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  1. Book ; Online ; E-Book: Smashing the core surgical training interview

    Joseph, Anokha O. / Joseph, Janso P.

    a holistic guide to becoming a surgeon

    2023  

    Abstract: Smashing Core Surgical Training Interviews is a crucial roadmap through the highly competitive world of surgery, written by previous Core Surgical Training National Recruitment panel members. It provides a realistic understanding of what is expected on ... ...

    Author's details edited by Anokha O. Joseph and Janso P. Joseph
    Abstract Smashing Core Surgical Training Interviews is a crucial roadmap through the highly competitive world of surgery, written by previous Core Surgical Training National Recruitment panel members. It provides a realistic understanding of what is expected on interview day and how best to prepare for it.
    Keywords Surgery ; Surgery, Operative ; United Kingdom
    Subject code 617.0071
    Language English
    Dates of publication 2023-2024
    Size 1 online resource (258 pages)
    Publisher CRC Press
    Publishing place Boca Raton, FL
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-335042-9 ; 1-003-35042-9 ; 1-000-92565-X ; 9781032395913 ; 978-1-00-335042-2 ; 978-1-003-35042-2 ; 978-1-000-92565-4 ; 1032395915
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Laparoscopic versus open surgery: aerosols and their implications for surgery during the COVID-19 pandemic.

    Joseph, Janso P / Joseph, Anokha O / Oomman, Susmita / Jayanthi, Naga V G

    European surgery : ACA : Acta chirurgica Austriaca

    2020  Volume 52, Issue 4, Page(s) 188–189

    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 2073941-2
    ISSN 1682-4016 ; 1682-8631 ; 1682-1769
    ISSN (online) 1682-4016
    ISSN 1682-8631 ; 1682-1769
    DOI 10.1007/s10353-020-00644-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 535: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Coronavirus outbreak: Reorganising the breast unit during a pandemic.

    Joseph, Anokha O / Joseph, Janso P / Pereira, Bernadette / Gahir, Jasdeep

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2020  Volume 46, Issue 6, Page(s) 1176–1177

    MeSH term(s) Betacoronavirus ; Breast Diseases/epidemiology ; Breast Diseases/therapy ; COVID-19 ; Comorbidity ; Coronavirus Infections/epidemiology ; Disease Management ; Disease Outbreaks/statistics & numerical data ; Female ; Hospitals, Special/organization & administration ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; United Kingdom/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-04-21
    Publishing country England
    Document type Letter
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2020.04.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1149: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 549: Show issues

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  4. Article: Laparoscopic versus open surgery: aerosols and their implications for surgery during the COVID-19 pandemic

    Joseph, Janso P / Joseph, Anokha O / Oomman, Susmita / Jayanthi, Naga V G

    Eur Surg

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #592451
    Database COVID19

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  6. Article ; Online: Laparoscopic versus open surgery

    Joseph, Janso P. / Joseph, Anokha O. / Oomman, Susmita / Jayanthi, Naga V. G.

    European Surgery

    aerosols and their implications for surgery during the COVID-19 pandemic

    2020  Volume 52, Issue 4, Page(s) 188–189

    Keywords Surgery ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2073941-2
    ISSN 1682-4016 ; 1682-8631 ; 1682-1769
    ISSN (online) 1682-4016
    ISSN 1682-8631 ; 1682-1769
    DOI 10.1007/s10353-020-00644-1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 535: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: COVID-19 Pandemic—Medical Education Adaptations

    Joseph, Janso P. / Joseph, Anokha O. / Conn, Gemma / Ahsan, Enamul / Jackson, Ruth / Kinnear, John

    the Power of Students, Staff and Technology

    2020  

    Abstract: The coronavirus pandemic has profoundly changed the way medical education is delivered globally. Our group reports an insight into the adaptations and innovations made by the School of Medicine at Anglia Ruskin University. ...

    Abstract The coronavirus pandemic has profoundly changed the way medical education is delivered globally. Our group reports an insight into the adaptations and innovations made by the School of Medicine at Anglia Ruskin University.
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publisher Springer
    Publishing country uk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody-Drug Conjugates.

    Ratnayake, Anokha S / Chang, Li-Ping / Tumey, L Nathan / Loganzo, Frank / Chemler, Joseph A / Wagenaar, Melissa / Musto, Sylvia / Li, Fengping / Janso, Jeffrey E / Ballard, T Eric / Rago, Brian / Steele, Greg L / Ding, WeiDong / Feng, Xidong / Hosselet, Christine / Buklan, Vlad / Lucas, Judy / Koehn, Frank E / O'Donnell, Christopher J /
    Graziani, Edmund I

    Bioconjugate chemistry

    2018  Volume 30, Issue 1, Page(s) 200–209

    Abstract: A potent class of DNA-damaging agents, natural product bis-intercalator depsipeptides (NPBIDs), was evaluated as ultrapotent payloads for use in antibody-drug conjugates (ADCs). Detailed investigation of potency (both in cells and via biophysical ... ...

    Abstract A potent class of DNA-damaging agents, natural product bis-intercalator depsipeptides (NPBIDs), was evaluated as ultrapotent payloads for use in antibody-drug conjugates (ADCs). Detailed investigation of potency (both in cells and via biophysical characterization of DNA binding), chemical tractability, and in vitro and in vivo stability of the compounds in this class eliminated a number of potential candidates, greatly reducing the complexity and resources required for conjugate preparation and evaluation. This effort yielded a potent, stable, and efficacious ADC, PF-06888667, consisting of the bis-intercalator, SW-163D, conjugated via an N-acetyl-lysine-valine-citrulline- p-aminobenzyl alcohol- N, N-dimethylethylenediamine (AcLysValCit-PABC-DMAE) linker to an engineered variant of the anti-Her2 mAb, trastuzumab, catalyzed by transglutaminase.
    MeSH term(s) Animals ; Antineoplastic Agents, Immunological/chemistry ; Biological Products/chemistry ; Cell Line, Tumor ; DNA/chemistry ; Depsipeptides/blood ; Depsipeptides/chemistry ; Depsipeptides/pharmacokinetics ; Echinomycin/chemistry ; Genes, erbB-2 ; Half-Life ; Heterografts ; Humans ; Immunoconjugates/chemistry ; Intercalating Agents/chemistry ; Mice ; Trastuzumab/chemistry
    Chemical Substances Antineoplastic Agents, Immunological ; Biological Products ; Depsipeptides ; Immunoconjugates ; Intercalating Agents ; Echinomycin (512-64-1) ; DNA (9007-49-2) ; Trastuzumab (P188ANX8CK)
    Language English
    Publishing date 2018-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.8b00843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3400: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Optimization of Tubulysin Antibody-Drug Conjugates: A Case Study in Addressing ADC Metabolism.

    Tumey, L Nathan / Leverett, Carolyn A / Vetelino, Beth / Li, Fengping / Rago, Brian / Han, Xiaogang / Loganzo, Frank / Musto, Sylvia / Bai, Guoyun / Sukuru, Sai Chetan K / Graziani, Edmund I / Puthenveetil, Sujiet / Casavant, Jeffrey / Ratnayake, Anokha / Marquette, Kimberly / Hudson, Sarah / Doppalapudi, Venkata Ramana / Stock, Joseph / Tchistiakova, Lioudmila /
    Bessire, Andrew J / Clark, Tracey / Lucas, Judy / Hosselet, Christine / O'Donnell, Christopher J / Subramanyam, Chakrapani

    ACS medicinal chemistry letters

    2016  Volume 7, Issue 11, Page(s) 977–982

    Abstract: As part of our efforts to develop new classes of tubulin inhibitor payloads for antibody-drug conjugate (ADC) programs, we developed a tubulysin ADC that demonstrated excellent in vitro activity but suffered from rapid metabolism of a critical acetate ... ...

    Abstract As part of our efforts to develop new classes of tubulin inhibitor payloads for antibody-drug conjugate (ADC) programs, we developed a tubulysin ADC that demonstrated excellent in vitro activity but suffered from rapid metabolism of a critical acetate ester. A two-pronged strategy was employed to address this metabolism. First, the hydrolytically labile ester was replaced by a carbamate functional group resulting in a more stable ADC that retained potency in cellular assays. Second, site-specific conjugation was employed in order to design ADCs with reduced metabolic liabilities. Using the later approach, we were able to identify a conjugate at the 334C position of the heavy chain that resulted in an ADC with considerably reduced metabolism and improved efficacy. The examples discussed herein provide one of the clearest demonstrations to-date that site of conjugation can play a critical role in addressing metabolic and PK liabilities of an ADC. Moreover, a clear correlation was identified between the hydrophobicity of an ADC and its susceptibility to metabolic enzymes. Importantly, this study demonstrates that traditional medicinal chemistry strategies can be effectively applied to ADC programs.
    Language English
    Publishing date 2016-06-22
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.6b00195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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