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Article ; Online: Efficacy and safety of carbohydrate restriction in patients with type 1 diabetes: A systematic review and meta-analysis.

Stamati, Athina / Sotiriou, Georgia / Karagiannis, Thomas / Christoforidis, Athanasios

2023 Volume 25, Issue 9, Page(s) 2770–2773

MeSH term(s)	Humans ; Diabetes Mellitus, Type 1 ; Diabetes Mellitus, Type 2 ; Diet, Carbohydrate-Restricted/adverse effects ; Carbohydrates
Chemical Substances	Carbohydrates
Language	English
Publishing date	2023-05-18
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.15124
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Zs.A 5442: Show issues

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Article ; Online: Reply to comment on: Glucose levels before the onset of asparaginase predicts transient hyperglycemia in children with acute lymphoblastic leukemia.

Christoforidis, Athanasios

Pediatric blood & cancer

2017 Volume 64, Issue 12

MeSH term(s)	Acute Disease ; Asparaginase ; Child ; Glucose ; Humans ; Hyperglycemia ; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Chemical Substances	Asparaginase (EC 3.5.1.1) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2017-07-11
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.26705
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Zs.A 1131: Show issues

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Article ; Online: Efficacy and safety of faster aspart in insulin pumps in children and adolescents with type 1 diabetes mellitus: A single-center study with real-world data.

Stamati, Athina / Sotiriou, Georgia / Dimitriadou, Meropi / Christoforidis, Athanasios

Journal of diabetes and its complications

2023 Volume 37, Issue 9, Page(s) 108587

Abstract: Aims: To assess the efficacy and safety of faster aspart (FIAsp) in paediatric population with type 1 diabetes mellitus (T1DM) and insulin pumps in real-world settings.: Methods: Of 44 patients, 20 used FIAsp, 16 of which switched from aspart to ... ...

Abstract	Aims: To assess the efficacy and safety of faster aspart (FIAsp) in paediatric population with type 1 diabetes mellitus (T1DM) and insulin pumps in real-world settings. Methods: Of 44 patients, 20 used FIAsp, 16 of which switched from aspart to FIAsp and 24 used aspart/lispro. We performed within-groups and between-groups analyses in three time points for anthropometric data, % of 24-h time in range of 70-180 mg/dl (TIR), time < 70 mg/dl and <54 mg/dl and time > 180 mg/dl and >250 mg/dl, bolus and basal insulins doses (units/kg/day and %), total daily dose (TDD, units/kg/day), glycaemic variability, frequency of set changes, sensor wear per week and meals per day. Results: Use of FIAsp over time increased TIR (P = 0.002) and TDD (P = 0.008 and P = 0.004, respectively for three months after the switch and recent use) and decreased time in hyperglycaemia (>180 P = 0.003 and > 250 mg/dl, P = 0.004). Frequency of set changes differ in the first 3 months (P = 0.042). Patients with FIAsp consumed more meals per day compared to those with aspart/lispro (P = 0.032). Conclusion: Real-world data confirm that use of FIAsp in insulin pumps in paediatric populations improves glycaemic control long-term.
MeSH term(s)	Humans ; Adolescent ; Child ; Insulin/adverse effects ; Diabetes Mellitus, Type 1/drug therapy ; Insulin Lispro ; Insulin, Regular, Human ; Hyperglycemia/prevention & control
Chemical Substances	Insulin ; Insulin Lispro ; Insulin, Regular, Human
Language	English
Publishing date	2023-08-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1105840-7
ISSN	1873-460X ; 1056-8727
ISSN (online)	1873-460X
ISSN	1056-8727
DOI	10.1016/j.jdiacomp.2023.108587
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Zs.A 2225: Show issues

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Article ; Online: Retrospective Evaluation of Oral Glucose Tolerance Test (OGTT) in Young Patients with Transfusion-Dependent Beta-Thalassemia.

Dritsa, Maria / Economou, Marina / Perifanis, Vasilios / Teli, Aikaterini / Christoforidis, Athanasios

Acta haematologica

2022

Language	English
Publishing date	2022-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	80008-9
ISSN	1421-9662 ; 0001-5792
ISSN (online)	1421-9662
ISSN	0001-5792
DOI	10.1159/000523874
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Ud II Zs.145: Show issues

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Article ; Online: The impact of COVID-19 vaccination on glycaemic control in children and adolescents with type 1 diabetes mellitus on continuous glucose monitoring.

Gouda, Niki / Dimitriadou, Meropi / Sotiriou, Georgia / Christoforidis, Athanasios

Acta diabetologica

2022 Volume 59, Issue 12, Page(s) 1609–1614

Abstract: Aims: To investigate the impact of SARS-COV-2 vaccination on the glycaemic control in children and adolescents with T1DM wearing continuous glucose monitoring (CGM).: Methods: Caregivers of children and adolescents with T1DM were questioned regarding ...

Abstract	Aims: To investigate the impact of SARS-COV-2 vaccination on the glycaemic control in children and adolescents with T1DM wearing continuous glucose monitoring (CGM). Methods: Caregivers of children and adolescents with T1DM were questioned regarding SARS-CoV-2 vaccination during their regular visits at the Pediatric Diabetes Outpatient Clinic. Data regarding Time in Range (TIR) (glucose levels: 70-180 mg/dl) 7 days prior and 7 days after a vaccination dose were collected in patients wearing CGM and data regarding insulin daily doses were also obtained for the insulin pump users. Results: From a total of 135 patients eligible for SARS-CoV-2 vaccination, 70 (51.9%) children (37 boys, 52.9%) were vaccinated with at least one dose. Seven patients received only one dose, whereas two children received a third booster shot. No statistically significant difference was observed in either TIR (64.19% post vs. 65.53% pre, p = 0.158) or total daily insulin dose (40.08 U/day post vs. 39.32 U/day pre, p = 0,282). Additionally, in ten patients on Hybrid Closed-Loop System the percentage of the automated insulin boluses given post-vaccination was not statistically significant different compared to the boluses given pre-vaccination (15.80% vs. 16.90%, p = 0,491). Conclusions: Vaccination against SARS-CoV-2 in children and adolescents with T1DM is safe and is not associated with immediate glucose imbalance.
MeSH term(s)	Male ; Adolescent ; Humans ; Child ; Diabetes Mellitus, Type 1/drug therapy ; Blood Glucose Self-Monitoring ; COVID-19 Vaccines ; Blood Glucose ; Glycemic Control ; COVID-19/prevention & control ; Hypoglycemic Agents/therapeutic use ; SARS-CoV-2 ; Insulin
Chemical Substances	COVID-19 Vaccines ; Blood Glucose ; Hypoglycemic Agents ; Insulin
Language	English
Publishing date	2022-09-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1097676-0
ISSN	1432-5233 ; 0940-5429
ISSN (online)	1432-5233
ISSN	0940-5429
DOI	10.1007/s00592-022-01968-y
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Zs.A 611: Show issues

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Article ; Online: Efficacy and safety of ultra-rapid insulin analogues in insulin pumps in patients with Type 1 Diabetes Mellitus: A systematic review and meta-analysis.

Stamati, Athina / Karagiannis, Thomas / Tsapas, Apostolos / Christoforidis, Athanasios

Diabetes research and clinical practice

2022 Volume 193, Page(s) 110144

Abstract: Aims: To assess the efficacy and safety of ultra-rapid insulin analogues used with continuous subcutaneous insulin infusion systems (CSII) in adults with type 1 diabetes (T1DM).: Methods: We searched MEDLINE and Cochrane Library up to May 2022 for ... ...

Abstract	Aims: To assess the efficacy and safety of ultra-rapid insulin analogues used with continuous subcutaneous insulin infusion systems (CSII) in adults with type 1 diabetes (T1DM). Methods: We searched MEDLINE and Cochrane Library up to May 2022 for randomized controlled trials comparing ultra-rapid with rapid-acting insulin analogues (RAIAs) used with CSII. We performed random effects meta-analyses for % of 24-h time in range of 70-180 mg/dl (TIR), time in hypoglycaemia (<70 mg/dl) and hyperglycaemia (>180 mg/dl), 1- and 2-hour post-prandial glucose [PPG] increment after a meal test, HbA1c and average insulin dose at endpoint, unplanned infusion set changes and severe hypoglycaemia. Results: Nine studies (1,156 participants) were included. Ultra-rapid insulins were superior to RAIAs on TIR (mean difference [MD] 1.1 %, 95 % CI 0.11-2.11), time spent in hypoglycaemia (MD -0.47 %, 95 % CI -0.63 to -30), and 1- and 2-hour PPG (MD -12.20 mg/dl, 95 % CI -19.85 to -4.54 and MD -17.61 mg/dl, 95 % CI -28.55 to -6.66, respectively). Ultra-rapid insulins increased odds of unplanned infusion set changes (odds ratio 1.60, 95 % CI 1.26-2.03). Conclusion: Ultra-rapid acting insulins provided better PPG control compared to RAIAs but their use might result in more infusion set changes.
MeSH term(s)	Adult ; Humans ; Insulin/adverse effects ; Diabetes Mellitus, Type 1/drug therapy ; Hypoglycemic Agents/adverse effects ; Hypoglycemia/chemically induced ; Hypoglycemia/prevention & control ; Insulin, Regular, Human ; Insulin, Short-Acting
Chemical Substances	Insulin ; Hypoglycemic Agents ; Insulin, Regular, Human ; Insulin, Short-Acting
Language	English
Publishing date	2022-11-06
Publishing country	Ireland
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2022.110144
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Zs.A 2047: Show issues

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Article ; Online: The association of serum vitamin D concentrations in paediatric migraine.

Ioannidou, Evangelia / Tsakiris, Charalampos / Goulis, Dimitrios G / Christoforidis, Athanasios / Zafeiriou, Dimitrios

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

2023 Volume 47, Page(s) 60–66

Abstract: Introduction: Migraine is a neurologic condition characterized by hypersensitivity to auditory, olfactory, visual, and cutaneous stimuli; vomiting and nausea; and severe headache. It is the most frequent headache syndrome in children and can be ... ...

Abstract	Introduction: Migraine is a neurologic condition characterized by hypersensitivity to auditory, olfactory, visual, and cutaneous stimuli; vomiting and nausea; and severe headache. It is the most frequent headache syndrome in children and can be categorized in chronic and/or episodic. Multiple dietary supplements have been inaugurated for the management of migraine, the most prevalent of which is vitamin D. Background: In recent years, vitamin D deficiency has been a global public health problem, with 30-80% of the worldwide population having vitamin D deficiency. The significant role of vitamin D in neurological disorders is underlined by its key role in the brain function of the central nervous system (CNS). Current approaches in paediatric neurology include nonsteroidal anti-inflammatory drugs (NSAID) for the treatment of paediatric migraine, among others. Vitamin D is one of the dietary factors that has been linked to migraine, however, this association has mostly been examined in the adult population. Objective: The aim of this study is to investigate the association between serum vitamin D and paediatric migraine by conducting a review of existing literature. The main question is described with the PICO format (population, intervention, control, and outcomes), while the assessment of the present research is under the PRISMA guidelines for systematic reviews. Results/conclusion: A systematic review of the literature reveals a remarkable association between vitamin D and migraine presentation in the paediatric population, affecting the frequency and duration of the episodes. That being the case, vitamin D supplementation could potentially improve the quality of life of paediatric patients suffering from migraine headaches.
MeSH term(s)	Adult ; Humans ; Child ; Vitamin D ; Quality of Life ; Migraine Disorders/drug therapy ; Migraine Disorders/epidemiology ; Headache ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2023-09-16
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1397146-3
ISSN	1532-2130 ; 1090-3798
ISSN (online)	1532-2130
ISSN	1090-3798
DOI	10.1016/j.ejpn.2023.09.007
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Zs.A 4867: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The efficacy of automated insulin delivery systems in children and adolescents with type 1 diabetes Mellitus: A systematic review and meta-analysis of randomized controlled trials.

Michou, Panagiota / Gkiourtzis, Nikolaos / Christoforidis, Athanasios / Kotanidou, Eleni P / Galli-Tsinopoulou, Asimina

Diabetes research and clinical practice

2023 Volume 199, Page(s) 110678

Abstract: Aims: Insulin administration is the treatment of choice for people with type 1 diabetes mellitus (T1D). Technological advances have led to the development of automated insulin delivery (AID) systems, aiming to optimize the quality of life of patients ... ...

Abstract	Aims: Insulin administration is the treatment of choice for people with type 1 diabetes mellitus (T1D). Technological advances have led to the development of automated insulin delivery (AID) systems, aiming to optimize the quality of life of patients with T1D. We present a systematic review and meta-analysis of the current literature about the efficacy of AID systems in children and adolescents with T1D. Methods: We conducted a systematic literature search for randomized controlled trials (RCTs) until August 8th, 2022, investigating the efficacy of AID systems in the management of patients < 21 years of age with T1D. A priori subgroup and sensitivity analyses based on different settings (free-living settings, type of AID system, parallel group or crossover design) were also conducted. Results: In total, 26 RCTs reporting a total of 915 children and adolescents with T1D were included in the meta-analysis. AID systems revealed statistically significant differences in the main outcomes, such as the proportion of time in the target glucose range (3.9-10 mmol/L) (p < 0.00001), in hypoglycemia (<3.9 mmol/L) (p = 0.003) and mean proportion of HbA1C (p = 0.0007) compared to control group. Conclusions: According to the present meta-analysis, AID systems are superior to insulin pump therapy, sensor-augmented pumps and multiple daily insulin injections. Most of the included studies have a high risk of bias because of allocation, blinding of patients and blinding of assessment. Our sensitivity analyses showed that patients < 21 years of age with T1D can use AID systems, after proper education, following their daily activities. Further RCTs examining the effect of AID systems on nocturnal hypoglycemia, under free-living settings and studies examining the effect of dual-hormone AID systems are pending.
MeSH term(s)	Child ; Adolescent ; Humans ; Diabetes Mellitus, Type 1/drug therapy ; Randomized Controlled Trials as Topic ; Hypoglycemia ; Insulin/therapeutic use ; Blood Glucose ; Insulin Infusion Systems ; Hypoglycemic Agents/therapeutic use
Chemical Substances	Insulin ; Blood Glucose ; Hypoglycemic Agents
Language	English
Publishing date	2023-04-23
Publishing country	Ireland
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2023.110678
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Article: Update on the Crosstalk Between Adipose Tissue and Mineral Balance in General Population and Chronic Kidney Disease.

Karava, Vasiliki / Christoforidis, Athanasios / Kondou, Antonia / Dotis, John / Printza, Nikoleta

Frontiers in pediatrics

2021 Volume 9, Page(s) 696942

Abstract: Adipose tissue is nowadays considered as a major endocrine organ, which apart from controlling lipid metabolism, displays a significant role in energy expenditure, food intake and in the regulation of various systemic physiological processes. Adipose ... ...

Abstract	Adipose tissue is nowadays considered as a major endocrine organ, which apart from controlling lipid metabolism, displays a significant role in energy expenditure, food intake and in the regulation of various systemic physiological processes. Adipose derived pro-inflammatory cytokines and adipokines, particularly leptin and adiponectin, provide inter-communication of adipose tissue with various metabolic pathways, ultimately resulting in a complex network of interconnected organ systems. Recent clinical and experimental research has been focused on exploring the direct interaction between adipokine profile and elements of mineral metabolism, including parathormone (PTH), fibroblast growth factor-23 (FGF23) and calcitriol. The emerging crosstalk between adipose tissue and calcium and phosphorus homeostasis suggests that metabolic disorders from one system may directly affect the other and
Language	English
Publishing date	2021-08-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2021.696942
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Article ; Online: Muscle-bone axis in children with chronic kidney disease: current knowledge and future perspectives.

Karava, Vasiliki / Dotis, John / Christoforidis, Athanasios / Kondou, Antonia / Printza, Nikoleta

Pediatric nephrology (Berlin, Germany)

2021 Volume 36, Issue 12, Page(s) 3813–3827

Abstract: Bone and muscle tissue are developed hand-in-hand during childhood and adolescence and interact through mechanical loads and biochemical pathways forming the musculoskeletal system. Chronic kidney disease (CKD) is widely considered as both a bone and ... ...

Abstract	Bone and muscle tissue are developed hand-in-hand during childhood and adolescence and interact through mechanical loads and biochemical pathways forming the musculoskeletal system. Chronic kidney disease (CKD) is widely considered as both a bone and muscle-weakening disease, eventually leading to frailty phenotype, with detrimental effects on overall morbidity. CKD also interferes in the biomechanical communication between two tissues. Pathogenetic mechanisms including systemic inflammation, anorexia, physical inactivity, vitamin D deficiency and secondary hyperparathyroidism, metabolic acidosis, impaired growth hormone/insulin growth factor 1 axis, insulin resistance, and activation of renin-angiotensin system are incriminated for longitudinal uncoordinated loss of bone mineral content, bone strength, muscle mass, and muscle strength, leading to mechanical impairment of the functional muscle-bone unit. At the same time, CKD may also interfere in the biochemical crosstalk between the two organs, through inhibiting or stimulating the expression of certain osteokines and myokines. This review focuses on presenting current knowledge, according to in vitro, in vivo, and clinical studies, concerning the pathogenetic pathways involved in the muscle-bone axis, and suggests approaches aimed at preventing bone loss and muscle wasting in the pediatric population. Novel therapeutic targets for preserving musculoskeletal health in the context of CKD are also discussed.
MeSH term(s)	Bone Diseases, Metabolic ; Bone and Bones/physiopathology ; Child ; Humans ; Muscles/physiopathology ; Renal Insufficiency, Chronic ; Vitamin D Deficiency
Language	English
Publishing date	2021-02-03
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-021-04936-w
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