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Article ; Online: Jie Geng Tang reverses cisplatin resistance through the Nrf2 pathway in lung cancer.

Zhao, Jing / Hou, Manting / Ding, Kaixin / Li, Shixiong / Li, Hui / Zhang, Xili / Bai, Zhaofang / Liu, Wenlong

The Journal of pharmacy and pharmacology

2023 Volume 75, Issue 6, Page(s) 784–805

Abstract: Objectives: Jie Geng Tang (JGT) is an ancient traditional Chinese herbal decoction that exhibits ...

Abstract	Objectives: Jie Geng Tang (JGT) is an ancient traditional Chinese herbal decoction that exhibits various pharmacological activities, however, is poorly understood in the sensitivity of lung cancer to chemotherapy. Here, we explored the effect of JGT on sensitizing cisplatin (DDP)-resistant A549 cells (A549/DDP). Methods: Cell viability was assessed using cell counting kit-8 assay. Flow cytometry was applied to detected cell apoptosis, mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) levels. Western blotting and qRT-PCR were performed to determine protein and mRNA levels. Key findings: The results demonstrated that DDP co-treatment with JGT significantly increased the cytotoxicity of A549/DDP cells and exhibited efficacy in suppressing the migration and proliferation. The rate of apoptosis was increased by co-treatment with DDP and JGT, along with a higher rate of Bax/Bcl-2, and increased loss of MMP. Furthermore, the combination promoted ROS accumulation and increased γ-H2AX levels. Moreover, Nrf2 levels were suppressed in a dose- and time-dependent manner, Nrf2 stability was reduced following treatment with JGT. Notably, the combination induced inhibition of the Nrf2/ARE pathway at the mRNA and protein levels. Conclusions: Collectively, these results indicate that co-treatment with JGT and DDP can be considered a combinational approach to treating DDP resistance.
MeSH term(s)	Humans ; Cisplatin/pharmacology ; NF-E2-Related Factor 2/metabolism ; Reactive Oxygen Species/metabolism ; Drug Resistance, Neoplasm ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Apoptosis ; Cell Proliferation ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor
Chemical Substances	Cisplatin (Q20Q21Q62J) ; NF-E2-Related Factor 2 ; Reactive Oxygen Species ; Antineoplastic Agents
Language	English
Publishing date	2023-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	3107-0
ISSN	2042-7158 ; 0022-3573 ; 0373-1022
ISSN (online)	2042-7158
ISSN	0022-3573 ; 0373-1022
DOI	10.1093/jpp/rgad018
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Article ; Online: Pedigree genome data of an early-matured Geng/japonica glutinous rice mega variety Longgeng 57.

Lei, Yuanbao / Zhang, Yunjiang / Xu, Linyun / Ma, Wendong / Zhou, Ziqi / Li, Jie / Quan, Pengyu / Faruquee, Muhiuddin / Yang, Dechen / Zhang, Fan / Zhou, Yongli / Quan, Guangjun / Zhao, Xiuqin / Wang, Wensheng / Liu, Bailong / Li, Zhikang / Xu, Jianlong / Zheng, Tianqing

Scientific data

2024 Volume 11, Issue 1, Page(s) 230

Abstract: ... a set of annotation data for an early-matured Geng/japonica glutinous rice mega variety genome, Longgeng ...

Abstract	By using PacBio HiFi technology, we produced over 700 Gb of long-read sequencing (LRS) raw data; and by using Illumina paired-end whole-genome shotgun (WGS) sequencing technology, we generated more than 70 Gb of short-read sequencing (SRS) data. With LRS data, we assembled one genome and then generate a set of annotation data for an early-matured Geng/japonica glutinous rice mega variety genome, Longgeng 57 (LG57), which carries multiple elite traits including good grain quality and wide adaptability. Together with the SRS data from three parents of LG57, pedigree genome variations were called for three representative types of genes. These data sets can be used for deep variation mining, aid in the discovery of new insights into genome structure, function, and evolution, and help to provide essential support to biological research in general.
MeSH term(s)	Oryza/genetics ; Phenotype ; Sequence Analysis, DNA ; Whole Genome Sequencing ; Genome, Plant
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-024-03057-x
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Article ; Online: Non-targeted metabolomics strategy reveals the role of Geng-Nian-Shu in regulating ferroptosis in perimenopausal syndrome.

Lv, Xinyan / Bi, Anqi / Zhang, Zhan / Li, Jinyan / Wei, Yingbo / Wan, Meiqi / Wang, Jinyu / Yan, Tingxu / Jia, Ying

Journal of pharmaceutical and biomedical analysis

2024 Volume 241, Page(s) 115980

Abstract: ... have shown that Geng-Nian-Shu (GNS) plays an important regulatory role in perimenopausal syndrome (PMS ...

Abstract	Ovariectomy (OVX) is usually accompanied by the occurrence of metabolic syndrome. Previous studies have shown that Geng-Nian-Shu (GNS) plays an important regulatory role in perimenopausal syndrome (PMS) rats. GNS is a traditional Chinese medicine (TCM) prescription which composed of Suanzaoren Decoction and Ganmai Dazao Decoction in "Jingui Yaolue" and Siwu Decoction in "Heji Jufang". Recently, metabolomics analysis has been used to identify slight changes in the metabolic profile and to help understand disease progression and therapeutic interventions in PMS. However, the mechanism of GNS in the treatment of PMS is still unknown. We purposed to study the metabolic characteristics of PMS by serum and fecal metabolomics, and revealed the internal mechanism of GNS regulating ferroptosis against PMS. The PMS model was established by surgical removal of 4/5 ovaries of rats. HPLC-Q-TOF/MS was used to analyze the metabolomics of rat plasma and feces to explore the potential mechanism of GNS in PMS. The expression of ferroptosis-related proteins in rat ovaries was detected by tissue Prussian blue staining, Elisa kit and Western blotting. Cluster analysis of differential metabolites in plasma and feces between the control group and the model group showed that organic acids and their derivatives, lipids and lipid molecules were mainly disturbed during PMS in rats. After GNS administration, 17 differential metabolites were adjusted, involving several major pathways, such as the tricarboxylic acid (TCA) cycle, biosynthesis of amino acids and biosynthesis of unsaturated fatty acids. Further, we found that GNS affected ferroptosis in ovarian cells by regulating endogenous substances in OVX rats. Our study provides new insights into the mechanism of OVX-induced metabolic syndrome based on non-targeted metabolomics. It provides new ideas for the development and application of GNS and the diagnosis and treatment of PMS.
MeSH term(s)	Female ; Rats ; Animals ; Metabolic Syndrome ; Ferroptosis ; Perimenopause ; Metabolomics ; Metabolome ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2024.115980
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Article ; Online: Evaluating traditional Chinese medicine (TCM) Jie Geng and Huang Qi combination on reducing surgical site infections in colorectal cancer surgeries: A systematic review and meta-analysis.

Chen, Shiwang / Tian, Xudong / Li, Shengcai / Wu, Zhengquan / Li, Yanlong / Liao, Ting / Liao, Zhifeng

International wound journal

2024 Volume 21, Issue 2, Page(s) e14769

Abstract: ... evaluated the efficacy of the traditional Chinese medicine (TCM) combination of Jie Geng and Huang Qi ... 95% CI: 0.16 to 0.36, p < 0.01). These findings suggest that Jie Geng and Huang Qi in TCM could be ...

Abstract	Postoperative wound infections (PWIs) pose a significant challenge in colorectal cancer surgeries, leading to prolonged hospital stays and increased morbidity. This systematic review and meta-analysis evaluated the efficacy of the traditional Chinese medicine (TCM) combination of Jie Geng and Huang Qi in reducing PWIs following colorectal cancer surgeries. Adhering to PRISMA guidelines, we focused on seven randomized controlled trials (RCTs) involving 1256 patients, examining the incidence of PWIs within 30 days post-surgery, alongside secondary outcomes such as length of hospital stay and antibiotic use. The analysis revealed a significant reduction in PWI incidence in the TCM-treated group compared to controls, with a Risk Ratio of 0.21 (95% CI: 0.14 to 0.30, p < 0.01), a notable decrease in hospital stay (Mean Difference: 1.2 days, 95% CI: 0.15 to 1.28 days, p < 0.01) and a significant reduction in antibiotic use (Risk Ratio: 0.24, 95% CI: 0.16 to 0.36, p < 0.01). These findings suggest that Jie Geng and Huang Qi in TCM could be an effective adjunct in postoperative care for colorectal cancer surgeries, underscoring the need for further high-quality RCTs to substantiate these results and explore the underlying mechanisms.
MeSH term(s)	Humans ; Medicine, Chinese Traditional ; Surgical Wound Infection/prevention & control ; Drugs, Chinese Herbal/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Colorectal Neoplasms/surgery ; Astragalus propinquus
Chemical Substances	Huang Qi (922OP8YUPF) ; Drugs, Chinese Herbal ; Anti-Bacterial Agents
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.14769
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Article ; Online: Cold-adaptive evolution at the reproductive stage in Geng/japonica subspecies reveals the role of OsMAPK3 and OsLEA9.

Lou, Qijin / Guo, Haifeng / Li, Jin / Han, Shichen / Khan, Najeeb Ullah / Gu, Yunsong / Zhao, Weitong / Zhang, Zhanying / Zhang, Hongliang / Li, Zichao / Li, Jinjie

The Plant journal : for cell and molecular biology

2022 Volume 111, Issue 4, Page(s) 1032–1051

Abstract: ... of rice. The Geng/japonica subpopulation gradually developed stronger cold adaptation than the Xian/indica ... alleles underlying the cold adaptability of intra-Geng subspecies remain largely unknown. Here ... as two important regulators for the cold adaptation of Geng subspecies from a combination ...

Abstract	Cold stress at the reproductive stage severely affects the production and geographic distribution of rice. The Geng/japonica subpopulation gradually developed stronger cold adaptation than the Xian/indica subpopulation during the long-term domestication of cultivated rice. However, the evolutionary path and natural alleles underlying the cold adaptability of intra-Geng subspecies remain largely unknown. Here, we identified MITOGEN-ACTIVATED PROTEIN KINASE 3 (OsMAPK3) and LATE EMBRYOGENESIS ABUNDANT PROTEIN 9 (OsLEA9) as two important regulators for the cold adaptation of Geng subspecies from a combination of transcriptome analysis and genome-wide association study. Transgenic validation showed that OsMAPK3 and OsLEA9 confer cold tolerance at the reproductive stage. Selection and evolution analysis suggested that the Geng version of OsMAPK3 (OsMAPK3
MeSH term(s)	Adaptation, Physiological/genetics ; Cold Temperature ; Genome-Wide Association Study ; Oryza/metabolism ; Plant Breeding
Language	English
Publishing date	2022-06-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1088037-9
ISSN	1365-313X ; 0960-7412
ISSN (online)	1365-313X
ISSN	0960-7412
DOI	10.1111/tpj.15870
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Article ; Online: Genomic insights on the contribution of introgressions from Xian/Indica to the genetic improvement of Geng/Japonica rice cultivars.

Cui, Di / Zhou, Han / Ma, Xiaoding / Lin, Zechuan / Sun, Linhua / Han, Bing / Li, Maomao / Sun, Jianchang / Liu, Jin / Jin, Guixiu / Wang, Xianju / Cao, Guilan / Deng, Xing Wang / He, Hang / Han, Longzhi

Plant communications

2022 Volume 3, Issue 3, Page(s) 100325

Abstract: Hybridization between Xian/indica (XI) and Geng/japonica (GJ) rice combined with utilization ...

Abstract	Hybridization between Xian/indica (XI) and Geng/japonica (GJ) rice combined with utilization of plant ideotypes has greatly contributed to yield improvements in modern GJ rice in China over the past 50 years. To explore the genomic basis of improved yield and disease resistance in GJ rice, we conducted a large-scale genomic landscape analysis of 816 elite GJ cultivars representing multiple eras of germplasm from China. We detected consistently increasing introgressions from three XI subpopulations into GJ cultivars since the 1980s and found that the XI genome introgressions significantly increased the grain number per panicle (GN) and decreased the panicle number per plant. This contributed to the improvement of plant type during modern breeding, changing multi-tiller plants to moderate tiller plants with a large panicle size and increasing the blast resistance. Notably, we found that key gene haplotypes controlling plant architecture, yield components, and pest and disease resistance, including IPA1, SMG1, DEP3, Pib, Pi-d2, and Bph3, were introduced from XI rice by introgression. By GWAS analysis, we detected a GN-related gene Gnd5, which had been consistently introgressed from XI into GJ cultivars since the 1980s. Gnd5 is a GRAS transcription factor gene, and Gnd5 knockout mutants showed a significant reduction in GN. The estimated genetic effects of genes varied among different breeding locations, which explained the distinct introgression levels of XI gene haplotypes, including Gnd5, DEP3, etc., to these GJ breeding pedigrees. These findings reveal the genomic contributions of introgressions from XI to the trait improvements of GJ rice cultivars and provide new insights for future rice genomic breeding.
MeSH term(s)	Alleles ; Disease Resistance/genetics ; Genomics ; Oryza/genetics ; Plant Breeding
Language	English
Publishing date	2022-04-13
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2590-3462
ISSN (online)	2590-3462
DOI	10.1016/j.xplc.2022.100325
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Article ; Online: Time-ordering japonica/geng genomes analysis indicates the importance of large structural variants in rice breeding.

Wang, Yu / Li, Fengcheng / Zhang, Fan / Wu, Lian / Xu, Na / Sun, Qi / Chen, Hao / Yu, Zhiwen / Lu, Jiahao / Jiang, Kai / Wang, Xiaoche / Wen, Siyu / Zhou, Yao / Zhao, Hui / Jiang, Qian / Wang, Jiahong / Jia, Ruizong / Sun, Jian / Tang, Liang /

Xu, Hai / Hu, Wei / Xu, Zhengjin / Chen, Wenfu / Guo, Anping / Xu, Quan

Plant biotechnology journal

2022 Volume 21, Issue 1, Page(s) 202–218

Abstract: Temperate japonica/geng (GJ) rice yield has significantly improved due to intensive breeding ...

Abstract	Temperate japonica/geng (GJ) rice yield has significantly improved due to intensive breeding efforts, dramatically enhancing global food security. However, little is known about the underlying genomic structural variations (SVs) responsible for this improvement. We compared 58 long-read assemblies comprising cultivated and wild rice species in the present study, revealing 156 319 SVs. The phylogenomic analysis based on the SV dataset detected the putatively selected region of GJ sub-populations. A significant portion of the detected SVs overlapped with genic regions were found to influence the expression of involved genes inside GJ assemblies. Integrating the SVs and causal genetic variants underlying agronomic traits into the analysis enables the precise identification of breeding signatures resulting from complex breeding histories aimed at stress tolerance, yield potential and quality improvement. Further, the results demonstrated genomic and genetic evidence that the SV in the promoter of LTG1 is accounting for chilling sensitivity, and the increased copy numbers of GNP1 were associated with positive effects on grain number. In summary, the current study provides genomic resources for retracing the properties of SVs-shaped agronomic traits during previous breeding procedures, which will assist future genetic, genomic and breeding research on rice.
MeSH term(s)	Oryza/genetics ; Plant Breeding ; Genomics/methods ; Phenotype ; Edible Grain
Language	English
Publishing date	2022-10-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2136367-5
ISSN	1467-7652 ; 1467-7652
ISSN (online)	1467-7652
ISSN	1467-7652
DOI	10.1111/pbi.13938
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Article ; Online: Genetic Dissection of Salt Tolerance and Yield Traits of Geng ( japonica ) Rice by Selective Subspecific Introgression

Simin Li / Ting Feng / Chenyang Zhang / Fanlin Zhang / Hua Li / Yanjun Chen / Lunping Liang / Chaopu Zhang / Wei Zeng / Erbao Liu / Yingyao Shi / Min Li / Lijun Meng

Current Issues in Molecular Biology, Vol 45, Iss 305, Pp 4796-

2023 Volume 4813

Abstract: ... from inter-subspecific crosses between an elite Geng ( japonica ) recipient and four Xian ( indica ) donors ... Thirty-four are Xian-Geng differentiated ones with the donor ( Xian ) alleles associated with ST ... genetic variation for developing superior Geng varieties with improved ST and YP, which could be efficiently ...

Abstract	Salinity is a major factor limiting rice productivity, and developing salt-tolerant (ST) varieties is the most efficient approach. Seventy-eight ST introgression lines (ILs), including nine promising lines with improved ST and yield potential (YP), were developed from four BC 2 F 4 populations from inter-subspecific crosses between an elite Geng ( japonica ) recipient and four Xian ( indica ) donors at the Institute of Crop Sciences, Chinese Academy of Agricultural Sciences. Genome-wide characterization of donor introgression identified 35 ST QTLs, 25 of which harbor 38 cloned ST genes as the most likely QTL candidates. Thirty-four are Xian-Geng differentiated ones with the donor ( Xian ) alleles associated with ST, suggesting differentiated responses to salt stress were one of the major phenotypic differences between the two subspecies. At least eight ST QTLs and many others affecting yield traits were identified under salt/non-stress conditions. Our results indicated that the Xian gene pool contains rich ‘hidden’ genetic variation for developing superior Geng varieties with improved ST and YP, which could be efficiently exploited by selective introgression. The developed ST ILs and their genetic information on the donor alleles for ST and yield traits would provide a useful platform for developing superior ST and high-yield Geng varieties through breeding by design in the future.
Keywords	salt tolerance ; selection ; correlated phenotypic responses ; QTL clusters ; rice ; Biology (General) ; QH301-705.5
Subject code	580
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Time‐ordering japonica/geng genomes analysis indicates the importance of large structural variants in rice breeding

Xu, Hai / Hu, Wei / Xu, Zhengjin / Chen, Wenfu / Guo, Anping / Xu, Quan

Plant Biotechnology Journal. 2023 Jan., v. 21, no. 1 p.202-218

2023

Abstract: Temperate japonica/geng (GJ) rice yield has significantly improved due to intensive breeding ...

Abstract	Temperate japonica/geng (GJ) rice yield has significantly improved due to intensive breeding efforts, dramatically enhancing global food security. However, little is known about the underlying genomic structural variations (SVs) responsible for this improvement. We compared 58 long‐read assemblies comprising cultivated and wild rice species in the present study, revealing 156 319 SVs. The phylogenomic analysis based on the SV dataset detected the putatively selected region of GJ sub‐populations. A significant portion of the detected SVs overlapped with genic regions were found to influence the expression of involved genes inside GJ assemblies. Integrating the SVs and causal genetic variants underlying agronomic traits into the analysis enables the precise identification of breeding signatures resulting from complex breeding histories aimed at stress tolerance, yield potential and quality improvement. Further, the results demonstrated genomic and genetic evidence that the SV in the promoter of LTG1 is accounting for chilling sensitivity, and the increased copy numbers of GNP1 were associated with positive effects on grain number. In summary, the current study provides genomic resources for retracing the properties of SVs‐shaped agronomic traits during previous breeding procedures, which will assist future genetic, genomic and breeding research on rice.
Keywords	biotechnology ; data collection ; food security ; genome ; genomics ; stress tolerance ; wild rice
Language	English
Dates of publication	2023-01
Size	p. 202-218.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2136367-5
ISSN	1467-7652 ; 1467-7644
ISSN (online)	1467-7652
ISSN	1467-7644
DOI	10.1111/pbi.13938
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Article: Cold‐adaptive evolution at the reproductive stage in Geng/japonica subspecies reveals the role of OsMAPK3 and OsLEA9

Lou, Qijin / Guo, Haifeng / Li, Jin / Han, Shichen / Khan, Najeeb Ullah / Gu, Yunsong / Zhao, Weitong / Zhang, Zhanying / Zhang, Hongliang / Li, Zichao / Li, Jinjie

plant journal. 2022 Aug., v. 111, no. 4

2022

Abstract: ... of rice. The Geng/japonica subpopulation gradually developed stronger cold adaptation than the Xian/indica ... alleles underlying the cold adaptability of intra‐Geng subspecies remain largely unknown. Here ... as two important regulators for the cold adaptation of Geng subspecies from a combination ...

Abstract	Cold stress at the reproductive stage severely affects the production and geographic distribution of rice. The Geng/japonica subpopulation gradually developed stronger cold adaptation than the Xian/indica subpopulation during the long‐term domestication of cultivated rice. However, the evolutionary path and natural alleles underlying the cold adaptability of intra‐Geng subspecies remain largely unknown. Here, we identified MITOGEN‐ACTIVATED PROTEIN KINASE 3 (OsMAPK3) and LATE EMBRYOGENESIS ABUNDANT PROTEIN 9 (OsLEA9) as two important regulators for the cold adaptation of Geng subspecies from a combination of transcriptome analysis and genome‐wide association study. Transgenic validation showed that OsMAPK3 and OsLEA9 confer cold tolerance at the reproductive stage. Selection and evolution analysis suggested that the Geng version of OsMAPK3 (OsMAPK3ᴳᵉⁿᵍ) directly evolved from Chinese Oryza rufipogon III and was largely retained in high‐latitude and high‐altitude regions with low temperatures during domestication. Later, the functional nucleotide polymorphism (FNP‐776) in the Kunmingxiaobaigu and Lijiangxiaoheigu version of the OsLEA9 (OsLEA9ᴷᴸ) promoter originated from novel variation of intra‐Geng was selected and predominantly retained in temperate Geng to improve the adaptation of Geng together with OsMAPK3ᴳᵉⁿᵍ to colder climatic conditions in high‐latitude areas. Breeding potential analysis suggested that pyramiding of OsMAPK3ᴳᵉⁿᵍ and OsLEA9ᴷᴸ enhanced the cold tolerance of Geng and promotes the expansion of cultivated rice to colder regions. This study not only highlights the evolutionary path taken by the cold‐adaptive differentiation of intra‐Geng, but also provides new genetic resources for rice molecular breeding in low‐temperature areas.
Keywords	Oryza rufipogon ; altitude ; cold ; cold stress ; cold tolerance ; domestication ; evolution ; genetically modified organisms ; genome-wide association study ; geographical distribution ; latitude ; mitogen-activated protein kinase ; proteins ; rice ; transcriptomics ; China
Language	English
Dates of publication	2022-08
Size	p. 1032-1051.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1088037-9
ISSN	1365-313X ; 0960-7412
ISSN (online)	1365-313X
ISSN	0960-7412
DOI	10.1111/tpj.15870
Database	NAL-Catalogue (AGRICOLA)

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