefs worldwide are under severe threat due to their inherent fragility and urgent need for conservation. The escalating tourism in coral reefs significantly impacts the marine ecosystem's biodiversity and conservation. This study analyzed the diversity and conservation status of macrobenthos in the Seixas coral reef, located in northeastern Brazil, and proposed a zoning plan. We employed monitoring protocols adapted from the Reef Check Program, the Rapid Assessment Protocol for Atlantic and Gulf Reefs, and the Protocol for Monitoring Coastal Benthic Habitats. Species identification was carried out by analyzing 25 transects, each divided into 1 m
MeSH term(s)	Humans ; Animals ; Coral Reefs ; Ecosystem ; Anthozoa ; Brazil ; Conservation of Natural Resources/methods ; Biodiversity
Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2023.115443
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Article ; Online: Deformation of Mitochondrial Cristae in Human Neural Progenitor Cells Exposed to Valproic Acid.

Costa, Rodrigo M DA / Karmirian, Karina / Rehen, Stevens K

Anais da Academia Brasileira de Ciencias

2018 Volume 90, Issue 2 suppl 1, Page(s) 2223–2232

Abstract: ... membrane potential in mitochondria from human neural progenitor cells (NPCs) exposed to VPA (da Costa et al. 2015). Here, we applied ...

Abstract	Neural development represents a dynamic process where mitochondrial integrity is decisive for neuronal activity. Structural changes in these organelles may be related to neurological disorders. Valproic acid (VPA) is an anticonvulsive drug commonly used for epilepsy treatment and its use is associated to increased risk of neuropsychiatric disorders. Recently we showed changes in shape and membrane potential in mitochondria from human neural progenitor cells (NPCs) exposed to VPA (da Costa et al. 2015). Here, we applied transmission electron microscopy and electron tomography to evaluate mitochondrial damage caused by VPA in NPCs. Results showed mitochondrial cristae disorganization in a dose dependent manner. Disturbance in mitochondrial ultrastructure may influence metabolism, leading to synaptic plasticity and neurogenesis impairment. These data contribute to understanding VPA exposure potential effects on brain development.
MeSH term(s)	Anticonvulsants/pharmacology ; Cells, Cultured ; Electron Microscope Tomography ; Humans ; Microscopy, Electron, Transmission ; Mitochondria/drug effects ; Mitochondria/ultrastructure ; Neural Stem Cells/drug effects ; Neural Stem Cells/ultrastructure ; Valproic Acid/pharmacology
Chemical Substances	Anticonvulsants ; Valproic Acid (614OI1Z5WI)
Language	English
Publishing date	2018-04-23
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2046885-4
ISSN	1678-2690 ; 0001-3765
ISSN (online)	1678-2690
ISSN	0001-3765
DOI	10.1590/0001-3765201820170762
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Article ; Online: The prevalence and perinatal repercussions of preeclampsia after the implementation of a prophylaxis protocol with aspirin.

Cardoso, Maria Isabel M P / Rezende, Karina B de C / Da Matta, Fabio G / Saunders, Cláudia / Cardoso, Fernanda F O / Costa Junior, Ivo B / Gama, Luiza B / Amim, Joffre / Bornia, Rita G

Pregnancy hypertension

2023 Volume 33, Page(s) 17–21

Abstract: Objectives: To evaluate the prevalence and perinatal repercussions of preeclampsia (PE) after the implementation of a prophylaxis protocol with aspirin in singleton pregnancy at Maternity School of Federal University of Rio de Janeiro, Rio de Janeiro, ... ...

Abstract	Objectives: To evaluate the prevalence and perinatal repercussions of preeclampsia (PE) after the implementation of a prophylaxis protocol with aspirin in singleton pregnancy at Maternity School of Federal University of Rio de Janeiro, Rio de Janeiro, Brazil (2015-2106). Methodology: PE prevalence according to gestational age (GA) and the prevalence ratio (PR) between PE and prematurity, small for gestational age (SGA), and fetal death were calculated in patients assisted during 2015 and 2016. Results: PE occurred in 373(10.75%) of 3468 investigated cases, where PE < 37 weeks was of 2.79% and PE greater than 37 weeks was of 7.95%. A total of 413 (11.9%) prematurity cases, 320 SGA (9.22%), and 50 fetal deaths (1.44%) occurred. In the PE group, 97 premature newborns (PR 0.90) and 51 SGA (PR 1.16) were born, and two fetal deaths occurred (PR 7.46). Concerning PE < 37 weeks, 27 SGA cases (PR 1.42) and two fetal deaths (PR 2.62) were observed. Regarding PE greater than 37 weeks, 24 SGA (PR 1.09) were born, and no fetal deaths were observed. Our findings were compared to previously published results. Conclusions: PE was significantly associated with SGA newborns, especially premature PE. Prescribing aspirin for PE prophylaxis based only on clinical risk factors in a real-life scenario does not appear to be effective but resulted in a PE screening and prophylaxis protocol review and update at ME/UFRJ.
MeSH term(s)	Pregnancy ; Female ; Humans ; Infant, Newborn ; Pre-Eclampsia/epidemiology ; Pre-Eclampsia/prevention & control ; Pre-Eclampsia/diagnosis ; Aspirin/therapeutic use ; Prevalence ; Brazil ; Infant, Small for Gestational Age ; Fetal Growth Retardation/epidemiology ; Fetal Growth Retardation/prevention & control ; Fetal Growth Retardation/diagnosis ; Fetal Death/prevention & control ; Gestational Age
Chemical Substances	Aspirin (R16CO5Y76E)
Language	English
Publishing date	2023-06-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2584464-7
ISSN	2210-7797 ; 2210-7789
ISSN (online)	2210-7797
ISSN	2210-7789
DOI	10.1016/j.preghy.2023.06.001
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Article: In Vitro Digestion of Peanut Skin Releases Bioactive Compounds and Increases Cancer Cell Toxicity.

Cordeiro-Massironi, Karina / Soares-Freitas, Rosana Aparecida M / Sampaio, Geni Rodrigues / Pinaffi-Langley, Ana Clara da C / Bridi, Raquel / de Camargo, Adriano Costa / Torres, Elizabeth Aparecida F S

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 7

Abstract: Peanut skin is a rich source of bioactive compounds which may be able to reduce the risk factors associated with metabolic syndromes. This study aimed to characterize bio-compounds from peanut skin ( ...

Abstract	Peanut skin is a rich source of bioactive compounds which may be able to reduce the risk factors associated with metabolic syndromes. This study aimed to characterize bio-compounds from peanut skin (
Language	English
Publishing date	2023-06-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12071356
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Article: Coronavirus disease 2019 pandemic and identifying insufflators with desufflation mode and surgical smoke evacuators for safe CO2 removal

da Costa, Karina M / Saxena, Amulya K

Asian j. endosc. surg

Abstract: INTRODUCTION: Given the propensity of severe acute respiratory syndrome coronavirus 2 to spread, it is imperative that those continuing to perform surgery take precautions to limit the potential generation of contaminated aerosols in smoke from energy- ... ...

Abstract	INTRODUCTION: Given the propensity of severe acute respiratory syndrome coronavirus 2 to spread, it is imperative that those continuing to perform surgery take precautions to limit the potential generation of contaminated aerosols in smoke from energy-based instruments. The aim of this study was to report current data regarding insufflators with desufflation mode and similar options to safely remove CO2 in minimal access surgery. METHODS: A non-systematic review of the scientific literature was conducted using the PubMed database, and the main companies that provide surgical devices were contacted for information. RESULTS: Most commercially available smoke evacuators use a combination of suction and mechanical filtering. There are also electrostatic precipitators that charge surgical smoke and retain the particles via electrostatic attraction. The search identified three insufflators with desufflation mode, four modular smoke evacuators using mechanical filtration, and only one device using electrostatic precipitation. However, none of these devices has been tested with viruses. CONCLUSION: This review identified commercially available equipment that employs mechanical filtering and electrostatic attraction principles that can be used for pneumoperitoneum evacuation during the present coronavirus disease 2019 pandemic. This pandemic should assist in raising awareness regarding protection measures and the risk of occupational exposure in surgery.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #679583
Database	COVID19

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Article ; Online: Boosting Titanium Surfaces with Positive Charges: Newly Developed Cationic Coating Combines Anticorrosive and Bactericidal Properties for Implant Application.

Silva, João Pedro Dos S / Costa, Raphael C / Nagay, Bruna E / Borges, Maria H R / Sacramento, Catharina M / da Cruz, Nilson C / Rangel, Elidiane C / Fortulan, Carlos A / da Silva, José H D / Ruiz, Karina G S / Barão, Valentim A R

ACS biomaterials science & engineering

2023 Volume 9, Issue 9, Page(s) 5389–5404

Abstract: Along with poor implant-bone integration, peri-implant diseases are the major causes of implant failure. Although such diseases are primarily triggered by biofilm accumulation, a complex inflammatory process in response to corrosive-related metallic ions/ ...

Abstract	Along with poor implant-bone integration, peri-implant diseases are the major causes of implant failure. Although such diseases are primarily triggered by biofilm accumulation, a complex inflammatory process in response to corrosive-related metallic ions/debris has also been recognized as a risk factor. In this regard, by boosting the titanium (Ti) surface with silane-based positive charges, cationic coatings have gained increasing attention due to their ability to kill pathogens and may be favorable for corrosion resistance. Nevertheless, the development of a cationic coating that combines such properties in addition to having a favorable topography for implant osseointegration is lacking. Because introducing hydroxyl (-OH) groups to Ti is essential to increase chemical bonds with silane, Ti pretreatment is of utmost importance to achieve such polarization. In this study, plasma electrolytic oxidation (PEO) was investigated as a new route to pretreat Ti with OH groups while providing favorable properties for implant application compared with traditional hydrothermal treatment (HT). To produce bactericidal and corrosion-resistant cationic coatings, after pretreatment with PEO or HT (Step 1), surface silanization was subsequently performed via immersion-based functionalization with 3-aminopropyltriethoxysilane (APTES) (Step 2). In the end, five groups were assessed: untreated Ti (Ti), HT, PEO, HT+APTES, and PEO+APTES. PEO created a porous surface with increased roughness and better mechanical and tribological properties compared with HT and Ti. The introduction of -OH groups by HT and PEO was confirmed by Fourier transform infrared spectroscopy and the increase in wettability producing superhydrophilic surfaces. After silanization, the surfaces were polarized to hydrophobic ones, and an increase in the amine functional group was observed by X-ray photoelectron spectroscopy, demonstrating a considerable amount of positive ions. Such protonation may explain the enhanced corrosion resistance and dead bacteria (
MeSH term(s)	Surface Properties ; Titanium/pharmacology ; Titanium/chemistry ; Silanes ; Cations
Chemical Substances	Titanium (D1JT611TNE) ; amino-propyl-triethoxysilane (L8S6UBW552) ; Silanes ; Cations
Language	English
Publishing date	2023-08-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.3c00491
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Article ; Online: Effects of a cardiopulmonary rehabilitation protocol on functional capacity, dyspnea, fatigue, and body composition in individuals with post-COVID-19 syndrome: A randomized controlled trial.

Gomes Dos Santos, Ewerton Graziane / Vieira da Costa, Karina / Cordeiro de Souza, Iara Tainá / Victor Dos Santos Felix, João / Furtado Brandão, Celso Brendo / Michelle de Souza Fernandes, Vanessa / Lugon Favero, Andressa Bomfim / Lucrécia de Aquino Gouveia, Maria / Tavares de Lima, Dyego / Heriston de Morais Lima, José / Pedrosa, Rafaela / Alves de Oliveira, Valéria Mayaly / da Cruz Santos, Amilton / Gama, Tatiana Onofre / Guedes de Brito, Geraldo Eduardo / Tenório de França, Eduardo Eriko

Physiotherapy research international : the journal for researchers and clinicians in physical therapy

2024 Volume 29, Issue 2, Page(s) e2086

Abstract: ... rehabilitation group increased the tolerance to submaximal exercise, with a difference of 100.46 m (95 ... confidence interval [CI]: 7.40-193 m) in the distance walked on the six-minute walk test, reduced dyspnea (-1.45, 95 ...

Abstract	Background and objective: Reduced functional capacity, dyspnea, fatigue, and changes in body composition are common in patients with post-COVID-19 syndrome (PCS), and cardiopulmonary rehabilitation may improve these parameters. Thus, the present study verified the effects of cardiopulmonary rehabilitation (respiratory, aerobic, and resistance muscle training) on submaximal exercise tolerance, dyspnea, fatigue, and body composition. Methods: This controlled and randomized clinical trial applied a six-week outpatient intervention protocol in individuals over 18 years old (n = 33) with a diagnosis of COVID-19 confirmed by polymerase chain reaction. These individuals were allocated to cardiopulmonary rehabilitation (n = 17) or control groups (i.e., educational lectures; n = 16). The cardiopulmonary rehabilitation group performed respiratory, aerobic, and resistance muscle training. Submaximal exercise tolerance, dyspnea, fatigue, and body composition were assessed before and after the protocol. Results: After 6 weeks, the cardiopulmonary rehabilitation group increased the tolerance to submaximal exercise, with a difference of 100.46 m (95% confidence interval [CI]: 7.40-193 m) in the distance walked on the six-minute walk test, reduced dyspnea (-1.45, 95% CI: -1.98--0.92) in the modified Medical Research Council, and increased 0.63 kg (95% CI: 0.09-1.18 kg) of muscle mass in the upper limbs compared with the control group. Conclusion: The six-week cardiopulmonary rehabilitation protocol improved functional capacity, reduced dyspnea, and increased muscle mass in the upper limbs in individuals with PCS. Thus, these results supported the protocol use in this population and encourage further studies to assess its effectiveness in a large sample.
MeSH term(s)	Humans ; Body Composition ; COVID-19 ; Dyspnea ; Exercise Tolerance/physiology ; Fatigue ; Post-Acute COVID-19 Syndrome ; Quality of Life ; Adult
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1432038-1
ISSN	1471-2865 ; 1358-2267
ISSN (online)	1471-2865
ISSN	1358-2267
DOI	10.1002/pri.2086
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