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  1. Book: Diagnostik viraler Hepatitiden

    Schüttler, Christian G. / Slanina, Heiko / Gärtner, Barbara / Huzly, Daniela / Modrow, Susanne

    (MiQ ; 25)

    2020  

    Institution Expertengremium Mikrobiologisch-Infektiologische Qualitätsstandards
    Author's details Christian G. Schüttler, Heiko Slanina, Barbara Gärtner, Daniela Huzly, Susanne Modrow ; Expertengremium Mikrobiolgisch-Infektiologische Qualitätsstandards (MiQ) der Deutschen Gesellschaft für Hygiene und Mikrobiologie (DGHM)
    Series title MiQ ; 25
    Collection
    Keywords Viruserkrankungen ; Diagnostik ; Analytik ; Leber ; Virushepatitis ; Mikrobiologische Diagnostik ; Qualitätssicherung
    Subject Beschaffenheitssicherung ; Unternehmen
    Subject code 610
    Language German
    Size VIII, 85 Seiten
    Edition 2. vollständig überarbeitete Auflage
    Publisher Elsevier
    Publishing place München
    Publishing country Germany
    Document type Book
    Note 1. Auflage unter dem Titel: Diagnostik von Infektionen der Leber
    Old title Vorangegangen ist
    HBZ-ID HT020557345
    ISBN 978-3-437-41538-8 ; 3-437-41538-7 ; 9783437180194 ; 3437180193
    Database Catalogue ZB MED Medicine, Health

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    2020 A 1188 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Conserved Characteristics of NMPylation Activities of Alpha- and Betacoronavirus NiRAN Domains.

    Slanina, Heiko / Madhugiri, Ramakanth / Wenk, Kai / Reinke, Tess / Schultheiß, Karin / Schultheis, Julia / Karl, Nadja / Linne, Uwe / Ziebuhr, John

    Journal of virology

    2023  Volume 97, Issue 6, Page(s) e0046523

    Abstract: Coronavirus genome replication and expression are mediated by the viral replication-transcription complex (RTC) which is assembled from multiple nonstructural proteins (nsp). Among these, nsp12 represents the central functional subunit. It harbors the ... ...

    Abstract Coronavirus genome replication and expression are mediated by the viral replication-transcription complex (RTC) which is assembled from multiple nonstructural proteins (nsp). Among these, nsp12 represents the central functional subunit. It harbors the RNA-directed RNA polymerase (RdRp) domain and contains, at its N terminus, an additional domain called NiRAN which is widely conserved in coronaviruses and other nidoviruses. In this study, we produced bacterially expressed coronavirus nsp12s to investigate and compare NiRAN-mediated NMPylation activities from representative alpha- and betacoronaviruses. We found that the four coronavirus NiRAN domains characterized to date have a number of conserved properties, including (i) robust nsp9-specific NMPylation activities that appear to operate largely independently of the C-terminal RdRp domain, (ii) nucleotide substrate preference for UTP followed by ATP and other nucleotides, (iii) dependence on divalent metal ions, with Mn
    MeSH term(s) Humans ; Nucleotides/metabolism ; RNA, Viral/metabolism ; RNA-Dependent RNA Polymerase/genetics ; RNA-Dependent RNA Polymerase/metabolism ; SARS-CoV-2/enzymology ; Viral Nonstructural Proteins/metabolism ; Coronaviridae/enzymology ; Coronaviridae/genetics ; Protein Domains/physiology ; Viral Proteins/metabolism ; Conserved Sequence ; Protein Structure, Secondary/genetics ; Vero Cells
    Chemical Substances Nucleotides ; RNA, Viral ; RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; Viral Nonstructural Proteins ; Viral Proteins
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00465-23
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  3. Article ; Online: 10 Jahre Nationales Referenzzentrum für Hepatitis-B-Viren und Hepatitis-D-Viren in Gießen: Tätigkeiten und Erfahrungen.

    Glebe, Dieter / Lehmann, Felix / Goldmann, Nora / Giese, Annika / Hida, Yassine / Gerlich, Wolfram H / Ziebuhr, John / Slanina, Heiko / Schüttler, Christian G

    Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz

    2022  Volume 65, Issue 2, Page(s) 220–227

    Abstract: The National Reference Center (NRC) for hepatitis B viruses (HBV) and hepatitis D viruses (HDV) has been located at the Institute of Medical Virology of the Justus Liebig University (JLU) in Giessen, Germany, since its establishment in 2011. This paper ... ...

    Title translation Ten years of the National Reference Center for hepatitis B viruses and hepatitis D viruses in Giessen, Germany: activities and experiences.
    Abstract The National Reference Center (NRC) for hepatitis B viruses (HBV) and hepatitis D viruses (HDV) has been located at the Institute of Medical Virology of the Justus Liebig University (JLU) in Giessen, Germany, since its establishment in 2011. This paper describes the NRC's areas of activity and related experience.The NRC offers comprehensive consulting services on all diagnostic and clinical aspects of acute and chronic HBV and HDV infections for the Public Health Service (ÖGD), diagnostic laboratories, clinics, research institutes, and physicians in private practice. Uncertain diagnostic findings can be analyzed and interpreted and epidemiological correlations clarified with the HBV/HDV special diagnostics established at the NRC using state-of-the-art molecular, biochemical, and genetic laboratory tools. The NRC has access to a strain collection of many well-characterized and cloned HBV/HDV isolates, allowing comparative analysis and evaluation of antiviral resistance mutations and immune escape variants. Together with its national and international partner institutions, the NRC initiates and supervises, among other things, interlaboratory studies for the diagnosis of HBV resistance and immune escape for the establishment and validation of international World Health Organization (WHO) standards and for the improvement of quantitative HDV genome determination. The NRC actively participates in current recommendations and guidelines on HBV and HDV and the recommendations of medical societies. It also highlights current HBV/HDV-relevant aspects with contributions in the form of national and international lectures as well as original articles and comments in national and international journals.
    MeSH term(s) Germany ; Hepatitis B/diagnosis ; Hepatitis B/epidemiology ; Hepatitis B virus ; Hepatitis D/diagnosis ; Hepatitis D/epidemiology ; Hepatitis Delta Virus/genetics ; Humans
    Language German
    Publishing date 2022-01-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1461973-8
    ISSN 1437-1588 ; 1436-9990
    ISSN (online) 1437-1588
    ISSN 1436-9990
    DOI 10.1007/s00103-021-03479-7
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  4. Article ; Online: A Novel Insertion in the Hepatitis B Virus Surface Protein Leading to Hyperglycosylation Causes Diagnostic and Immune Escape.

    Lehmann, Felix / Slanina, Heiko / Roderfeld, Martin / Roeb, Elke / Trebicka, Jonel / Ziebuhr, John / Gerlich, Wolfram H / Schüttler, Christian G / Schlevogt, Bernhard / Glebe, Dieter

    Viruses

    2023  Volume 15, Issue 4

    Abstract: Chronic hepatitis B virus (HBV) infection is a global health threat. Mutations in the surface antigen of HBV (HBsAg) may alter its antigenicity, infectivity, and transmissibility. A patient positive for HBV DNA and detectable but low-level HBsAg in ... ...

    Abstract Chronic hepatitis B virus (HBV) infection is a global health threat. Mutations in the surface antigen of HBV (HBsAg) may alter its antigenicity, infectivity, and transmissibility. A patient positive for HBV DNA and detectable but low-level HBsAg in parallel with anti-HBs suggested the presence of immune and/or diagnostic escape variants. To support this hypothesis, serum-derived HBs gene sequences were amplified and cloned for sequencing, which revealed infection with exclusively non-wildtype HBV subgenotype (sgt) D3. Three distinct mutations in the antigenic loop of HBsAg that caused additional N-glycosylation were found in the variant sequences, including a previously undescribed six-nucleotide insertion. Cellular and secreted HBsAg was analyzed for N-glycosylation in Western blot after expression in human hepatoma cells. Secreted HBsAg was also subjected to four widely used, state-of-the-art diagnostic assays, which all failed to detect the hyperglycosylated insertion variant. Additionally, the recognition of mutant HBsAg by vaccine- and natural infection-induced anti-HBs antibodies was severely impaired. Taken together, these data suggest that the novel six-nucleotide insertion as well as two other previously described mutations causing hyperglycosylation in combination with immune escape mutations have a critical impact on in vitro diagnostics and likely increase the risk of breakthrough infection by evasion of vaccine-induced immunity.
    MeSH term(s) Humans ; Hepatitis B virus/genetics ; Hepatitis B Surface Antigens/genetics ; Hepatitis B, Chronic ; Hepatitis B Antibodies ; Hepatitis B Vaccines ; Mutation ; Immunologic Factors ; Nucleotides ; Membrane Proteins/genetics ; Hepatitis B
    Chemical Substances Hepatitis B Surface Antigens ; Hepatitis B Antibodies ; Hepatitis B Vaccines ; Immunologic Factors ; Nucleotides ; Membrane Proteins
    Language English
    Publishing date 2023-03-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15040838
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  5. Article ; Online: Coronavirus replication-transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit.

    Slanina, Heiko / Madhugiri, Ramakanth / Bylapudi, Ganesh / Schultheiß, Karin / Karl, Nadja / Gulyaeva, Anastasia / Gorbalenya, Alexander E / Linne, Uwe / Ziebuhr, John

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 6

    Abstract: RNA-dependent RNA polymerases (RdRps) of ... ...

    Abstract RNA-dependent RNA polymerases (RdRps) of the
    MeSH term(s) Amino Acid Sequence ; Amino Acid Substitution ; Asparagine/genetics ; Cell Line ; Conserved Sequence ; Coronavirus 229E, Human/genetics ; Coronavirus 229E, Human/physiology ; Coronavirus RNA-Dependent RNA Polymerase/genetics ; Coronavirus RNA-Dependent RNA Polymerase/metabolism ; Humans ; Manganese/metabolism ; Protein Domains ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; SARS-CoV-2/genetics ; Transcription, Genetic ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism ; Virus Replication
    Chemical Substances NSP9 protein, SARS-CoV-2 ; RNA-Binding Proteins ; Recombinant Proteins ; Viral Nonstructural Proteins ; Manganese (42Z2K6ZL8P) ; Asparagine (7006-34-0) ; Coronavirus RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; NSP12 protein, SARS-CoV-2 (EC 2.7.7.48)
    Language English
    Publishing date 2021-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2022310118
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  6. Article ; Online: Humoral and cellular immune responses to the mRNA-1273 SARS-CoV-2 vaccine booster in patients on maintenance dialysis.

    Karakizlis, Hristos / Agarwal, Vipul / Aly, Mostafa / Strecker, Kevin / Csala, Benjamin / Esso, Isla / Chen, Jiangping / Nahrgang, Christian / Wolter, Martin / Slanina, Heiko / Schüttler, Christian G / Jessen, Sönke / Ronco, Claudio / Seeger, Werner / Weimer, Rolf / Sester, Martina / Birk, Horst-Walter / Husain-Syed, Faeq

    Journal of nephrology

    2022  Volume 36, Issue 1, Page(s) 183–186

    MeSH term(s) Humans ; Renal Dialysis ; 2019-nCoV Vaccine mRNA-1273 ; COVID-19 Vaccines ; COVID-19/prevention & control ; SARS-CoV-2 ; Immunity, Cellular ; Immunity, Humoral
    Chemical Substances 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; COVID-19 Vaccines
    Language English
    Publishing date 2022-06-22
    Publishing country Italy
    Document type Letter
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-022-01371-4
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  7. Article ; Online: Data on immunogenicity and reactogenicity to COVID-19 vaccination among patients receiving maintenance dialysis.

    Karakizlis, Hristos / Nahrgang, Christian / Strecker, Kevin / Chen, Jiangping / Aly, Mostafa / Slanina, Heiko / Schüttler, Christian G / Esso, Isla / Wolter, Martin / Todorova, Darina / Jessen, Sönke / Adamik, Andrea / Ronco, Claudio / Seeger, Werner / Weimer, Rolf / Sester, Martina / Birk, Horst-Walter / Husain-Syed, Faeq

    Data in brief

    2022  Volume 42, Page(s) 108271

    Abstract: Compared with the general population, patients receiving maintenance dialysis are at increased risk for morbidity and mortality associated with coronavirus disease 2019 (COVID-19). Currently, data on severe acute respiratory syndrome coronavirus type 2 ( ... ...

    Abstract Compared with the general population, patients receiving maintenance dialysis are at increased risk for morbidity and mortality associated with coronavirus disease 2019 (COVID-19). Currently, data on severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2)-specific immunity post-vaccination in patients on maintenance dialysis are scarce given that the effectiveness of the vaccines has not been explicitly tested in this population due to their common exclusion from SARS-CoV-2 vaccination trials. We herein present data of the specific cellular (interferon-γ and interleukin-2 ELISpot assays) and humoral immune responses (dot plot array and chemiluminescent microparticle immunoassay) at 4 weeks and 6 weeks following a single dose or a complete homologous dual dose SARS-CoV-2 vaccine regimen in 60 adult patients on maintenance dialysis (six with a history of COVID-19). The data was produced in a framework of a project focused on a) quantifying the immune response after full vaccination, b) evaluating the short-term durability of immune response, and c) examining the reactogenicity of SARS-CoV-2 vaccine regimens in patients on maintenance dialysis.
    Language English
    Publishing date 2022-05-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409 ; 2352-3409
    ISSN (online) 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2022.108271
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  8. Article ; Online: Immunogenicity and reactogenicity of homologous mRNA-based and vector-based SARS-CoV-2 vaccine regimens in patients receiving maintenance dialysis.

    Karakizlis, Hristos / Nahrgang, Christian / Strecker, Kevin / Chen, Jiangping / Aly, Mostafa / Slanina, Heiko / Schüttler, Christian G / Esso, Isla / Wolter, Martin / Todorova, Darina / Jessen, Sönke / Adamik, Andrea / Ronco, Claudio / Seeger, Werner / Weimer, Rolf / Sester, Martina / Birk, Horst-Walter / Husain-Syed, Faeq

    Clinical immunology (Orlando, Fla.)

    2022  Volume 236, Page(s) 108961

    Abstract: Patients receiving maintenance dialysis (MD) are vulnerable to COVID-19-related morbidity and mortality. Currently, data on SARS-CoV-2-specific cellular and humoral immunity post-vaccination in this population are scarce. We conducted a prospective ... ...

    Abstract Patients receiving maintenance dialysis (MD) are vulnerable to COVID-19-related morbidity and mortality. Currently, data on SARS-CoV-2-specific cellular and humoral immunity post-vaccination in this population are scarce. We conducted a prospective single-center study exploring the specific cellular (interferon-γ and interleukin-2 ELISpot assays) and humoral immune responses (dot plot array and chemiluminescent microparticle immunoassay [CMIA]) at 4 weeks and 6 weeks following a single dose or a complete homologous dual dose SARS-CoV-2 vaccine regimen in 60 MD patients (six with a history of COVID-19). Our results show that MD patients exhibit a high seroconversion rate (91.7%) but the anti-spike IgG antibodies (CMIA) tend to wane rapidly after full immunization. Only 51.7% of the patients developed T cell immune response. High anti-spike IgG antibodies may predict a better cellular immunity. While patients with prior COVID-19 showed the best response after one, SARS-CoV-2-naïve patients may benefit from a third vaccine injection.
    MeSH term(s) Antibodies, Viral ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Immunity, Humoral ; Prospective Studies ; RNA, Messenger ; Renal Dialysis ; SARS-CoV-2
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; RNA, Messenger ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2022.108961
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  9. Article ; Online: Schorf nach Aufenthalt im Wald.

    Slanina, Heiko / Schüttler, Christian G / König, Matthias / Mayser, Peter

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2015  Volume 13, Issue 10, Page(s) 1045–1047

    Title translation Eschar after a journey to the forest.
    MeSH term(s) Animals ; Arm ; Cats ; Cowpox/pathology ; Cowpox/transmission ; Diagnosis, Differential ; Female ; Forests ; Humans ; Skin Diseases, Viral/pathology ; Skin Diseases, Viral/virology ; Travel ; Young Adult
    Language German
    Publishing date 2015-10
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.130_12661
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  10. Article ; Online: Eschar after a journey to the forest.

    Slanina, Heiko / Schüttler, Christian G / König, Matthias / Mayser, Peter

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2015  Volume 13, Issue 10, Page(s) 1045–1047

    MeSH term(s) Animals ; Arm ; Cats ; Cowpox/pathology ; Cowpox/transmission ; Diagnosis, Differential ; Female ; Forests ; Humans ; Skin Diseases, Viral/pathology ; Skin Diseases, Viral/virology ; Travel ; Young Adult
    Language English
    Publishing date 2015-10
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.12661
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