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Article ; Online: A Survey Exploring How Watch Officers Manage Effects of Sleep Restrictions during Maritime Navigation.

Giot, Claire / Lejeune, Laure / Bessot, Nicolas / Davenne, Damien

International journal of environmental research and public health

2023 Volume 20, Issue 2

Abstract: ... activities that they consider effective, which are not yet validated, (i.e., social interactions ...

Abstract	Merchant marine officers work shifted hours with a sometimes very tiring work/rest rhythm that can lead to sleep restrictions and increased sleepiness during navigation. The aim of this study is to assess the risk of sleep deprivation-related sleepiness during navigation and the factors contributing to this risk. A second objective is to evaluate the use and effectiveness of sleepiness countermeasures. An online quantitative survey of 43 questions was conducted on 183 French maritime officers. A total of 39.9% of the participants experienced at least occasionally severe sleepiness and 29% had fallen asleep during navigation. A total of 42.6% reported not being able to experience enough sleep on board. Sleep requirements were affected by time spent on board, area of activity, and watch system. Sleepiness was more common during monotonous than demanding sailing. Officers frequently use caffeine, as well as vigilance-enhancing activities that they consider effective, which are not yet validated, (i.e., social interactions). However, they are not inclined to seek replacements in case of severe sleepiness. Sleep deprivation is common among maritime officers and leads to the risk of severe sleepiness while operating the vessel, with few effective countermeasures available. Strategies used for sleep management and sleepiness prevention should focus more on sleep duration, safety culture, and improving countermeasures to sleepiness.
MeSH term(s)	Humans ; Sleep Deprivation/prevention & control ; Sleepiness ; Work Schedule Tolerance ; Sleep ; Wakefulness
Language	English
Publishing date	2023-01-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20020986
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Article ; Online: SARS-CoV-2 in carotid body.

Lambermont, Bernard / Davenne, Eric / Maclot, François / Delvenne, Philippe

Intensive care medicine

2021 Volume 47, Issue 3, Page(s) 342–343

MeSH term(s)	Adult ; COVID-19 ; Carotid Body/virology ; Humans ; Male ; Respiratory Distress Syndrome/virology ; SARS-CoV-2
Language	English
Publishing date	2021-01-22
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-021-06351-z
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Article: Coronavirus et COVID-19 : le point sur une pandémie galopante.

Davenne, E / Giot, J B / Huynen, P

Revue medicale de Liege

2020 Volume 75, Issue 4, Page(s) 218–225

Abstract: The international community is currently facing a pandemic of acute respiratory syndrome caused by a new coronavirus, SARS-CoV-2. This syndrome has been named COVID-19 for CoronaVIrus Disease 2019 by the World Health Organization. The starting point of ... ...

Title translation	Coronavirus and COVID-19 : focus on a galopping pandemic.
Abstract	The international community is currently facing a pandemic of acute respiratory syndrome caused by a new coronavirus, SARS-CoV-2. This syndrome has been named COVID-19 for CoronaVIrus Disease 2019 by the World Health Organization. The starting point of the epidemic is the city of Wuhan (China), where the virus is said to have been transmitted from animals to humans before inter-human transmission. This is the third epidemic caused by a coronavirus after those of severe acute respiratory syndrome (SARS) in 2003 and Middle East respiratory syndrome (MERS) started in 2012. COVID-19 has rapidly spread to China and is currently spreading all over the world. The infection mainly affects patients over 40 years of age and mortality is increased in the presence of comorbidities. Children are pauci- or asymptomatic. The diagnosis is most often based on the detection of the viral genome in the nasopharynx by molecular biology methods. In the absence of specific anti-viral molecules, treatment is currently mainly symptomatic. It is clear that the COVID-19 pandemic is more difficult to control than what the first data suggested. The key strategy to SARS-CoV-2 is to limit its transmission. Preventive measures are mainly based on the application of adequate hand hygiene measures and disinfection of the environment, as well as measures of social distance aimed at limiting contacts in the population and protecting populations at risk.
MeSH term(s)	Adult ; Age Factors ; Aged ; Animals ; Asymptomatic Diseases ; Betacoronavirus/genetics ; Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Child ; China/epidemiology ; Clinical Laboratory Techniques ; Coronavirus ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Hand Disinfection ; Humans ; Infection Control/methods ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Zoonoses
Keywords	covid19
Language	French
Publishing date	2020-04-16
Publishing country	Belgium
Document type	Journal Article
ZDB-ID	414001-1
ISSN	0370-629X ; 0035-3663
ISSN	0370-629X ; 0035-3663
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Zs.A 597: Show issues

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Article: [Coronavirus and COVID-19 : focus on a galopping pandemic]

Davenne, E. / Giot, J. B. / Huynen, P.

Rev Med Liege

Abstract: The international community is currently facing a pandemic of acute respiratory syndrome caused by a new coronavirus, SARS-CoV-2 This syndrome has been named COVID-19 for CoronaVIrus Disease 2019 by the World Health Organization The starting point of the ...

Abstract	The international community is currently facing a pandemic of acute respiratory syndrome caused by a new coronavirus, SARS-CoV-2 This syndrome has been named COVID-19 for CoronaVIrus Disease 2019 by the World Health Organization The starting point of the epidemic is the city of Wuhan (China), where the virus is said to have been transmitted from animals to humans before inter-human transmission This is the third epidemic caused by a coronavirus after those of severe acute respiratory syndrome (SARS) in 2003 and Middle East respiratory syndrome (MERS) started in 2012 COVID-19 has rapidly spread to China and is currently spreading all over the world The infection mainly affects patients over 40 years of age and mortality is increased in the presence of comorbidities Children are pauci- or asymptomatic The diagnosis is most often based on the detection of the viral genome in the nasopharynx by molecular biology methods In the absence of specific anti-viral molecules, treatment is currently mainly symptomatic It is clear that the COVID-19 pandemic is more difficult to control than what the first data suggested The key strategy to SARS-CoV-2 is to limit its transmission Preventive measures are mainly based on the application of adequate hand hygiene measures and disinfection of the environment, as well as measures of social distance aimed at limiting contacts in the population and protecting populations at risk
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #52031
Database	COVID19

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Article: Coronavirus et COVID-19 : le point sur une pandémie galopante./ [Coronavirus and COVID-19 : focus on a galopping pandemic]

Davenne, E / Giot, J B / Huynen, P

Rev Med Liege

Abstract	The international community is currently facing a pandemic of acute respiratory syndrome caused by a new coronavirus, SARS-CoV-2. This syndrome has been named COVID-19 for CoronaVIrus Disease 2019 by the World Health Organization. The starting point of the epidemic is the city of Wuhan (China), where the virus is said to have been transmitted from animals to humans before inter-human transmission. This is the third epidemic caused by a coronavirus after those of severe acute respiratory syndrome (SARS) in 2003 and Middle East respiratory syndrome (MERS) started in 2012. COVID-19 has rapidly spread to China and is currently spreading all over the world. The infection mainly affects patients over 40 years of age and mortality is increased in the presence of comorbidities. Children are pauci- or asymptomatic. The diagnosis is most often based on the detection of the viral genome in the nasopharynx by molecular biology methods. In the absence of specific anti-viral molecules, treatment is currently mainly symptomatic. It is clear that the COVID-19 pandemic is more difficult to control than what the first data suggested. The key strategy to SARS-CoV-2 is to limit its transmission. Preventive measures are mainly based on the application of adequate hand hygiene measures and disinfection of the environment, as well as measures of social distance aimed at limiting contacts in the population and protecting populations at risk.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32267109
Database	COVID19

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Article: Lésions pulmonaires dans la COVID-19 sévère : confrontation anatomoclinique.

Delvenne, M / de Froidmont, S / Davenne, E / Detrembleur, N / Oury, C / Delvenne, P

Revue medicale de Liege

2020 Volume 75, Issue S1, Page(s) 101–108

Abstract: We report the fatal outcome of two patients infected by SARS-CoV-2 and exhibiting severe lung lesions at the thoracic imaging and autopsic examination. We also describe the biosecurity measures to adopt when performing autopsies during the Covid-19 ... ...

Title translation	Lung lesions in severe COVID-19 : anatomoclinical confrontation.
Abstract	We report the fatal outcome of two patients infected by SARS-CoV-2 and exhibiting severe lung lesions at the thoracic imaging and autopsic examination. We also describe the biosecurity measures to adopt when performing autopsies during the Covid-19 pandemia.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Lung/diagnostic imaging ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Keywords	covid19
Language	French
Publishing date	2020-11-19
Publishing country	Belgium
Document type	Case Reports
ZDB-ID	414001-1
ISSN	0370-629X ; 0035-3663
ISSN	0370-629X ; 0035-3663
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 597: Show issues

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Article ; Online: Deoxyguanosine is a TLR7 agonist.

Davenne, Tamara / Bridgeman, Anne / Rigby, Rachel E / Rehwinkel, Jan

European journal of immunology

2019 Volume 50, Issue 1, Page(s) 56–62

Abstract: Toll-like receptor 7 (TLR7) is an innate immune sensor for single-strand RNA (ssRNA). Recent structural analysis revealed that TLR7 has an additional binding site for nucleosides such as guanosine, and is activated when both guanosine and ssRNA bind. The ...

Abstract	Toll-like receptor 7 (TLR7) is an innate immune sensor for single-strand RNA (ssRNA). Recent structural analysis revealed that TLR7 has an additional binding site for nucleosides such as guanosine, and is activated when both guanosine and ssRNA bind. The nucleoside binding site also accommodates imidazoquinoline derivatives such as R848, which activate TLR7 in the absence of ssRNA. Here, we report that deoxyguanosine (dG) triggered cytokine production in murine bone marrow derived macrophages and plasmacytoid dendritic cells, as well as in human peripheral blood mononuclear cells, including type I interferons and pro-inflammatory factors such as TNF and IL-6. This signalling activity of dG was dependent on TLR7 and its adaptor MyD88 and did not require amplification via the type I interferon receptor. dG-triggered cytokine production required endosomal maturation but did not depend on the concurrent provision of RNA. We conclude that dG induces an inflammatory response through TLR7 and propose that dG is an RNA-independent TLR7 agonist.
MeSH term(s)	Animals ; Deoxyguanosine/immunology ; Deoxyguanosine/metabolism ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Toll-Like Receptor 7/agonists
Chemical Substances	Toll-Like Receptor 7 ; Deoxyguanosine (G9481N71RO)
Language	English
Publishing date	2019-11-14
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.201948151
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Zs.A 489: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Coronavirus et COVID-19

Davenne, Eric / GIOT, Jean-Baptiste / HUYNEN, Pascale

Coronavirus et COVID-19 : le point sur une pandémie galopante. Revue Médicale de Liège, 75 .Liège, BelgiumUniversité de Liège. Revue Médicale de Liège. (2020).

le point sur une pandémie galopante. ; Coronavirus and COVID-19 : focus on a galopping pandemic.

2020

Abstract: La communauté internationale fait actuellement face à une pandémie de syndrome respiratoire aigu due à un nouveau coronavirus, le SARS-CoV-2. Ce syndrome a été nommé COVID-19 pour COronaVIrus Disease 2019 par l’Organisation Mondiale de la Santé. Le point ...

Abstract	La communauté internationale fait actuellement face à une pandémie de syndrome respiratoire aigu due à un nouveau coronavirus, le SARS-CoV-2. Ce syndrome a été nommé COVID-19 pour COronaVIrus Disease 2019 par l’Organisation Mondiale de la Santé. Le point de départ de l’épidémie est la ville de Wuhan (Chine), où le virus aurait été transmis de l’animal à l’homme préalablement à la transmission inter-humaine. Il s’agit de la 3ème épidé-mie causée par un coronavirus après celles du syndrome respiratoire aigu sévère (SARS) en 2003 et du syndrome respiratoire du Moyen-Orient (MERS) débutée en 2012. Le COVID-19 s’est rapidement propagé en Chine et se répand actuellement à travers le monde entier. L’infection touche surtout les patients de plus de 40 ans et la mortalité est accrue en présence de comorbidités. Les enfants sont, quant à eux, pauci- ou asymptomatiques. Le diagnostic repose, le plus souvent, sur la détection du génome viral au niveau du nasopharynx par des méthodes de biologie moléculaire. En l’absence de molécules anti-virales spéci-fiques, le traitement reste, à l’heure actuelle, principalement symptomatique. Force est de constater que la pandémie de COVID-19 est plus difficile à contrôler que ce que les premières données ne laissaient présager. L’élément clé face au SARS-CoV-2 est de limiter sa transmission. Les mesures de prévention reposent, principalement, sur l’application de mesures d’hygiène des mains adéquates et la désinfection de l’environnement, ainsi que sur des mesures de distance sociale visant à limiter les contacts dans la population et à protéger les populations à risque. Peer reviewed
Keywords	Coronavirus ; SARS-CoV-2 ; COVID-19 ; Human health sciences :: Immunology & infectious disease ; Sciences de la santé humaine :: Immunologie & maladie infectieuse ; covid19
Language	English
Publishing country	be
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Alterations of the axon initial segment in multiple sclerosis grey matter.

Senol, Aysegul Dilsizoglu / Pinto, Giulia / Beau, Maxime / Guillemot, Vincent / Dupree, Jeffrey L / Stadelmann, Christine / Ranft, Jonas / Lubetzki, Catherine / Davenne, Marc

Brain communications

2022 Volume 4, Issue 6, Page(s) fcac284

Abstract: ... in the cerebellum and performed analysis on the parameters known to control neuronal excitability, i.e. axon initial ...

Abstract	Grey matter damage has been established as a key contributor to disability progression in multiple sclerosis. Aside from neuronal loss and axonal transections, which predominate in cortical demyelinated lesions, synaptic alterations have been detected in both demyelinated plaques and normal-appearing grey matter, resulting in functional neuronal damage. The axon initial segment is a key element of neuronal function, responsible for action potential initiation and maintenance of neuronal polarity. Despite several reports of profound axon initial segment alterations in different pathological models, among which experimental auto-immune encephalomyelitis, whether the axon initial segment is affected in multiple sclerosis is still unknown. Using immunohistochemistry, we analysed axon initial segments from control and multiple sclerosis tissue, focusing on layer 5/6 pyramidal neurons in the neocortex and Purkinje cells in the cerebellum and performed analysis on the parameters known to control neuronal excitability, i.e. axon initial segment length and position. We found that the axon initial segment length was increased only in pyramidal neurons of inactive demyelinated lesions, compared with normal appearing grey matter tissue. In contrast, in both cell types, the axon initial segment position was altered, with an increased soma-axon initial segment gap, in both active and inactive demyelinated lesions. In addition, using a computational model, we show that this increased gap between soma and axon initial segment might increase neuronal excitability. Taken together, these results show, for the first time, changes of axon initial segments in multiple sclerosis, in active as well as inactive grey matter lesions in both neocortex and cerebellum, which might alter neuronal function.
Language	English
Publishing date	2022-11-04
Publishing country	England
Document type	Journal Article
ISSN	2632-1297
ISSN (online)	2632-1297
DOI	10.1093/braincomms/fcac284
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Article ; Online: Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGAS.

Hertzog, Jonny / Zhou, Wen / Fowler, Gerissa / Rigby, Rachel E / Bridgeman, Anne / Blest, Henry Tw / Cursi, Chiara / Chauveau, Lise / Davenne, Tamara / Warner, Benjamin E / Kinchington, Paul R / Kranzusch, Philip J / Rehwinkel, Jan

The EMBO journal

2022 Volume 41, Issue 14, Page(s) e109217

Abstract: Varicella-Zoster virus (VZV) causes chickenpox and shingles. Although the infection is associated with severe morbidity in some individuals, molecular mechanisms that determine innate immune responses remain poorly defined. We found that the cGAS/STING ... ...

Abstract	Varicella-Zoster virus (VZV) causes chickenpox and shingles. Although the infection is associated with severe morbidity in some individuals, molecular mechanisms that determine innate immune responses remain poorly defined. We found that the cGAS/STING DNA sensing pathway was required for type I interferon (IFN) induction during VZV infection and that recognition of VZV by cGAS restricted its replication. Screening of a VZV ORF expression library identified the essential VZV tegument protein ORF9 as a cGAS antagonist. Ectopically or virally expressed ORF9 bound to endogenous cGAS leading to reduced type I IFN responses to transfected DNA. Confocal microscopy revealed co-localisation of cGAS and ORF9. ORF9 and cGAS also interacted directly in a cell-free system and phase-separated together with DNA. Furthermore, ORF9 inhibited cGAMP production by cGAS. Taken together, these results reveal the importance of the cGAS/STING DNA sensing pathway for VZV recognition and identify a VZV immune antagonist that partially but directly interferes with DNA sensing via cGAS.
MeSH term(s)	DNA/metabolism ; Herpesvirus 3, Human/genetics ; Herpesvirus 3, Human/immunology ; Humans ; Immunity, Innate ; Interferon Type I/immunology ; Membrane Proteins/immunology ; Nucleotidyltransferases/antagonists & inhibitors ; Nucleotidyltransferases/immunology ; Viral Proteins/immunology
Chemical Substances	Interferon Type I ; Membrane Proteins ; STING1 protein, human ; Viral Proteins ; DNA (9007-49-2) ; Nucleotidyltransferases (EC 2.7.7.-) ; cGAS protein, human (EC 2.7.7.-)
Language	English
Publishing date	2022-06-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.15252/embj.2021109217
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